• 제목/요약/키워드: BAU

검색결과 136건 처리시간 0.034초

Benzylacyclouridines의 적혈구에 있어서 Nucleoside 수송 억제 (Benzylacyclouridines ad Nucleoside Transport Inhibitors in Human Erythrocytes)

  • 이강현;차승만
    • 대한약리학회지
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    • 제24권1호
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    • pp.11-16
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    • 1988
  • Uridine phosphorylase 효소의 강력한 억제제로 개발된 유리딘 비고리핵산들(Benzylacyclouridine: BAU, HM-BAU, suc-BAU, BBAU, HM-BBAU, suc-BBAU, and BBBAU)이 uridine,의 사람 적혈구 내로의 수송(Zero-trans influx)에 미치는 영향에 관하여 rapid sampling technique을 이용하여 고찰하였다. 이 실헙에서 유리딘-비고리핵산들은 parent compounds인 BAU, BBAU와 같이 uridine 수송에 상경적인 억제작용을 보였다. 그러나 suc-BBAU와 BBBAU는 비상경적인 억제요소도 나타냈다. Uridine 수송억제제로서 효력의 크기는 $BBAU{\sim}HM-BBAU{\sim}suc-BBAU>BAU{\sim}suc-BAU{\sim}HM-BAU$이었으며, 그 억제상수는 각각 19, 23, 38, 112, 124, 174 그리고 $176\;{\mu}M$이었다. 본 실험 결과에서는 uridine 수송에 있어서 BAU의$C_5$ 자리의 친지방성 치환 group의 크기에 따라 억제효력이 다른 것이 시사되었다.

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Integrated Management of Foot Rot of Lentil Using Biocontrol Agents under Field Condition

  • Hannan, M.A.;Hasan, M.M.;Hossain, I.;Rahman, S.M.E.;Ismail, Alhazmi Mohammed;Oh, Deog-Hwan
    • Journal of Microbiology and Biotechnology
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    • 제22권7호
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    • pp.883-888
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    • 2012
  • The efficacy of cowdung, Bangladesh Institute of Nuclear Agriculture (BINA)-biofertilizer, and Bangladesh Agricultural University (BAU)-biofungicide, alone or in combination, was evaluated for controlling foot rot disease of lentil. The results exhibited that BINA-biofertilizer and BAU-biofungicide (peat soil-based Rhizobium leguminosarum and black gram bran-based Trichoderma harzianum) are compatible and have combined effects in controlling the pathogenic fungi Fusarium oxysporum and Sclerotium rolfsii, which cause the root rot of lentil. Cowdung mixing with soil (at 5 t/ha) during final land preparation and seed coating with BINA-biofertilizer and BAU-biofungicide (at 2.5% of seed weight) before sowing recorded 81.50% field emergence of lentil, which showed up to 19.85% higher field emergence over the control. Post-emergence deaths of plants due to foot rot disease were significantly reduced after combined seed treatment with BINA-biofertilizer and BAU-biofungicide. Among the treatments used, only BAU-biofungicide as the seed treating agent resulted in higher plant stand (84.82%). Use of BINA-biofertilizer and BAU-biofungicide as seed treating biocontrol agents and application of cowdung in the soil as an organic source of nutrient resulted in higher shoot and root lengths, and dry shoot and root weights of lentil. BINA-biofertilizer significantly increased the number of nodules per plant and nodules weight of lentil. Seeds treating with BAU-biofungicide and BINA-biofertilizer and soil amendment with cowdung increased the biomass production of lentil up to 75.56% over the control.

Seroprevalence of specific Brucella infection of cattle in Bangladesh Agricultural University Veterinary Clinics and its surrounding areas

  • Rahman, Md. Siddiqur;Alam, Nur;Rahman, A.K.M. Anisur;Huque, A.K.M. Fazlul;Ahasan, Md. Shamim;Song, Hee-Jong
    • 한국동물위생학회지
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    • 제32권3호
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    • pp.219-225
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    • 2009
  • A cross sectional survey was conducted to determine the seroprevalence of brucellosis in cattle in Bangladesh Agricultural University (BAU) Veterinary Clinics, in BAU Dairy Farm and Vabokhali from June 2008 to November 2008. A total of 200 serum samples were collected from BAU Veterinary Clinic, from BAU Dairy Farm and Vabokhali. Among the serum samples 143 sera samples were collected from BAU Veterinary Clinic, 42 serum samples from BAU Dairy Farm and 15 serum samples from Vabokhali. Sera were separated from blood samples and tested with specific Brucella abortus antigen (BAA) test and B. melitensis antigen (BMA) test. The overall seroprevalence of brucellosis in cattle was 5% in BAA and 0.5% in BMA. It was observed that, a significant higher prevalence of B. abortus was found in female than male. An insignificant higher prevalence of brucellosis was found in adult cattle (aged above 5 years), in cross breed cattle, in cattle with grazing, cattle breed by natural breeding, and in pregnant cows. Although insignificant but a higher prevalence of brucellosis was found in aged cattle than young cattle, cross bred cattle, pregnant cattle than non pregnant cattle, cattle with grazing. A higher prevalence of brucellosis was found in female cattle than male.

MESSAGE 모델링을 이용한 승용차 부문의 그린카 도입 전망 분석 (A Long Term Market Forecasting of Passenger Car using MESSAGE Modelling)

  • 유종훈;김후곤
    • 에너지공학
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    • 제21권1호
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    • pp.33-42
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    • 2012
  • 본 연구에서는 MESSAGE를 이용하여 승용 부문의 중장기 온실가스 감축잠재량 전망을 위한 방법론과 그 결과를 제시하고 있다. 승용부문의 실질적인 온실가스 감축잠재량을 구하는 것이 아니라 가장 대표적인 중형차 부문의 4가지 차종인, 기존 내연기관차, 하이브리드, 플러그인 하이브리드, 전기차를 이용하여 2050년까지 시장점유율 변화를 알아는데 중점을 두었다. 승용 부문의 감축잠재량 분석을 위해 녹색위원회의 그린카 로드맵을 중심으로 한 BAU 시나리오, 그린카 보급을 강화하는 시나리오, 학습 곡선을 이용하여 학습률에 따른 차량 가격 시나리오, 그린카의 학습률을 강화하는 시나리오 등 4가지 시나리오를 구성하였다. 그린카 보급 강화 시나리오에서 2050년에는 BAU 시나리오 대비 13%의 배출량이 감소하였고, 학습률에 따른 차량 가격 시나리오 및 학습률 강화 시나리오에서는 14%의 배출량이 감소함을 알 수 있었다.

전력부문 온실가스 감축정책 평가를 위한 상향식 모형화 방안 (A Study on Constructing Bottom-up Model for Electric Sector)

  • 김후곤;백천현;정용주;안영환
    • 에너지공학
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    • 제25권3호
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    • pp.114-129
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    • 2016
  • 국가온실가스 감축 로드맵을 통해 2020년 BAU 대비 약 30%의 온실가스감축을 목표로 하고 있는데, 전력부문의 경우 가장 많은 온실가스 배출을 하고 있어서 감축잠재량 산정에 매우 중요한 부문이다. 전력부문의 경우 온실가스 감축을 위해 수요관리, 전원믹스개선, 연료전환 등과 신재생에너지 비중 확대 등의 정책 및 기술확산 등을 통해 2020년 온실가스 감축 목표달성을 하게 된다. 이처럼 매우 복잡한 전력부문 온실가스 감축 정책 수립 및 평가를 위해 대부분의 국가에서는 상향식 모형 또는 하향식 모형을 이용하고 있다. 본 연구에서는 전력부문 상향식 모형의 일반적인 현황 및 적용방안에 대해서 알아보고, 이를 위해 전력부문의 가장 큰 특징인 구간부하(load region)을 분석하고, 이를 이용하여 수력 및 양수 등을 모형화하는 방안을 제시한다. 또한 전력부문에 대한 상향식 기반의 BAU 모형을 제안하고, 이 모형을 이용하는데 필요한 데이터 및 이슈들을 정리한다.

Immunogenicity of the ChAdOx1 nCoV-19 vaccine in patients with hematologic malignancies

  • Chayapa Thookhamme;Manassamon Navinpipat;Aimwipa Sasakul;Pakthipa Pattarakosol;Kamoltip Lertchaisataporn;Kriangkrai Tawinprai;Pannee Praditsuktavorn
    • Clinical and Experimental Vaccine Research
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    • 제12권2호
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    • pp.107-115
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    • 2023
  • Purpose: The present study aimed to study the immunogenicity of the ChAdOx1 nCoV-19 vaccine in patients with hematologic malignancies. Materials and Methods: This prospective cohort study of hematology patients aimed to evaluate their antibody levels against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 spike protein and seroconversion rates following two doses of the ChAdOx1 nCoV-19 vaccine. Between June and July 2021, we enrolled 61 patients and included 44 patients in our analysis. Antibody levels were assessed 8 and 4 weeks after the first and second injections, respectively, and compared with those of a healthy group. Results: Eight weeks after the first dose, the geometric mean antibody level was 1.02 binding antibody units (BAU)/mL in the patient group and 37.91 BAU/mL in the healthy volunteer group (p<0.01). Four weeks after the second dose, the geometric mean antibody level was 9.44 BAU/mL in patients and 641.6 BAU/mL in healthy volunteers (p<0.01). The seroconversion rates 8 weeks after the first dose were 27.27% and 98.86% in the patient and healthy volunteer groups, respectively (p<0.001). The seroconversion rate 4 weeks after the second dose was 47.73% in patients and 100% in healthy volunteers. Factors leading to lower seroconversion rates were rituximab therapy (p=0.002), steroid therapy (p<0.001), and ongoing chemotherapy (p=0.048). Factors that decreased antibody levels were hematologic cancer (p<0.001), ongoing chemotherapy (p=0.004), rituximab (p<0.001), steroid use (p<0.001), and absolute lymphocyte count <1,000/mm3 (p=0.009). Conclusion: Immune responses were impaired in individuals with hematologic malignancies, particularly patients undergoing ongoing therapy and B-cell-depleting therapy. Additional vaccinations should be considered for these patients, and further investigated.

대단면터널 특성을 고려한 지보설계 개선방안 연구 (Large-span Tunnel Support Design supplemented by Analytical Methods)

  • 정재호;이희석;허종석;윤상길
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2006년도 춘계 학술발표회 논문집
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    • pp.949-959
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    • 2006
  • Despite of the popularity of using empirical methods for support design, empirical rules suffer from the inherent problem of providing no indication of the safety degree of the design. For the support design of large span tunnel, it was considered that the empirical design guidelines should be augmented by more explicit design methods. This paper presents an overview of the analytical support design methodology that is used to refine initial empirical recommendations. The initial support design supplemented by analytical methods is validated by probabilistic and deterministic approach applied to stress-induced and structurally controlled gravity-driven instability problem each. As a result, the extent of the potential failure zone is sorted out and numerical parametric studies were performed to gain insight into the overall behavior of tunnel in the potential failure zone. Concequently, it was decided that additional conservation techniques have to be planed as a reserved support pattern.

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