• Journal of dental hygiene science
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• v.23 no.3
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• pp.216-224
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• 2023

Background: Smilax glabra has various pharmacological activities and is widely used as a herbal medicine. Although the incidence of oral cancer is low, the recurrence rate is high, and the 5-year survival rate is poor. It is necessary to search for anticancer drugs that increase the effect of cancer chemotherapy on heterogeneous oral tissues and reduce the side effects on normal cells. This study aimed to investigate the effects and mechanism of ethanol extract of Smilax glabra (EESG) as an anticancer drug for oral cancer. Methods: Smilax glabra root components extracted with 70% ethanol were used to analyze their effects on cancer cells. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide assay was performed for cytotoxicity analysis. Flow cytometry was performed to determine the cell cycle phase distribution. To observe apoptotic cells, terminal deoxynucleotidyl transferase dUTP nick end labeling and γH2AX were detected by fluorescence microscope. The protein levels of cleaved PARP and caspase were analyzed using western blotting. The activation of procaspase-3 was confirmed by measuring caspase-3 activity. Results: EESG was no cytotoxic to normal gingival fibroblast but was high in YD10B oral squamous cell carcinoma (OSCC) cells. EESG treatment increased the subdiploid DNA content of YD10B cells by assessing DNA content distribution. Chromatin condensation and DNA strand breaks increased in YD10B cells treated with EESG. EESG-treated YD10B cells had high Annexin V and low propidium iodide levels, confirming that early apoptosis was induced. In addition, increased levels of γH2AX foci, a marker of DNA damage, were observed in the nuclei of EESG-treated YD10B cells. The EESG-treated YD10B cells also exhibited decreased procaspase-3 and procaspase-9 levels, increased PARP cleavage and caspase-3 activity. Conclusion: These results indicate that EESG inhibited cancer cell proliferation by inducing apoptosis in YD10B OSCC cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.6A
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• pp.510-516
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• 2005

In this paper, we discuss parameters of line code and simulate a same optical ethernet having minimum bandwidth(MB810) and non-minimum bandwidth line code(8B/10B) to present the possibility of improving of transmission performance using minimum bandwidth line code on the high speed optical ethernet. We design the high speed optical ethernet using Serial type LAN PHY 10GBASE-E(WDM type LAN PHY 10GBASE-LX4) for the single(multi) channel link. To compare the transmission performance of MB810, 8B/10B line code we measure the bit error rate(BER) according to the received optical power of single and multi channel link.

• Proceedings of the KSPS conference
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• 1994.02a
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• pp.45-53
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• 1994

음 변화 규칙을 음성규칙(A)와 음운규칙(B)와 기타(C)로 분류한다면, A.음성규칙의 발생 총계는 B.음운규칙의 발생 총계보다 2배 이상 더 많다. 여기에 가장 발생 빈도가 높은 규칙부터 순서대로 10개만 정리하면 다음과 같다. 순위 규칙부류 명칭 백분율 1 A 음절 말 유성자음의 불파화 31.84, 2 A 유성음화 19.37 3 B 장모음화 10.00, 4 A 설측음화 9.78, 5 B 경음화 6.43, 6 B 음절말 장애음 중화 5.16, 7 A ㅅ 구개음화 3.71, 8 C 음절 조정 규칙 3.10, 9 B 단모음화 1.60, 10 A ㄴ 구개음화 1.42 별도로 진행한 총체적 연구(이상억에 의하면, 음성규칙, 즉 A가 총 6개 있는데 그 중 5규칙이 10위 내에 나타나 상위 쪽에 3번이나 포함되어 있는 점이 주목된다. 특히 규칙 1과 2의 합계는 전체 중 51.2%를 넘는다. 규칙 10위까지의 합계는 전체 중 92.4%를 차지한다. 13.장모음화(10%)는 12.단모음화(1.6%)보다 훨씬 높은 출현빈도를 보인다. 또 각종 구개음화 규칙의 순위는 ㅅ(7위), ㄴ(10위), ㄹ(17위), ㄷ(26위) 구개음화로 분포되어 있음이 밝혀졌다. 한편 삭제규칙(음운탈락 및 단순화) 계열이 14, 15, 19, 21, 25, 28위에 널리 나열되어 있는 데 반해, 삽입규칙은 23위에 ㄴ삽입 하나가 보일 뿐이다.

• Development and Reproduction
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• v.26 no.2
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• pp.79-90
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• 2022

Krüppel-like factor 10 (KLF10) regulates various cellular functions, such as proliferation, differentiation and apoptosis, as well as the homeostasis of several types of tissue. In the present study, we attempted a loss-of-function analysis of zebrafish Klf11a and Klf11b, which constitute human KLF10 homologs. Embryos injected with klf11b-morpholino (MO) showed developmental retardation and cell death, whereas klf11a-MO-injected embryos showed normal development. In klf11b-MO-injected embryos, a dramatic increase in the amount of zebrafish p53 mRNA might be the cause of the increase in that of bax. The degree of apoptosis decreased in the klf11b-MO and p53-MO co-injected embryos. These findings imply that KLF10 is a negative regulator of p53-dependent transcription, suggesting that the KLF10/p53 complex may play an important role in apoptosis for maintenance of tissue homeostasis during embryonic development.

• Journal of The Korean Society of Agricultural Engineers
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• v.51 no.2
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• pp.35-41
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• 2009

The impacts of climate change on paddy irrigation requirements for Nakdong river basin in Korea have been analyzed. The HadCM3 model outputs for SRES A2 and B2 scenarios and International Water Management Institute $10'{\times}10'$ pixels observed data were used with kriging method. Maps showing the predicted spatial variations of changes in climate parameters and paddy irrigation requirements have been produced using the GIS. The results showed that the average growing season temperature was projected to increase by $2.2^{\circ}C$ (2050s A2), $0.0^{\circ}C$ (2050s B2), $3.7^{\circ}C$ (2080s A2) and $2.9^{\circ}C$ (2080s B2) from the baseline (1961-1990) value of $21{\circ}C$. The average growing season rainfall was projected to increase by 15.2% (2050s A2), 24.2% (2050s B2), 41.4% (2080s A2) and 16.7% (2080s B2) from the baseline value of 900 mm. Average volumetric irrigation demands were projected to decrease by 3.7% (2050s A2), 7.0% (2050s B2), 10.2% (2080s A2) and 1.4% (2080s B2) from the baseline value of $1.25{\times}10^9\;m^3$. These results can be used for the agricultural water resources development planning in the Nakdong river basin for the future.

• Journal of the korean academy of Pediatric Dentistry
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• v.11 no.1
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• pp.41-56
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• 1984

The purpose of this study is to obtain the normal range of mandibular movement for 13 year old boys and girls, and to compare it to the range of mandibular movement of class III patient and normal adult for diagnosis and prognosis of class III malocclusion and TMJ dysfunction. The subjects were 20 normal boys 20 normal girls 22 class III boys and 18 class III girls. The author measured the ranges and shapes of movement of the mandible in the frontal, sagittal and horizontal trajectories using Saphon visitrainer C II (Tokyo Shizaisha Inc.) for the subjects. The results obtained are as follows: 1) The mean for maximum right laterotrusion in the frontal trajectory were 11.96mm in N.B., 11.10mm in N.G., 11.32mm in III. B., 11.24mm in III G. The mean for maximum left laterotrusion were 11.48mm, 11.0mm, 10.91mm, 10.44mm respectively, Area of border movement were 7.16cm in N.B., 6.59cm in N.G., 7.29cm in III. B., 7.50cm in III. G. 2) The mean for maximum protrusion in the sagittal trajectory were 11.7mm in N.B., 11.4mm in N.G.,11.87mm in III B., and 11.02mm in III. G. 3) The mean for maximum protrusion in the horizontal trajectory were 10.20mm in N.B.,10.00 mm in N.G., 9.12mm for III. B. and 9.36mm in III. G. 4) The mean for maximum protrusion of Class III subjects were shorter than those of normal subjects. 5) There was no sexual difference in the range of mandibular movement for 13 year old subjects. N.B; Normal boys N.G.; Normal girls III.B.; Class III boys III. G.; Class III girls.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.278-280
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• 2007

This survey was carried out to provide a sound and a vibration level of bridges on the Han river. A sound and a vibration level of 6 bridges(Ban po, Cheon ho, Olympic, Jam soo, Young dong, Dong ho) were measured. The X-axis vibration level($L_{10}$) was $42{\sim}60$ dB(H), Y-axis vibration level was $41{\sim}52$ dB(H) and Z-axis vibration level was $44{\sim}77$ dB(V). The Z-axis vibration level($L_{10}$) on the midpoint of bridges was 68 dB(V), and on the joint point was 56 dB(V). The sound level was $77{\sim}84$ dB(A). The sound level of Jam soo bridge was higher than any other bridges.

• Biomedical Science Letters
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• v.26 no.1
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• pp.8-13
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• 2020

Cervical cancer is the fourth most common cancer in women, with approximately 528,000 new cases and 266,000 women dying of it per year in the world. MicroRNAs have recently been in the spotlight as potential biomarkers that regulate gene expression and are involved in tumorigenesis. In the present study, we evaluated miR-1260b as a potential biomarker for screening of cervical cancer by quantitative reverse transcription PCR. We profiled the TCGA data of miR-1260b in 307 cervical cancer tissues. Then, miR-1260b expression levels in 10 cervical cancer tissues and 10 noncancerous tissues were investigated in a pilot study. miR-1260b was found to be significantly up-regulated in cervical cancer FFPE tissues as compared to those in cervical normal FFPE tissues (P = 0.006). The mean expression level of miR-1260b in late-stage (IIB-IVB) was higher than in those with early-stage (IA-IIA). Furthermore, high miR-1260b was found to be associated with high hTERT and Ki-67 mRNA expression, which are representative of tumor prognosis. The results of the pilot study suggest that miR-1260b may be used as a novel biomarker for improving the diagnosis of cervical cancer.

• Korean journal of food and cookery science
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• v.18 no.1
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• pp.43-50
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• 2002

This study was carried out to evaluate the quality attributes of frozen soy yogurts prepared by freezine soy yogurts, which are made of different types of Bifidobacteria (B. bifidum, B.breve, B. infantis) and oligosaccharides (fructooligosaccharides, galactooligosaccharides, isomaltooligosaccharides) containing $\alpha$-chymotrypsin treated soy protein isolate were evaluated in terms of overrun, melt-down quality, changes in the total number of Bifidobacteria after freezing, and sensory evaluation. The quality attributes of soy yogurts were also evaluated in terms of changes in the number of viable cells of Bifidobacteria in soy yogurts after incubation at 37$\^{C}$, pH 3.0 for 90 min, water holding capacity, and viscosity. The overrun of frozen soy yogurts fermented by B. bifidum showed the hiehest value but those fermented by B. infantis showed the lowest, while the melt-down quality of soy yogurts were vice versa. The total numbers of Bifidobacteria after freezing for 30 min in ice cream maker showed more than 10$\^$9/ CFU/ml. In sensory evaluation, all $\alpha$-chymotrypsin treated frozen soy yogsurt showed little beany flavor. In sour, sweet, and bitter tastes and mouth feel, the frozen soy yogurts fermented by B. bifidum evaluated better but those fermented by B. infantis evaluated worse. Also in the overall quality, the frozen soy yogurts fermented by B. bifidum were evaluated desirable but those fermented by B. infantis were evaluated undesirable. The water holding capacity and viscosity of soy yogurts fermented by B. bifidum showed the highest values but those fermented by B. infantis showed the lowest values. The total numbers of Bifidobacteria of all soy yogurts decreased from 10$\^$9/ CFU/ml to 10$\^$8/ CFU/ml after incubation at 37$\^{C}$, pH 3.0 for 90 min.

• Kyungpook Mathematical Journal
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• v.54 no.4
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• pp.521-529
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• 2014

In this paper we derive some optimal convex combination bounds related to arithmetic mean. We find the greatest values ${\alpha}_1$ and ${\alpha}_2$ and the least values ${\beta}_1$ and ${\beta}_2$ such that the double inequalities $${\alpha}_1T(a,b)+(1-{\alpha}_1)H(a,b)<A(a,b)<{\beta}_1T(a,b)+(1-{\beta}_1)H(a,b)$$ and $${\alpha}_2T(a,b)+(1-{\alpha}_2)G(a,b)<A(a,b)<{\beta}_2T(a,b)+(1-{\beta}_2)G(a,b)$$ holds for all a,b > 0 with $a{\neq}b$. Here T(a,b), H(a,b), A(a,b) and G(a,b) denote the second Seiffert, harmonic, arithmetic and geometric means of two positive numbers a and b, respectively.