• Journal of Korean Society on Water Environment
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• v.28 no.6
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• pp.933-942
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• 2012

The purpose of this study is to evaluate the degree of waterbody impairment according to the flow conditions and present to the appropriate water quality improvement alternatives using observed water quality and flow for Total Maximum Daily Load (TMDL) implementation at 39 unit watersheds the nakdong river basin. Observed water quality data for 7 years are divided into five cumulative flow frequency group and comparing the each observed water quality data and TMDL Target water quality (TWQ) the last evaluate the water quality is impaired group. We found that the cumulative flow frequency group-specific the average excess rate of V group was the highest (32.86%), followed by the IV group (26.04%), group III (23.36%), II group (22.67%), I group (20.70%), the degree of impaired waterbody tended to be inversely proportional to the flow rate. Resulted from cumulative flow frequency group of impaired water quality assessment, 13 unit watersheds are impaired from a group IV and group V affected by point sources. Therefore, improvement of sewage discharge and the initial composition of the riparian buffer zone are needed. Nakbon F, Namkang D and Namkang E within 13 unit watersheds are impaired from group II and III affected by non-point sources. Therefore, application of Best Management Practices (BMPs) is needed for these watersheds. Evaluation of impaired waterbody using Cumulative flow frequency group is able to determine the extent of the judgment to TWQ exceeded by the flow conditions and helps proper setting Standard flow and planning pollutant reduction for TMDL.

• Journal of Korean Society on Water Environment
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• v.34 no.3
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• pp.293-300
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• 2018

Ihe purpose of this study is to evaluate the effects the storage type of permeable concrete block paving (ST-PCBP) have on runoff reduction and infiltration increasement at Andong Maskdance Festival Square. This was accomplished using the NRCS-curve number method over the last 10 years. Two different scenarios were developed in this study for low impact development (LID) design. For the $1^{st}$ scenario, the walking path and parking lot were install using the ST-PCBP and runoff from the inline skating rink ($3,808m^2$) and lawn ($11,191m^2$) were routed to the ST-PCBP, but the rooftop runoff flowed into the storm water drainage system. For the $2^{nd}$ scenario, one of the non-structural BMPs, disconnected impervious surface (DIS), was applied so additional runoff from rooftop would enter the ST-PCBP. It was determined that ST-PCBP could significantly reduce surface runoff from the study area and increase infiltration with 71% and 88% of surface runoff reduction and 151% and 215% of infiltration increasement for scenarios 1 and 2, respectively. The effect of LID in the $2^{nd}$ scenario was better than the $1^{st}$ scenario, therefore DIS in conjunction with ST-PCBP could be a more cost-effective LID application.

• Journal of Periodontal and Implant Science
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• v.38 no.sup2
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• pp.355-362
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• 2008

Purpose: The carrier for the delivery of bone morphogenetic proteins(BMPs) should also serve as a scaffold for new bone growth. In addition, predictable bone formation in terms of the volume and shape should be guaranteed. This study evaluated the ectopic bone formation of recombinant human BMP-2(rhBMP-2) using a micro macroporous biphasic calcium phosphate (MBCP: mixture of ${\beta}TCP$ and HA) block as a carrier in a rat subcutaneous assay model. Materials and Methods: Subcutaneous pockets were created on the back of 40 male Sprague-Dawley rats. In the pockets, rhBMP-2/MBCP and MBCP alone were implanted. The blocks were evaluated by histological and histometric parameters after a healing interval of 2 weeks (each 10 rats; MBCP and rhBMP-2/MBCP) or 8 weeks (each 10 rats; MBCP and rhBMP-2/MBCP). Results: The shape and volume of the block was maintained stable over the healing period. No histological bone forming activity was observed in the MBCP alone sites after 2 weeks and there was minimal new bone formation at 8 weeks. In the rhBMP-2/MBCP sites, new bone formation was evident in the macropores of the block. The new bone area at 8 weeks was greater than at 2 weeks. There was a further increase in the quantity of new bone with the more advanced stage of remodeling. Conclusions: A MBCP block could serve as a carrier system for predictable bone tissue engineering using rhBMPs.

• Journal of Wetlands Research
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• v.11 no.2
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• pp.55-66
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• 2009

The increase of pollutant loadings from nonpoint sources affect the water quality of the major rivers in Korea. Consequently, the need for managing the nonpoint source (NPS) pollution becomes the main concern of the Korean Ministry of Environment (MOE). Recently, the policy was changed from pollutant concentration-restricting approach to the total maximum daily load (TMDL) approach to improve the water quality and protect the aquatic ecosystem. Part of the program is the construction of Best Management Practice (BMP) pilot facilities basically to control NPS. Most of the BMPs adopted were foreign technologies which could not be properly employed in the country due to some limitations such as climate, watershed characteristics, etc. In other words, to be able to apply the BMPs, research on its applicability is necessary. In this study, a three-year monitoring has been conducted to assess the treatment performance of the BMP installed in highway toll plaza and parking lot. The data gathered aid in the characterization of NPS pollutants in runoff and estimation of the pollutant removal efficiency of the BMP. The results will be used for the future implementation of BMP in different land uses as well as for the determination of optimum operation and maintenance.

• Molecules and Cells
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• v.40 no.8
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• pp.550-557
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• 2017

The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ligament progenitor cells. The periodontitis is a representative oral disease where the PDL tissue is collapsed, and regeneration of this tissue is important in periodontitis therapy. Fibroblast growth factor-2 (FGF-2) stimulates proliferation and differentiation of fibroblastic MSCs into various cell lineages. We evaluated the dose efficacy of FGF-2 for cytodifferentiation of hPDLSCs into ligament progenitor. The fibrous morphology was highly stimulated even at low FGF-2 concentrations, and the expression of teno/ligamentogenic markers, scleraxis and tenomodulin in hPDLSCs increased in a dose dependent manner of FGF-2. In contrast, expression of the osteo/cementogenic markers decreased, suggesting that FGF-2 might induce and maintain the ligamentogenic potential of hPDLSCs. Although the stimulation of tenocytic maturation by $TGF-{\beta}1$ was diminished by FGF-2, the inhibition of the expression of early ligamentogenic marker by $TGF-{\beta}1$ was redeemed by FGF-2 treatment. The stimulating effect of BMPs on osteo/cementogenesis was apparently suppressed by FGF-2. These results indicate that FGF-2 predominantly differentiates the hPDLSCs into teno/ligamentogenesis, and has an antagonistic effect on the hard tissue differentiation induced by BMP-2 and BMP-4.

• The Journal of the Korean dental association
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• v.52 no.4
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• pp.218-233
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• 2014

Bispbosphonates are a class of pharmaceutic agents, which induce apoptosis of osteoclast as well as impair osteoclastic activity to suppress bone resorption. Thus, bisphophonates are effectively used to treat osteoporosis, multiple myeloma and to prevent bone metastases of malignant cancer. However, recently dental disease have been reported associated with Bisphosphonates. Thus, there are a number of discussions about proper prevention and treatment of bisphosphonate-related osteonecrosis of jaw(BRONJ). Marshall R. Urist in 1965 made the seminal discovery that a specific protein, BMP(bone morphogenetic protein), found in the extracellular matrix of demineralized bone could induce bone formation newly when implanted in extraosseous tissues in a host. BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this study, patients of BRONJ were recieved who visited Department of oral and maxillofacial surgery, school of dentistry, Wonkwang university for past 3 years from 2011 to 2013. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and LFA(Lidocaine-Fibrinogen-Aprotinin)-collagen scaffold for patients of BRONJ. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and LFA collage scaffold.

• Journal of Korea Water Resources Association
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• v.51 no.7
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• pp.585-597
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• 2018

This study aims to investigate the variation of water quality and discharge under the condition of climate change and Best Management Practices (BMPs), which is one of the reduction methods for non-point source pollution. Soil and Water Assessment Tool (SWAT) model is applied to case in Cheongmicheon watershed. The coefficients required for SWAT model were calibrated using SWAT Calibration and Uncertainty Program. Climate change is considered by using Representative Concentration Pathway (RCP) scenarios, RCP 4.5 and RCP 8.5. It is known from simulation results that the non-point source pollutant increases under the climate change scenario assuming worse condition. It is also found in this study that an appropriate application of BMPs is able to reduce the quantity and temporal variation of non-point source pollutant effectively.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.324-324
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• 2019

최근 급격한 기후변화 및 도시화로 인해 강우시 첨두유량이 증가하고, 도심 및 농촌지역에 비점오염원과 관련된 문제가 빈번하게 발생하고 있는 실정이다. 비점오염원에 대한 관리는 발생원 및 특성 파악이 어려운 특성으로 인해 관리가 미흡하며, 이에 따라 비점오염원 관리의 중요성이 커지고 있다. 각 토지이용별로 발생하는 비점오염원을 적절하게 관리하기 위해서는 유역별 비점오염원 발생특성에 대한 파악이 우선적으로 이루어져야 하며 다양한 관리기법에 대한 분석이 필요하다. 이에 본 연구에서는 SWAT모형을 이용하여 비점저감시설을 적용하였을 때의 비점오염부하량의 변화에 대한 분석을 진행하였다. 본 연구에서는 도시유역, 농업유역, 복합유역을 대상으로 비점저감시설을 적용하였을 때 비점오염부하량의 변화를 분석하였다. 우선 유역별 유출량 및 비점오염부하량을 모의하기 위하여 SWAT모델을 사용하였다. 모의된 유출량 및 비점오염부하량은 수질 측정 성과를 이용하여 보정을 수행하였다. 이후 비점오염 취약 소유역 선정을 위해 수질항목별 연간 비점오염부하량 크기에 따라 순위를 산정하고, 순위를 산술 평균하여 소유역별 전체 오염원에 대한 비점오염부하량 순위를 산정하였다. 비점오염 취약 소유역에 BMPs 및 LID를 적용한 결과, 도촌천의 비점오염 취약 소유역에서 SS, $NO_3-N$, TP의 평균 저감효율은 각각 11.17%, 3.47%, 18.85%로 나타났다. 공지천 도시지역에 LID 적용시 비점오염 취약 소유역에서 SS, $NO_3-N$, TP의 평균 저감효율은 각각 0.67%, 5.77%, 1.86%로 나타났다. 또한 공지천 농촌지역에 BMPs 적용시 SS, TN, TP의 평균 저감효율은 각각 14.22%, 1.67%, 4.43%로 나타났다. 또한 설성천의 비점오염 취약 소유역에서의 SS, TN, TP의 평균 저감효율은 각각 57.29%, 7.48%, 14.84%로 나타났다.

• Journal of Korean Society on Water Environment
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• v.37 no.2
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• pp.103-113
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• 2021

In this study, an Excel-based model (ROADMOD) was developed to estimate pollutant loading from the road and evaluate BMPs. ROADMOD employs the Chezy-Manning equation and empirical expression for estimating surface runoff, and power function for pollutant buildup, and exponential function for pollutant washoff in SWMM. The results of model calibration for buildup and washoff using observed data revealed a good match between the simulation results and the observed data. The long-term surface runoff and sediment simulated by ROADMOD demonstrated a good match with those by SWMM with 2 ~ 14% of relative error. The shorter sweeping interval (within 8 days) remarkably decreased sediment loads from the road. It was found that the effect of reducing sediment loads from the road was greatly affected not only by the sweeping interval but also by sweeping on the day before a rainfall event. The 48% of removal efficiency of sediment loads from the road was achieved with 26 times of road sweeping per year when sweeping was performed on the day before the rainfall event. A 4-day sweeping interval showed similar removal efficiency (48%) with 96 times of sweeping per year. It is considered that the road sweeping on the day before a rainfall event could maximize the effect of reducing the non-point source pollution from the road with minimization of the number of road sweeping. So, the road sweeping on the day before a rainfall event can be considered as one of the useful and best management practices (BMPs) on road.

• Journal of The Korean Society of Agricultural Engineers
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• v.64 no.4
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• pp.1-10
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• 2022

A vegetative filter strip (VFS) is one of the best management practices (BMPs) to reduce pollutant loads. This study aims to assess the effectiveness of VFS in dense upland field areas. The study areas are agricultural fields in the Maedae (MD), Gaa (GA), and Jaun (JU) watersheds, where severe sediment yields have occurred and the Korean government has designated them as non-point management regions. The agricultural fields were divided into three or four clusters for each watershed based on their slope, slope length, and area (e.g., MD1, MD2). To assess the sediment trapping (STE) and pesticide reduction efficiency (PRE) of VFS, the Vegetative Filter Strip Modeling System (VFSMOD) was applied with three different scenarios (SC) (SC1: VFS with rye vegetation; SC2: VFS with rye vegetation and a gentle slope in VFS range; and SC3: VFS with grass mixture). For SC1, there were relatively short slope lengths and small areas in the MD1 and GA3 clusters, and they showed higher pollutant reduction (STE>50%, PRE>25%). For SC2 and SC3, all clusters in GA and some clusters (MD1 and MD3) in MD show higher pollutant reduction (>25%), while the uplands in JU still show a lower pollutant (<25%). With correlation analysis between geographic characteristics and VFS effectiveness slope and slope length showed relative higher correlations with the pollutant efficiency than a area. The results of this study implied that slope and slope length should be considered to find suitable upland conditions for VFS installations.