• Journal of Acupuncture Research
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• 제21권4호
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• pp.177-196
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• 2004

Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

• 한국직업건강간호학회지
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• 제7권2호
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• pp.164-176
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• 1998

This study deals with the current medical utilization for migrant workers and the characteristics of them. The purpose of this study is to provide the basic information to establish proper medical policy. For the study self-made questionnaire was used, which was answered by 453 migrant workers working in the area of manufacturing and non-technical work in 10 cities like Seoul, Inchon, Namyangju, Sungnam, Kwangju, Pyungchon, Kunpo, Kimpo, Masuk in Kyungki-do and Chunan in Chungchungnam-do. Besides, 303 medical records of those who had visited free medical check-up center were analyzed. The period of accumulating data is 6 months, from November 1st, 1996 to April 30th, 1997. The characteristics of migrant workers and current medical utilization are analyzed by percentage and the relation between characteristics and current medical utilization were analyzed using ${\chi}^2$-test, t-test, ANOVA. The finding of this study was as follows : 1) The number of nationality was 16. The first majority was Philippians as 32.0%. Among 16 nationalities Southeastern and Northern Asians were 48.9%, Southwestern Asian was 46.5%, the rest was 7.3%. Men were 81.0%, those who are aged from 26 to 30 were 39.0%, Graduatee from high school 92.7%, Christians 56.3%, unmarried 55.4% and salary from 600,000 Won to 800,000 Won 53.8% averaging monthly payment 669,810 Won. As for their residence, those who resided over 3 years were 31.9% and the illegal residence reached 77.4%. As for Korean language, those who speak in middle level were 5.6%. 2) As for kind of work and circumstances, manufacturing was 81.1%, 4 off-days per month 72.2% and 9-10 working hours per day 42.1%. As for accommodation, residence in fabric was 62.6% and one or two members as roommate 40.2%. 3) The characteristics of health behavior showed that 89.4% of migrant workers had 3 meals, 70.9% of them did not drink alcohol, 73.5% of them did not smoke. 4) As a characteristic of health status, 71.8% of them perceived of their health. 76.1% thought that they had no illness before coming Korea. Among them who recognized their illness, those who had problem in circulatory system was 35.3%, respiratory system ENT 19.1% and nervous system 19.1%.66.2% of those having illness had already had sickness when coming to Korea. 5) During last one month, 79.2% of them were known as ones having no illness. Among the sick, those who had problem in circulatory system was 31.6%, nervous system 23.7% and respiratory system 21.1%. 60.3% of the sick were not cured at that time. 6) Sorting the symptom of those who visited free medical check up, dental care was 24.2%, orthopedic 14.0% and digestive system 13.8%. Teethache was 34.4%, stomach problem 11.6%, upper respiratory inflammation 10.2% and back pain 5.9%. Averagely they visited free medical check up 1-2 times. According to symptom, epilepsy 25.5 times, heart and vascular disease 9 times, constipation 2.8%, neurosis 2.38 times and stomach problem 2.34 times. 7) The most frequently visited medical service by migrant workers was hospital. The most mentioned reason was good healing as 36.3%. The medical service satisfied migrant workers mostly was hospital as 64.3%. The reason of satisfaction was also good healing as 45.9%. 8) 77.2% of respondents did not spend money for medical check. Average monthly medical cost was 25,100 Won, 3.7% of income. Those who had no medical security was 73.4%. In their case, 67.7% got discount from hospital or support from working place and religious organization. 9) As for the difference of medical utilization according for the characteristics of migrant workers, legal workers and no-Korean speaker used hospital more frequently. 10) Those who were satisfied most of all with the service of hospital were female workers, hinduists and buddhists, legal workers or manufacture workers. 11) Christians, those who have 3 meals or recognize themselves as healthy ones mostly had no illness. As a result, the most of migrant workers in Korea are from Asia. They are good educated but are working in manufacturing and illegal. Their average income is under 700,000 Won which in not enough for medical cost. They have no medical security and medical fee is supported by religious organization or discounted. Considering these facts the medical policy by government is to be established.

• 시큐리티연구
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• 제24호
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• pp.33-51
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• 2010

본 연구의 목적은 민간경호원의 규칙적인 척추안정화 운동프로그램 적용 유 무에 따른 근기능 및 보행능력의 변화를 분석하는 것으로 다음과 같은 결론을 얻었다. 첫째, 척추안정화 운동프로그램과 관련된 근기능의 변화에 있어서 최대 요부신전근력 및 요부굴곡근력의 경우 운동그룹에서는 처치 전 후 요부신전근력과 요부굴곡근력 모두 증가되었고 비운동그룹에서도 처치 전 후 요부신전근력과 요부굴곡근력이 증가하는 것으로 나타났다. 그리고 처치전에는 두그룹간 차이가 없었으나, 처치후에는 운동그룹과 비운동그룹이 차이가 있는 것으로 나타났으며, 통계적으로도 유의한 차이가 나타났다. 둘째, 척추안정화 운동프로그램과 관련된 근기능의 변화에 있어서 요부 굴곡 신전근 비율의 경우 운동그룹과 비운동그룹 모두 처치 전에는 요부 신전근의 기능적 소실을 나타냈으나, 처치 후 운동그룹은 정상적으로 회복되었고, 비운동그룹은 요부 신전근의 기능적 소실을 나타내었으며, 통계적으로도 유의한 차이가 나타났다. 셋째, 척추안정화 운동프로그램과 관련된 근기능의 변화에 있어서 요부안정화근력의 변화에 있어서 총 8가지 방향으로 요부안정화근력을 분석하였으며, 운동그룹에서는 각도별로 요부 안정화근력이 증가하였고 비운동그룹에서는 각도별로 요부안정화근력이 감소하거나 변화가 없었으며, 통계적으로 유의한 차이가 나타났다. 넷째, 척추안정화 운동프로그램과 관련된 보행능력의 변화에 있어서 10m 보행검사를 이용하여 최대 보행시 속도와 보폭에 대하여 분석하였으며, 척추안정화 운동프로그램 적용 유 무에 따른 운동그룹에서 비운동그룹 보다 보행능력을 증가시키는 것으로 나타났으며, 통계적으로도 유의한 차이가 나타났다. 결론적으로 민간경호원에게 규칙적인 척추안정화 운동프로그램 적용은 요부신전근력, 요부 굴곡근력, 요부 굴곡 및 신전근 비율, 요부안정화근력, 보행능력 등에서 긍정적인 효과가 있는 것으로 나타났다. 이러한 결과는 척추안정화 운동프로그램이 민간경호원들의 요통의 완화 및 근력향상에 긍정적인 효과가 있으며, 환자들의 빠른 회복으로 보다 빠르게 사회로의 복귀를 도와줄 수 있을 것이다. 또한 경호원들을 대상으로 예방적인 또는 기능을 향상시키기 위한 운동처방 프로그램으로 활용가능하다고 생각한다.

• 대한간호
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• 제31권4호
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• pp.77-99
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• 1992

The study was carried out at W. hospital, an affiliated hospital of Y university, involved a total of 163 patients who were discharged from the hospital between May 1990 und March 199J. Data collection was twice, just prior to discharge and a minimum of three months post discharge. Thirty patients who lived within a hour travel time of the hospital received home care during the three months post discharge. Nursing diagnoses and nursing interventions For these patients were analyzed in this study. The results of the study are summarized as follows : 1. Discharge needs for the subjects of the study were analyzed using Gordon's eleven Functional categories and it was found that 48.3% of the total sample had identified nursing needs. Of these, the needs most frequently identified were in the categories of sexuality, 79.3 %, health perception, 68.2 % self concept, 62.5 %, and sleep and rest 62.5 %. Looking ut j he nursing diagnosis that were made for the 30 patients receiving home care, the following diagnoses were the most frequently given; alteration in sexual pattern 79.3%, alterations in health maintenance, 72.6%, alteration in comfort, 68.0%, depression, 64.0%, noncompliance with diet therapy, 6.3.7%, alteration in self concept, 55.6%, and alteration in sleep pattern, 53%. 2. In looking at the effects of home nursing care as demonstrated by changes in the functional categories over the three month period, it was Found that of the 11 functional categories, the need level for health perception, nutrition, activity and self concept decreased slightly over the three month period. On the average sleep patterns improved, but restfulness was slightly less and bowel elimination patterns improved but satisfaction with urinary elimination was slightly less. On the other hand, role enactment, sexuality, stress management and spirituality decreased slightly. The only results that were statistically significant at the 0.05 level were improvement. in digestion and decrease in pain. No statistically significant changes were found in ability related to ADL, the total ADL Score at discharge was $19.78{\pm}8.234, and after 3 months $19.01{\pm}8.12$. Considering that a majority of the patients were over 60 years of age and that many had brain or spinal cord injuries, the fact that their ADL ability did nor deteriorate after discharge can be interpreted as related to a positive impact by the home health care nurses. Similarly there was a slight be not statistically significant decrease in the quality of life scores between the two lest times(l47.83 at discharge and 113.02 at the three month period). Again, when the chronic nature of thee problems facing these patients is considered this maintenance of quality of life can be interpreted as a positive impact by the home health care nurses. 3. One of the home care nursing activities was diagnosis. For this activity it was found that for nine functional health categories(sexuality and spirituality excepted) there were 20 nursing diagnoses. The most frequent were noncompliance, alteration in skin integrity both actual and potential, and impaired physical mobility in that order. 4. Delivery of home health care by the home health nurses included the following nursing activities; assessment, patient education, demonstration of care activities, counselling, direct care to the patient and referrals. Direct care included changing dressings, bladder irrigations, changing Foley catheters, measurement of residual urine, perineal care, position change, back care, oral hygiene, exercise and massage of motion exercises, cleansing enemas, tracheostomy suctioning and tracheostomy care, care of dentures, applications of heat and other similar nursing activities. In conclusion almost 50% of (he sample indicated a need for continued nursing care at the time of discharge and for the patients in the sample who received home care there was a slight decrease in nursing needs but while the patients had chronic and debilitation problems there was ill decrease in ADL abilities or in quality of life. Further study needs Lo be done La increase the reliability and validity of the tool that was used to measure home health care needs. It is also recommended that study by done using a randomized sampling with a control group to compare patients who receive home care with those who do not.

• 한국의학물리학회지:의학물리
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• 제21권1호
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• pp.70-77
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• 2010

골다공증 환자를 대상으로 이중 에너지 X선 흡수(DEXA) 방법을 이용한 골밀도 영상에서는 T-score를 측정하고 자기공명영상 기법 중 확산강조영상에서는 신호대 잡음비와 현성 확산 계수를 측정한 다음 T-score변화에 따라 신호대 잡음비와 현성 확산 계수가 어떻게 변화하는지 알아보았다. 골다공증이 없는 건강한 사람 30명과 2009년 1월부터 2009년 12월까지 허리 통증으로 내원한 환자 중 단순 방사선 촬영에서 골다공증 소견이 보이는 환자 30명을 대상으로 Dual Energy X-ray Absorptiometry (DEXA)를 이용하여 척추 L1-L4부위의 T-score를 측정 후 각각의 척추에 대해서 골감소증, 골다공증으로 분류하였다. 1.5T MR scanner를 이용하여 b value를 $400\;s/mm^2$으로 획득한 확산강조영상에서는 L1-L4 네 부위에서 신호 강도(signal intensity)측정을 하였고 현성 확산 계수(apparent diffusion coefficient; ADC) map 영상에서는 현성 확산 계수를 측정하였다. 정량적 분석방법으로 관심영역의 T-score와 신호대 잡음비(signal to noise ratio)와 ADC를 구하고 평균화 하여 관심영역에서 T-score변화에 따른 신호대 잡음비와 현성확산계수의 변화를 비교하였고 T-score에 의해 골감소증, 골다공증으로 분류하여 그룹별로 신호대 잡음비와 현성확산계수의 변화도 비교하였다. 정성적인 분석방법은 육안적으로 건강한 그룹과 골감소증, 골다공증그룹의 T1강조 시상면 영상에서 요추체중 L4 부위에서의 신호강도 차이를 알아보았다. 정량적 분석에서 골감소증 그룹과 골다공증그룹은 T-score가 감소함에 따라 확산강조영상에서의 신호대 잡음비가 감소하여 나타났으며 골다공증 그룹에서 신호대 잡음비가 가장 크게 감소하였다. ADC map영상에서는 골감소증그룹과 골다공증 그룹은 T-score가 감소함에 따라 현성 확산 계수는 감소해서 나타났고 건강한 그룹과 골감소증 및 골다공증 그룹의 경우 현성 확산 계수 차이는 골다공증 그룹에서 현성 확산 계수가 가장 낮게 나타났다. 정성적 분석에서는 건강한 그룹과 골감소증 및 골다공증 그룹에서 L4 부위의 신호강도는 건강한 그룹에서 가장 낮게 나타났고 골다공증그룹에서 높게 나타났다. 골다공증이 진행 될수록 신호대 잡음비와 현성 확산계수는 감소하고 T1강조 영상에서는 신호강도가 증가 하는 결과를 얻었고 자기공명검사가 골다공증 진단에 유용함을 알 수 있었다.

• 정신신체의학
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• 제14권1호
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• pp.62-66
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• 2006

서론: 치료저항성 환자 치료 시 선택될 수 있는 여러 약물들의 병용 투여에 의해 예측할 수 없는 심각한 부작용을 야기하는 약물 상호작용이 일어날 수 있다. 저자들은 만성 정신분열병 환자에서 클로자핀(clozapine)과 부스피론(buspirone)을 병용 투여한 후 상부위장관 출혈이 의심되는 사례가 있어 보고하고자 한다. 증례: 망상형 정신분열병으로 진단받은 69세 여자 환자로 입원 당시 혈색소가 약간 감소된 것을 제외하고는 신체검사와 검사실 검사 상 다른 특이 소견은 없었다. 불안 증상이 심하여 부스피론 15mg을 올란자핀(olnazapine) 30mg과 같이 투여하였다. 하지만, 병력상 약물에 반응이 좋지 않고 본원 입원 치료에서 치료 반응이 없어 올란자핀을 클로자핀으로 교체하였다 인원 11주째, 클로자핀으로 교체한 지 4주가 지난 후, 환자는 클로자핀 300mg과 부스피론 60mg을 복용하고 있었다. 이 시점에서 약 4일 동안 간헐적으로 복통, 발한, 저혈압, 구토, 발열과 함께 토혈, 흑색변 소견 보였지만, 위내시경과 위장조영촬영에서 상복부위장관 출혈 소견은 발견되지 않았다. 모든 약물을 중단한 후, 상부위장관 출혈 의심 증상은 사라졌다. 이후 클로자핀만 단독으로 투여한 후, 정신병적 증상 호전을 보였고 상부위장관 출혈 소견도 재발하지 않았다. 고찰: 상부위장관 출혈은 클로자핀과 부스피론 각각의 약리학적 작용 및 부작용의 측면에서는 예상할 수 없었던 부작용이었으나, 정신분열병 치료를 위해 투여하고 있던 클로자핀에 추가적으로 항불안 효과가 있는 부스피론을 복합 투여하는 동안 발생하였으며 부스피론을 중단한 이후에는 동일한 부작용이 재발하지 않았다. 따라서, 저자들은 상부위장관 출혈 부작용의 발생 원인을 클로자핀과 부스피론 두 약물의 상호작용에 의한 것으로 보고 참고 문헌에 기초하여 몇 가지 가능한 기전들에 대해 고찰해 보았다. 두 약물의 상호작용에 대한 명백한 기전은 아직 밝혀지지 않았으나 상부위장관 출혈은 잠재적으로 생명에 치명적인 부작용이므로 클로자핀과 부스피론의 병용 투여 시 특별한 주의를 요한다.

• 한국콘텐츠학회논문지
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• 제10권6호
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• pp.323-328
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• 2010

견관절 탈구나 골절로 인해 arm sliding를 착용한 환자에서 외전(abduction)이 불가능한 경우 superior-inferior axial projection view를 대신하여 시행하는 velpeau view는 탈구나 골절 환자가 상체를 뒤로 젖히는 자세를 취하기가 어려워 고통이 가중되었다. 하지만 환자의 상체를 숙여 검사하는 새로운 검사법인 'modified velpeau view'를 제안하며 검사 시 자세고정의 용이함과 임상적 유용성에 대해 알아 보고자 2009년 10월부터 2010년 1월까지 견관절 탈구나 골절로 의심되어 본원에 내원한 환자들 중 velpeau view 처방을 받은 환자 20명과 정상인 30명을 대상으로 velpeau view와 modified velpeau view에서 wall-bucky와 환자의 상체 숙임각(30도, 45도, 60도, 75도)의 변화에 따른 골 구조의 차이를 비교하였다. 영상의학과 전문의와 정형외과 전문의에게 영상평가 기준을 제시하고 0점부터 5점을 만점으로 영상이 평가되었다. 정상인군에서 wall-bucky와 상체의 숙임각 변화에 따른 골구조의 비교결과 45도와 60도가 velpeau view 와 비슷한 진단수준을 보였으며, 진단 가치를 증명하기 위한 영상평가 결과 velpeau view에서는 shoulder head의 anterior와 posterior, glenoid fossa의 anterior와 posterior를 관찰할 수 있었지만, modified velpeau view에서는 velpeau view에서 관찰되는 부위 뿐만 아니라 acromioclavicular joint와 coracoid process도 관찰할 수 있었다. modified velpeau view가 velpeau view와 비교시 velpeau view를 대체할 만한 수준의 진단적 가치를 지닌 유용한 검사임이 확인 되었다. 또한 modified velpeau view는 velpeau view position이 어려운 환자를 대상으로 적용 가능한 대체법으로서 뿐만 아니라 어깨 골절과 탈구 이외의 어깨 질환의 진단을 위한 새로운 검사로서의 임상적 적용을 위해 다양한 시각에서의 연구와 개선의 노력이 필요함을 시사한다.

• 한국산학기술학회논문지
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• 제18권1호
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• pp.336-344
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• 2017

본 연구는 뇌손상 진단을 받고 병원에서 재활치료를 실시하고 있는 환자의 가족 간병인 340명을 대상으로 근골격계증상을 알아보고 그 관련요인을 파악하고자 자기 기입식 설문조사를 실시하였다. 설문조사 내용은 일반적 특성, 간병활동 특성, 근골격계 자각 증상이였다. 본 연구의 조사 기간은 2014년 3월부터 4월이며, 재활병원 및 요양병원에서 수집하였다. 연구결과 독립변수에 따른 자각증상 호소율은 신체부위별로 다르게 나타났다. 요인분석의 결과는 목의 경우 초졸의 학력이 영향을 끼쳤고, 어깨의 경우 여자, 나이 50~59세, 학력 중졸, 간병기간 1년 이내와 1년 7개월 이상 2년 이내가 영향을 끼쳤다. 팔/팔꿈치의 경우 나이 40~49세, 학력 대졸, 간병기간 1년 이내와 1년 7개월 이상 2년 이내 변인이 유의한 영향을 끼쳤다. 손/손목/손가락의 경우 나이 50~59세, 간병기간 1년 이내와 1년 7개월 이상 2년 이내 변인이 통증에 유의한 영향을 끼쳤다. 다리/발의 경우 나이 50~59세, 간병기간 6개월 이내 변인이 통증에 유의한 영향을 미치는 것으로 나타났다. 허리의 경우 학력 초졸 중졸 고졸, 간병기간 1년 이내와 1년 7개월 이상 2년 이내, 독립보행 불가능 변인이 통증에 유의한 영향을 미치는 것으로 나타났다. 진단명 별 간병활동 특성에서 근골격계 자각증상 호소율은 통계적으로 유의하지 않았다. 근골격계 자각증상 호소에 가장 영향을 미치는 간병활동 동작으로는 이동하기와 보행이었다. 근골격계 자각증상에 영향을 미치는 전체 요인에 대해서는 간병 기간 1년 이내가 전체 통증에 유의한(p<.05) 영향을 미치는 것으로 나타났다. 본 연구의 결론으로는 뇌손상 환자의 가족 간병인은 환자를 간병하는 간병활동 특성에서 근골격계 질환의 위험에 노출되어 생활하는 것을 알 수 있었다. 또한 뇌손상 환자를 돌보는 가족 간병인의 신체부위별 근골격계 증상에 영향을 미치는 요인이 다르므로 이러한 요인에 대한 체계적이며 종합적인 예방 교육과 연구가 마련되어야 할 것이다.

• Journal of Acupuncture Research
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• 제24권6호
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• pp.1-14
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• 2007

Backgrounds : Rheumatoid Arthritis(RA) is known as the chronic inflammatory diseasethat induces persistent inflammation in the joint cavity. The destruction of cartilage occurs as the result of bones destoyed by pannus, several influential cytokines induced by the synovial capsulitis, varieties of proteinases, $O_2$ radicals, and the secondary degenerative changes of articular cartilage. The type 2 collagen-induced arthritis model is used in recent experimental research on rheumatoid arthritis. Cervus elaphus sibiricus (Nockyong) has the effect of relieving pain by nourishing the muscles, joints, and bones. It is also known to be efficacious in promoting and enhancing the immune system. The objective of this study was to investigate the effect of Cervus elaphus sibiricus herbal acupuncture to inhibit the generation of proinflammatory enzyme on type 2 collagen-induced arthritis. I investigated the inhibition of mRNA transcription of MIF(macrophage migration inhibitory factor), $TNF-{\alpha}$(Tumor necrosis $factor-{\alpha}$) and MMP-9 (matrix metalloproteinase-9) of Cervus elaphus sibiricus herbal acupuncture using an in vitro test. Also investigated was the inhibition of differentiation of Th 1 cells and activation of cytokines(MIF, $TNF-{\alpha}$, IL-6, MMP-9), which are known to cause initial RA ,and are also related to the morphology of the synovial membranes of the joint capsule, by an in vivo test, using CIA(collagen induced arthritis) model mice. Materials & methods : The laboratory animals used in this experiment were 4 week-old DBA female mice, weighing approximately 20 grams, and adjusted to the laboratory environment. The experiment was divided into the normal group(NOR)-no treated group, control group(CON)-CIA induced group, and sample group(SAM)-Cervus elaphus sibiricus herbal acupuncture treated group. RA was induced in the mice via injection of $50{\mu}{\ell}$ C II mixed CFA. The Cervus elaphus sibiricus herbal acupuncture solution was applied on $GB_{35}$(陽陵泉) for 26 days from the 3rd day of RA inducement. The concentration of the solution was determined via a MTT assay. To research the effect on the expression of MIF, $TNF-{\alpha}$ and MMP-9 mRNA, RT-PCR was performed on synovial membrane cells from the knee joint of CIA mice. C II induced RA knee joint's histo-chemical synovial membrane was observed using a specimen model via the Hematoxilin and Eosin dying technique. Results : The expression of mRNA of RA-related cytokines such as MIF, $TNF-{\alpha}$, and MMP-9 dosedependently decreased in the cell from the synovial membranes of the joint, which is treated with Cervus elaphus sibiricus herbal acupuncture solution. In mice treated with Cervus elaphus sibiricusherbal acupuncture, the damage of synovial membranes of the joint was lessened, and differentiation of Th 1 cells was suppressed. The activation of RA-related cytokines such as MIF was suppressed, and the generation of $TNF-{\alpha}$ and MMP-9 showed a statistically significant decreas. Conclusions : It is speculated that Cervus elaphus sibiricus herbal acupuncture has the therapeutic effect of palliating the damage of the tissue impaired by RA by inhibition of the initial RA progression and by regulating excessive differentiation of Th 1 cell as it suppresses the generation of RA-related cytokines during the highest stage of RA by acting on pro-inflammatory enzymes.

• 간호행정학회지
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• 제3권1호
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• pp.119-133
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• 1997

Continuing shift service of clinical nurses can be not only the cause of occupational dissatisfaction by being connected with the change of circadian rhythm and the burden of duties to be applicable to such changes. But also of inviting the lowering of nursing quality by being affected to the resignation of the nurses as the threat to the health of the nurses. This study has selected 500 nurses at random under non-probability sampling who have been serving by shift in 7 general hospitals which have over 400 sickbeds for the purpose of cross-sectional survey design from Sep. 7 through 20, 1996. Standardized modification of the CMI has been used which was designed for Koreans with Cornell Medical Index developed by Broadman and his fellow workers as the study device. The structure of the device was composed of 35 questions on physical appeal(Chronbach's ${\alpha}=8507$) and 22 questions of mental appeal(Cronbach's ${\alpha}=.8166$ totalling 57 questions. The collected data has been computerrized by using SPSS. General character, present symptom, perceived symptom and others are sought by practical number and percentage, and the health condition comparison followed by general characters was conducted by t-test and ANOVA. The post test was by Duncan's test by the level of p<.05. 1) The items of the answer that they have the physical symptom presently by 50% or over of the nurses were as "Do you often have spells of severe dizziness", "Are your eyes often red or inflamed", "Does press or pain in the head often make like miserable", "Are your ankles often badly swollen", "Do pains in the back make it hard for you to keep up with your work". 2) The items of the answer by over 50% of the nurses as the mental symptom at present were "do you fell bad when criticized?", "Do you get angry when everything is against your will?", "do you get angry when ordered to do this and that?", "do you feel uneasy by such a trifle thing?", "do you tremble or are you freightened by sudden sound?". The mental and physical symptoms which have appeared presently in connection with the shift service have been agreed with each other. But the physical condition has been worse than the mental one. 3) In the physical health conditions followed by demosociological character, there were the significant differences by sex, religion and place of residence(p<.05), and in the mental health conditions, there were the significant differences by age, marital status, residence place and the required time for attending hospital(p<.05). 4) There was significant difference by the degree of satisfaction about the duty in both the physical and mental health conditions. In short, the higher the degree of duty satisfaction, the better the health conditions. 5) There were the significant difference according to the times of night duty and whether they take the drug or not or the kinds of the drugs in the physical health conditions related with the characters of night shift. Mental health conditions in the night shift case showed significant differences according to their taking drug or not or the kinds of the drugs(p<.05). I can confirm that the nurses have been affected continuously by the shift service mentally and physically. The maintenance of the physical and mental health of the nurses and its promotion are very important problem to guarantee the quality nursing in the performance of the nursing service continuously and effectively, so the hospital should make every effort to improve the duty conditions by finding out the causes affecting to their health. In the nursing management viewpoint, I think that elevating the satisfaction degree about the duty would be a great help to the promotion of physical and mental health conditions. But what is most important is that the nurses themselves should take care of themselves in maintaining the good conditions in their service in the hospital.