• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.3
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• pp.320-326
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• 2017

This study investigated the water extracts of fallen pear (FPWE) on tyrosinase activity and melanogenesis. In the present study, we examined the effects of FPWE on mushroom tyrosinase activity in vitro, B16F10 melanoma cell tyrosinase activity, melanin contents, and expression of melanogenic enzyme proteins such as tyrosinase. An apparent down-regulatory effect on tyrosinase activity was observed when B16F10 cells were incubated with FPWE. Results of melanin assay using B16F10 cells treated with different concentrations (50, 125, and $250{\mu}g/mL$) of FPWE showed a dose-dependent decrease in melanin content. To determine whether or not FPWE indirectly affects tyrosinase activity, we assessed mushroom tyrosinase activity upon treatment with various concentrations (125, 250, 500, and $1,000{\mu}g/mL$) of FPWE. In addition, we investigated changes in the protein level of tyrosinase by using Western blotting. Tyrosinase and microphthalmia-associated transcription factor expression levels in B16F10 melanoma cells were reduced in a dose-dependent manner by FPWE. These results suggest that FPWE reduced melanin formation by inhibition of tyrosinase activity. Therefore, we suggest that FPWE could be used an effective whitening agent for skin.

• Journal of the Korean Magnetics Society
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• v.14 no.1
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• pp.7-12
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• 2004

The annealing-temperature dependence of magnetic properties in compressed powder cores being composed of ball-milled F $e_{73.5}$C $u_1$N $b_3$S $i_{15.5}$ $B_{7}$ alloy powders (size 250∼850${\mu}{\textrm}{m}$) and 5 wt% of ceramic insulators has been investigated. When annealed at 5$50^{\circ}C$ for 1 h and so transformed to $\alpha$-Fe phase nanocrystalline structure with the grain size of 11 nm (electrical resistivity : 110 $\mu$Ω$.$cm), the highest effective permeability of 125 and quality factor of 53 were obtained, and the permeability persisted up to about 500 KHz. Further the core loss measured at the frequency of 50 KHz and the induction amplitude of 0.1 T was very low (230 mW/㎤). However the dc bias characteristics was not satisfactory as compared to that of conventional powder core materials(MPP, Sendust etc.). The inferior dc bias property of F $e_{73.5}$C $u_1$N $b_3$S $i_{15.5}$ $B_{7}$ alloy powder cores was attributed to the fact that the size of powder was too large for obtaining the same permeability with that of conventional materials.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.1
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• pp.7-13
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• 2011

This study was conducted to investigate the antimicrobial activity of Ginkgo biloba L. leaves, seed and outer seedcoat against bacteria. Antimicrobial effects of Ginkgo biloba L. leaves (GBL), seed (GBS) and outer seedcoat (GBO) were examined by paper disc method and optical density method to determine minimum inhibition concentration (MIC), and observed by scanning electron microscope (SEM) to figure out the morphological change on the surface when Ginkgo biloba leaves extract was treated. The extracts of GBL, GBS and GBO were extracted by solvents such as methanol, ethanol, water. The methanol extract of GBL and GBO showed the highest antimicrobial activity against Bacillus cereus, Bacillus subtilis, Klebsiella pneumoniae, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus, Yersinia enterocolitica except Escherichia coli and thus was further fractionated. The MICs of the chloroform fraction of GBL methanol extract were $125{\mu}g$/mL against B. subtilis, and L. monocytogenes; GBO methanol extract were $62.5{\mu}g$/mL against B. cereus and $125{\mu}g$/mL against B. subtilis, and L. monocytogenes. The microorganisms were treated with chloroform extracts ($2000{\mu}g$/mL) of GBL and GBO methanol extracts. It was observed by scanning electron microscope (SEM). The cells were expanded and a part of cell wall was completely destructed by GBL and GBO. Thus Ginkgo biloba L. leaves and outer seedcoat could be further developed into a natural antimicrobial agent.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.1
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• pp.1-4
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• 1999

Beijing White Chickens laying larger eggs and smaller eggs were respectively used as parental individuals for mating to produce the F1 progeny and then the F1 progeny individuals mated to produce 125 individuals of the F2 progeny. Three bands associated with the egg weight performance were identified from DNA fingerprints of the 125 individuals generated with a bovine minisatellite probe BM6.5B. The simple linear correlation analysis showed that the coefficients of correlation between frequencies of the three bands (DB1, DB2 and DB3) and egg weights were -0.6, -0.6 and 0.9, respectively.

• Journal of Electrical Engineering and Technology
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• v.3 no.1
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• pp.125-129
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• 2008

A new genetic algorithm for the solution of a multi-tasking problem is presented in this paper. The approach introduces innovative genetic operation that guides the genetic algorithm more directly towards better quality of the population. A wide variety of standard genetic parameters are explored, and results allow the comparison of performance for cases both with and without the new operator. The proposed algorithm improves the convergence speed by reducing the number of generations required to identify a near-optimal solution, significantly reducing the convergence time in each instance.

• Geomechanics and Engineering
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• v.9 no.2
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• pp.125-144
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• 2015

This paper presents the probabilistic seismic microzonation of densely populated Kolkata city, situated on the world's largest delta island with very soft alluvial soil deposit. At first probabilistic seismic hazard analysis of Kolkata city was carried out at bedrock level and then ground motion amplification due to sedimentary deposit was computed using one dimensional (1D) wave propagation analysis SHAKE2000. Different maps like fundamental frequency, amplification at fundamental frequency, peak ground acceleration (PGA), peak ground velocity (PGV), peak ground displacement (PGD), maximum response spectral acceleration at different time period bands are developed for variety of end users, structural and geotechnical engineers, land use planners, emergency managers and awareness of general public. The probabilistically predicted PGA at bedrock level is 0.12 g for 50% exceedance in 50 years and maximum PGA at surface level it varies from 0.095 g to 0.18 g for same probability of exceedance. The scenario of simulated ground motion revealed that Kolkata city is very much prone to damage during earthquake.

• Structural Engineering and Mechanics
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• v.70 no.1
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• pp.125-131
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• 2019

A nine node isoparametric plate bending element is used for bending analysis of laminated composite skew cylindrical shell panels. Both thick and thin shell panels are solved. Rotary inertia and shear deformation are incorporated by considering first order shear deformation theory. The analysis is performed considering shallow shell theory. Both shallow and moderately deep skew cylindrical shells are investigated. Skew cylindrical shell panels having different thickness ratios (h/a), radius to length ratios (R/a), ply angle orientations, number of layers, aspect ratio (b/a), boundary conditions and various loading (concentrated, uniformly distributed, linear varying and doubly sinusoidal varying) conditions are analysed. Various new results are presented.

• Bulletin of the Society of Naval Architects of Korea
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• v.21 no.4
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• pp.1-9
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• 1984

This study is concerned with the economic aspects of $125,000m^3$ class LNG carriers with different propulsion plant such as conventional steam turbine and slow speed diesel engine with reliquefaction plant. The ship's speed and L/B ratio were optimized with criterion of required freight rate(RFR) by using the PROCAL computer program package. In order to investigate the effect of fuel oil price, round trip distance and boil-off rate on the RFR and the optimum speed, sensitivity analysis were also performed.

• JSTS:Journal of Semiconductor Technology and Science
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• v.2 no.2
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• pp.125-131
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• 2002

This paper presents MMIC drive and power amplifiers covering 6-18 ㎓. For simple wideband impedance matching and less sensitivity to fabrication variation, modified distributed topologies are employed in the both amplifiers. Cascade amplifiers with a self-biasing circuit through feedback resistors are used as unit gain blocks in the drive amplifier, resulting in high gain, high stability, and compact chip size. Self impedance matching and high-pass, low-pass impedance matching networks are used in the power amplifier. In measured results, the drive amplifier showed good return losses ($S_11,{\;}S_{22}{\;}<{\;}-10.5{\;}dB$), gain flatness ($S_{21}={\;}16{\;}{\pm}0.6{\;}dB$), and $P_{1dB}{\;}>{\;}22{\;}dBm$ over 6-18 GHz. The power amplifier showed $P_{1dB}{\;}>{\;}28.8{\;}dBm$ and $P_{sat}{\;}{\approx}{\;}30.0{\;}dBm$ with good small signal characteristics ($S_{11}<-10{\;}dB,{\;}S_{22}{\;}<{\;}-6{\;}dB,{\;}and{\;}S_{21}={\;}18.5{\;}{\pm}{\;}1.25{\;}dB$) over 6-18 GHz.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8489-8493
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• 2014

Objective: To verify the basic preoperative evaluation in the discrimination between benign and malignant adnexal masses in our clinical practice. Materials and Methods: Data were collected on the records of 636 women with adnexal masses who had undergone surgery either by open or endoscopic approaches. Those with obvious signs of malignancy, any history of cancer, emergency surgeries without basic evaluation were excluded. The preoperative features by age, ultrasound and serum Ca125 level were compared with final histopathological diagnosis at the four departments of the institution. These are the general gynecology (Group 1: exploratory laparotomy), the gynecologic endoscopy (Group 2: laparoscopy and adnexectomy), the gynecological oncology (Group 3: staging laparotomy) and the gynecologic endocrinology and infertility (Group 4: laparoscopy and cystectomy). Results: There were simple and complex cyst rates of 22.3% and 77.2%, respectively. There were 86.3% benign, 4.1% (n:20) borderline ovarian tumor (BOT) and 6.4% (n:48) malignant lesions. There were 3 BOT and 9 ovarian cancers in Group 1 and one BOT and two ovarian cancer in the Group 2. During the surgery, 15 BOT (75%) and 37 ovarian cancer (77%) were detected in the Group 3, only one BOT was encountered in the Group 4. The risk of rate of unsuspected borderline or focally invasive ovarian cancer significantly increased by age, size, complex morphology and Ca125 (95% CI, OR=2.72, OR=6.60, OR=6.66 and OR=4.69, respectively). Conclusions: Basic preoperative evaluation by comprehensive ultrasound imaging combined with age and Ca125 level has proved highly accurate for prediction of unexpected malignancies. Neither novel markers nor new imaging techniques provide better information that allow clinicians to assess the feasibility of the planned surgery; consequently, the risk of inadvertent cyst rupture during laparoscopy may be significantly decreased in selected cases.