• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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• pp.46-46
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• 2002

본 연구는 돼지의 미성숙 난포란을 체외에서 성숙, 수정시킨 후, 생산된 체외수정란을 NCSU 23 체외배양액에 항산화제 (NAC, ebselen 및 glutathione) 와 glutathione 합성억제제인 BSO의 첨가가 돼지 체외 수정란의 체외 발육에 미치는 영향을 검토하였다. Glutathione 합성 억제제인 BSO가 돼지 수정란의 체외 발육에 미치는 영향을 검토한 결과, 0, 1.0 및 5.0mM의 BSO 을 첨가하여 상실배기 이상 발육된 체외 발육 성적은 각각 35.9, 15.7 및 8.4%로서 BSO 첨가구가 대조구에 비해 통계적으로 유의하게 낮은 체외배율성적을 나타냈으며 (P＜0.05), NAC 1.0mM, ebselen 10μM 및 glutathione 100μM 과 BSO 1.0 mM 을 각각 첨가하여 체외 배양을 실시한 경우, 상실배 이상 발육된 체외 발육율은 40.5, 44.2, 36.0 및 10.9%로서 항산화제 첨가구가 BSO 첨가구보다 통계적으로 유의하게 높은 체외 발육 성적을 나타냈다 (P＜0.05). 모든 처리구에서 체외 수정 후 생산된 배반포기 수정란의 세포수에는 차이가 인정되지 않았다. (중략)

• 한국도서관정보학회지
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• 제14권
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• pp.149-179
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• 1987

The concept of a "switching language " between different indexing languages and information retrieval systems has been discussed since the mid-1960s. Some preliminary investigates into the feasibility of switching between mediating tool yielded positive results. The Broad system of ordering(BSO) , a general classification scheme for information exchange and switching, has been under development as a joint FID/UNESCO project since 1973. The purpose of this study is to find out the origin, development, definition, and principle of BSO. The results of the study can be summarized as follows: (1) BSO is a switching language for the purpose of interconnection of information system which is located different regions, or using different indexing languages. (2) BSO is in effect, fully faceted and broad classification system. (3) BSO is not only a subject code but also an ordering system. (4) BSO can be used information retrieval system because the notation of composite subjects is formed by combining notation. (5) BSO has to some extent sacrificed brevity by leaving large unused notational gap for future use. (6) The structure of the scheme is in no way dependent upon the notation. notation.

• 한국가축번식학회지
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• 제26권3호
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• pp.223-228
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• 2002

본 연구는 돼지의 미성숙 난포란을 체외에서 성숙, 수정시킨 후, 생산된 체외수정란을 NCSU 23 체외배양액에 항산화제NAC, ebselen 및 glutathione)와 BSO의 첨가가 돼지 체외수정란의 체외발육에 미치는 영향을 검토하였다. Glutathione 합성억제제인 BSO가 돼지수정란의 체외발육에 미치는 영향을 검토한 결과 0, 1.0 및 5.0 mM의 BSO을 첨가한 구에서 상실배기 이상 발육된 체외발육성적은 각각 35.9, 15.7 및 8.4%로서 BSO 첨가구가 대조구에 비해 통계적으로 유의하게 낮은 체외배율성적을 나타냈으며(P<0.05), NAC 1.0 mM ebselen 10 $\mu\textrm{m}$ 및 glutathione 100 $\mu\textrm{m}$ BSO 1.0 mM을 첨가하여 배양한 결과 상실배 이상 발육된 체외발육율은 40.5, 44.2, 36.0 및 10.9%로서 항산화제 첨가구가 BSO 첨가구보다 통계적으로 유의하게 높은 체외발육성적을 나타냈다P<0.05). 체외수정후 생산된 배반포기 수정란의 세포수는 BSO 농도(0, 1 및 5 mM)에 따른 차이는 인정되지 않았으나, 항산화제를 첨가한 경우에는 ebslene, NAC 및 glutathione 첨가구가 BSO 첨가구보다 유의하게 높은 세포수을 나타냈다(P<0.05).

• Biomolecules & Therapeutics
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• 제21권5호
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• pp.358-363
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• 2013

In the present study, we investigated the effect of intracellular glutathione (GSH) depletion in heart-derived H9c2 cells and its mechanism. L-buthionine-S,R-sulfoximine (BSO) induced the depletion of cellular GSH, and BSO-induced reactive oxygen species (ROS) production was inhibited by glutathione monoethyl ester (GME). Additionally, GME inhibited BSO-induced caspase-3 activation, annexin V-positive cells, and annexin V-negative/propidium iodide (PI)-positive cells. Treatment with rottlerin completely blocked BSO-induced cell death and ROS generation. BSO-induced GSH depletion caused a translocation of PKC-${\delta}$ from the cytosol to the membrane fraction, which was inhibited by treatment with GME. From these results, it is suggested that BSO-induced depletion of cellular GSH causes an activation of PKC-${\delta}$ and, subsequently, generation of ROS, thereby inducing H9c2 cell death.

• 한국초전도ㆍ저온공학회논문지
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• 제18권4호
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• pp.1-4
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• 2016

We investigated the relation between the Cu-O bond length and the superconducting properties of $BaSnO_3$ (BSO)-added $GdBa_2Cu_3O_{7-x}$ (GdBCO) thin films by using extended x-ray absorption fine structure (EXAFS) spectroscopy. 4 wt.% $BaSnO_3$ (BSO) added $GdBa_2Cu_3O_{7-x}$ (GdBCO) thin films with varying thickness from $0.2{\mu}m$ to $1.0{\mu}m$ were fabricated by using pulsed laser deposition (PLD) method. The transition temperature ($T_c$) and the residual resistance ratio (RRR) of the GdBCO films increased with increasing thickness up to $0.8{\mu}m$, where the crystalline BSO has the highest peak intensity, and then decreased. This uncommon behaviors of $T_c$ and RRR are likely to be created by the addition of BSO, which may change the ordering of GdBCO atomic bonds. Analysis from the Cu K-edge EXAFS spectroscopy showed an interesting thickness dependence of ordering behavior of BSO-added GdBCO films. It is noticeable that the ordering of Cu-O bond and the transition temperature are found to show opposite behaviors in the thickness dependence. Based on these results, the growth of BSO seemingly have evident effect on the alteration of the local structure of GdBCO film.

• 한국초전도ㆍ저온공학회논문지
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• 제19권3호
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• pp.18-22
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• 2017

Addition of $BaSnO_3$ (BSO) to $GdBa_2Cu_3O_{7-{\delta}}$ (GdBCO) is reported to enhance the flux pinning property of GdBCO thick films. To investigate the effect of growth condition on the pinning properties, 700 nm-thick BSO-added GdBCO films deposited with varying temperatures and growth rates were prepared by using a pulsed laser deposition method. As the deposition temperature increases, the critical current density and the pinning force density show an improved field dependence up to $750^{\circ}C$ due to the increase in the formation of the a-axis growth and the BSO nanostructures. The films deposited at higher temperatures show degraded surfaces and as a result, degraded pinning behaviors. For the change in growth rate, the critical current density and the pinning force increase as the repetition rate increase at low magnetic fields, but this behavior is reversed in high magnetic fields. These results indicate that the film growth conditions significantly affect the formation of BSO nanostructures and the pinning properties of BSO-added GdBCO films.

• 한국초전도ㆍ저온공학회논문지
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• 제19권3호
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• pp.13-17
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• 2017

We investigated the effect of self-assembled BSO nano-defects as pinning centers in BSO-added GdBCO films when the thicknesses of films were varied. 3.5 vol. % BSO-added GdBCO films with varying thicknesses from 200 nm to 1000 nm were deposited on $SrTiO_3$ (STO) substrate by using pulsed laser deposition (PLD) process. For the films with thicknesses of 400 nm and 600 nm, 'anomaly shoulders' in $J_c-H$ characteristic curves were observed near the matching field. The anomaly shoulders appeared in the field dependence of $J_c$ may be attributed to the existence of double pinning mechanisms in thin films. The fit to the pinning force density as a function of reduced field h ($H/H_{irr}$) using the Dew-Hughes' scaling law shows that both the 400 nm- and the 600 nm-thick films have double pinning mechanisms while the other films have a single pinning mechanism. These results indicate that the self-assembled property of BSO result in different role as pinning centers with different thickness.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권2호
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• pp.511-527
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• 2024

This paper proposes a block-based self-organizing time-division multiple access (BSO-TDMA) protocol for very high frequency (VHF) data exchange system (VDES) in shipborne ad-hoc networks (SANETs). The BSO-TDMA reduces the collisions caused by the simultaneous transmission of automatic identification system (AIS) messages by uniformly allocating channel resources using a block-wise frame. For this purpose, the BSO-TDMA includes two functional operations: (1) frame configuration and (2) slot allocation. The first operation consists of block division and block selection. A frame is divided into multiple blocks, each consisting of fixed-size subblocks, by using the reporting interval (RI) of the ship. Then, the ship selects one of the subblocks within a block by considering the number of occupied slots for each subblock. The second operation allocates the slots within the selected subblock for transmitting AIS messages. First, one of the unoccupied slots within the selected subblock is allocated for the periodic transmission of position reports. Next, to transmit various types of AIS messages, an unoccupied slot is randomly selected from candidate slots located around the previously allocated slot. Experimental simulations are conducted to evaluate the performance of BSO-TDMA. The results show that BSO-TDMA has better performance than that of the existing SOTDMA.

• 한국식품영양과학회지
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• 제44권7호
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• pp.961-969
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• 2015

본 실험의 복분자종자유는 리놀렌산 238.3 mg/g, 리놀레산과 감마리놀렌산 427.1 mg/g을 포함하며 이는 고시된 범위내의 섭취량이므로 독성시험 없이 4주 동안 매일 경구 투여로 암컷과 수컷 쥐 모두에게 섭취하도록 하였다. 또한 성인 정상체중을 약 60 kg으로 설정하고 60 kg의 성인이 하루 1 g, 2 g을 각각 섭취할 때의 혈중 지방의 감소 효과를 알아보기 위해 급이군의 설정을 1 g/60 kg BW/d(BSO 1 g), 2 g/60 kg BW/d(BSO 2 g)로 정하였다. 양성대조군의 경우에 판매되는 연어유 1,000 mg 캡슐을 2정 섭취하는 것을 권장하였고, 이에 맞추어 2 g/60 kg BW/d로 설정하게 되었다. 실험기간 종료 후 마우스를 희생시켜 혈액을 얻었으며, 복분자종자유(BSO 2 g)를 섭취한 마우스에서 총콜레스테롤 및 HDL, LDL/VLDL-콜레스테롤과 혈중 중성지방이 유의적으로 감소하는 것을 확인할 수 있었다(P<0.05). 이를 종합해 보았을 때 복분자종자유는 고지혈증 상태를 개선하고 미약하지만 항응고 활성을 통해 혈액의 항상성을 유지하도록 돕는 작용을 한다고 할 수 있다. 따라서 앞으로 동물 유래가 아닌 식물유래 복분자종자유를 이용한다면 고지혈증 개선 효과와 혈액 항응고 활성을 조절할 수 있을 것이며, 더욱 다양한 표적 인자 분석을 통하여 복분자종자유의 고지혈, 항응고 및 혈행개선 기전연구가 가능할 것이라 판단된다.

• Molecules and Cells
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• 제26권2호
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• pp.158-164
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• 2008

Arsenic trioxide (ATO) affects many biological processes such as cell proliferation, apoptosis, differentiation and angiogenesis. L-buthionine sulfoximine (BSO) is an inhibitor of GSH synthesis. We tested whether ATO reduced the viability of lung cancer A549 cells in vitro, and investigated the in vitro effect of the combination of ATO and BSO on cell viability in relation to apoptosis and the cell cycle. ATO caused a dose-dependant decrease of viability of A549 cells with an $IC_{50}$ of more than $50{\mu}m$. Low doses of ATO or BSO ($1{\sim}10{\mu}m$) alone did not induce cell death. However, combined treatment depleted GSH content and induced apoptosis, loss of mitochondrial transmembrane potential (${\Delta}{\Psi}_m$) and cell cycle arrest in G2. Reactive oxygen species (ROS) increased or decreased depending on the concentration of ATO. In addition, BSO generally increased ROS in ATO-treated A549 cells. ROS levels were at least in part related to apoptosis in cells treated with ATO and/or BSO. In conclusion, we have demonstrated that A549 lung cells are very resistant to ATO, and that BSO synergizes with clinically achievable concentration of ATO. Our results suggest that combination treatment with ATO and BSO may be useful for treating lung cancer.