• Title/Summary/Keyword: Back-extraction

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Physiological Activity of Supercritical Poria cocos back Extract and Its Skin Delivery Application using Epidermal Penetrating Peptide (초임계 복령피 추출물의 생리활성 및 경피투과 펩티드를 이용한 경피 약물전달의 응용)

  • Kim, Min Gi;Park, Su In;An, Gyu Min;Heo, Soo Hyeon;Shin, Moon Sam
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.3
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    • pp.766-778
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    • 2019
  • In this study, Poria cocos bark were extracted by supercritical process, and anti-inflammatory, whitening, and antioxidant effects were measured in comparison with ethanol extract. Also, An effective percutaneous permeation method using a selected formulation of the extract and a drug delivery peptide was proposed. Pachymic acid, known as the anti-cancer and anti-inflammatory compound of the ventricle, is an indicator component and the HPLC analysis shows that the supercritical extract of the pericardium is more than twice that of the Poria cocos bark extract. In order to confirm antioxidative effect of Bombyx mori, DPPH scavenging ability and ABTS scavenging ability test showed that the ethanol extract of Poria cocos Back had lower concentration than the supercritical extract of Poria cocos back. However, RAW 264.7 Measurements of Nitric oxide (NO) production in cells showed lower NO production at the same concentration than the Poria cocos back ethanol extract. In addition, after 72 hours of processing of $20{\mu}g/mL$ of the Poria cocos back extract in B16 melanoma cells, both the intracellular and extracellular melanin extract were effective and the supercritical extract was lower melanin content. No toxicity was observed at the concentration of $800{\mu}g/mL$ in RAW 264.7 cells used in NO production experiments. However, in B16 melanoma cells, even at $50{\mu}g/mL$, both Poria cocos back ethanol extract and supercritical extract showed a survival rate of less than 60%. The liposome formulation and drug delivery peptides were shown to be useful for percutaneous permeation of Supercritical Extract of Poria cocos back using a liposome formulation and a drug delivery peptide. it is expected that there will be great potential for development as a variety of cosmetic materials for Poria cocos back.

Improvement of Light Extraction Efficiency of GaN-Based Vertical LED with Microlens Structure

  • Kwon, Eunhee;Kang, Eun Kyu;Min, Jung Wook;Lee, Yong Tak
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.221-221
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    • 2013
  • Vertical LED (VLED) has been recognized as a way to obtain the high-power LED due to their advantages [1]. However, approximately 4% of the light generated from the active region is extracted, if the light extraction from side walls and back side is neglected because of Fresnel reflection (FR) and total internal reflection (TIR) [2,3]. In this study, the optical simulation of the VLED with the various microstructures was performed. Among them, the microlens having the diameter of 3 ${\mu}m$ and the height of 1.5 ${\mu}m$ shown the best result was chosen, and then, optimized microlens was formed on a GaN template using conventional semiconductor process. Various microstructures were proposed to improve the light extraction efficiency (LEE) of the VLED for the simulation. The LEE was simulated using LightTools based on a Monte Carlo ray tracing. The microstructures with hemisphere, cone, truncated and cylinder pattern having diameter of 3 ${\mu}m$ were employed on the top layer of the VLED respectively. The improvement of the LEE by using the microstructure is 87% for the hemisphere, 77% for the cone, 53% for the truncated, 21% for the cylinder, compared with the LEE of the flat surface at the reflectance of 85%. The LEE was increased by 88% at the height of 1.5 ${\mu}m$, compared with the LEE of the flat surface. We found that the microlens on the top layer is the most suitable for increasing the LEE. In order to apply the proposed microlens on n-GaN surface, we fabricated microlens on a GaN template. A photoresist array having hexagonal-closed packed microlens was fabricated on the GaN template. Then, optimization of etching the GaN template was performed using a dry etching process with ICP-RIE. The dry etching carried out using a gas mixture of Cl2 and Ar, each having a flow rate of 16 sccm and 10 sccm, respectively with RF power of 50 W, ICP power of 900 W and chamber pressure of 2 mTorr was the optimum etching condition as shown in Fig. 2(a).

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Soccer Game Analysis I : Extraction of Soccer Players' ground traces using Image Mosaic (축구 경기 분석 I : 영상 모자익을 통한 축구 선수의 운동장 궤적 추출)

  • Kim, Tae-One;Hong, Ki-Sang
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.1
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    • pp.51-59
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    • 1999
  • In this paper we propose the technique for tracking players and a ball and for obtaining players' ground traces using image mosaic in general soccer sequences. Here, general soccer sequences mean the case that there is no extreme zoom-in or zoom-out of TV camera. Obtaining player's ground traces requires that the following three main problems be solved. There main problems: (1) ground field extraction (2) player and ball tracking and team indentification (3) player positioning. The region of ground field is extracted on the basis of color information. Players are tracked by template matching and Kalman filtering. Occlusion reasoning between overlapped players in done by color histogram back-projection. To find the location of a player, a ground model is constructed and transformation between the input images and the field model is computed using four or more feature points. But, when feature points extracted are insufficient, image-based mosaic technique is applied. By this image-to-model transformation, the traces of players on the ground model can be determined. We tested our method on real TV soccer sequence and the experimental results are given.

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Studies on Partition and Extraction Equilibria of Metal-Dithiocarbamate Complexes(II). Metal Complexes of Ammonium Pyrrolidine Dithiocarbamate (Dithiocarbamate 금속착물의 분배 및 추출평형(제2보). Ammonium Pyrrolidine Dithiocarbamate의 금속착물)

  • Lee, Jong-Sun;Choi, Jong-Moon;Choi, Hee-Seon;Kim, Young-Sang
    • Analytical Science and Technology
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    • v.8 no.3
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    • pp.321-334
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    • 1995
  • Basic studies for the effective extraction of ammonium pyrrolidine dithiocarbamate(APDC) complexes of Co(II), Ni(II) and Cu(II) into a solvent have been performed. The maximum distribution ratio was appeared (log D=1.3543) at pH 2.0 and the partition coefficient was 2.489 in the extraction of $4{\times}10^{-5}M$ APDC itself into chloroform. From the UV/visible spectra of metal-chelates in aqueous and organic solutions, the pH to form stable 1:2 metal-ligand complexes were Co(II):5.0, Ni(II):8.0 and Cu(II):8.0, respectively and only 1 minute was enough to be partitioned into the chloroform. Besides, the partition and extraction equilibria of the complexes were investigated by back-extracting $10.0{\mu}g/ml$ metal-chelates from the solvent into an aqueous solution beacuse of their slight solubilities in the aqueous solution. The distribution coefficients and extractabilities were as follows : at pH 6.5~8.5 of the aqueous solution, log D=2.834 : E(%)=99.9% for $Co(PDC)_2$, at pH 11, log D=5.699 E%=100 for $Ni( PDC)_2$, and at pH 6.0, log D=2.025 : E(%)=99.1% for $Cu(PDC)_2$. And the extraction and formation constants were log $K_{ex}=9.671$ : log ${\beta}_2=6.938$ for $Co(PDC)_2$, log $K_{ex}=9.646$ : log ${\beta}_2=7.071$ for $Ni( PDC)_2$, and log $K_{ex}=9.074$ : log ${\beta}_2=7.049$ for $Cu(PDC)_2$, respectively. From these results, an optimum extraction procedure can be constructed for the separative concentration of trace metallic ions, and the quantitative determination of them in advanced materials and environmental samples will be expected without any influence of sample matrixes.

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Factor Constructs Exploration and Model Goodness-of-fit Verification of Empathy for Dementia Patient among Nurses (간호사의 치매환자에 대한 공감도 요인구조 탐색 및 모형적합성 검증)

  • Back, Kyung-Mi;Lee, Hye-Kyung;Back, Jong-Nam
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.2
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    • pp.287-295
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    • 2020
  • The purpose of this study is to analyze what constitutes the sympathetic component of nurses care of dementia patients. For this study, 219 nurses in nursing dementia patients were treated in nursing hospitals. Using the Empathy Consensus Rating Scale (ECRS), basic model extraction, model modification, and model suitability verification were performed through factor structure search and confirmation factor analysis (CFA). The results of this study confirmed the validity and reliability of the constituents with 49 questions, including 3 factors including the acceptance of other emotions, the suppression of one's own emotions, and the exchange and interaction of emotions. According to these results, it is expected that the ECRS that can secure validity and reliability can be used for the study to confirm the nurse's Empathy in the dementia patients' nursing field.

Non-Parametric Texture Extraction using Neural Network (신경 회로망을 사용한 비 파라메테 텍스춰 추출)

  • Jeon, Dong-Keun;Hong, Sun-Pyo;Song, Ja-Yoon;Kim, Sang-Jin;Kim, Ki-Jun;Kim, Song-Chol
    • The Journal of the Acoustical Society of Korea
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    • v.14 no.2E
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    • pp.5-11
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    • 1995
  • In this paper, a method using a neural network was applied for the purpose of urilizing spatial features. The adopted model of neural network the three-layered architecture, and the training algorithm is the back-propagation algorithm. Co-occurrence matrix which is generated from original imge was used for imput pattern to the neural network in order to tolerate variations of patterns like rotation of displacement. Co-occurrence matrix is explained in appendix. To evaluate this method, classification was executed with this method and texture features method over the city area and sand area, which cannot be separated with the conventional method mentioned aboved. In the results of this method and texture features proposed by Haralick the method using texture features was separation rate of 67%~89%. On the contrary, the method using neural network proposed in this research was stable and high separation rate of 80%~98%.

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Determination of terbutaline in human plasma by coupled column chromatography (커플드칼럼크로마토그래피에 의한 사람 혈장 중 테르부탈린의 정량)

  • Ko, Mi Young;Jeon, Sang-Seol;Kim, Kyeong Ho
    • Analytical Science and Technology
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    • v.28 no.2
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    • pp.125-131
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    • 2015
  • A method was developed and fully validated for the determination of terbutaline, a β2-receptor agonist, in human plasma. Plasma samples were prepared by solid-phase extraction with Sep-Pak silica, followed by high-performance liquid chromatography (HPLC). The terbutaline was pre-separated from the interfering components in plasma on a Luna C18 (2) column, and terbutaline and salbutamol as an internal standard were resolved and determined on a Luna Silica column. The two columns were connected by a switching valve equipped with silica pre-column. The pre-column was used to concentrate the terbutaline in the eluent from the C18 column before back-flushing onto the silica column with fluorescence detection at an excitation/emission wavelength of 276/306 nm. The method was shown to be specific by testing six different human plasma sources. Linearity was established for a concentration range of 0.4-20.0 ng/mL with a correlation coefficient of 0.9999. The lower limit of quantitation was 0.4 ng/mL with a precision of 10.1% as C.V.%.

HMM-based Korean Named Entity Recognition (HMM에 기반한 한국어 개체명 인식)

  • Hwang, Yi-Gyu;Yun, Bo-Hyun
    • The KIPS Transactions:PartB
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    • v.10B no.2
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    • pp.229-236
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    • 2003
  • Named entity recognition is the process indispensable to question answering and information extraction systems. This paper presents an HMM based named entity (m) recognition method using the construction principles of compound words. In Korean, many named entities can be decomposed into more than one word. Moreover, there are contextual relationships among nouns in an NE, and among an NE and its surrounding words. In this paper, we classify words into a word as an NE in itself, a word in an NE, and/or a word adjacent to an n, and train an HMM based on NE-related word types and parts of speech. Proposed named entity recognition (NER) system uses trigram model of HMM for considering variable length of NEs. However, the trigram model of HMM has a serious data sparseness problem. In order to solve the problem, we use multi-level back-offs. Experimental results show that our NER system can achieve an F-measure of 87.6% in the economic articles.

Study of the Curing Time of Cementless Cold Central Plant Recycled Asphalt Base-Layer through Field-Application Review (무시멘트 상온 재활용 아스팔트 기층의 현장 적용성을 통한 양생기간에 관한 연구)

  • Choi, Jun Seong;Jung, Chul Ho;Lee, Chan Hee;Lim, in su
    • International Journal of Highway Engineering
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    • v.19 no.2
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    • pp.67-74
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    • 2017
  • PURPOSES : The objective of this study is to ascertain the curing period of cementless cold central plant recycled asphalt base-layer, using mechanical analyses and specimen quality tests on the field. METHODS : Cold central plant recycled asphalt base-layer mixture was produced in the plant from reclaimed asphalt, natural aggregate, filler for the cold mix, and the modified emulsion AP using asphalt mix design and plant mix design. In order to examine the applicability of the curing period during the field test, the international standards for the possibility of core extraction and the degree of compaction and LFWD deflection were analyzed. Moreover, Marshall stability test, porosity test, and indirect tensile strength test were performed on the specimens of asphalt mix and plant mix design. RESULTS : The plant production process and compaction method of cementless cold central plant recycled asphalt base-layer were established, and the applicability of the optical moisture content for producing the mixture was verified through the field test. In addition, it was determined that the core extraction method of the conventional international curing standard was insufficient to ensure performance, and the LFWD test demonstrated that the deflection converges after a two-day curing. However, the back-calculation analysis reveals that a three-day curing is satisfactory, resulting in a general level of performance of dense asphalt base-layer. Moreover, from the result of the specimen quality test of the asphalt mix design and plant mix design according to the curing period, it was determined that the qualities satisfied both domestic and international standards, after a two-day curing. However, it was determined that the strength and stiffness after three-day curing are higher than those after a two-day curing by approximately 3.5 % and 20 %, respectively. CONCLUSIONS:A three-day curing period is proposed for the cementless cold central plant recycled asphalt base-layer; this curing period can be demonstrated to retain the modulus of asphalt-base layer in the field and ensure stable quality characteristics.

A PHOTOELASTIC STUDY ON THE INITIAL STRESS DISTRIBUTION OF THE MOLAR ANCHORING SPRING(MAS) DURING RETRACTION OF THE MAXILLARY CANINE (상악견치 후방견인시 저항원 조절을 위한 MAS(Molar Anchoring Spring)의 초기 응력분포에 관한 광탄성학적 연구)

  • Chun, Youn-Sic
    • The korean journal of orthodontics
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    • v.26 no.4
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    • pp.341-348
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    • 1996
  • The efficiency of maxillary canine retraction by means of sliding mechanics along an 0.016 continuous labial arch and an 0.009 inch in diameter with a lumen of 0.030 inch NiTi closed coil spring was compared with that using the same NiTi closed coil spring and Molar Anchoring Spring(MAS) which was designed by author. MAS was made of .017" X .025" TMA wire and was given 60 degree tip-back bend on the wire close to the molar tube. This study was designed to investigate molar and canine root control during retraction into an extraction site with continuous arch wire system. Two techniques were tested with a continuous arch model embedded in a photoelastic resin. A photoelastic model was employed to visualize the effects of forces applied to canine and molar by two retraction mechanics. With the aid of polarized light, stresses were viewed as colored fringes. The photoelastic overview of the upper right quadrant showed that stress concentrations were observed in its photoelastic model. The obtained results were as follows. 1. Higher concentration of compression can be seen clearly at the distal curvature of the canine and mesial curvature of the molar and premolar when NiTi closed coil spring was applied only, which means severe anchorage loss of the molar and uncontrolled tipping of the canine. 2. The least level compression was presented at the mesial root area of the molar and premolar, and mesial root area of the canine when NiTi closed coil spring and MAS were used simultaneously. Especially mesial alveolar crest region of the canine was shown moderate level of compression that means MAS can be used as a appliance for anchorage control and prevention of canine extrusion and uncontrolled tipping during canine retraction.

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