• Anxiety and mood
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• v.10 no.1
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• pp.44-51
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• 2014

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous functional neuroimaging studies. Methods : Resting-state functional magnetic resonance imaging data was obtained in 19 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and perigenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality in superficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.05a
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• pp.909-917
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• 2007

Recently the trend of automobile industry is that IQS evaluation index against a sensitivity quality is increasing. To reduce rattle noise due to speaker sound at low frequencies, it is required the advanced investigation of a package tray panel and a door module panel. This paper optimized the design parameters of package tray panel according to the theoretical background about robust design and suggested the design guideline for resonance avoidance and the reduction of vibrational sensitivity considering the excitation frequency of woofer speaker. In addition, it is suggested the design guideline of a door module panel through the sensitivity analysis in case of the speaker excitation. Finally, the design factor analysis of the quality deviation of a mother-car will make it possible to guarantee the stable characteristics of vehicle vibration in the early stage of vehicle development. These improvements can lead to shortening the time needed to develop better vehicles.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.8
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• pp.673-682
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• 2007

Recently the trend of automobile industry is that IQS evaluation index against a sensitivity quality is increasing. To reduce rattle noise due to speaker sound at low frequencies, it is required the advanced technology analysis process of body structure. This paper optimized the design parameters of package tray panel according to the theoretical background about robust design and suggested the design guideline for resonance avoidance and the reduction of vibrational sensitivity considering the excitation frequency of woofer speaker. And this paper described the design process of a door module panel through the sensitivity analysis in case of the door speaker excitation. Finally, the analysis of the quality deviation using mother car is suggested to guarantee the stable characteristics of vehicle vibration in the early stage of vehicle development. These improvements can lead to shortening the time needed to develop better vehicles.

• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.511-524
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• 2023

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.734-742
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• 2016

Global warming and the depletion of fossil fuels have been caused by decades of reckless development. Wind energy is one form of renewable energy and is considered a future energy source. The wind tower is designed with a fundamental frequency in the soft-stiff design between the 1P and 3P range to avoid resonance. Usually, to perform natural frequency analysis of a wind tower, the boundary condition is set to the Fixed-End, and soil-pile interaction is not considered. In this study, consideration of the effect of soil-pile interaction on the wind tower was included and the difference in the natural frequency was studied. The fixed boundary condition was not affected by the soil condition and depth of the pile and the coupled spring boundary condition was unaffected by the depth of pile but affected by the depth of the pile, and the Winkler spring boundary condition is affected by both the soil condition and the depth of the pile. Therefore, the coupled spring boundary condition should be used in shallow depth soil conditions because the soil condition does not take the shallow depth soil into consideration.

• Journal of Korean Neurosurgical Society
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• v.53 no.4
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• pp.235-240
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• 2013

Fusiform aneurysms on the basilar artery (BA) trunk are rare. The microsurgical management of these aneurysms is difficult because of their deep location, dense collection of vital cranial nerves, and perforating arteries to the brain stem. Endovascular treatment is relatively easier and safer compared with microsurgical treatment. Selective occlusion of the aneurysmal sac with preservation of the parent artery is the endovascular treatment of choice. But, some cases, particularly giant or fusiform aneurysms, are unsuitable for selective sac occlusion. Therefore, endovascular coiling of the aneurysm with parent vessel occlusion is an alternative treatment option. In this situation, it is important to determine whether a patient can tolerate parent vessel occlusion without developing neurological deficits. We report a rare case of fusiform aneurysms in the BA trunk. An 18-year-old female suffered a headache for 2 weeks. Computed tomography and magnetic resonance image revealed a fusiform aneurysm of the lower basilar artery trunk. Digital subtraction angiography revealed a $7.1{\times}11.0$ mm-sized fusiform aneurysm located between vertebrovasilar junction and the anterior inferior cerebellar arteries. We had good clinical result using endovascular coiling of unruptured fusiform aneurysm on the lower BA trunk with parent vessel occlusion after confirming the tolerance of the patient by balloon test occlusion with induced hypotension and accompanied by neurophysiologic monitoring, transcranial Doppler and single photon emission computed tomography. In this study, we discuss the importance of preoperative meticulous studies for avoidance of delayed neurological deficit in the patient with fusiform aneurysm on lower basilar trunk.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.5
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• pp.351-358
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• 2013

In the electric power supplying industry, outdoor sealing end (pothead) is used and sometimes it is necessary to check the seismic qualification analysis or test which is intended to demonstrate that the equipment have adequate integrity to withstand stress of the specified seismic event and still performs their function. And since the pothead is mounted on the supporting jig, the avoidance of resonance between the pothead and jig is required. In order to design jig, three types of optimization are performed to get the minimum weight while satisfying the natural frequency constraint using ANSYS. Optimal array, position and thickness of truss members of the jig are obtained through topology, shape and sizing optimization process, respectively. And seismic analysis of the pothead on the jig for given RRS acceleration computes the displacement and stress of the pothead which shows the safety of the pothead. The obtained natural frequency, mass, and member thickness of the jig are compared with those of the reference jig which was used for seismic experimental test. The numerical results of the jig in the research is more optimized than the jig used in the experimental test.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.04a
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• pp.835-841
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• 2013

Modern solid-state gyroscopes (HRG) with hemispherical resonators from high-purity quartz glass and special surface superfinishing and ultrathin gold coating become the best instruments for precise-grade inertial reference units (IRU) targeting long-term space missions. Designing of these sensors could be a notable contribution into development of Korea as a space nation. In participial, 40mm diameter thin-shell resonator from high-purity fused quartz, fabricated as a single-piece with its supporting stem has been designed, machined, etched, tuned, tested, and delivered by STM Co. (ATS of Ukraine) several years ago; an extremely-high Q-factor (upto 10~20 millions) has been shown. Understanding of the best way how to match such a unique sensor with inner glass assembly of the gyro means how to use the high potential in a maximal extent; and this has become the urgent task. Inner quartz glass assembly has a very thin indium (In) layer soldered the resonator and its silica base (case), but effects of internal resonances between operational modal pair of the shell-cup and its side (parasitic) modes can notable degrade the potential of the sensor as a whole, instead of so low level of resonator's intrinsic losses. Unfortunately, there are special combinations of dimensions of the parts (so-called, "resonant sizes"), when intensive losses of energy occurs. The authors proposed to use the length of stem's fixture as an additional design parameter to avoid such cases. So-called, a cyclic scheme of finite element method (FEM) and ANSYS software were employed to estimate different combinations of gyro assembly parameters. This variant has no mismatches of numerical origin due to FEM's discrete mesh. The optimum length and dangerous "resonant lengths" have been found. The special attention has been paid to analyses of 3D effects in a cup-stem transient zone, including determination of a difference between the positions of geometrical Pole of the resonant hemisphere and of its "dynamical Pole", i.e., its real zone of oscillation node. Boundary effects between the shell (cup) and 3D short "beams" (inner and outer stems) have been ranged. The results of the numerical experiments have been compared with the classic model of a quasi-hemispherical shell band with inextensional midsurface, and the solution using Rayleigh's functions of the $1^{st}$ and $2^{nd}$ kinds. To guarantee the truth of the recommended sizes to a designer of the real device, the analytical and FEM results have been compared with experimental data for a party of real resonators. The consistency of the results obtained by different means has been shown with errors less than 5%. The results notably differ from the data published earlier by different researchers.