• Clinical and Experimental Pediatrics
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• 제60권11호
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• pp.365-372
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• 2017

Purpose: The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and a disruption in cardiac-specific gene expression. Apoptosis has also been proposed as being involved in cardiac dysfunction. The purpose of this study was to determine if apoptosis might play a role in ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were separated into 2 groups: the control group (C group) and the experimental group (ADR 5 mg/wk for 3 weeks through intraperitoneal injections; A group). Echocardiographic images were obtained at week 3. Changes in caspase-3, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), interleukin (IL)-6, tumor necrosis $factor-{\alpha}$, brain natriuretic peptide (BNP), troponin I, collagen 1, and collagen 3 protein expression from the left ventricle tissues of C and A group rats were determined by Western blot. Results: Ascites and heart failure as well as left ventricular hypertrophy were noted in the A group. Ejection fraction and shortening fraction were significantly lower in the A group by echocardiography. The expression of caspase-3, Bax, IL-6, BNP, collagen 1, and collagen 3 were significantly higher in the A group as compared with the C group. Protein expression of Bcl-2 decreased significantly in the A group compared with the C group. Conclusion: ADR induced an upregulation of caspase-3, Bax, IL-6, and collagen, as well as a depression in Bcl-2. Thus, apoptosis and fibrosis may play an important role in ADR-induced cardiomyopathy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권7호
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• pp.2952-2971
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• 2016

Outsourcing jobs to a public cloud is a cost-effective way to address the problem of satisfying the peak resource demand when the local cloud has insufficient resources. In this paper, we studied the management of deadline-constrained bag-of-tasks jobs on hybrid clouds. We presented a binary nonlinear programming (BNP) problem to model the hybrid cloud management which minimizes rent cost from the public cloud while completes the jobs within their respective deadlines. To solve this BNP problem in polynomial time, we proposed a heuristic algorithm. The main idea is assigning the task closest to its deadline to current core until the core cannot finish any task within its deadline. When there is no available core, the algorithm adds an available physical machine (PM) with most capacity or rents a new virtual machine (VM) with highest cost-performance ratio. As there may be a workload imbalance between/among cores on a PM/VM after task assigning, we propose a task reassigning algorithm to balance them. Extensive experimental results show that our heuristic algorithm saves 16.2%-76% rent cost and improves 47.3%-182.8% resource utilizations satisfying deadline constraints, compared with first fit decreasing algorithm, and that our task reassigning algorithm improves the makespan of tasks up to 47.6%.

• 한국전기전자재료학회논문지
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• 제19권2호
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• pp.130-138
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• 2006

We have investigated pattern scaling down of silicon stamps through the oxidation technique, During oxidizing the silicon stamps, silicon dioxide that has 300 nm and 500 nm thickness was grown, and critical deformations were not observed in the patterns. There was positive effect to reduce size of patterns because vertical and horizontal patterns have different orientation. We achieved pattern reduction rate of $26\%$. In addition, the formation of polymer patterns had been investigated with varied temperature and pressure conditions to improve the filling characteristics of polymers during nanoimprint lithography when pattern sizes were few micrometers. In these varied conditions, polymers had been affected by free space compensation and elastic stress relaxation for filling the cavities. Based on the results, defect control which is an important issue in the nanoimprint lithography were facilitated.

• 통상정보연구
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• 제7권1호
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• pp.75-94
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• 2005

With most major full service banks having launched transactional Internet banking, attention is shifting to the realities of managing the Internet channel as a profitable component of an overall delivery strategy. In addition to examining Case Study and Internet Bank Model. Services of Internet Banking available through the Internet are as follows. 1. credit card loans, personal loans. 2. high-yield financial products. 3. insurance products. 4. securities products. 5. Case study of Foreign Internet Banking(ING, BNP, HSNC, City Bank). The study reviewed fields, including financial services, customer service, Website formation and design, convenience of use and system safety, Internet Banking Model, and many related areas. Internet Banking earned high marks in most fields. This study review focuses on the following: Understanding and meeting consumer expectations for us ability, site performance and functionality. Integrating the Internet channel into overall marketing, product delivery and customer service strategies. Strategies to increase customer satisfaction with Internet Banking and to attract new Internet bankers. therefore this study review activity model concretion of Internet Banking Model and Case Study.

• 경영과정보연구
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• 제30권1호
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• pp.107-128
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• 2011

본 연구는 고용인들의 직무 불만족과 그들의 창의성이 유의한 관계를 가지는가를 알아보기 위한 연구이다. 고용인들은 직무 불만족에 대한 반응으로 4가지의 방법 중 한 가지 방법을 선택하게 된다. 첫째, 직무와 관련되지 않는 일에 관심을 가지고 주위를 기울이며 자신이 맡은 직무를 전혀 하지 않을 수도 있고(무시), 더 나은 상황에서 일할 수 있도록 노력할 수도 있다.(의사표현). 또 다른 직장을 찾거나 현재 하고 있는 자신의 일을 그만 둘 수도 있고(이탈), 변화와 향상에 대한 노력없이 조직에 머물러 있을 수도 있다. 본 연구는 직무 불만족에 대한 고용인의 반응 중에서 의사표현(Voice)이 창의성으로 유발될 수 있다는 점에 근거하여 직무 불만족과 창의성의 관계를 알아보고자 하였다. 고용인의 직무 불만족이 창의성으로 나타나기 위해서는 창의성에 대한 인지된 조직지원과 동료의 도움과 지원을 고용인이 인지하는 것이 필요하다. 그리고 의사표현이라는 것은 고용인이 조직을 이탈하는 것이 아니라 조직에 머물러 있으며 이는 지속적 몰입과도 관련이 있음을 이론적으로 밝혀 보았다. 문헌 검증을 통해 실증 분석을 실시하여 본 결과 직무 불만족과 창의성은 매우 유의한 관계를 가지는 것으로 나타났다. 그러나 직무 불만족과 지속적 몰입과의 상호작용이 창의성과 유의한 관계를 가질 것이라는 가설은 지지되지 않았다. 그리고 직무 불만조고가 지속적 몰입의 상호작용이 창의성에 미치는 영향을 창의성에 대한 인지된 조직지원이 조절할 것이라는 가설은 지지되지 않았다. 또 직무 불만족과 지속적 몰입의 상호작용이 창의성에 미치는 영향을 동료의 도움과 지원이 조절할 것이라는 가설 역시 지지되지 않았다. 본 연구의 많은 가설들이 지지되지 않는 이유에 대해 생각해 보고자 한다.

• 생명과학회지
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• 제22권6호
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• pp.736-743
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• 2012

본 연구에서는 부산 신항 공사 지역 주변 해역의 총 16개 지역에서 2005년부터 2011년까지 분기별로 매년 4회씩 수달의 배설물을 수집하여 배설물 내 생물 잔해 즉 먹이의 종류를 알아보고, 신항 개발이 수달의 섭식 변화에 미치는 영향에 대해서 조사하였다. 그 결과, 수달은 주로 어류를 섭취하지만 갑각류와 복족류 등도 소수 섭취하는 것이 밝혀졌고, 숭어목이 수달의 주 먹이임이 밝혀졌다. 한편 어류는 모든 계절에 출현했지만 대부분의 어목의 출현 빈도와 어획량이 계절별로 매우 유사한 점으로부터, 수달이 섭취하는 어류의 양은 이 지역에 서식하는 어류의 양과 매우 밀접한 관련이 있음이 시사되었다. 한편 배설물에 출현한 대부분의 어류, 갑각류 및 복족류의 출현 빈도가 2010년 이후에 감소했는데, 이는 공사에 의해서 수달의 먹이가 감소했고, 가까운 장래에 수달의 개체 수가 감소할 수 있음을 시사한다. 이러한 추론은 2010년 이후 수달의 배설물 수가 감소했고, 최근에 이 지역의 어획량이 급감했고, 수질 오염도 증가했다는 연구들로부터 뒷받침된다.

• 한국식품저장유통학회지
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• 제22권3호
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• pp.421-427
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• 2015

고품질 참외와인을 제조하기 위하여 브랜칭 및 착즙 처리를 하여 발효와 숙성에 따른 이화학적 특성 및 항산화능을 조사하였다. 발효 중 참외와인의 이화학적 특성은 모든 처리구가 유사한 추이를 보였으며, 브랜칭 및 착즙 처리가 알코올 발효에 영향을 미치지 않았다. 숙성 후 이화학적 특성을 측정한 결과는 알코올 함량, 가용성 고형분 함량, 환원당 함량, 적정 산도, pH가 각각 11.5~11.8%, 10.7~11.2%, 0.25~0.49 g/100 mL, 0.60~0.81%, 3.75~3.89 범위로 나타났으며, 숙성 전에 비하여 가용성 고형분, 환원당, 알코올 함량, 적정산도는 감소하고 pH는 증가하는 것으로 나타났다. 항산화능은 DPPH 라디칼 소거 활성, FRAP 활성이 각각 $563.00{\sim}785.00{\mu}M\;TE$, $504.60{\sim}811.93{\mu}M\;TE$ 범위로 나타났으며, 브랜칭 처리구의 항산화 활성이 높았다. 총페놀성 화합물 함량은 287.53~312.08 mg/L 범위로 전처리 방법에 따른 유의적인 차이가 나타나지 않았으며(p<0.05), 총플라보노이드 함량은 39.06~141.03 mg/L 범위로 브랜칭 처리구의 함량이 높았다. 또한 QDA profile 결과는 색, 맛, 풋내, 이취, 종합적 기호도 항목에서 모두 브랜칭 처리구가 더 높은 점수를 얻었다. 브랜칭 처리는 참외와인의 항산화능을 증가시키고 기호성을 좋게 하는 반면, 착즙 처리는 참외와인 제조 시 영향을 미치지 않는 것으로 나타났다.

• Journal of Ginseng Research
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• 제47권1호
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• pp.106-116
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• 2023

Background: Pirarubicin (THP) is an anthracycline antibiotic used to treat various malignancies in humans. The clinical usefulness of THP is unfortunately limited by its dose-related cardiotoxicity. Ginsenoside F1 (GF1) is a metabolite formed when the ginsenosides Re and Rg1 are hydrolyzed. However, the protective effects and underlying mechanisms of GF1 on THP-induced cardiotoxicity remain unclear. Methods: We investigated the anti-apoptotic and anti-oxidative stress effects of GF1 on an in vitro model, using H9c2 cells stimulated by THP, plus trigonelline or AKT inhibitor imidazoquinoxaline (IMQ), as well as an in vivo model using THP-induced cardiotoxicity in rats. Using an enzyme-linked immunosorbent test, the levels of malondialdehyde (MDA), brain natriuretic peptide (BNP), creatine kinase (CK-MB), cardiac troponin (c-TnT), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione (GSH) were determined. Nuclear factor (erythroid-derived2)-like 2 (Nrf2) and the expression of Nrf2 target genes, including heme oxygenase-1 (HO-1), glutathione-S-transferase (Gst), glutamate-cysteine ligase modifier subunit (GCLM), and expression levels of AKT/Bcl-2 signaling pathway proteins were detected using Western blot analysis. Results: THP-induced myocardial histopathological damage, electrocardiogram (ECG) abnormalities, and cardiac dysfunction were reduced in vivo by GF1. GF1 also decreased MDA, BNP, CK-MB, c-TnT, and LDH levels in the serum, while raising SOD and GSH levels. GF1 boosted Nrf2 nuclear translocation and Nrf2 target gene expression, including HO-1, Gst, and GCLM. Furthermore, GF1 regulated apoptosis by activating AKT/Bcl-2 signaling pathways. Employing Nrf2 inhibitor trigonelline and AKT inhibitor IMQ revealed that GF1 lacked antioxidant and anti-apoptotic effects. Conclusion: In conclusion, GF1 was found to alleviate THP-induced cardiotoxicity via modulating Nrf2 and AKT/Bcl-2 signaling pathways, ultimately alleviating myocardial oxidative stress and apoptosis.

• Journal of Ginseng Research
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• 제47권6호
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• pp.755-765
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• 2023

Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important role in store-operated Ca²⁺ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protection against myocardial ischemia (MI) injury. SOCE, comprising STIM1, ORAI1 and TRPC1, contributes to intracellular Ca²⁺ ([Ca²⁺]_i) accumulation in cardiomyocytes. The purified extract of steamed Panax ginseng (EPG) attenuated [Ca²⁺]_i overload against MI injury. Thus, the aim of this study was to investigate the possibility of EPG affecting p-caveolin-1 to further mediate SOCE/[Ca²⁺]_i against MI injury in neonatal rat cardiomyocytes and a rat model. Methods: PP2, an inhibitor of p-caveolin-1, was used. Cell viability, [Ca²⁺]_i concentration were analyzed in cardiomyocytes. In rats, myocardial infarct size, pathological damages, apoptosis and cardiac fibrosis were evaluated, p-caveolin-1 and STIM1 were detected by immunofluorescence, and the levels of caveolin-1, STIM1, ORAI1 and TRPC1 were determined by RT-PCR and Western blot. And, release of LDH, cTnI and BNP was measured. Results: EPG, ginsenosides accounting for 57.96%, suppressed release of LDH, cTnI and BNP, and protected cardiomyocytes by inhibiting Ca²⁺ influx. And, EPG significantly relieved myocardial infarct size, cardiac apoptosis, fibrosis, and ultrastructure abnormality. Moreover, EPG negatively regulated SOCE via increasing p-caveolin-1 protein, decreasing ORAI1 mRNA and protein levels of ORAI1, TRPC1 and STIM1. More importantly, inhibition of the p-caveolin-1 significantly suppressed all of the above cardioprotection of EPG. Conclusions: Caveolin-1 phosphorylation is involved in the protective effects of EPG against MI injury via increasing p-caveolin-1 to negatively regulate SOCE/[Ca²⁺]_i.

• 한국정보과학회논문지:소프트웨어및응용
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• 제36권4호
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• pp.320-328
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• 2009

일반적으로 명사구는 기본명사구와 최장명사구로 분류되는데 최장명사구에 대한 정확한 식별은 문장의 전체적인 구문구조를 파악하고 정확한 지배용언을 찾아내는데 중요한 역할을 하게 된다. 본 논문에서는 확장된 청크(chunk) 개념과 다섯 개의 클래스로 세분화된 문장부호 정보를 자질로 사용한 두 단계 최장명사구 식별 기법을 제안한다. 제안한 기법은 기본모델보다 2.65% 향상된 평균 89.66%($F_1$-measure)의 우수한 성능을 보인다.