• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5685-5689
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• 2014

Background: It is well known that smoking is a preventable factor for all-cause mortality; however, it is still questionable how many years after smoking cessation that people will have reduced risk for mortality, in particular in those with a high interest in their own health. We aimed to examine the association between time since quitting smoking and total mortality among past-smokers relative to current smokers. Materials and Methods: We enrolled 36,446 health examinees that voluntarily taken with diverse health check-up packages of high cost burden in 1995-2003 and followed them till death by 2004. The history of cigarette smoking consumption was collected using a self-administrative questionnaire at the first visit time. Mortality risk by smoking cessation years was analyzed using Cox's proportional hazard model. Results: Compared to non-smokers, male smokers over 15 pack-years had higher risk for total mortality (HR=1.60, 95%CI 1.23-2.14). The mortality risk in female smokers with same pack-years was more pronounced than that in male smokers (HR=2.83, 95%CI 1.17-7.04) despite a small number of cases. Compared to current smokers, a decrease of total mortality was observed among those who ceased smoking, and inverse dose-response was found with years after cessation: RR 0.98 (95%CI, 0.64-1.41) (<2 yrs), 0.60 (95%CI, 0.43-0.83) (3-9 yrs), and 0.58 (95%CI, 0.43-0.79) (${\geq}10$ yrs). Conclusions: A reduced risk of total mortality was observed after 3 years of smoking cessation. Our findings suggest that at least 3 years of smoking cessation may contribute to reduce premature mortality among Asian men.

• 대한한의진단학회지
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• 제12권1호
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• pp.103-130
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• 2008

Background: For standardizing of Han-Yeol [寒熱], which is a kind of diagnosis method in oriental medicine, it is necessary to investigate into relationship of symptoms and signs representative of Han-Yeol [寒熱] to the biofunctional medical signals; thermal temperature by Thermography, Pulse-Respiration Ratio and so on. By correlation analysis of these data items acquired from patients, it could be provides the fundamental data for standardizing of Han-Yeol [寒熱]. Objectives: We performed this study to check the characteristics of thermal temperature with Han-Yeol [寒熱] statue by pulse-respiration ratio. Methods: We selected nine regions around acupoints including Yin dang[印堂], Sugu[水溝, GV26], Ch'ondol[天突, CV22], Chonjung[CV17], Chung-wan[中脘, CV12], Chonchu[天樞 S25], No-gung[勞官, P8], and calculated based on the utility of R.O.I.(Region of Integer) by IR-2000 these points temperature from 68 subjects. In practicing pulse-respiration ratio over 4.0 means the statues of Yeol [熱], pulse-respiration ratio below 4.0 means the statues of Han [寒]. To optimum conditions thermal temperature, which are not effected by internal and external variables, we studied preceding research. The results shows that optimal time period is 20minutes after undressed and the optimal region is the region around acupoints including Sugu [水溝, GV26]. Based on a preceding research results, we analyzed these data by Paired T-test between GV26 Region and 8-Thermography Regions and two-way repeated ANOVA with thermography$({\Delta}T)$ and Han-Yeol [寒熱] statue by pulse-respiration ratio. Results: 1. In applying of two-way repeated ANOVA with thermography$({\Delta}T)$ and Han-Yeol [寒熱] statue by pulse-respiration ratio, Sugu [水溝穴, GV26] - [印堂穴, HN1], Sugu 水溝, GV26] - Chonjung[CV17], Sugu [水溝, GV26] -Chung-wan[中脘, CV12]had significant differences. 2. In applying of Paired T-test between Sugu [水溝穴, GV26] Region and 8- Thermography Regions, there were significant differences except of Sugu [水溝穴, GV26] -Chondolp[天突, CV22]. 3. In the difference of Sugu [水溝, GV26] -Chung-wan[中脘, CV12], thermal temperature increases a lot in the statues of Yeol [熱], thermal temperature decreases a lot in the statues of Han [寒]. Conclusions: On the analysis of Thermography, we obtain the measurement conditions were considered the individual variations. And it is different that the thermal temperature change on Thermography according to Han-Yeol [寒熱] statue by pulse-respiration ratio.

• 스마트미디어저널
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• 제3권4호
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• pp.28-34
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• 2014

최근 깊이 영상 기반 합성 방법을 이용한 가상시점 합성 방법이 3차원 영상의 적용 분야에서 많이 사용되고 있다. 가상 시점 영상은 기존에 알고 있는 영상과 이와 관련된 깊이 영상 정보를 이용하여 카메라로 촬영 하지 않은 가상시점 영상을 생성하게 된다. 하지만 깊이 영상 기반 합성 방법을 이용해 가상시점 영상을 생성할 경우, 깊이 영상을 기반으로 합성하기 때문에 이미지 워핑 과정에서 폐색 영역이 발생하게 된다. 이러한 폐색 영역을 제거하기 위해 지금까지 다양한 홀 채움 방법들이 제안되어 왔다. 동일 색상영역 검색, 수평방향 보간 방법, 수평방향 보외 방법 그리고 다양한 인페인팅 방법들이 홀 채움 방법들로 제안되었다. 하지만 이러한 방법들을 사용하여 텍스쳐 영역의 홀을 제거할 경우 다른 종류의 간섭 현상이 발생하는 문제가 있다. 본 논문에서는 이러한 문제점을 해결하기 위해 다양한 방향성을 고려한 홀 채움 방법을 새롭게 제안하여 확장된 홀 영역을 효율적으로 채우는 방법을 설명한다. 제안된 방법들은 복잡한 텍스쳐들이 있는 배경부분에서 발생하는 홀 영역을 채울 때 성능 효율성을 나타낸다. 방향성을 고려한 홀 채움 방법은 픽셀 단위로 홀 채움 영역 값을 측정하는 과정에서 홀 영역의 주변 텍스쳐 픽셀 값들을 사용하게 된다. 제안한 방법을 이용해 가상시점 영상 합성 결과 발생하는 홀 영역을 기존의 홀 채움 방법보다 보다 더 효율적으로 채울 수 있는 것을 확인할 수 있었다.

• 보건행정학회지
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• 제30권2호
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• pp.185-191
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• 2020

Background: From January 2018, a policy was applied to differentially apply the co-payment for medical expenses of 15,000 won or more from 30% to 10%-30% for each medical fee. This policy lowers the burden on the medical use of the elderly, and it is necessary to analyze the effect of the policy by confirming changes in medical use and supply behavior after 2 years. Methods: The National Health Insurance Service's national medical use database was used. As for the analysis method, first, the medical use and medical supply behavior change over the age of 65 years were confirmed, and second, in order to check the net effect of the policy, the 66-year-old as the experimental group and the 63-year-old as the control group were selected as the control group. The propensity score matching was performed using the variables of age, living alone, income quartile, residence, disability, chronic disease, and co-morbid disease scores, and then it was analyzed using the difference in difference analysis method. Results: The share of the number of treatments under 15,000 won decreased from 37.0% in 2017 to 20.2% in 2018, while the share of the number of treatments under 15,001-20,000 won increased from 8.0% to 22.7%. It was confirmed that the reason for the increase in the cost of treatment per treatment was the result of the increase in the amount of physical therapy and examination. As a result of the policy effect, the burden of co-payment per person was reduced, and as a result, the number of hospital visits per person and the total medical cost per person increased. Conclusion: The self-pay rate differential policy reduced the burden of medical expenses for the elderly and confirmed the increase in medical use. However, the interpretation of the increase in medical use was not able to distinguish whether the unsatisfactory medical care was satisfied or the inducement demand. Efficient allocation of resources is a more important point in the future when the super-aged society is in front. It is necessary to prepare a plan to induce rational medical use within a range that does not impair the medical accessibility of the elderly.

• 공학교육연구
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• 제11권4호
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• pp.64-75
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• 2008

본 연구는 평생학습 능력의 중심 개념인 자기주도학습의 측정을 위한 자기주도학습 준비도 검사도구(SDLRS)의 신뢰도, 타당도를 검증하여, 공학교육의 프로그램 학습성과 항목 중 평생학습 능력의 평가도구로서의 활용 가능성을 제시하고자 한다. 이를 위한 구체적인 연구목표는 다음과 같다. 즉, 자기주도학습 준비도 검사도구의 신뢰도와 타당도를 검증하고 공과대학 학생들의 개인 변인에 따른 자기주도학습 준비도의 차이를 검증하는 것이다. 연구의 목적을 달성하기 위해 문헌연구와 조사연구를 수행하였는데, 평생학습과 자기주도학습에 대한 문헌연구를 토대로 Gugliemino(1977)의 자기주도학습 준비도 검사도구를 이용하여 경기도 소재 A대학의 기계공학 전공 학생들 218명을 대상으로 조사연구를 수행하였다. 검사도구는 5점 척도로 구성되어 있으며 수집된 자료는 기술통계, 요인분석, t검증, ANOVA에 의한 F검증 등의 분석 방법이 이용되었다. 58개의 원검사 도구는 7차례에 걸친 요인분석 결과 23개 문항으로 압축되었다. 또한 학습에 대한 사랑, 학습에 대한 개방성, 자아개념, 기본학습기능과 독립성, 학습에 대한 책임수용, 주도성과 미래지향성, 독창성과 탐구적 특성의 7개 요인으로 재구조화되었으며 전체 변량의 약 58%를 설명하였으며 Cronbach $\alpha$값은 .8332이었다. 개인적 배경에 따른 자기주도학습 준비도 분석 결과 학년, 산업체 근무기간, 대학원 진학계획, 학점에 대해서는 통계적으로 유의한 차이가 있었으나, 성별, 산업체 근무여부, 부모의 학력, 가구의 소득 수준에 따라서는 통계적으로 유의한 차이가 없는 것으로 나타났다. 이상과 같은 연구를 기초로 하여 향후에는 보다 많은 모집단을 대상으로 연구를 수행함으로써 연구결과를 검증해 볼 필요가 있다. 또한, 다양한 검사도구의 적용을 통해 검사도구간의 상관관계 및 평생학습에 영향을 주는 능력과의 상관관계에 대한 후속연구를 수행함으로써 평생학습 능력을 향상시킬 수 있는 방안에 대한 연구를 보다 체계적으로 수행해야 할 것이다.

• Journal of Ginseng Research
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• 제40권4호
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• pp.437-444
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• 2016

Background: Although Korean Red Ginseng (KRG) has been traditionally used for a long time, its anti-inflammatory role and underlying molecular and cellular mechanisms have been poorly understood. In this study, the anti-inflammatory roles of KRG-derived components, namely, water extract (KRG-WE), saponin fraction (KRG-SF), and nonsaponin fraction (KRG-NSF), were investigated. Methods: To check saponin levels in the test fractions, KRG-WE, KRG-NSF, and KRG-SF were analyzed using high-performance liquid chromatography. The anti-inflammatory roles and underlying cellular and molecular mechanisms of these components were investigated using a macrophage-like cell line (RAW264.7 cells) and an acute gastritis model in mice. Results: Of the tested fractions, KGR-SF (but not KRG-NSF and KRG-WE) markedly inhibited the viability of RAW264.7 cells, and splenocytes at more than 500 mg/mL significantly suppressed NO production at $100{\mu}g/mL$, diminished mRNA expression of inflammatory genes such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interferon-${\beta}$ at $200{\mu}g/mL$, and completely blocked phagocytic uptake by RAW264.7 cells. All three fractions suppressed luciferase activity triggered by interferon regulatory factor 3 (IRF3), but not that triggered by activator protein-1 and nuclear factor-kappa B. Phospho-IRF3 and phospho-TBK1 were simultaneously decreased in KRG-SF. Interestingly, all these fractions, when orally administered, clearly ameliorated the symptoms of gastric ulcer in HCl/ethanol-induced gastritis mice. Conclusion: These results suggest that KRG-WE, KRG-NSF, and KRG-SF might have anti-inflammatory properties, mostly because of the suppression of the IRF3 pathway.

• 한국광물학회지
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• 제31권3호
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• pp.193-213
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• 2018

베트남 북부 네안성 뀌홉지역에서 희토류 원소의 광화작용과 관련된 이상대 확인을 위해 토양지구화학탐사를 수행하였다. 시료채취 간격은 가로 250 m 13 line (총 4.2 km), 세로 300 m 25 line (총 7.5 km)으로 총 325개의 시료가 채취되었다. 또한, 토양지구화학탐사 결과를 바탕으로 총 희토류(Total rare-earth oxides, TREO) 함량이 높은 8개 격자점을 대상으로 피트탐사를 수행하여 73개의 토양시료를 채취하였다. 조사지역은 반찌응(Ban Chieng) 흑운모 화강암 복합체가 편암, 편마암, 석회암으로 구성된 부캉(Bu Kang)층을 관입하고 있다. 본 지역의 주요 광화작용은 주석, 루비, 그리고 화강암 복합체의 주변부 변질대에 분포하고 있는 것으로 사료되는 함희토류 모나자이트(Monazite)와 제노타임(Xenotime)의 산출이 특징적이다. 채취한 토양시료의 ICP-MS 분석 결과, 총 희토류 평균 함량은 지각의 총 희토류 함량(248 ppm)보다 평균 약 1.4배 높게 나타났다. 한편, 경희토류의 평균 함량은 44.6 ppm으로서 지각 평균(200 ppm)보다 결핍되어 있고, 중희토류는 평균 함량(44 ppm)이 지각평균(26 ppm)의 약 1.5배 부화되어있다. 피트탐사에서 채취한 토양시료에 대한 희토류원소의 화학성분 분석 결과, 6개의 피트에서 총 희토류 함량(TREO)이 1,000 ppm 이상의 값이 확인되었다. 이는 뀌차우(Quy Chau)지역의 탐사 및 분석 결과와 비교해보면, 북동-남서 방향으로 희토류 이상대가 발달하고 있는 것으로 사료된다.

• IMMUNE NETWORK
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• 제6권2호
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• pp.86-92
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• 2006

Background: Germanium compounds are increased to use in nutrient foods and medicines in terms of antibiotics to microbes, anticancer, modulation of immune system and neutralizing heavy metal toxins. Geranti Bio-Ge Yeast, containing stable organic germanium and bound to the yeast protein was developed by Geranti Pharm. LTD. and the modulation effect in the immune system was examined in vivo and in vitro. Methods: The compound, Geranti Bio-Ge Yeast, was fed to female Balb/c mice (each group has 10 mice) for 4 weeks and the yeast powder and steamed red ginseng powder were used as control during the same feeding time points. During 4 weeks there was no symptom to be considered, and after 4 weeks feeding all mice were sacrificed to check the changes of related immune cells and subsidiary responses (i.e. cell counting, FACS, MTT, LDH, PFC assay). Results: In pre-post comparison, B cell population was increased in the group of Geranti Bio-Ge Yeast in a dose dependent manner (100 to 800 mg/kg). However, the population of T cell, dendritic cell and macrophage was not comparably changed in all doses. The ability of cytokine production and proliferation was almost same level as shown in control group. In contrast, PFC assay informed that the compound increase the antibody production ability when fed over 200 mg/kg implying that the increase of PFC number might be due to the increase of B cells. Conclusion: Over the entire study, we concluded that the compound, Geranti Bio-Ge Yeast has better potential in immune response in terms of B cell proliferation than that of positive control, red ginseng, and the compound can be one of the future candidates for a new supplementary source improving immune system activity.

• Journal of Radiation Protection and Research
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• 제42권1호
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• pp.9-15
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• 2017

Background: The purpose of this study is to assign an appropriate density to virtual phantom for 2D diode array detector with different dose calculation algorithms to guarantee the accuracy of patient-specific QA. Materials and Methods: Ten VMAT plans with 6 MV photon beam and ten VMAT plans with 15 MV photon beam were selected retrospectively. The computed tomography (CT) images of MapCHECK2 with MapPHAN were acquired to design the virtual phantom images. For all plans, dose distributions were calculated for the virtual phantoms with four different materials by AAA and AXB algorithms. The four materials were polystyrene, 455 HU, Jursinic phantom, and PVC. Passing rates for several gamma criteria were calculated by comparing the measured dose distribution with calculated dose distributions of four materials. Results and Discussion: For validation of AXB modeling in clinic, the mean percentages of agreement in the cases of dose difference criteria of 1.0% and 2.0% for 6 MV were $97.2%{\pm}2.3%$, and $99.4%{\pm}1.1%$, respectively while those for 15 MV were $98.5%{\pm}0.85%$ and $99.8%{\pm}0.2%$, respectively. In the case of 2%/2 mm, all mean passing rates were more than 96.0% and 97.2% for 6 MV and 15 MV, respectively, regardless of the virtual phantoms of different materials and dose calculation algorithms. The passing rates in all criteria slightly increased for AXB as well as AAA when using 455 HU rather than polystyrene. Conclusion: The virtual phantom which had a 455 HU values showed high passing rates for all gamma criteria. To guarantee the accuracy of patent-specific VMAT QA, each institution should fine-tune the mass density or HU values of this device.

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.529-537
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• 2018

Background: Serum albumin and uric acid have been positively linked to metabolic syndrome (MetS). However, the association of MetS incidence with the combination of uric acid and albumin levels has not been investigated. We explored the association of albumin and uric acid with the risk of incident MetS in populations divided according to the levels of these two parameters. Methods: In this retrospective longitudinal study, 11,613 non-MetS participants were enrolled among 24,185 individuals who had undergone at least four annual check-ups between 2006 and 2012. The risk of incident MetS was analyzed according to four groups categorized by the sex-specific medians of serum albumin and uric acid. Results: During 55,407 person-years of follow-up, 2,439 cases of MetS developed. The risk of incident MetS increased as the uric acid category advanced in individuals with lower or higher serum albumin categories with hazard ratios (HRs) of 1.386 (95% confidence interval [CI], 1.236 to 1.554) or 1.314 (95% CI, 1.167 to 1.480). However, the incidence of MetS increased with higher albumin levels only in participants in the lower uric acid category with a HR of 1.143 (95% CI, 1.010 to 1.294). Conclusion: Higher levels of albumin were associated with an increased risk of incident MetS only in individuals with lower uric acid whereas higher levels of uric acid were positively linked to risk of incident MetS regardless of albumin level.