• Journal of Genetic Medicine
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• v.4 no.1
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• pp.53-63
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• 2007

Purpose : Tandem mass spectrometry (MS/MS) is effective screening test for inherited metabolic diseases. In this study, we estimate potential costs and benefits of using tandem mass spectrometry (MS/MS) to screen new borns for inherited metabolic diseases (phenylketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency) in Korea. Methods : From April 2001 to March 2004, 79,179 new borns were screened for amino acid disorders, organic acid disorders, and fatty acid oxidative disorders. Twenty-eight new borns were diagnosed with one of the metabolic disorder and the collective estimated prevalence amounted to 1 in 2,800 with a sensitivity of 97.67%, a specificity of 99.28%, a recall rate of 0.05%, and a positive preditive value of 6.38%. We calculated and compared the total costs in case when neonatal screening on pheny lketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency is implemented, and when not. Results : If the neonatal screening on pheny lketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency is implemented, total benefits far exceed costs at a ratio of 1.40:1. Conclusion : Although, this study only concerns the monetary aspects of the neonatal screening, tandem mass spcetrometry for neonatal screening is cost-effective compared with not screening. The study appears to support the introduction of tandem mass spectrometry into a Korea neonatal screening programme for inherited metabolic diseases.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.2
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• pp.239-246
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• 2014

Purpose: This study was performed to investigate the effect of induced ametropia on static posture for body balance. Methods: Twenty subjects (10 males, 10 females) of average age $23.4{pm}2.70$ years were participated and ametropia(binocular myopia; BM, simple myopic anisometropia; SMA, binocular hyperopia; BH, and simple hyperopic anisometropia; SHA) were induced with ${pm}0.50D$, ${\pm}1.00D$, ${\pm}1.50D$, ${\pm}2.00D$, ${\pm}3.00D$, ${\pm}4.00D$, ${\pm}5.00D$, respectively. General stability (ST), weight distribution index (WDI), and fall risk index (FI) were measured using TETRAX the biofeedback systems. Each index of the body balance was evaluated for 32 seconds in each ametropic condition and those value was compared with the value in fully corrected condition. Results: The ST showed significant increase from +0.50 D under condition of BM, from +1.00 D under condition of SMA, from -1.00 D under condition of BH, and from -1.50 D under condition of SHA compared with under condition of fully corrected condition, respectively. The FI showed significant increases from +4.00 D under condition of BM, from -1.00 D under condition of BH, and from -1.50 D under condition of SHA. The WDI show no change in all ametropia condition. Conclusions: Whatever ametropia is, uncorrected refractive error could reduce the general stability of body balance and increase the falling risk.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.3
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• pp.233-239
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• 2013

A 100 W fuel cell system using chemical storage method has been applied for a propulsion system of the SUAV(Small Unmanned Aerial Vehicle). A fuel cell and battery have been combined for both the small/light hydrogen generation control system and the hybrid power supply system. A small hydrogen generation device was implemented to utilize NaBH4 aqueous solution and dead-end type PEMFC system, which were evaluated on the ground and by the flight tests. The system pressurized at a 45kpa stably operates and get higher fuel efficiency. The pressure inside of the hydrogen generation control system was maintained at between 45 kPa and 55 kPa. The 100W fuel cell system satisfies the required weight and power consumption rate as well as the propulsion system, and the fuel cell system performance was demonstrated through flight test.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.3
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• pp.226-232
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• 2013

A compact hydrogen generation device of fuel cell system using chemical hydride storage technique was designed to fit the propulsion device requirement of a small unmanned aerial vehicle(SUAV). For high efficient, compact, and lightweight hydrogen generation control device, the Co-B catalyst hydrogen conversion rate by $NaBH_4$ aqueous solution flux is measured so that the proper amount of Co-B catalyst for maximum hydrogen generation of 100W stack was proposed. A compact hydrogen generation device is controlled by pump's on/off using its own internal pressure and consumes fuel in high efficiency through a dead-end type fuel cell. The fuel cell system has stable operation for a planed flight profile. The system operates up to maximum 7 hours and at least 4 hours for tough flight profiles.

• Journal of Microbiology and Biotechnology
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• v.30 no.6
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• pp.937-945
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• 2020

N-acyl-homoserine lactone (AHL)-mediated quorum sensing (QS) plays a major role in development of biofilms, which contribute to rise in infections and biofouling in water-related industries. Interference in QS, called quorum quenching (QQ), has recieved a lot of attention in recent years. Rhodococcus spp. are known to have prominent quorum quenching activity and in previous reports it was suggested that this genus possesses multiple QQ enzymes, but only one gene, qsdA, which encodes an AHL-lactonase belonging to phosphotriesterase family, has been identified. Therefore, we conducted a whole genome sequencing and analysis of Rhodococcus sp. BH4 isolated from a wastewater treatment plant. The sequencing revealed another gene encoding a QQ enzyme (named jydB) that exhibited a high AHL degrading activity. This QQ enzyme had a 46% amino acid sequence similarity with the AHL-lactonase (AidH) of Ochrobactrum sp. T63. HPLC analysis and AHL restoration experiments by acidification revealed that the jydB gene encodes an AHL-lactonase which shares the known characteristics of the α/β hydrolase family. Purified recombinant JydB demonstrated a high hydrolytic activity against various AHLs. Kinetic analysis of JydB revealed a high catalytic efficiency (k_cat/K_M) against C4-HSL and 3-oxo-C6 HSL, ranging from 1.88 x 10⁶ to 1.45 x 10⁶ M^-1 s^-1, with distinctly low K_M values (0.16-0.24 mM). This study affirms that the AHL degrading activity and biofilm inhibition ability of Rhodococcus sp. BH4 may be due to the presence of multiple quorum quenching enzymes, including two types of AHL-lactonases, in addition to AHL-acylase and oxidoreductase, for which the genes have yet to be described.

• Journal of Veterinary Clinics
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• v.28 no.1
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• pp.7-12
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• 2011

This study was performed to evaluate the size and asymmetry of the lateral ventricles in CT images of three different small breed dogs. CT examinations were performed on thirty Yorkshire terriers, malteses, and shihtzu dogs, respectively. The size and asymmetry of their lateral ventricles were evaluated at three different levels of brain, and dogs were categorized on the basis of the percentage of their ventricular height (Vh) to brain height (Bh). Degree of asymmetry was also categorized based on the rVh (ratio of right and left ventricular heights) as normal (rVh < 1.5), mild (1.5 < rVh < 2.0), or severe (2.0 < rVh). Clinically insignificant ventricular dilation was common in these breed dogs. However, severe asymmetry was not presented in clinically normal dogs. We suggested 11 mm as an upper limit of ventricular size in normal small breed dogs.

• Korean Journal of Materials Research
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• v.11 no.8
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• pp.685-689
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• 2001

We carried out these experiments to examine the effects of element substitution of Co and La-Co for Sr-ferrite. The calcined properties of Co and La-Co element substitution were examined, and also the sintered magnetic properties were measured with the stoichiometric condition. The magnetic properties of $(La-Co)_{0.3}-SrM$ composition are as follows; $(M_s)$: 71.08 emu/g, $iH_c$: 4.38 kOe and $B_r$ : 4.18 kG, $iH_ c$ :4.35 kOe, $BH_{max}$: 4.3 MGOe. The $BH_{max}$ value was increased up to 10 % compared with conventional values. Our results imply that the magnetic properties of Sr-ferrite can be improved by the substitution of those elements.

• Journal of Fisheries and Marine Sciences Education
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• v.8 no.1
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• pp.41-47
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• 1996

The fishing experiment was carried out in order to analyses the mesh selectivity for trawl cod - end in the Southern Korean Sea and East China Sea from June,1991 through December, 1992. The mesh selectivity was examined for the five kinds with opening mesh size, of which having mesh s izes 51.2mm, 70.2mm, 77.6mm, 88.0mm and 111.2mm. In this report, mesh selectivity were taken analyses trawl cod - end for Priacanthus macracanthus. The main results obtained were as follows : 1. The relation equations between total length(TL) and body height(BH), body girth(BG) and body weight(BW) were BH=0.256 TL+2.963, BG=0.620 TL+8.650 and $BW=7.34{\times}10^{-5}TL^{2.6956}$, respectively. 2. 50% selection length and selection factor of trial cod - end with opening mesh size having 51.2mm, 70.2mm, 77.6mm, 88.0mm were 94.8mm, 1.85 ; 159mm, 2.27 ; 204mm, 2.09 ; 217.3mm, 2.18, respectively. 3. Range of opening mesh size from 51.2mm to 88.0mm, parameters of master curve were slope 2.70, intercept - 5.7 and selection factor 2.11.

• Korean Journal of Remote Sensing
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• v.36 no.6_1
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• pp.1291-1302
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• 2020

To verify the field-effectiveness of Terrestrial Laser Scanner (TLS), a terrestrial LiDAR was deployed to examine the damage properties of woods in forest fire area, then the data was compared with the results surveyed by a forestry expert. Four sample plots (30 m × 50 m, 0.15 ha) were set from the foot to the top of the mountain, and DBH, height, clear length, burned height, and crown length were investigated. Next, TLS collected information on damage characteristics found in the sample plots. This information was then compared with that amassed by the expert. The expert and the TLS survey results showed 30.8 cm and 29.9 cm for DBH, 15.8 m and 17.5 m for tree height, 8.4 m and 8.4 m for clear length, 4.0 m, 3.5 m for burned height, and 7.4 cm and 9.1 cm for crown length. With the exceptions of height and clear length, no notable discrepancy was observed between two methods. H/D ratio, CL/H ratio, and BH/CL ratio, all of which contribute to stability and decay rate of the stand, from the two methods were also compared. The human survey rated each ratio (H/D, CL/H, BH/CL in order) 51.3%, 47.1%, and 53.6%, while the TLS presented the results of 58.8%, 52.0%, and 38.7%.

• Journal of the Korean Wood Science and Technology
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• v.31 no.5
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• pp.65-71
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• 2003

In this paper, bending capacities of glulams with different configurations of cross-section were evaluated. These configurations included horizontal(BH), vertical(BVN), vertical with vertical plywood (BVV) and vertical combination of lamination with horizontal plywood(BVH). Full-scale bending tests were performed to investigate the effect of different section configurations on bending strength(MOR) and stiffness(MOE) of glulam. Compared with type BH, MOR of glulam with type BVN configuration was improved about 23%, which was considered to be caused by defect dispersion effect, while MOE of glulams with these two types of configurations were similar. Because MOE of plywood is generally smaller than that of solid wood laminar, MOE of type BVH glulam decreased about 15%, but in the case of type BVV glulam, MOR was improved without any reduction of MOE. The reason of this result could be undersood in the view of shear-reinforcement effect, which was verified from analysis of fracture mode. From the results of this study, it was concluded that bending capacity of glulam could be improved by proper section design, such as laminar arrangement and shear reinforcement.