• 수산해양교육연구
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• 제27권3호
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• pp.821-832
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• 2015

The aims of this study are to estimate the optimal vessel reduction scales and these direct economic effects of coastal and offshore fisheries in the Republic of Korea. To estimate respectively optimal fishing efforts of individual fishery by species in coastal and offshore fisheries, we adopted appropriate fishing power of each species published by National Fisheries Research and Development Institute and also considered biological and socio-economic factors such as the bycatch rate, the profit rate, the efficiency of resource use, the average age of fishing vessel, the intention of vessel reduction, and the annual changes in vessels by other factors. The direct economic effects of the optimal vessel reduction in coastal and offshore fisheries based on maximum sustainable yield and 2/3 maximum sustainable yield was calculated by a cost-benefit analysis. This study showed that optimal reduction numbers of vessels engaged in coastal and offshore fisheries were 4,431 and 374 vessels and the direct economic effects in coastal and offshore fisheries were about 371.7 and 569.4 billion won and these NPV and BCR were 111.7 billion won and 1.65 and 342.6 billion won and 4.97 respectively.

• Journal of Electrical Engineering and Technology
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• 제9권4호
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• pp.1240-1247
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• 2014

The applications of Distributed Generation (DG) in a smart distribution grid environment are widely employed especially for power balancing and supporting demand responses. Using these applications can have both positive and negative impacts on the distribution system. The sizing and location of their installations are the issues that should be taken into consideration to gain the maximum benefit from them when considering the economic aspects. This paper presents an application of the Bat Algorithm (BA) for the optimal sizing and siting of DG in a smart distribution power system in order to maximize the Benefit to Cost Ratio (BCR), subjected to system constraints including real and reactive power generation, line and transformer loading, voltage profile, energy losses, fault level as well as DG operating limits. To demonstrate the effectiveness of the proposed methodology and the impact of considering economic issues on DG placement, a simplify 9-bus radial distribution system of the Provincial Electricity Authority of Thailand (PEA) is selected for the computer simulation to explore the benefit of the optimal DG placement and the performance of the proposed approach.

• Molecules and Cells
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• 제44권7호
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• pp.444-457
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• 2021

Although the mechanism of chronic myeloid leukemia (CML) initiation through BCR/ABL oncogene has been well characterized, CML cell differentiation into erythroid lineage cells remains poorly understood. Using CRISPR-Cas9 screening, we identify Chromobox 8 (CBX8) as a negative regulator of K562 cell differentiation into erythrocytes. CBX8 is degraded via proteasomal pathway during K562 cell differentiation, which activates the expression of erythroid differentiation-related genes that are repressed by CBX8 in the complex of PRC1. During the differentiation process, the serine/threonine-protein kinase PIM1 phosphorylates serine 196 on CBX8, which contributes to CBX8 reduction. When CD235A expression levels are analyzed, the result reveals that the knockdown of PIM1 inhibits K562 cell differentiation. We also identify TRIM28 as another interaction partner of CBX8 by proteomic analysis. Intriguingly, TRIM28 maintains protein stability of CBX8 and TRIM28 loss significantly induces proteasomal degradation of CBX8, resulting in an acceleration of erythroid differentiation. Here, we demonstrate the involvement of the CBX8-TRIM28 axis during CML cell differentiation, suggesting that CBX8 and TRIM28 are promising novel targets for CML research.

• 항공우주의학회지
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• 제31권3호
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• pp.82-83
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• 2021

Chronic myeloid leukemia (CML) is myeloproliferative neoplasm associated with a characteristic chromosomal translocation (bcr-abl) called Philadelphia chromosome which plays a key role in the pathogenesis. Approximately 85% of patients with CML are in the chronic phase at the time of diagnosis. During this phase, patients are well tolerated and have few symptoms. But untreated, over the course of several years progresses to an accelerated phase and ultimately to a blast crisis, the terminal phase. CML is largely treated with targeted drug therapy called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since 2001. These drugs became standard treatment of this disease and allow most patients to have much better quality of life when compared to the former chemotherapy drugs and the bone marrow transplantation. Imatinib (Gleevec or Glivec, Norvatis) was the first of these TKIs and found to inhibit the progression of CML in the majority of patients (65%-75%) sufficiently to achieve remission. Since the advent of imatinib, CML has become the first neoplasm in which a medical treatment can give to the patient a normal life expectancy.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.602-607
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• 2013

Financial risks associated with capital investments are often measured with different feasibility indicators such as the net present value (NPV), the internal rate of return (IRR), the payback period (PBP), and the benefit-cost ratio (BCR). This paper aims at demonstrating practical applications of probabilistic feasibility analysis techniques for an integrated feasibility evaluation of the IRR and PBP. The IRR and PBP are concurrently analyzed in order to measure the profitability and liquidity, respectively, of a cash flow. The cash flow data of a real wind turbine project is used in the study. The presented approach consists of two phases. First, two newly reported analysis techniques are used to carry out a series of what-if analyses for the IRR and PBP. Second, the relationship between the IRR and PBP is identified using Monte Carlo simulation. The results demonstrate that the integrated feasibility evaluation of stochastic cash flows becomes a more viable option with the aide of newly developed probabilistic analysis techniques. It is also shown that the relationship between the IRR and PBP for the wind turbine project can be used as a predictive model for the actual IRR at the end of the service life based on the actual PBP of the project early in the service life.

• 한국수소및신에너지학회논문집
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• 제16권3호
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• pp.238-243
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• 2005

Mg and Mg-based alloys are most important hydrogen storage materials. It is a lightweight and low-cost materials with high hydrogen storage capacity. However, the formation of hydride at high temperature, the deterioration effect, the hydriding and dehydriding kinetics are bad factor for application. In this study, Mg and Ni have been produced by hydrogen induced mechanical alloying(HIMA) process. The raw materials, Mg(purity 99.9%) chip and Ni(purity 99.95%) chip was prepared by using a planetary ball mill apparatus(FRITSCH pulverisette 5). The balls to chips mass ratio(BCR) are 30:1. The hydrogen pressure induced 2.0MPa and milling times were 12, 24, 48, 72, 96 hours with a rotating speed of 200rpm. X-ray diffraction(XRD) analysis was made to characterize the crystallite size and misfit strain. The crystallite size measured by laser particle size analysis(PSA). Microstructure changes were investigated by scanning electron microscopy(SEM) and the transmission electron microscopy(TEM). The hydrogen storage properties were evaluated by using an Sivert's type automatic pressure-composition-therm(PCT) apparatus.

• 대한토목학회논문집
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• 제14권2호
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• pp.335-341
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• 1994

본 논문은 Geogrid로 보강된 사질토층에 지지되고 있는 정방향 얕은 기초 지지력에 대한 실내 모형실험 결과를 제시하였다. Geogrid의 사용은 연약 지반의 강도 특성 및 하중-침하 관계에서의 개선을 위한 경제적이면서도 시간 절약의 효과를 가져올 수 있다. 특히 Geogrid로 보강된 지반은 기계 기초, 철로 제방, 그리고 지진 예상 지역의 구조물 기초 등에 필수적이다. 모형 실험결과 얕은 기초의 한계 침하에서 극한 지지력에 대한 지지력 비율이 결정되었다. 또한 상대 밀도가 중간 정도인 사질토층에 보강재를 설치하였을 때 극한 지지력이 상당량 증가됨을 알 수 있었으며, 향후 현장에서 유용하게 사용될 새로운 보강토 방법을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7343-7350
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• 2015

Genetic changes associated with acute lymphoblastic leukemia (ALL) provide very important diagnostic and prognostic information with a direct impact on patient management. Detection of chromosome abnormalities by conventional cytogenetics combined with fluorescence in situ hybridization (FISH) play a very significant role in assessing risk stratification. Identification of specific chromosome abnormalities has led to the recognition of genetic subgroups based on reciprocal translocations, deletions and modal number in B or T-cell ALL. In the last twelve years 102 newly diagnosed childhood/adult ALL bone marrow samples were analysed for chromosomal abnormalities with conventional G-banding, and FISH (selected cases) using specific probes in our hospital. G-banded karyotype analysis found clonal numerical and/or structural chromosomal aberrations in 74.2% of cases. Patients with pseudodiploidy represented the most frequent group (38.7%) followed by high hyperdiploidy group (12.9%), low hyperdiploidy group (9.7%), hypodiploidy (<46) group (9.7%) and high hypertriploidy group (3.2%). The highest observed numerical chromosomal alteration was high hyperdiploidy (12.9%) with abnormal karyotypes while abnormal 12p (7.5%) was the highest observed structural abnormality followed by t(12;21)(p13.3;q22) resulting in ETV6/RUNX1 fusion (5.4%) and t(9;22)(q34.1;q11.2) resulting in BCR/ABL1 fusion (4.3%). Interestingly, we identified 16 cases with rare and complex structural aberrations. Application of the FISH technique produced major improvements in the sensitivity and accuracy of cytogenetic analysis with ALL patients. In conclusion it confirmed heterogeneity of ALL by identifying various recurrent chromosomal aberrations along with non-specific rearrangements and their association with specific immunophenotypes. This study pool is representative of paediatric/adult ALL patients in Oman.

• 한국지하수토양환경학회지:지하수토양환경
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• 제21권6호
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• pp.169-178
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• 2016

The Standards, Measurement and Testing Programme (SM&T-formerly BCR) extraction procedure was applied to fractionate Cr, Cu, Ni, Pb and Zn in 23 top soil samples into: (i) exchangeable phase; (ii) reducible phase; (iii) oxidisable(sulfides and organics bound) phase; and (iv) residual phase. Fractions of Cr and Ni were in the order of residual > oxidisable > reducible > exchangeable phase. The oxidisable phase was identified as dominant for Cu and Pb. Zn had the highest ratio of exchangeable phase in comparision to the other metals. The bioavailability and mobility were assessed to be the greatest for Zn, followed by a decreasing order of Pb, Cu, Ni and Cr. All metal average concentrations in topsoil samples was higher in industrial sites than in agricultural sites. Our results revealed higher concentrations in topsoil samples (0~15 cm) than in sub soils (15~30 cm, 30~60 cm) for most metals at six sites (No. 5, 6, 17, 19, 20, 23). The fractions of exchangeable, reducible ad oxidisable phases showed relatively high correlation with soil pH, Fe/Mn oxide concentrations and organic matter contents, respectively.

• 정보관리학회지
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• 제27권1호
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• pp.185-206
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• 2010

핵심 학술저널이 디지털화하면서 도서관에서 구독한 자료에 대한 항구 접근 및 장기 보존에 대한 요구가 증대하였다. 이러한 요구에 부응하여 국내외에서는 다양한 기관 및 기구를 수행 주체로 하여 디지털 학술자료의 보존 활동을 해오고 있다. 본 논문은 국가출연기관인 KISTI가 국내외 학술논문 아카이빙 데이터의 활용성을 증진시킬 수 있는 시스템 및 서비스 전략을 중심으로 논의하고자 한다. 또한 KISTI의 전략을 국내외 연구와 비교하였고, NDA 체제 구축의 비용편익 분석을 통해 본 연구에서 제안한 연구의 타당성을 밝히고자 하였다. 마지막으로 아카이빙 데이터 활용성 증진을 위해 정책적, 법제적 기반 마련 방안과 아카이빙 데이터의 고부가가치 서비스 제공 방안을 제안함으로써 향후 연구 방향을 제시하였다.