• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.128-128
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• 1998

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that degrade extracellular matrix and basement membrane. These enzymes are play important roles in tumor cell invasion and metastasis, as well as angiogenesis and other connective tissue diseases. In our screening program for inhibitors of MMP-2 from fungal metabolites, we have isolated novel non-peptidic inhibitors of MMPs, designated gelastatin A and B from the culture broth of Westerdykella multispora F50733. The structures of gelastatin A and B were determined to be 3-(5E-hexa-2E,4E-dienylidene-2-oxo-5,6-dihydro-2H-pyran-3yl)-propanoic acid and 3-(5Z-hexa-2E,4E-dienylidene-2-oxo-5,6-dihydro-2H-pyran-3yl)-propanoic acid, respectively. Gelastatin A and B exist as a mixture of two stereoisomers in a ratio of 2: 1. The 2: 1 mixture of gelastatin A and B inhibited activated MMP-2 and MMP-9 with an IC$\sub$50/ value of 0.63, 5.29 ${\mu}$M, respectively. They inhibited the invasion of B16F10 melanoma cells through basement membrane Matrigel with dose dependent.

• Restorative Dentistry and Endodontics
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• v.37 no.2
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• pp.96-103
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• 2012

Objectives: This study evaluated the effect of camphorquinone (CQ)-amine ratio on the C=C double bond conversion of resins with binary and ternary photoinitiation systems. Materials and Methods: Two monomer mixtures (37.5 Bis-GMA/37.5 Bis- EMA/25 TEGDMA) with binary systems (CQ/DMAEMA in weight ratio, group A [0.5/1.0] and B [1.0/0.5]) and four mixtures with ternary system (CQ/OPPI/DMAEMA, group C [0.1/1.0/0.1], D [0.1/1.0/ 0.2], E [0.2/1.0/0.1] and F [0.2/1.0/0.2]) were tested: 1 : 2 or 2 : 1 CQ-amine ratio in binary system, while 1 : 1 ratio was added in ternary system. The monomer mixture was cured for 5, 20, 40, and 300 sec with a Demetron 400 curing unit (Demetron). After each exposure time, degree of conversion (DC) was estimated using Fourier transform infrared (FTIR) spectrophotometer (Nicolet 520, Nicolet Instrument Corp.). The results were analyzed by ANOVA followed by Scheffe test, with p = 0.05 as the level of significance. Results: DC (%) was expressed in the order of curing time (5, 20, 40, and 300 sec). Group A ($14.63{\pm}10.42$, $25.23{\pm}6.32$, $51.62{\pm}2.69$, $68.52{\pm}2.77$); Group B ($4.04{\pm}6.23$, $16.56{\pm}3.38$, $37.95{\pm}2.79$, $64.48{\pm}1.21$); Group C ($16.87{\pm}5.72$, $55.47{\pm}2.75$, $60.83{\pm}2.07$, $68.32{\pm}3.31$); Group D ($23.77{\pm}1.64$, $61.05{\pm}1.82$, $65.13{\pm}2.09$, $71.87{\pm}1.17$); Group E ($28.66{\pm}2.92$, $56.68{\pm}1.33$, $60.66{\pm}1.17$, $68.78{\pm}1.30$); Group F ($39.74{\pm}6.31$, $61.07{\pm}2.58$, $64.22{\pm}2.29$, $69.94{\pm}2.15$). Conclusion: All the monomers with ternary photoinitiation system showed higher DC than the ones with binary system, until 40 sec. Concerning about the effect of CQ-amine ratio on the DC, group A converted into polymer more than group B in binary system. However, there was no significant difference among groups with ternary system, except group C when cured for 5 sec only.

• Analytical Science and Technology
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• v.10 no.5
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• pp.315-324
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• 1997

The retention behaviors of 16 PAHs and 4 nitro-PAHs were studied with several parameters involved numbers of carbon atoms, F factor, aqueous solubility, L/B ratio, and numbers of interfering hydrogen atom pairs on the chemical structures of PAHs by using reversed-phase liquid chromatography/diode array detection method (RPLC/DAD) and gradient elution method. It was obtain that the log k' for most of PAHs with increasing the number of carbon and the F factor in their molecules. Chromatographic retention of PAH isomers and nitro-PAHs were examined with aqueous solubility, L/B ratio and number of interfering hydrogen atom pairs. As a result of comparison with these factors and retention times, it was found that those solutes having larger aqueous solubilities and greater L/B ratios were retained longer on stationary phase. This tendency was also occured in the molecules having the more number of interfering hydrogen atom pairs. Detection limits of PAHs which were obtained with three times measurements by RPLC/DAD were in the range of 100~500ng/mL and method detection limit(MDL) for water sample were in the range of 0.1~0.5ng/mL.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.1
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• pp.90-96
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• 2008

We compared the effects of supplementing $L-lysine{\cdot}SO_4$ to L-lysine HCl on growth performance, nutrient digestibility and nitrogen retention in weaning pigs. A total of 96 crossbred pigs, weaned at $21{\pm}3$ days of age and with an average initial body weight (BW) $6.23{\pm}0.01kg$, were given one of 4 treatments, which translated into 6 replicates of 4 pigs in each pen. The animals were randomly assigned to four dietary treatments according to a randomized completely block design (RCBD) as follows: 1) control-no synthetic lysine, lysine deficient (0.80% total lysine); 2) L-C (= 0.2% L-lysine HCl); 3) K-L-S (= 0.332% $L-lysine{\cdot}SO_4$, A company); 4) C-L-S (= 0.332% $L-lysine{\cdot}SO_4$, B company). Diets were formulated with corn, soy bean meal, and corn gluten meal as the major ingredients, and all nutrients except the lysine met or exceeded NRC requirements (1998). The lysine content of supplemented synthetic lysine was the same in all treatment groups except the control. No clinical health problems associated with the dietary treatments were observed. During the entire experimental period, body weight, average daily gain (ADG) and feed efficiency (G:F ratio) increased (p<0.01) in pigs fed the experimental diets supplemented with L-lysine??HCl or $L-lysine{\cdot}SO_4$ produced by A company, irrespective of the two synthetic lysine sources. Although the supplementation of $L-lysine{\cdot}SO_4$ produced by B company tended to improve the ADG and G:F ratio, significant differences were not seen among all treatments and tended to be lower than the L-C (L-lysine HCl) and K-L-S ($L-lysine{\cdot}SO_4$ groups using the product from A company). The digestibility of crude protein (CP) was increased by the supplementation of synthetic lysine (p<0.05), irrespective of the L-lysine source (L-C, K-L-S, C-L-S). The results of this study showed that ADG, G:F ratio, and CP digestibility improved when $L-lysine{\cdot}SO_4$ or L-lysine HCl was supplemented into the weaning pigs' diet. There was a clear difference in efficacy between the two $lysine{\cdot}SO_4$ products based upon the growth performance of weaning pigs. Consequently, the bioavailability of $lysine{\cdot}SO_4$ products should be evaluated before supplementation of synthetic lysine in swine diets.

• Journal of Sericultural and Entomological Science
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• v.21 no.2
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• pp.1-6
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• 1979

Diallel crosses among six silkworm varieties were used as the materials. by the randomized block design, and diallel cross analyse were conducted to determine the relationships between parents and their F$_1$hybrids. The six parents and their 30 F$_1$crosses were evaluated for five quantitative characters in each female and male silkworms. All methods utilized were similar in detecting lines giving unexpected performance in the F$_1$generation. Mean values of total cocoon weight and weight of cocoon layer of female silkworms were more than those of male silkworms, but mean values of cocoon layer ratio of female silkworms were less than those of male silkworms in both parents and 30 F$_1$hybrids. Over dominance was exhibited by total cocoon weight and weight of cocoon layer, and partial dominance was exhibited by periods (days) of larval stage, periods (days) of 5th instar and cocoon layer ratio (weight of cocoon layer/total cocoon weight). Furthermore, it was recognized that varieties F (Yunil) and E (Kyung-choo) were recommendable varieties as the parents in breeding of silkworms for increasing the total cocoon weight and weight of cocoon layer, etc.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.3
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• pp.627-631
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• 2007

The factors affecting on sludge sedimentation are reported as F/M ratio, ingredient, composition of influent substrate, dissolved oxygen concentration, temperature, pH, filamentous bacteria and SRT. Aeration tank applying Bacillus sp. has an important role for maintaining the dominant microorganism species to make steady progress for spore growth affecting sedimentation. This research aims to investigate the affecting factor for the sedimentation in B3 system and RABC system with aeration tank applying tapered aeration. Extracellular polymeric substances(EPS), protein and carbohydrate can be produced for the extreme condition, that is down to 0.2 mg/L of dissolved oxygen in the aeration tank. This research found out the relation between the sedimentation and the EPS production, especially the ratio of protein/carbohydrate. The spore of Bacillus sp. was formed at the low DO then microorganisms produced EPS. The results showed that the production of EPS was 109.95 mgEPS/gSS at 1.6 mg/L of DO, however it was 131.77 mgEPS/gSS at 0.5 mg/L of DO. The sedimentation was affected by protein content in EPS and the ratio of protein and carbohydrate. The settleability of sludge was not affected by the ratio of protein/carbohydrate in B3 process, meanwhile settleability was affected by the ratio of it in RABC process, respectively.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.11a
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• pp.613-616
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• 2003

Steel-concrete composite columns are used extensively in modern buildings. Extensive research on composite columns in which structural steel are in concrete have been carried out. In-filled composite columns, however have received limited attention compared to encased columns. In this paper, interrelationship of parameters is examined into analyzing and comparing with data through ABAQUS program and experiment on concrete filled tubular column under axial load and propriety of model is checked out by FEM analysis. The main variations of this paper are width-thickness ratio of the section(B/t =33.3, 38.9, 44.4), concrete strength($f_{ck}$=240, 360kgf/$\textrm{cm}^2$), and width-length ratio($L_o$/B=8.0, 10.0, 12.0, 15.0, 20.0). The ultimate value obtained through analysis is compared with test value and calculated by design code of other countries and previous studies.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.05a
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• pp.157-162
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• 2003

An experimental investigation was conducted to study the behavior of high-strength RC wide beam-column joints with slab subjected to reversed cyclic loads under constant axial load. Six half scale interior wide beam-column assemblies representing a portion of a frame subjected to simulated seismic loading were tested, including three specimens without slab and three specimens with slab. The primary variables were compressive strength of concrete($f_ck$=285, 460kgf/$cm^2$), the ratio of the column-to-beam flexural capacity($M_r$=$\Sigma M_c / \Sigma M_b$ ; 0.77 -2.26), extended length of the column concrete($l_d$ ; 0, 12.5, 30cm), ratio of the column-to-beam width(b/H ; 1.54, 1.67). Test results are shown that (1) the behavior of specimen using high-strength concrete satisfied for required minimum ductile capacity according to increase the compressive strength, (2) the current design code and practice for interior joints(type 2) are apply to the wide beam-high strength concrete column.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.11 no.6
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• pp.952-958
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• 2000

다양한 구조위 트랜스미션 라인과 힌지들을 갖는 고주파용 마이크로머신드 용량성 스위치들이 새롭게 디자인되었고 전기도금 기술, 저온 공정기술, 그리고 건식 식각기술들을 이용하여 제작되었다. 특히, 집적화된 용량성 스위치들이 높은 스위칭 on/off ratio와 on 캐패시턴스를 갖도록 하기 위하여 고유전율을 갖는 SrTiO3라는 상유전체를 절연체로 사용하였다. 제작된 스위치들은 8V의 구동전압, 0.08dB의 삽입손실, 42dB의 높은 isolation, 600의 on/off ratio, 그리고 50pF의 on 캐패시턴스의 특성들을 갖는다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.226-234
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• 2017

The physical properties of lightweight foamed concrete mixed with EPS waste and flame resistant EPS waste were investigated. For this purpose, the main variables considered were a cement content of 300 and $400kgf/m^3$ and an EPS replacement ratio of 0, 10, 20, 30, and 40% by the volume ratio of the foam. The water-cement ratio and the dilution concentration were fixed to 0.5 and 10% respectively. The test results showed that the apparent density meets degrees 0.5 and 0.6 of KS F4039, and they showed little difference between the two mixes of Type A and Type B, regardless of the unit cement content. The bending strength obtained through the compressive strength also met the degree of KS F 4039. The thermal conductivity was 1~3% higher for the mixes of EPS than the case of flame resistant EPS, but both mixes met the 0.4 degree of KS F4039. The absorption ratio showed the values above 20% with a 1~3% difference for the two mixes, which mean further studies will be needed to reduce the absorption ratio.