Biomaterials and Biomechanics in Bioengineering

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Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration

  • Ahn, Jongchan (Department of Biomedical Science, CHA University) ;
  • Park, Seah (Department of Biomedical Science, CHA University) ;
  • Cha, Byung-Hyun (Department of Biomedical Science, CHA University) ;
  • Kim, Jae Hwan (Department of Biomedical Science, CHA University) ;
  • Park, Hansoo (Department of Integrative Engineering, Chung-Ang University) ;
  • Joung, Yoon Ki (Department of Biomedical Science, CHA University) ;
  • Han, Inbo (Department of Neurosurgery, Bundang Medical Center, CHA University) ;
  • Lee, Soo-Hong (Department of Biomedical Science, CHA University)
  • Received : 2014.09.29
  • Accepted : 2014.09.30
  • Published : 2014.09.25
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Abstract

Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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