• The Journal of Korean Society for School & Community Health Education
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• v.15 no.2
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• pp.39-49
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• 2014

Objectives: University students's oral health care practice and oral health status are very important. Because its affect their systemic disease, so as to have confidence, and to be eager to study. However if they feel dental fear, they avoid dental treatment. It is miss opportunities of early treatment and prevention treatment and have little effect on dental treatment. The aim of this study was to investigate the factors influencing dental fear of university students to reduce their dental fear. Methods: A total of 366 self-administered questionnaires were collected from university student in Cheon-an. To investigate the factors influencing dental fear of university students, t-test, one-way ANOVA, correlation analysis, linear regression analysis were carried out by using SPSS ver. 18.0 Results: University students feel the most fear of specific dental stimuli. Especially, 'Feeling the needle injected'. University Students felt dental fear in order of 'fear of specific dental stimuli', 'physiologic arousal', 'avoidance fear'. 'Feeling the needle injected', they felt severe dental fear. 'My muscles become tense' of Symptoms they feel dental fear was the most frequent Sex affects avoidance fear, physiologic arousal, fear of specific dental stimuli and dental fear. Femal feel more its than male. The time since last dental clinic visit affects physiologic arousal, fear of specific dental stimuli and dental fear. Group do not visit the dental clinic within a year feel more its than others. Conclusions: To reduce dental fear in university students, it is necessary to make them visit dental clinics frequently and dental staffs consider their sex. Therefore, Department of dental hygiene and dentistry must be added the management of dental fear of the curriculum. In addition, it must be emphasized that to visit dental clinics frequently for university students.

• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.277-285
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• 2010

The purpose of this study was to examine the influential relationship between the type of dental treatment and the dental fear of teens in a bid to seek ways of relieving adolescents of dental anxiety and fear. The subjects were teenaged students in South Gyeongsang Province. After a survey was conducted for eight days from December 2 to 9, 2009, the answer sheets from 420 students were analyzed. The findings of the study were as follows: When a correlation analysis was employed to look for connections between dental treatment experiences and dental fear, the components of dental treatment experiences had a significant correlation to those of dental fear. As a result of making a regression analysis, overall dental fear was under the significant influence of prosthodontic treatment experiences, and avoidance of dentistry was significantly affected by conservative treatment experiences. Oral and maxillofacial treatment experiences had a significant impact on physiologic response, and dental stimulus was significantly affected by prosthodontic treatment experiences. Therefore dental institutions should direct their efforts into the development of manuals geared toward different types of treatment and different patients in order for adolescents to receive dental treatment without any anxiety or fear, to get a regular dental checkup, to receive more preventive treatment, to promote their oral health and ultimately to lead a healthy life.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.6
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• pp.519-525
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• 2001

The oral cavity has frequent contacts with many carcinogenic compounds and its soft tissue is continuously stimulated by numerous dental factors. We have examined the detailed dental factors and its correlation with oral squamous cell carcinoma, and denture-wearing effects to analyze the effect of the dental factors on the genesis of oral squamous cell carcinoma. We have studied clinical contributing factors and the dental factors in the genesis of oral squamous cell carcinoma when the effects of smoking and drinking are controlled. The study cases are 100 patients(75 males and 25 females) who were diagnosed histo-pathologically as squamous cell carcinoma at the Yonsei Medical Center. The control group was 154 patients who have no systemic malignant tumors. The effects of 6 dental factors were analyzed in this study. They were divided into the smoking group, the non smoking group, the drinking group, and the non-smoking group. The effects of dental factors were analyzed in each group. In this study, we have drawn some conclusions on the relationship between the dental factors and oral squamous cell carcinoma using $x^2$-test. 1. The repaired teeth have statistical significance on the genesis of squamous cell carcinoma. This is probably due to the combining effects of past poor oral hygiene and continuous stimulation due to poor prosthesis. 2. There is statistical significance of the lost teeth in the smoking group, and the repaired teeth and the degree of alveolar bone resorption had statistical significance in the non-smoking group. 3. Smoking and drinking by-itself have no statistical significance in the genesis of oral squamous cell carcinoma. However, in combination, they have statistical significance. In this study, dental factors had a synergistic effect with smoking and drinking. Together with avoidance of smoking and drinking, appropriate restoration and oral hygiene control are most important factors in the preventive aspects of the oral squamous cell carcinoma.

• Journal of Oral Medicine and Pain
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• v.23 no.4
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• pp.387-401
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• 1998

This study was performed to investigate the emotional state related to dental fear, hospital anxiety and depresison, and frequency of stress symproms of orofacial region. For this study, Dnetal Fear Surfey(DFS) scale, the Hospital ANxiety and Depression(HAD) scale, and Stress Symptom Questionnaire(SSQ) designed by the author were used in 549 dental outpatients. Dental Fear Survey scale is composed of avoidance of dentistry(AVOI), physiologic response scale(PRS) and dental stimulus response scale(DSRS). The Hospital anxiety and Depresiosn scale is composed of hospital anxiety(HA) and hospital depressoin (HD). Data were analyzed statistically with SPSS program and the results were as follows : 1. The item of the highest positive response rate in DFS scale was 'feeling drill'(82.0%), and in the HAD scale was ' feel as if I am slowed down'(84.1%). 2. Mean score of AVOI, PRS, DSRS and HD were higher in the older group(>25yr) than the yoiunger group(<25yr) and female patients showed higher score of DSRS, HA than male patients. 3. Mean number of items of stress symptoms in extraoral region were 3.4, and in intraoral region, were 4.7. Tongue wymptoms were increased in the older toup and female patients had more stress symptoms than male patients. 4. Correlation between DFS scale and HAD scale were significantly positive and these scales were also apositively correlated with tongue symptoms. 5. As for treatment types, the patients treated in the department of periodontics,conservative dentistry, and oral surgery showed higher score of DFS scale than the patients with temporomandibular disorders or treatedin the department of orthodontics.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.28 no.1
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• pp.54-60
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• 2019

Objective: Dental fear is a feeling of anxiety and fear without intervention during a dental visit, mainly due to past negative dental treatment experiences, and in adults, despite the recognition of the need for dental treatment, it can lead to avoidance of dental treatment, which may cause deterioration of oral health. Therefore, this study was conducted to measure dental fear and anxiety level in some adults, and to identify related factors and their causes. Methods: This study used Kleinknecht's Dental Fear Survey scale and the SPSS 21 program (IBM SPSS Statistics 21) was used for analysis. Result: When the dental fear was the higher, the "access to the dental clinic" was found to be the highest, followed by "sitting in dental unit chair" and "smell of dental clinic" in that order. Conclusions: Dentists and dental hygienists should be able to understand the fear, anxiety, and concerns of the dentist office and to find various ways to provide systematic medical services.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.47-57
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• 2022

Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models of epilepsy. The objective of the present study was to investigate effects of post-treatment with stiripentol on cognitive deficit and neuronal damage in the cornu ammonis 1 (CA1) region of the hippocampus proper following transient ischemia in the forebrain of gerbils. To evaluate ischemia-induced cognitive impairments, passive avoidance test and 8-arm radial maze test were performed. It was found that post-treatment with stiripentol at 20 mg/kg, but not 10 or 15 mg/kg, reduced ischemia-induced memory impairment. Transient ischemia-induced neuronal death in the CA1 region was also significantly attenuated only by 20 mg/kg stiripentol treatment after transient ischemia. In addition, 20 mg/kg stiripentol treatment significantly decreased ischemia-induced astrocyte damage and immunoglobulin G leakage. In brief, stiripentol treatment after transient ischemia ameliorated transient ischemia-induced cognitive impairment in gerbils, showing that pyramidal neurons were protected and astrocyte damage and blood brain barrier leakage were significantly attenuated in the hippocampus. Results of this study suggest stiripentol can be developed as a candidate of therapeutic drug for ischemic stroke.

• Journal of Oral Medicine and Pain
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• v.23 no.4
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• pp.403-418
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• 1998

The aim of this study was to measure effects of the following items to pain and pain behavior reaction in patients with chronic orofacial pain. Items that contribute to the first factor(Environmental Influences) measure environmental sources of information that may affect illness behavior; Second factro(Loss of Control) measure appraisals and attributions perceived to influence personal views aobut pain; Third factor(Health Care Avoidance) measures a variety of avoidant behaviors; Fouth factor(Past and Current Experiences) measures experiences with treatment); Fifth factor(Physiological Responsivity) measures physiological parameters that are experienced in association with pain; Sixth factor(Thoughts of Disease Progression) measures thoughts regarding the etiology and progression of disease in relation to pain. 150 patients that were consist of 40 male and 110 female were participated in this study. The obtained results of this study were as follows : 1. Environmental influences and loss of control scales were recorded high score in patients with chronic orofacial pain 2. "Physician's descriptions of what your pain will be like" and "Physician's facial expression when they ask about your pain" items from the environmental influences were recorded high score. These results indicated that responsibility of doctro is very important to the pain reaction behavior of patients. Also, items from thoughts regarding the etiology and progression of disease in relation to pain influenced to the pain reaction. 3. There were significant defferences on the "nurses' descriptions of what you pain will be like", "physician's and nurses' facial expression when they ask about your pain", "TV and radio", and "Literature" items from the environmental influences between male and female patients. 4. There were no significant differences on the each scale between arthrogenous and combitnation group and significant correlated with all 6 scales.

• Korean Journal of Medicinal Crop Science
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• v.17 no.6
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• pp.388-396
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• 2009

The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.

• The Journal of Korean Society for School & Community Health Education
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• v.15 no.3
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• pp.67-80
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• 2014

Objectives: This study is aimed to analyze the influential factors on the fear that college students and elderly people feel during the dental treatment and provide basic data needed to develop a plan which can lead them to have a positive perspective on dentistry. Methods: A questionnaire was distributed to 241 outpatients (39 college students, 202 elderly people) visiting dental clinic of 'K' University Hospital in Seoul from January to April, 2013. It was filled in a self-administered manner and collected right away. Results: factor analysis, three factors were configured when the factors with 1.0 or higher of eigenvalue were extracted using 19 questions through which dental fear and anxiety were measured against college students and elderly people. The questionnaires were classified into three categories: Factor I (stimulus response), Factor II (avoidance of the treatment) and Factor III (physiological response which occurs when a patient feels fear). As a result, it was confirmed that the questionnaire tool is highly feasible. In college students, the responses they felt during the dental treatment in the said three factors were as follows: 52.00% in Factor II, 14.14% in Factor II and 6.99% in Factor III (73.129% in total). In elderly people, on the contrary, they were 52.41% in Factor I, 10.57% in Factor II and 7.98% in Factor III (70.958% in total), lower than the college student group. Conclusions: This study is significant in that it confirmed complex relations between dental fear and related variables against college students and elderly people.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.11 no.1
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• pp.117-129
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• 1989

The commercial availability of processed heterogenous bone has provided the surgeons with almost unlimited supply, avoidance of additional operation and prevention of the postoperative complications. In addition to these merits, unnecessary bone bank, easy availibility and storage have been achieved. The purpose of this study was to compare and examine the healing capacity of Kiel bone, Pyrost and Osteovit which used as the processed heterografts for the reconstruction of bony defect. Twenty rabbits weighing about 1.7-2.0 Kg were selected and divided into two groups. In experimental group A, the left mandibular defect was allowed to fill with blood, and the right defect was filled with Kiel bone. In experimental group B, the left defect was grafted with Pyrost, and the right with Osteovit. The experimental animals were sacrified after 1, 2, 4 and 8 weeks and the grafted site was studied histologically. To evaluate the strength of healed bone, 2 rabbits from each experimental group and a nonoperated control were sacrified at the 6th week after implantation and used for biometric testing on universal testing machine. The results obtained were as follows : 1. It was considered that these heterogenous bone grafts has feeble or absent immunogenicity since all of them appeared to evoke little inflammatory or forign body reaction. 2. In all experimental groups, new bone formation began from the adjacent region of host bone and extended progressively into the defect sites. New bone was partly formed within the intertrabecular space of the implant and gradually united with the bone that formed at the margin of the host bone. 3. With Pyrost bone formation was rapid and prominent comparing with other graft materials. 4. Osteovit was begun to be absorbed from 2 weeks, and Kiel bone from 4 weeks, however Pyrost was remained to be intact until the end of 8 weeks. 5. As the results of tensile test, the mean values of maximum tensile stress were 1.11${\uparrow}$ $Kgf/mm^{2}$ in Pyrost implanted specimens, 0.85 $Kgf/mm^{2}$ in Osteovit, 0.42 $Kgf/mm^{2}$ in Kiel bone, 0.66 $Kgf/mm^{2}$ in blood filled specimens and 1..13 $Kgf/mm^{2}$ in control. These results indicate that heterogenous bones grafted have little antigenicity to the host tissue, and that they mediate effectively osteoconduction by providing the scaffold for the bone formation. Pyrost and Osteovit appeared to be suitable for the clinical use.