• Journal of the Korean Data and Information Science Society
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• 제18권4호
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• pp.1103-1113
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• 2007

LOD scores and a permutation test for detecting and locating Quantitative trait loci(QTL) from the Hanwoo economic trait have been described and we selected a considerable major BMS941 locus. K -means clustering analysis of eight markers in BMS941 and four traits resulted in three cluster groups. Finally, we applied the bootstrap test method to calculate confidence intervals for finding major DNA markers. We conclude that the major markers of BMS941 locus in Hanwoo chromosome 17 are markers 85bp and 105bp.

• 한국마린엔지니어링학회:학술대회논문집
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• 한국마린엔지니어링학회 2005년도 후기학술대회논문집
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• pp.11-12
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• 2005

BMS & Governor System은 선박용 추진 기관으로 사용되는 저속 디젤 엔진의 원격 운전 및 제어를 담당하는 시스템으로 선박 추진과 엔진 제어에 필수적인 중요 구성 요소이며, 조선 기자재관련 고부가가치 산업의 한 부분이다. 그러나 조선관련 산업에 있어서 세계 최강국의 위상에 걸맞지 않게 국내에는 BMS & Governor System의 독자 모델이 없는 실정이고, 유럽이나 일본의 제품으로 전량 수입에 의존하고 있는 상황이다. 이에 선박 추진용 저속 디젤 엔진을 위한 제어 시스템의 관련 기술을 연구하여, SEA-CAPS를 개발하였다. 본 연구에서는 BMS & Governor System에 대한 개요와 SEA-CAPS의 개발 내용, 그리고 환경 및 성능 시험에 관한 내용을 언급하고자 한다.

• Journal of Oral Medicine and Pain
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• 제24권4호
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• pp.467-477
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• 1999

Personality characteristics of orofacial pain patients was analyzed psychologically by means of the SCL-90-R. 36 TMD patients, 20 burning mouth syndrome(BMS) patients, 31 trigeminal neuralgia(TN) patients, 20 control I and 28 control II were subjected at Orofacial pain clinic, Department of Oral Medicine and Health Promotion Center, Pusan National University Hospital during the period from 1998 to 1999. The obtained results were as follows: 1. Mean values of T-scores on 9 basic scales in all the groups were within normal range. 2. The T-scores of SOM, O-C, ANX and HOS in TMD patient group were significantly higher than those in control I group, but there was no significant difference in all scales between TMD patient group and control II group. 3. The T-scores of SOM in BMS patient group was significantly higher than those in control I group, but there was no significant difference in all scales between BMS patient group and control II group. 4. The T-scores of SOM in TN patient group was significantly higher than those in control II group. 5. As compared with present and absent of the history of systemic diseases, there was no significant difference of the scales in TMD, BMS and TN patient groups but the T-scores of the patient groups with the history of systemic diseases tended to higher than those of the patient group without the history of systemic diseases. 6. As compared with acute and chronic groups, the T-scores of O-C, I-S, PAR, PSY in chronic BMS patient group were significantly higher than those in acute BMS patient.

• 대한한방내과학회지
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• 제37권6호
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• pp.978-989
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• 2016

Objectives: This study evaluated the diagnostic values of measuring the number of fungiform papillae in patients with burning mouth syndrome (BMS). Methods: Seventy participants (35 BMS patients and 35 Healthy control) participated in this study. The number of fungiform papillae (FP) was measured on the anterior part of the tongue within an area of $9mm^2$ using a digital camera. The subjects were evaluated on their yin deficiency and blood stasis conditions using the Yin-Deficiency Questionnaire (YDQ) and Blood Stasis Questionnaire (BSQ). Moreover, the severities of subjective tongue pain in the BMS patients were assessed using Visual Analog Scale. Results: There were significant differences in the number of FP and the YDQ and BSQ scores between the two groups. The number of FP and the YDQ scores in the BMS group showed statistically significant correlations with the VAS score of tongue pain. In the bivariate logistic regression analysis, the factor that most strongly contributed to BMS was the number of FP. The optimal cut-off value of the number of fungiform papillae was calculated as 5.5 with 71.4% sensitivity and 82.9% specificity. There was no statistically significant correlation between the number of FP and the YDQ or BSQ score. Conclusions: According to these findings, measuring the number of FP could be a valuable evaluation indicator of BMS.

• 대한한방내과학회지
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• 제34권2호
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• pp.122-133
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• 2013

Objectives : Burning mouth syndrome (BMS) is characterized by chronic pain or a burning sensation in the mouth. There is limited evidence available to provide clear guidelines for treating BMS patients and a variety of different treatments have been used. This study was designed to investigate the Effects of Korean medicine therapies on oral pain in patients with BMS. Methods : We surveyed 30 BMS patients who newly visited the Oral Diseases Clinic in the Kyung Hee University Korean Medicine Hospital from February 2012 to March 2013. When the patients visited the clinic for the first time, they were evaluated on sociodemographic characteristics, BMS questionnaire, severity of pain using visual analogue scale (VAS) and pressure pain threshold (PPT) of the acupuncture point CV17. After 3 weeks of Korean medicine therapies (acupuncture, electroacupuncture, pharmacopuncture and herbal medicine), they were re-evaluated with the VAS and the PPT. Results : After 3 weeks of Korean medicine therapies, 30 patients' oral pain improved and the PPT score on CV17 rose, which means decrease of qi-stagnation score. Conclusions : Korean medicine therapies were effective on oral pain in patients with BMS. To confirm the additional curative effect and evaluate the efficacy of each treatment, well-designed randomized controlled trials will be needed in the future.

• Journal of Oral Medicine and Pain
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• 제34권2호
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• pp.189-195
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• 2009

부산대학병원 구강내과에 내원한 환자 중에 구강검사 및 방사선검사를 통해 구강 작열감 증후군으로 진단된 환자를 실험군으로 선택하고, 같은 기간 구강 작열감 증후군의 증상 및 병력이 전혀 없고 구강내 병소가 없는 환자를 대조군으로 선택하여 사회적 재적응 평정척도 설문지를 이용하여 생활변화를 조사 분석한 결과 다음과 같은 결론을 얻었다. 1. BMS환자군은 최근 1년간 생활상의 변화를 대조군에 비해 다소 많이 경험하였고, 이는 내원 전 7개월에서 12개월 이내에서 차이를 보였다. 2. 고점자(생활변화량 150점이상)의 환자군과 대조군 간의 유의한 차이는 인정할 수 없었다. 3. 설문내용을 6개 범주로 나누었을 때, 6개의 범주에서 유의한 차이를 보이지 않았지만, 사회생활 범주에서 환자군이 다소 높은 경향을 나타내었다.

• Journal of Oral Medicine and Pain
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• 제44권1호
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• pp.25-30
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• 2019

Purpose: The exact causes of burning mouth syndrome (BMS) is unclear so far. There are many studies to elucidate the relation between oral disease and genetic predisposition. In this study, we first tried to investigate salivary exosomal genetic components that could play an important role for diagnosing and elucidating the progression of BMS. Methods: We compared salivary exosomal micro RNAs (miRNAs) of BMS Patients to those of control using next generation sequencing (NGS). Unstimulated whole saliva from 15 patients with BMS and 10 control subjects were divided into two sets. Isolated exosomes and their total RNAs were subject to NGS for the screening of miRNAs. Results: There were up-regulated 10 exosomal miRNAs (hsa-miR-1273h-5p, hsa-miR-1273a, hsa-miR-1304-3p, hsa-miR-4449, hsa-miR-1285-3p, hsa-miR-6802-5p, hsa-miR-1268a, hsa-miR-1273d, hsa-miR-1273f, and hsa-miR-423-5p) and down-regulated 18 exosomal miRNAs (hsa-miR-27b-3p, hsa-miR-16-5p, hsa-miR-186-5p, hsa-miR-142-3p, hsa-miR-141-3p, hsa-miR-150-5p, hsa-miR-374a-5p, hsa-miR-93-5p, hsa-miR-29c-3p, hsa-miR-29a-3p, hsa-miR-148a-3p, hsa-miR-22-3p, hsa-miR-27a-3p, hsa-miR-424-5p, hsa-miR-19b-3p, hsa-miR-99a-5p, hsa-miR-548d-3p, and hsa-miR-19a-3p) in BMS patients comparing with those of control subjects. Conclusions: We show that there are 28 differential expression of miRNAs between the patients with BMS and those of control subjects. The specific function of indicated miRNAs should be further elucidated.

• 대한한방내과학회지
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• 제43권1호
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• pp.53-67
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• 2022

Objectives: This study aimed to identify the characteristics of the heart rate variability (HRV) index in patients with burning mouth syndrome (BMS) and to evaluate the predictive value of HRV for Korean medical treatment responsiveness to tongue pain in BMS. Methods: Among BMS patients who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from January 1, 2018, to May 31, 2021, we reviewed the clinical records of 217 women aged 50 years and over. HRV and unstimulated saliva flow rate (USFR) measurements were carried out, and all patients were asked to indicate their degree of tongue pain using the visual analog scale (VAS). The subjects were classified into subgroups according to the presence or absence of hyposalivation and VAS improvement, and each subgroup was compared using the HRV index. Logistic regression analysis was conducted to confirm whether cause-effect relationships were present between statistically significant values. Results: BMS patients had lower LF and HF than healthy people. Subgroup analysis demonstrated that there were some statistically significant differences in the HRV index according to salivation rate and degree of pain. In addition, as the LF/HF ratio increased, the pain improvement rate decreased after treatment. Conclusion: The autonomic nerve activity of BMS patients was lower than that of healthy people; however, autonomic balance was not impaired. In addition, tongue pain in BMS patients responded more favorably to Korean medical treatment when patients fell within a normal range of the LF/HF ratio, suggesting that autonomic imbalance could be used as one of the predictable factors in clinical practice.

• 대한한방내과학회지
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• 제41권5호
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• pp.838-847
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• 2020

Objectives: The aim of this study was to investigate the clinical characteristics of patients with Burning Mouth Syndrome (BMS) due to hyposalivation (HS). Methods: We reviewed the clinical records of 39 BMS patients who visited the Department of Digestive Diseases of Kyunghee Korean Medicine Hospital from March 1st, 2020 to July 31st, 2020. The subjects were classified according to the presence or absence of hyposalivation and both groups were compared for the proportion of coated tongue, heart rate variability (HRV), Ryodoraku, and the numeral rating scale (NRS) score of tongue pain results. Results: The BMS with Hyposalivation (HS group) and the BMS without Hyposalivation (Non-HS group) showed a significant difference in the proportion of coated tongue and the NRS score for tongue pain. The NRS score was significantly higher in the Non-HS group and the proportion of coated tongue was lower. However, no significant differences were noted in several HRV parameters between the two groups. The most frequent accompanying symptoms were xerostomia and dyspepsia. Conclusions: The results of this study suggest that hyposalivation might be one of the main causes of tongue pain, the key complaint in BMS patients. Sympathetic/parasympathetic imbalance might not be a main contribution of hyposalivation in BMS. Instead, factors such as the number of medications taken seem to correlate with hyposalivation in BMS. This results could be useful in the management of BMS patients with hyposalivation in clinical practice.

• Journal of Oral Medicine and Pain
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• 제38권4호
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• pp.313-318
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• 2013

수면은 외부의 자극에 대해 반응하지 않는 상태로 만성통증을 지닌 환자는 수면 장애를 겪고 있으며 수면장애는 통각과 민한 상태를 유발하고 통증인지에 영향을 미친다. 구강작열감 증후군은 구강점막에 화끈거리는 감각을 포함하는 만성 안면통증으로 감각과 통증 역치가 변성되고 신경병증 징후를 보인다. 구강작열감 증후군은 첫 번째로 국소적, 전신적 요인 즉, 흡연, 투약 등 작열감 증상의 원인으로 가능한 요인을 제거하고, 두 번째로는 환자를 안심시키는데 있다. 수면박탈 내인성, 외인성 아편유사제의 진통효과는 수면 계속성 즉, 선택적인 렘수면 박탈은 아편유사제 진통효과를 방해 하고 opioid protein synthesis 억제를 야기하고 ${\mu}$ 와 ${\delta}$ opioid 수용체 친화력을 감소시킨다. enkephalinase-inhibitor와 MAO-B inhibitor 적용으로 나타나는 아편유사제의 진통상승효과는 렘수면 박탈시에 무효화 된다. 렘수면 박탈후에는 5-HT 와 5-hydroxy indole acetic acid 레벨이 유의하게 감소되고, 아편유사체에 활성에 의해 유발되는 통증억제를 지지하는 세로토닌 체계를 가능하지 않게 한다. 구강작열감 증후군은 설말단 신경섬유에서 추삭변성 변화가 있고 특히, 열자극, 냉자극 및 미각 유해수용성 자극의 인지를 포함한 감각변화가 폐경기후 생식스테로이드의 급격한 감소가 신경활성 스테로이드 생성에 변성을 일으켜며, 이것은 말초성 변성와 중추성 변성이 존재함을 제시한다. 구강작열감 증후군은 기본적으로 가능한 요인을 제거하는 것이 중요하므로 구강작열감의 진행을 방지하고, 만정적인 작열감의 경감을 위하여 증상 경과에 영향을 미칠 수 있는 수면에 대하여 고찰하고자 한다.