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Next-generation gene targeting in the mouse for functional genomics

  • Gondo, Yoichi;Fukumura, Ryutaro;Murata, Takuya;Makino, Shigeru
    • BMB Reports
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    • v.42 no.6
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    • pp.315-323
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    • 2009
  • In order to elucidate ultimate biological function of the genome, the model animal system carrying mutations is indispensable. Recently, large-scale mutagenesis projects have been launched in various species. Especially, the mouse is considered to be an ideal model to human because it is a mammalian species accompanied with well-established genetic as well as embryonic technologies. In 1990', large-scale mouse mutagenesis projects firstly initiated with a potent chemical mutagen, N-ethyl-N-nitrosourea (ENU) by the phenotype-driven approach or forward genetics. The knockout mouse mutagenesis projects with trapping/conditional mutagenesis have then followed as Phase II since 2006 by the gene-driven approach or reverse genetics. Recently, the next-generation gene targeting system has also become available to the research community, which allows us to establish and analyze mutant mice carrying an allelic series of base substitutions in target genes as another reverse genetics. Overall trends in the large-scale mouse mutagenesis will be reviewed in this article particularly focusing on the new advancement of the next-generation gene targeting system. The drastic expansion of the mutant mouse resources altogether will enhance the systematic understanding of the life. The construction of the mutant mouse resources developed by the forward and reverse genetic mutagenesis is just the beginning of the annotation of mammalian genome. They provide basic infrastructure to understand the molecular mechanism of the gene and genome and will contribute to not only basic researches but also applied sciences such as human disease modelling, genomic medicine and personalized medicine.

Efficient Method to Support Mobile Virtualization-based Cloud Resource Management (모바일 가상화기반 클라우드 자원관리를 지원하는 효율적 방법)

  • Kang, Yongho;Jang, Changbok;Lee, Wanjik;Heo, Seokyeol;Kim, Jooman
    • Journal of Digital Convergence
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    • v.12 no.2
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    • pp.277-283
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    • 2014
  • Recently, various cloud service has been being provided on mobile devices as well as desktop pc and server computer. Also, Smartphone users are very rapidly increasing, and they are using it for enjoying various services(cloud service, game, banking service, mobile office, etc.). So, research to utilize resources on mobile device has been conducted. In this paper, We have suggested efficient method of cloud resource management by using information of available physical resources(CPU, memory, storage, etc.) between mobile devices, and information of physical resource in mobile device. Suggested technology is possible to guarantee real-time process and efficiently manage resources.

A study on the publication of illustration book of Korean coastal and offshore fishing boats (우리나라 연근해 어선도감 발간을 위한 연구)

  • JEONG, Seongjae;KIM, Inok;PARK, Changdoo;BAE, Bongseong;KIM, Seonghun;JEONG, Geumcheol
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.55 no.4
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    • pp.392-401
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    • 2019
  • This study describes how the illustration book of Korean coastal and offshore fishing boats was published. The illustration book provides information on fisheries which need boats for their fishing operation. The book contains 25 fishing boats belonging to 15 offshore fisheries and six boats belonging to five coastal fisheries totalling 31 boats belonging to 20 kinds of fisheries. Until now, no books were available in Korea on fishing boats which provided illustrated descriptions of their use in fishing. We carried out field and literature surveys of fishing boats for three years (2016-2018) and the results were compiled into three-dimensional modeling images with schematic drawings of fishing boats, along with text explanations. The particulars and technical drawings of lines, general arrangement (GA), fishing gears and methods are collected and summarized. All fishing boats are modeled with 3D color graphics. The particulars and names of the main items of the fishing equipment are presented besides structural parts. In addition the fishing gear, fishing season and grounds, number of crews and target species for each boat are correctly described. The illustration book of Korean coastal and offshore fishing boats will contribute to understanding the current status of fishing techniques in Korea and will assist in developing new types of fishing boats.

Adaptive Management: a key tool for natural resource management (자연자원관리를 위한 핵심도구: 적응관리)

  • Park, Young Cheol;Yoo, Jae Won;Jeong, Su-young;Oh, Tae-Geon;Kim, Jong Ryol;Choe, Mi Kyung;Choi, Ok-in
    • Journal of Wetlands Research
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    • v.21 no.4
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    • pp.267-280
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    • 2019
  • Adaptive Management (AM) is one of the best available approaches for managing natural resources in the presence of uncertainty. In spite of the limitations, AM has been widely applied in nature resource management policies and plans internationally, while application of AM in nature resource management in Korea is limitedly used. Accordingly, this study reviews application of AM in nature resource management research in Korea with respect to its definitions, procedures, impediments and considerations. The present study also reviews recent ecological modelling studies which is an essential component of AM approach. Finally, management of artificial sea forest, coastal wetlands and fisheries are suggested as the recommended fields to adopt AM.

Environmental Regulations and Measurement of Market Power in a Depletable Resource Industry (환경규제를 고려한 고갈성 자원산업의 시장지배력 측정)

  • Lee, Myunghun
    • Environmental and Resource Economics Review
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    • v.18 no.4
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    • pp.745-766
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    • 2009
  • It is not valid to measure the degree of market power based on the markup of price over marginal market cost in an industry for which the market price of some inputs is not available because those inputs are then excluded in estimating the dual total cost function. If the roles of those inputs are ignored, the markup of price over marginal market cost is likely to be positive in the perfectly competitive industry. In order to have accurate market power markups for the environmentally regulated Korean iron and steel industry, in which the market price of raw material and the price of abatement capital are hard to obtain, in this paper, a dual cost function is derived given the optimal quantities of raw material and abatement capital, and then estimated jointly with the supply relation. The annual average degree of market power for the industry is estimated to be 0.49 over the period 1982~2001. Ignoring environmental regulation would overstate the degree of market power by about 8 percent.

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Efficient Support for Adaptive Bandwidth Scheduling in Video Servers (비디오 서버에서의 효율적인 대역폭 스케줄링 지원)

  • Lee, Won-Jun
    • The KIPS Transactions:PartC
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    • v.9C no.2
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    • pp.297-306
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    • 2002
  • Continuous multimedia applications require a guaranteed retricval and transfer rate of streaming data, which conventional file server mechanism generally does not provide. In this paper we describe a dynamic negotiated admission control and dick bandwidth scheduling framework for Continuous Media (CM : e.g., video) servers. The framework consists of two parts. One is a reserve-based admission control mechanism and the other part is a scheduler for continuous media streams with dynamic resource allocation to achieve higher utilization than non-dynamic scheduler by effectively sharing available resources among contending streams to improve overall QoS. Using our policy, we could increase the number of simultaneously running: clients that coo]d be supported and cot]d ensure a good response ratio and better resource utilization under heavy traffic requirements.

MAC Schemes for Best Effort Service in Wireless MAN: Design and Performance Analysis (무선 MAN에서 Best Effort 서비스를 위한 MAC 방식의 설계 및 성능 분석)

  • Park, Jin-Kyung;Shin, Woo-Cheol;Ha, Jun;Choi, Cheon-Won
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.43 no.11 s.353
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    • pp.128-140
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    • 2006
  • In the IEEE 802.16 Wireless MAN standard specifies the air interface of fixed point-to-multipoint broadband wireless access systems providing multiple services. Among the service classes supported between the base station and subscriber stations in the wireless MAN, the best effort service class is ranked on the lowest position in priority and is assisted by a MAC scheme based on reservation ALOHA. The wireless MAN standard, however, does not reveal every detail of the MAC scheme but only describes the skeleton of the MAC scheme. Focusing on the amount of resource that a subscriber demands by a request and the amount of resource that the base grants to a request we thus present a number of resource demand rules and resource grant rules. Also, we construct a candidate MAC scheme by implanting a pair of resource demand and grant rules into the skeleton of the MAC scheme. Meanwhile a difficult situation for the best effort service is expected wherein only scarce resource is available after most of the resource is already preempted by other services. Perceiving such a situation, we evaluate the throughput and delay performance of each candidate MAC scheme. Especially we develop an analytical method to approximately calculate the throughput in the saturated environment. From the numerical results, we observe that the candidate MAC scheme which adopts the non-gated exhaustive demand rule paired with the full grant rule attains superior performance at the expense of the fairness.

The trends and evaluations for Governmental system of redressing consumers' losses in Japan: comparison to Korea (일본의 소비자피해구제 행정체제 현황 및 평가: 한국과의 비교를 중심으로)

  • HUh Kyung Ok
    • Journal of Family Resource Management and Policy Review
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    • v.8 no.1
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    • pp.1-13
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    • 2004
  • This study examined in detail the Japanese system of redressing consumers' losses and the overall consumer administrative system and compared them with the Korean counterpart to seek for a direction of reforming the systems. Several policy suggestions could be made as follows to activate the systems and improve the performances of the consumer administration in both Japan and Korea. First, in Japan, consumer center must be efficiently operated while private consumer groups, firms, consumer agencies and other organizations must actively join to actively redress consumers' losses and implement other consumer policies. Second, in Korea, regional consumer policies are weak so that they must learn Japanese well-developed regional consumer administration system by examining their current development, strengths, and weaknesses. Third, working conditions must be urgently improved, increasing the number of consumer counselors who are involved in consumer policies as well as to guarantee minimum level of their payment. On the other hand, the trend of hiring married and old employees being responsible for implementing consumer policies in Japan must be improved. Fourth, divisions of works in consumer policies among consumer groups as well as their specialization in Korea are necessary. Finally, as counseling of consumers through internet were not available in Japan, that type of counseling must introduce and become more popular in the future.

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Vegetation and Habitat Environment of Sageretia thea in Jeju Island (제주지역 상동나무의 자생지 생육환경 및 식생조사)

  • Song, Sang Churl;Song, Chang Khil;Kim, Ju Sung
    • Korean Journal of Medicinal Crop Science
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    • v.22 no.4
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    • pp.301-305
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    • 2014
  • This study was carried out to investigate the vegetation and habitat environment of Sageretia thea which is distributed in Jeju island, Korea. Sageretia thea were mainly distributed to the west area in Jeju island. Soil pH and EC of Sageretia thea habitat were 5.8 and $0.34dS{\cdot}m^{-1}$. The contents of organic matter, available phosphate, exchangeable potassium, exchangeable sodium, exchangeable magnesium and exchangeable calcium were 15.27%, $13.6mgkg^{-1}$, $0.27cmol_+kg^{-1}$, $1.3cmol_+kg^{-1}$, $1.7cmol_+kg^{-1}$, $4.9cmol_+kg^{-1}$, respectively. Thirty one taxa including 25 families, 31 genus, 27 species and 4 varieties were identified surrounding Sageretia thea habitat. Specific plant species were 1 taxon in III grade, 1 taxon in I grade and 3 taxa in I grade.

The Effect of the Recycling Industry in Public Sector (공공부문 자원재활용사업의 국민경제적 효과분석)

  • Kwak, Seung-Jun;Yoo, Seung-Hoon;Ryu, Mun-Hyun
    • Environmental and Resource Economics Review
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    • v.11 no.3
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    • pp.465-491
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    • 2002
  • Korea is one of the countries which have a remarkable record of high and sustained economic growth. However, as the national economy has continued to grow and the industrial structure has become increasingly advanced, the amount of wastes being generated has been rapidly on the rise. recycling wastes to cope with the environmental problems caused by wastes has become an increasingly important policy issue in developing countries such as Korea, as well as in developed countries. This situation demands that researchers provide policy-makers with available and responsible information regarding the effect of the recycling industry in the public sector. This study employs input-output (I-O) analysis to examine the effect of public sector recycling industry in the national economy, using a specific application to Korea. The paper, therefore, has two major goals. The first is the development of a static I-O framework for looking into the effect of public sector recycling industry in the short run. The second goal is obtaining at least a preliminary indication of the effect of the recycling industry- in public sector. Moreover, we discuss the role of a public firm that established with an objective of promoting and facilitating the reutilization of recyclable wastes. The overall results indicate that the recycling utilities may have a significant influence on the standard of living and industrial production.

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