• Title/Summary/Keyword: BAU

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Benzylacyclouridines ad Nucleoside Transport Inhibitors in Human Erythrocytes (Benzylacyclouridines의 적혈구에 있어서 Nucleoside 수송 억제)

  • Lee, Kang-Hyun;Cha, Sung-Man
    • The Korean Journal of Pharmacology
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    • v.24 no.1
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    • pp.11-16
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    • 1988
  • Various Benzylacyclouridine (BAU, HM-BAU, suc-BAU, BBAU, HMBBAU, suc-BBAU, and BBBAU) developed as specifc inhibitors of uridine phosphorylase (UrdPase), inhibit transport (zero-trans influx) of ridine (Urd) in human erythrocytes. The inhibition pattern of these compounds is competitive, though suc-BBAU and BBBAU show a slight noncompetivieness. The order of potency as an inhibitor of the nucleoside transport system is BBAU ${\sim}$ HM-BBAU ${\sim}$ suc-BBAU > BBBAU > BAU ${\sim}$ suc-BAU ${\sim}$ HM-BAU ($K_1$ values of 19, 23, 38, 112, 124, 174 and 176 ${\mu}M$, respectively). These data indicate that there is a differnece in potency of Urd transport inhibition between the analogs of BAU and BBAU. Further, the potency correlates with the hydrophobicity of the compound, but it has a limit in the size of $C_5$ substitution. Abbreviation: BAU (5-benzylacyclouridine), 5-benzyl-1-(2'-hydroxyethoxymethyl) uracil; HM-BAU (3'-hydroxymethyl-BAU), 5-benzyl-1- [(1',3'-dihydroxy-2-propoxy) methyl]uracil; suc-BAU, 3'-succinyl-BAU; BBAU (benzyloxybenzylacyclouridine), 5-( m-benzyloxybenByl)-1-(2'-hydroxyethoxymethyl)uracil; HM-BBAU (3'-hydroxymethyl-BBAU), 5-(m-benzyloxybenzyl)-1- [(1'3'-dihyd.oxy-2-p.epoxy)methyll u.acil; suc-BAU, 3'-succinyl-BBAU; BBBAU, 5- f 3-(4-benzyloxyben-Eyl)benzyll -1-(2'-hydroxyethoxymethyl)uracil; Urdpase, uridine phosphorylase; Urd, Uridine; Fd-Urd, 5-fluoro-2'-deoxyuridine; AcThd, aoyclothyrnidine; AcUrd, acyclouridine; dThd, thymidine; NBMPR, nitrobenzylthioisone; FUra, 5-fluorouracil.

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Integrated Management of Foot Rot of Lentil Using Biocontrol Agents under Field Condition

  • Hannan, M.A.;Hasan, M.M.;Hossain, I.;Rahman, S.M.E.;Ismail, Alhazmi Mohammed;Oh, Deog-Hwan
    • Journal of Microbiology and Biotechnology
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    • v.22 no.7
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    • pp.883-888
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    • 2012
  • The efficacy of cowdung, Bangladesh Institute of Nuclear Agriculture (BINA)-biofertilizer, and Bangladesh Agricultural University (BAU)-biofungicide, alone or in combination, was evaluated for controlling foot rot disease of lentil. The results exhibited that BINA-biofertilizer and BAU-biofungicide (peat soil-based Rhizobium leguminosarum and black gram bran-based Trichoderma harzianum) are compatible and have combined effects in controlling the pathogenic fungi Fusarium oxysporum and Sclerotium rolfsii, which cause the root rot of lentil. Cowdung mixing with soil (at 5 t/ha) during final land preparation and seed coating with BINA-biofertilizer and BAU-biofungicide (at 2.5% of seed weight) before sowing recorded 81.50% field emergence of lentil, which showed up to 19.85% higher field emergence over the control. Post-emergence deaths of plants due to foot rot disease were significantly reduced after combined seed treatment with BINA-biofertilizer and BAU-biofungicide. Among the treatments used, only BAU-biofungicide as the seed treating agent resulted in higher plant stand (84.82%). Use of BINA-biofertilizer and BAU-biofungicide as seed treating biocontrol agents and application of cowdung in the soil as an organic source of nutrient resulted in higher shoot and root lengths, and dry shoot and root weights of lentil. BINA-biofertilizer significantly increased the number of nodules per plant and nodules weight of lentil. Seeds treating with BAU-biofungicide and BINA-biofertilizer and soil amendment with cowdung increased the biomass production of lentil up to 75.56% over the control.

Seroprevalence of specific Brucella infection of cattle in Bangladesh Agricultural University Veterinary Clinics and its surrounding areas

  • Rahman, Md. Siddiqur;Alam, Nur;Rahman, A.K.M. Anisur;Huque, A.K.M. Fazlul;Ahasan, Md. Shamim;Song, Hee-Jong
    • Korean Journal of Veterinary Service
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    • v.32 no.3
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    • pp.219-225
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    • 2009
  • A cross sectional survey was conducted to determine the seroprevalence of brucellosis in cattle in Bangladesh Agricultural University (BAU) Veterinary Clinics, in BAU Dairy Farm and Vabokhali from June 2008 to November 2008. A total of 200 serum samples were collected from BAU Veterinary Clinic, from BAU Dairy Farm and Vabokhali. Among the serum samples 143 sera samples were collected from BAU Veterinary Clinic, 42 serum samples from BAU Dairy Farm and 15 serum samples from Vabokhali. Sera were separated from blood samples and tested with specific Brucella abortus antigen (BAA) test and B. melitensis antigen (BMA) test. The overall seroprevalence of brucellosis in cattle was 5% in BAA and 0.5% in BMA. It was observed that, a significant higher prevalence of B. abortus was found in female than male. An insignificant higher prevalence of brucellosis was found in adult cattle (aged above 5 years), in cross breed cattle, in cattle with grazing, cattle breed by natural breeding, and in pregnant cows. Although insignificant but a higher prevalence of brucellosis was found in aged cattle than young cattle, cross bred cattle, pregnant cattle than non pregnant cattle, cattle with grazing. A higher prevalence of brucellosis was found in female cattle than male.

A Long Term Market Forecasting of Passenger Car using MESSAGE Modelling (MESSAGE 모델링을 이용한 승용차 부문의 그린카 도입 전망 분석)

  • Yoo, Jong-Hun;Kim, Hu-Gon
    • Journal of Energy Engineering
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    • v.21 no.1
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    • pp.33-42
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    • 2012
  • In this study, long-term greenhouse gas reductions expected passenger sector was used for the MESSAGE. Green Car road map proposed BAU scenario, Enhanced diffusion green car scenario, and price 1, 2 scenarios was configured with four scenarios. Enhanced diffusion green car in the scenario, in 2050 compared to BAU scenario 13% of the emissions will decrease. Price 1 and Price 2 scenario is emissions reduction of 14% compared to BAU. This study consists of six chapters. Introduction of MESSAGE, creation and RES in the year and the target year set a different base line and the passenger building materials sector activities, steps for passenger sector scenario and Based on the results of running the emissions reductions were to describe.

A Study on Constructing Bottom-up Model for Electric Sector (전력부문 온실가스 감축정책 평가를 위한 상향식 모형화 방안)

  • Kim, Hugon;Paik, Chunhyun;Chung, Yongjoo;Ahn, Younghwan
    • Journal of Energy Engineering
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    • v.25 no.3
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    • pp.114-129
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    • 2016
  • Since the release of mid-term domestic GHG goals until 2020, in 2009, some various GHG reduction policies have been proposed to reduce the emission rate about 30% compared to BAU scenario. There are two types of modeling approaches for identifying options required to meet greenhouse gas (GHG) abatement targets and assessing their economic impacts: top-down and bottom-up models. Examples of the bottom-up optimization models include MARKAL, MESSAGE, LEAP, and AIM, all of which are developed based on linear programming (LP) with a few differences in user interface and database utilization. The bottom-up model for electric sector requires demand management, regeneration energy mix, fuel conversation, etc., thus it has a very complex aspect to estimate some various policies. In this paper, we suggest a bottom-up BAU model for electric sector and how we can build it through step-by-step procedures such that includes load region, hydro-dam and pumping storage.

Large-span Tunnel Support Design supplemented by Analytical Methods (대단면터널 특성을 고려한 지보설계 개선방안 연구)

  • Jeong, Jae-Ho;Lee, Hee-Suk;Heo, Jong-Seok;Yoon, Sang-Gil
    • Proceedings of the Korean Geotechical Society Conference
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    • 2006.03a
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    • pp.949-959
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    • 2006
  • Despite of the popularity of using empirical methods for support design, empirical rules suffer from the inherent problem of providing no indication of the safety degree of the design. For the support design of large span tunnel, it was considered that the empirical design guidelines should be augmented by more explicit design methods. This paper presents an overview of the analytical support design methodology that is used to refine initial empirical recommendations. The initial support design supplemented by analytical methods is validated by probabilistic and deterministic approach applied to stress-induced and structurally controlled gravity-driven instability problem each. As a result, the extent of the potential failure zone is sorted out and numerical parametric studies were performed to gain insight into the overall behavior of tunnel in the potential failure zone. Concequently, it was decided that additional conservation techniques have to be planed as a reserved support pattern.

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Estimation of Greenhouse Gas Emissions (GHG) Inventory and Reduction Plans for Low Carbon Green Campus in Daegu University (저탄소 그린캠퍼스 조성을 위한 온실가스 인벤토리 구축 및 감축잠재량 분석 - 대구대학교를 중심으로)

  • Jeong, YeongJin;Li, KaiChao;Kim, TaeOh;Hwang, InJo
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.7
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    • pp.506-513
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    • 2014
  • The objective of this study is to establish the greenhouse gases (GHG) inventories and estimate the GHG reduction plans for Daegu University from 2009 to 2011. The annual average of GHG emissions in Daegu University was estimated to be 19,413 ton $CO_2$ eq during the study period. Emissions of electricity usage in Scope 2 most contributed about 55.4% of the total GHG emissions. Also, GHG emissions of Scope 2, Scope 1, and Scope 3 contributed 60.4%, 22.6%, and 17.0%, respectively. In order to estimate reduction potential of GHG, the Long-range Energy Alternatives Planning (LEAP) model was calculated using three scenarios such as sensor installation, LED replacement, and solar facility. The GHG will be reduced by 1,656 ton $CO_2$ eq for LED scenario, by 1,041 ton $CO_2$ eq for sensor scenario, and by 737 ton $CO_2$ eq for solar scenario compared to 2020 business as usual (BAU). Therefore, the total GHG emissions in 2020 apply three scenarios can be reduced by 15% compared with 2020 BAU.