• 대한치주과학회:학술대회논문집
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• 2001.12a
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• pp.106-106
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• 2001

• 대한치주과학회:학술대회논문집
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• 2007.11a
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• pp.128-129
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• 2007

• Journal of Life Science
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• v.29 no.3
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• pp.303-310
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• 2019

The purpose of the study was to compare the effect of either moderate or high intensity aerobic exercise on inflammasome, M1, M2 macrophage infiltration and brown adipocyte markers in subcutaneous adipose tissue of the high fat diet-induced obese mice. The 4 weeks male C57BL/6 mice were randomly assigned to four groups: normal diet control (NC; n=10), high-fat diet control (HC; n=10), high fat diet with moderate intensity exercise (HME; n=10), or high fat diet with high intensity exercise (HIE; n=10) groups. The high fat diet was given 60% calories from fat whereas normal diet was given 18% calories from fat. The moderate intensity exercise group (HME) was set at 10m/min in the first 2 weeks, 12m/min in 3-5 weeks and 14m/min in 6-16 weeks and the high intensity exercise group (HIE) was set at 14m/min in the first 2 weeks, 17m/min in 3-5 weeks and 18m/min in 6-16 weeks. The semi quantitative reverse transcription-polymerase chain reaction (RT PCR) was used to analyze the gene expression. The moderate intensity exercise significantly reduced the expression of NLRP3, F480, CD11c and CD86. Further, the moderate intensity exercise significantly increased CD206 and $PGC1{\alpha}$, BMP7 and PRDM. The high intensity exercise significantly reduced NLRP3, CD11c and CD86. Further, the high intensity exercise significantly increased $PGC1{\alpha}$ and BMP7. In conclusion, moderate intensity exercise has more positive effects on inflammasome, M1, M2 macrophage infiltration and brown adipocyte maskers compared to high intensity exercise in high fat diet induced obese mice.

• Journal of Environmental Impact Assessment
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• v.20 no.6
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• pp.857-866
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• 2011

This research categorized EIA target highways into following three types in order to minimize non-point source pollution from highway runoff. 1. Big drainage basin. 2. Small drainage basin. 3. Bridge section. The Natural, Filter and Swirl-Type devices were evaluated in terms of removal efficiency of TSS, BOD, COD, T-N, T-P, compatibility of site selection, economic feasibility, and maintenance convenience through which the final BMP was selected. According to the removal efficiency result, the area of Big and Small Drainage basin and bridge section had higher removal efficiency with natural facility than that of the Filter or Swirl-Type device. To make appropriate selection of highways'BMP for non-point source pollution, this study will aim to contribute to building more environmentally friendly highways by proposing the selection process that is made of 5 stages. 1. Selecting the target drainage basin. 2. Selecting the land for the mitigation facility. 3. Analysing the ease of maintenance. 4. Technically evaluating each installation. 5. Evaluating the effective implementation methods.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.1
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• pp.55-62
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• 2012

This study is to assess the reduction of nonpoint source pollution by applying Best Management Practice (BMP) in Chungju-dam watershed (6,585.1 $km^2$) using Soil and Water Assessment Tool (SWAT). The model was calibrated using 3 years (1998-2000) daily streamflow at 3 locations and monthly water quality of sediment (SS), total nitrogen (T-N) and total phosphorus (T-P) data at 2 locations and validated for another 3 years (2001-2003) data. The 5 BMPs of streambank stabilization, porous gully plugs, recharge structures, terrace, and contour farming were applied to stream and area with the specific criteria of previous researches. Through the parameter sensitivity analysis, the farming practice P-factor and Manning's roughness of stream were sensitive. Overall, the NPS reduction effect was high for streambank stabilization, terrace, and contour farming. At the watershed outlet, the SS, T-P, and T-N were reduced by 64.4 %, 62.8 % and 17.6 % respectively.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.39 no.4
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• pp.150-155
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• 2013

Objectives: The objective of this study is to determine the adequate concentration and to evaluate the osteogenic potential of simvastatin in human maxillary sinus membrane-derived stem cells (hSMSC). Materials and Methods: Mesenchymal stem cells derived from the human maxillary sinus membrane were treated with various concentrations of simvastatin. The adequate concentration of simvastatin for osteogenic induction was determined using bone morphogenetic protein (BMP-2). The efficacy of osteogenic differentiation of simavastatin was verified using osteocalcin mRNA, and the mineralization efficacy of hSMSCs and simvastatin treatment was compared with alkaline phosphatase and von Kossa staining. Results: Expression of BMP-2 mRNA and protein was observed after three days and was dependent on the concentration of simvastatin. Expression of osteocalcin mRNA was observed after three days in the $1.0{\mu}M$ simvastatin-treated group. Mineralization was observed after three days in the simvastatin-treated group. Conclusion: These results suggest that simvastatin induces the osteogenic potential of mesenchymal stem cells derived from the human maxillary sinus membrane mucosa.

• Journal of Soil and Groundwater Environment
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• v.15 no.2
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• pp.40-46
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• 2010

In this study, microwave irradiation, which is reflected by metals, was used to reduce the amount of sewage sludge, and the results were used to verify solubilization efficiency and determine optimum operation conditions. Biogas production and methane content of the gas under optimized conditions were measured with the biochemical methane potential (BMP) test. The sludge was taken from a thickened sludge tank at J sewage treatment plant (JSTP) in Seoul, Korea. For the experiments, 50 mL of sludge was filled in vessels and the vessels were irradiated with the power of 500, 600, 700, and 800W for 2~5 min. In addition, Fe powder was added by 0.01, 0.05, and 0.1 g to compare the efficiency with and without Fe powder. The results confirmed that solubilization efficiency was higher in the presence of Fe powder. The optimum conditions of 0.01 g addition of Fe powder with 800W irradiation for 5 min, yielded nearly 22.95% higher solubilization efficiency than without Fe powder. The BMP tests were carried out using sludge obtained from the experiments carried out under the optimum conditions. As a result, sludge subjected by 800W with 0.01 g of Fe powder for 5 min displayed the highest level of gas production and methane content. Through this study, it could be confirmed that solubilization efficiency increased by addition of Fe powder.

• Biomaterials and Biomechanics in Bioengineering
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• v.1 no.3
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• pp.151-162
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• 2014

Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.

• Journal of Internet Computing and Services
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• v.2 no.2
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• pp.37-50
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• 2001

To access massive and various HTML documents that are in the web using wireless Internet equipments, another WML document that is equal to the HTML document must be written, In the case Web documents written by HTML are massive, the construction of a WML site with the same information needs much cost of space and time, This paper designs and implements the HTML-XML converter that alleviates such a problem. The HTML-WML converter translates the Web document written by HTML to the WML document for portable wireless equipments, The HTML-XML converter has advantages that it reconstructs WML document dynamically according to portable wireless equipments and processes various image formats such as GIF, JPG, BMP, and so on, The HTML-WML converter can be used as not only a utility of the WML editor but also a real-time converter on wireless Internet.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.6
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• pp.374-378
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• 2003

Aim : Several injectable materials have been used in the application of osteogenic bone substitute; however, nothing has won universal acceptance. This study was performed to investigate whether chitosan-alginate gel/MSCs/BMP-2 composites are potentially injectable materials for new bone formation. Material and Methods : The composites were injected into the subcutaneous space on the dorsum of the nude mouse to investigate whether new bone would be tissue engineered in the mouse. The composites were examined histologically over a 12-week period. Results : The composites implanted in the mouse were able to tissue engineer new bone, and the newly formed bone consisted of trabecular bone and calcified bone matrix. Conclusions : The present study shows that chitosan-alginate gel/MSCs/BMP-2 composites have the potential to become real injectable materials for new bone formation.