• 경영과정보연구
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• 제39권2호
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• pp.17-37
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• 2020

본 연구의 목적은 2007년~2010년 유로 도입 이후 금융위기 및 그에 따른 EU 부채위기까지의 기간 내에 미국, 유럽 및 BRIC 금융시장 간의 선형과 비선형 인과관계의 존재를 통해 글로벌 전이효과를 조사하는데 있다. 금융위기로 인한 글로벌 전이효과가 잘 설명되어 있지만, 미국, 유럽 및 BRIC 주식시장 간의 변동성 전이효과의 특성 뿐만 아니라 전달 메커니즘은 체계적으로 조사되지 않았다. 동적 선형 및 비선형 인과관계를 조사하기 위해 단계적인 필터링 방법론이 도입되었는데, 이는 벡터자기회귀모형과 다변량 GARCH 모형을 포함한다. 본 논문의 표본은 유로 이후 기간을 포함하고 또한 2007년 금융위기, 2008년 글로벌 금융위기, 2010년 유로존 부채위기도 포함한다. 본 연구의 실증결과는 BRIC 주식시장의 효율성에 많은 함의를 가질 수 있는데 시장의 예측가능성에 영향을 미칠 뿐만 아니라 시장의 금융통합의 과정을 수량화하기 위해서 미래의 연구에 유용할 수 있다. 미국, 유럽 및 BRIC 간의 상호 의존성이 감지되면 금융시장 규제, 헤징 및 거래 전략에 대한 중요한 함의를 나타낼 수 있다. 또한 결과는 BRIC이 미국발 서브프라임 금융위기 이후 국제적으로 통합되고 있고 전이효과가 더욱 구체화 되어 현저하게 나타나고 있다는 것을 보여준다. 더욱이, 탈동조화 견해를 지지하는 일관된 증거가 전혀 없다. 일부 비선형 인과관계는 조사기간 동안 필터링 후에도 지속된다. 비록 꼬리분포 의존성과 고적률이 나머지 상호 의존성의 유의한 요소일 수 있을지라도, 이것은 비선형 인과관계가 단순한 변동성 효과에 의해 대체로 설명될 수 있다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권2호
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• pp.122-126
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• 2012

Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by multiple recurrent episodes of severe cholestatic jaundice without obstruction of extrahepatic bile duct. We present the case of a 7-year-old boy with BRIC confirmed by mutation analysis in the ATP8B1 gene and typical clinical manifestation. Despite inheritance of BRIC, we detected a mutation on only one allele. To our knowledge, this is the first report of BRIC with a confirmed single heterozygote novel mutation in the ATP8B1 gene in Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권2호
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• pp.201-206
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• 2019

Benign recurrent intrahepatic cholestasis (BRIC), a rare cause of cholestasis, is characterized by recurrent episodes of cholestasis without permanent liver damage. BRIC type 2 (BRIC2) is an autosomal recessive disorder caused by ABCB11 mutations. A 6-year-old girl had recurrent episodes of jaundice. At two months of age, jaundice and hepatosplenomegaly developed. Liver function tests showed cholestatic hepatitis. A liver biopsy revealed diffuse giant cell transformation, bile duct paucity, intracytoplasmic cholestasis, and periportal fibrosis. An ABCB11 gene study revealed novel compound heterozygous mutations, including c.2075+3A>G in IVS17 and p.R1221K. Liver function test results were normal at 12 months of age. At six years of age, steatorrhea, jaundice, and pruritus developed. Liver function tests improved following administration of phenylbutyrate and rifampicin. Her younger brother developed jaundice at two months of age and his genetic tests revealed the same mutations as his sister. This is the first report of BRIC2 confirmed by ABCB11 mutations in Korean siblings.

• 과학과기술
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• 1호통권440호
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• pp.28-29
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• 2006

• Molecules and Cells
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• 제43권7호
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• pp.591-599
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• 2020

Complex cell-to-cell communication underlies the basic processes essential for homeostasis in the given tissue architecture. Obtaining quantitative gene-expression of cells in their native context has significantly advanced through single-cell RNA sequencing technologies along with mechanical and enzymatic tissue manipulation. This approach, however, is largely reliant on the physical dissociation of individual cells from the tissue, thus, resulting in a library with unaccounted positional information. To overcome this, positional information can be obtained by integrating imaging and positional barcoding. Collectively, spatial transcriptomics strategies provide tissue architecture-dependent as well as position-dependent cellular functions. This review discusses the current technologies for spatial transcriptomics ranging from the methods combining mechanical dissociation and single-cell RNA sequencing to computational spatial re-mapping.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1996년도 한국생물과학협회 국제학술대회
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• pp.264.1-264
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• 1996

No Abstract, See Full Text

• 한국식물학회:학술대회논문집
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• 한국식물학회 1999년도 제13회 식물생명공학심포지움 New Approaches to Understand Gene Function in Plants and Application to Plant Biotechnology
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• pp.94-94
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• 1999

• Child Health Nursing Research
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• 제22권1호
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• pp.45-53
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• 2016

Purpose: The study was done to investigate behavioral problems in toddlers who were born prematurely and to analyze related factors. Methods: A cross-sectional explorative study was conducted with 72 preterm birth (PTB) children at 24 to 41 months of corrected age who were born at 28 to 37 weeks' gestation. During home visits, behavior problems were assessed using the Behavior Rating Index for Children (BRIC). Using a BRIC score of ${\geq}30$, children with suspected behavior problems were grouped in the non-regular behavior group. Results: Of the children, 38.9% belong to the non-regular behavior group. The mental development index score for the Korean-Bayley Scale of Infant Development- II was higher for the non-regular behavior group compared to the regular behavior group (t=2.26, p=.027). Logistic regression analysis showed that lower maternal attachment (<96, OR=3.4, 95% CI[1.1, 10.4]) and higher parenting stress (${\geq}97$, OR=4.8, 95% CI[1.3, 17.3]) were independently related to non-regular behavior. Conclusion: PTB Toddlers are at risk for behavior problems which are associated with low cognitive performance. Maternal-child attachment and maternal parenting stress were strongly related to behavior problems in these children. More attention is needed to understand possible behavior problems in young children with PTB, particularly focusing on maternal-child interaction and maternal mental well-being.

• 무역상무연구
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• 제47권
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• pp.25-48
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• 2010

The principle of parties' autonomy is one of general and dominant principles in an international trade contract. When we consider the determinants of negotiation outcomes, the negotiation is affected its result by their culture and custom. A negotiation has extensively been used a lot as a business process. As we negotiate with our clients, we have to check a lot of factors like strategies, their behaviors, culture shock and custom. That why most people have their different life and circumstance. The same words which are used its contract have several meaning. Because the words are influenced by culture and own custom. Also most people abide by their social pattern. Each culture in the world follows its own customs and traditions. Therefore, when we have the negotiation of trade contract, we have to think these factors. Then the negotiation is leaded very successful This dissertation examines the effects of the negotiators' personality and different culture and custom. On the point of a negotiating power, contracting parties are affected a lot by their usage. The culture which is influenced by contracting parties is possible to apply as a key point. So, this study will be analyzed these factors.

• 아태비즈니스연구
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• 제12권4호
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• pp.13-40
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• 2021

Purpose - The purpose of this study is to predict corporate corruption in emerging markets such as Brazil, Russia, India, and China (BRIC) using different machine learning techniques. Since corruption is a significant problem that can affect corporate performance, particularly in emerging markets, it is important to correctly identify whether a company engages in corrupt practices. Design/methodology/approach - In order to address the research question, we employ predictive analytic techniques (machine learning methods). Using the World Bank Enterprise Survey Data, this study evaluates various predictive models generated by seven supervised learning algorithms: k-Nearest Neighbour (k-NN), Naïve Bayes (NB), Decision Tree (DT), Decision Rules (DR), Logistic Regression (LR), Support Vector Machines (SVM), and Artificial Neural Network (ANN). Findings - We find that DT, DR, SVM and ANN create highly accurate models (over 90% of accuracy). Among various factors, firm age is the most significant, while several other determinants such as source of working capital, top manager experience, and the number of permanent full-time employees also contribute to company corruption. Research implications or Originality - This research successfully demonstrates how machine learning can be applied to predict corporate corruption and also identifies the major causes of corporate corruption.