• Title/Summary/Keyword: BDM

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Tissue Transglutaminase Antibody and Its Association with Duodenal Biopsy in Diagnosis of Pediatric Celiac Disease

  • Meena, Daleep K.;Akunuri, Shalini;Meena, Preetam;Bhramer, Ashok;Sharma, Shiv D.;Gupta, Rajkumar
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.22 no.4
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    • pp.350-357
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    • 2019
  • Purpose: This study aimed to evaluate a possible association between the anti-tissue transglutaminase antibody (anti-tTG) titer and stage of duodenal mucosal damage and assess a possible cut-off value of anti-tTG at which celiac disease (CD) may be diagnosed in children in conjunction with clinical judgment. Methods: This observational study was conducted at a gastroenterology clinic in a tertiary hospital from April 2012 to May 2013. Seventy children between 6-months and 18-years-old with suspected CD underwent celiac serology and duodenal biopsy. Statistical analyses were done using SPSS 16. Diagnostic test values were determined for comparing the anti-tTG titer with duodenal biopsy. An analysis of variance and Tukey-Kramer tests were performed for comparing the means between groups. A receiver operating characteristics curve was plotted to determine various cut-off values of anti-tTG. Results: The mean antibody titer increased with severity of Marsh staging (p<0.001). An immunoglobulin (Ig) A-tTG value at 115 AU/mL had 76% sensitivity and 100% specificity with a 100% positive predictive value (PPV) and 17% negative predictive value (NPV) for diagnosis of CD (p<0.001, 95% confidence interval [CI], 0.75-1). Conclusion: There is an association between the anti-tTG titer and stage of duodenal mucosal injury in children with CD. An anti-tTG value of 115 AU/mL (6.4 times the upper normal limit) had 76% sensitivity, 100% specificity, with a 100% PPV, and 17% NPV for diagnosing CD (95% CI, 0.75-1). This cut-off may be used in combination with clinical judgment to diagnose CD.

Probabilistic Project Duration Estimation by Combination of PERT and PLET in High-Risk Project (고위험 사업에서 PERT와 PLET기법 결합에 의한 확률적 사업공기 추정)

  • Kim, Seon-Gyoo;Kim, Junyoung
    • Korean Journal of Construction Engineering and Management
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    • v.17 no.3
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    • pp.71-80
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    • 2016
  • PERT(Project Evaluation and Review Technique) is typical method in order to probabilistically establish the schedule plan for large scale complex project or mega project. PERT technique is impossible to estimate relationship of each activity probabilistically when there are overlapping relationships because it is limited to Finish-to-Start(FS) relationship. In order to overcome this kind of limitation of PERT technique, PLET(Probabilistic Linkage Evaluation Technique) has been suggested to probabilistically estimate project duration for various overlapping relationships for each activity. However, estimating project duration by PLET technique only considers uncertainty of relationship between activities and not activity time, thus it is not the perfect duration estimating method. The main objective of this research is to propose the integration model of PERT and PLET and verify its probabilistic validity. By verifying application of time calculation method of integration model in practical case, this research will suggest probabilistic project duration estimating method in schedule plan of high-risk construction industry.

An Analysis of Verbal Interaction among Science-Gifted Students in Inquiry Learning Based on Analogical Experimental Design Strategy Emphasizing Understanding and Checking Stages (이해와 검토 단계를 강조한 비유 실험 설계 전략을 활용한 탐구수업에서 나타나는 과학영재 사이의 언어적 상호작용 분석)

  • You, Ji-Yeon;Noh, Tae-Hee
    • Journal of The Korean Association For Science Education
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    • v.32 no.4
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    • pp.671-685
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    • 2012
  • In this study, we developed an analogical experimental design strategy emphasizing understanding and checking stages and applied it to four groups consisting of 7th grade science-gifted students. We classified the patterns of experimental design processes and analyzed the verbal interactions among the science-gifted students at the levels of turn and interaction unit. The analyses of the results reveled that three groups were relevant to reinitiated motion and the other to backward-divergent motion. In the analyses of turn and interaction unit, the frequencies of the statements related to the task were high, especially 'making suggestion' and 'elaborated symmetrical interaction'. The analyses for each stage of strategy indicated that the frequencies of 'explain', 'question', and 'cumulative interaction' at understanding stage were high. At designing stage, the frequencies of 'making suggestion', 'cumulative interaction', and 'disputative interaction' were found to be high. At checking stage, 'making suggestion', 'receiving opinion', and 'disputative interaction' were high. In the comparison of the patterns, the qualitative differences among interaction unit were found at all the stages, whereas there were differences only between designing and checking stages in the turn cases. Educational implications of these findings are discussed.

Success Factors of Scheduling in Small-Scale Building Construction with Owner-CM Delivery Method (건축주-CM 방식의 소규모 건축공사에서 공정관리 성공 요인)

  • Kim, Seon-Gyoo;Kim, Junyoung
    • Korean Journal of Construction Engineering and Management
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    • v.20 no.1
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    • pp.96-104
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    • 2019
  • Recently, projects are being actively promoted to develop a new residential district centered around the metropolitan area, or to redevelop the residential area that was established long ago as unplanned land development. In this residential area, the owner can directly construct the building, and the way the building owner builds the residential house is called the direct construction of the owner. If the owner has the construction management (CM) capability while conducting direct management of the owner, the direct construction can be carried out by the CM method. This type of construction is called Owner-CM delivery method. However, it is very rare for small-scale construction in Korea to be implemented by the Owner-CM method. This may be due to the lack of knowledge and experience about the CM of the owner. In this study, we investigated the actual cases of the scheduling for the residential houses of similar size which were built at the same time in the residential housing complex developed near the metropolitan area. The purpose of this study is to derive the success factors of the scheduling in the small-scale construction from the cases carried out by the Owner-CM method. These success factors of the scheduling can be used as meaningful reference for the owners who want to build their own house in the future.