• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.217-224
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• 2011

Subsyndromal bipolar symptoms are common during maintenance treatment and appear to be associated with relapse into an episode of the same polarity. This implies subsyndromal symptoms are an important problem in recurrent bipolar disorder and require more additive and infallible therapeutic intervention. Undetected, untreated subsyndromal states lead patients to have poor prognosis and quality of life. The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention vital for the treatment of bipolar disorders. Methods for early identification includes finding prodromes, using screening tools such as the HCL-32 (Hypomania Checklist-32) and the BSDS (bipolar spectrum diagnostic scale). Various augmentation treatment methods would be needed to reduce subsyndromal symptoms, especially, psychosocial treatment has the potential to help patients address the multiple psychosocial problems associated with this chronic illness. To overcome difficulties of diagnosing subsyndromal disorder and to treat it appropriately, a staging system was suggested by some researchers. It assumes that earlier stages have better prognosis and require simpler therapeutic regimens. Staging may assist in treatment planning and prognosis of bipolar disorder, and emphasize the importance of early intervention. Further research is required in this exciting and novel area.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.8
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• pp.2928-2947
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• 2015

Adaptive Gaussian filter (AGF) is a recently developed switching filter to remove salt and pepper noise. AGF first directly identifies pixels of gray levels 0 and 255 as noise pixels, and then only restored noise pixels using a Gaussian filter with adaptive variance based on the estimated noise density. AGF usually achieves better denoising effect in comparison with other filters. However, AGF still fails to obtain good denoising effect on images with noise-free pixels of gray levels 0 and 255, due to its severe false alarm in its noise detection stage. To alleviate this issue, a modified version of AGF is proposed in this paper. Specifically, the proposed filter first performs noise detection via an image block based noise density estimation and sequential noise density guided rectification on the noise detection result of AGF. Then, a modified Gaussian filter with adaptive variance and window size is used to restore the detected noise pixels. The proposed filter has been extensively evaluated on two representative grayscale images and the Berkeley image dataset BSDS300 with 300 images. Experimental results showed that the proposed filter achieved better denoising effect over the state-of-the-art filters, especially on images with noise-free pixels of gray levels 0 and 255.

• Journal of the Korean Society for Precision Engineering
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• v.31 no.3
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• pp.233-241
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• 2014

This paper contributes to development of a new method for detecting rear-side vehicles and estimating the positions for blind spot region or providing the lane change information by using vision systems. Because the real image acquired during car driving has a lot of information including the target vehicle and background image as well as the noises such as lighting and shading, it is hard to extract only the target vehicle against the background image with satisfied robustness. In this paper, the target vehicle has been detected by repetitive image processing such as sobel and morphological operations and a Kalman filter has been also designed to cancel the background image and prevent the misreading of the target image. The proposed method can get faster image processing and more robustness rather than the previous researches. Various experiments were performed on the highway driving situations to evaluate the performance of the proposed algorithm.

• Wind and Structures
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• v.28 no.5
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• pp.271-284
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• 2019

This paper describes the application of a novel virtual prototyping methodology to wind turbine blade design. Numeric modelling data and experimental data about turbine blade geometry and structural/dynamical behaviour are combined to obtain an affordable digital twin model useful in reducing the undesirable uncertainties during the entire turbine lifecycle. Moreover, this model can be used to track and predict blade structural changes, due for example to structural damage, and to assess its remaining life. A new interactive and recursive process is proposed. It includes CAD geometry generation and finite element analyses, combined with experimental data gathered from the structural testing of a new generation wind turbine blade. The goal of the research is to show how the unique features of a complex wind turbine blade are considered in the virtual model updating process, fully exploiting the computational capabilities available to the designer in modern engineering. A composite Sandia National Laboratories Blade System Design Study (BSDS) turbine blade is used to exemplify the proposed process. Static, modal and fatigue experimental testing are conducted at Clarkson University Blade Test Facility. A digital model was created and updated to conform to all the information available from experimental testing. When an updated virtual digital model is available the performance of the blade during operation can be assessed with higher confidence.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.129-132
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• 2022

Super-resolution is the process of converting a low-quality image into a high-quality image. This study was conducted using ESPCN. In a super-resolution deep neural network, different quality images can be output even when receiving the same input data according to the activation function that determines the weight when passing through each node. Therefore, the purpose of this study is to find the most suitable activation function for super-resolution by applying the activation functions ReLU, ELU, and Swish and compare the quality of the output image for the same input images. The CelebaA Dataset was used as the dataset. Images were cut into a square during the pre-processing process then the image quality was lowered. The degraded image was used as the input image and the original image was used for evaluation. As a result, ELU and swish took a long time to train compared to ReLU, which is mainly used for machine learning but showed better performance.

• The Korean Journal of Pharmacology
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• v.18 no.1
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• pp.43-54
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• 1982

Bile formation is a complex process comprised of three separate physiologic mechanism operating at two anatomical sites. At present time, it was known that at least two processes are responsible for total canalicular secretion at the bile canaliculus. One of the processes is bile salt-dependent secretion (BSDS) hypothesis that the active transport of bile salts from plasma to bile provided a primary stimulus for bile formation: the osmotic effect of actively transported bile acid was responsible for the movement of water and ions into bile. The other process is bile salt-independent secretion (ESIS), which is unrelated to bile salt secretion at the canaliculus and which may involve the active transport of sodium. The third process for bile formation involves the biliary ductal epithelium. Secretin-stimulated bile characteristically contained bicarbonate in high concentration. Therefor, it was suggested that secretin stimulated water and bicarbonate secretion from the biliary ductules. One the other hand, it was found that a large amounts of cAMP was present in canine bile but no apparent relationship between bile salt secretion and cAMP content in dog bile. However, bile flow studies in human have demonstrated that secretin and glucagon increase bile cAMP secretion as does secretin in baboons. Secretin increases baboon bile duct mucosal cAMP levels in addition to bile CAMP levels suggesting that in that species secretin-stimulated bile flow may be cAMP mediated. It has been postulated that glucagon and theophylline which increase the bile salt-independent secretion in dogs might act through an increased in liver cAMP content. In a few studies, the possible role of cAMP on bile formation has teen tested by administration of an exogenous derivative of cAMP, dibutyryl cAMP. In the rat, DB cAMP did not modify bile flow, but injection of DB cAMP in the dog promoted an increase in the bile salt-independent secretion. Because of these contradictory results, this study was carried out to examine the relationship between cyclic nucleotides and bile flow due to various bile salts as well as secretin or theophylline. Experiments were performed in rabbits with anesthesia produced by the injection of seconal(30 mg/kg). Rabbits had the cystic duct ligated and the proximal end of the divided common duct cannulated with an appropriately sized polyethylene catheter. A similar catheter was placed into the inferior vena cava for administration of drugs. Bile was collected for determination of cyclic nucleotides and total cholate in 15 min. intervals for a few hours. The results are summerized as followings. 1) Administrations of taurocholic acid or chenodeoxycholic acid increased significantly the concentrations of cAMP and cGMP in bile of rabbits. 2) Concentration of cAMP in bile during the continuous infusion of ursodeoxycholic acid, was remarkedly increased in accordance with the increase of bile flow, while on the contrary concentration of cGMP in bile was decreased significantly. 3) Dehydrocholic acid and deoxycholic acid significantly increased bile flow, total cholate output and cyclic nucleotides in bile. 4) Only cAMP concentration in bile was significantly increased from control value by secretin, while theophylline increased cAMP as well as cGMP in rabbit bile. 5) In addition, the administration of secretin to taurocholic acid-stimulated bile flow increased cAMP while theophylline produced the increases of cAMP and cGMP in bile. 6) The administration of insulin to taurocholic acid-stimulated bile flow decreased cAMP concentration, while on the contrary cGMP was remarkedly increased in rabbit bile.