• 동의신경정신과학회지
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• 제21권2호
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• pp.75-85
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• 2010

Objectives : This study was designed to evaluate the correlation between patterns of dyspepsia(acute dyspepsia, functional dyspepsia, dyspepsia with the organic disease) and autonomic nerve system dysfunction using HRV analysis. Methods : The patient group consisted of 88 patients diagnosed as a dyspepsia (Acute dyspepsia group-35 patients, Functional dyspepsia group-28 patients, Dyspepsia with the organic disease group-28 patients) who visited in the Oriental Medical Hospital of Dong-eui University from 2005.3.OO to 2008.8.OO. And the control group consisted of 33 patients diagnosed as a normal state of stomach during the same period. We checked HRV of the 4 groups over 5 minutes and compared the HRV index between groups. Results : 1. HF, LF, VLF and TP were significantly lower in the acute dyspepsia, functional dyspepsia and organic dyspepsia patient group than in the control group. 2. HF, LF, VLF and TP were higher in the acute dyspepsia patient group than in the organic dyspepsia patient group, but the differences were not statistically significant. 3. HF, LF, VLF and TP were higher in the acute dyspepsia patient group than in the functional dyspepsia patient group, but the differences were not statistically significant. 4. HF, LF, VLF and TP were lower in the functional dyspepsia patient group than in the organic dyspepsia patient group, but the differences were not statistically significant. Conclusions : Compared to the control group, all of the dyspepsia patient groups showed the tendency that the overall activity of the autonomic nervous system and the activity of sympathetic nerves decreased. Although there was no significant difference in the suppression of the autonomic nervous system, chronic dyspepsia patient group was lower than acute dyspepsia patient group, functional dyspepsia patient group was lower than the organic dyspepsia patient group in HRV.

• 생물정신의학
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• 제17권1호
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• pp.44-48
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• 2010

Objectives : Social phobia is frequently accompanied with autonomic nerve system symptoms. QT dispersion(QTd) is the maximum inter-lead difference in QT interval, an indicator of the autonomic nerve system(ANS) disparity of the heart itself. The objective of this study is to investigate the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia. Methods : This research have compared QT dispersion of 25 physically healthy social phobia outpatients(16 men, 9 women, the average age $35.5{\pm}12.9$) and age and sex matched control group of mentally and physically healthy 25 volunteers(16 men, 9 women, the average age $34.83{\pm}12.7$). QTd was measured by previously described method. Results : QTd and rate-corrected QTd were significantly higher on the patient group than the control group[QTd(patients vs. controls : $52.60{\pm}27.63ms$ vs. $27.53{\pm}14.29ms$, p<0.0001), QTd(patients vs. controls : $55.79{\pm}27.98ms$ vs. $29.10{\pm}14.24ms$, p<0.0001)]. Conclusion : Our study showed that the patients with social phobia have higher QTd than the normal controls. These results suggest that the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia.

• Journal of Acupuncture Research
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• 제22권6호
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• pp.51-60
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• 2005

Objectives : This study was designed to evaluate the effect of inbalance of autonomic nerve system on peripheral facial palsy patients in comparison of Heart Rate Variability results of healthy control group with that of peripheral facial palsy group. Methods : The peripheral facial palsy patiens who visited the Dongguk university Bundang oriental medicine hospital from April to June in 2005 were tested Heart Rate Variability items which are Mean Heart Rate(MHRT), Standard Deviation of all the Normal RR intervals (SDNN), Root Mean Square of Successive Differences Between The Normal Heart Beats(RMSSD), Total Power(TP), Low Frequency, High Frequency, ratio between the Low Frequency and High Frequency power(LF/HF ratio). The Heart Rate Variability test results of peripheral facial palsy group were compared with the HRV test results of healthy control group who didn't have nervous disease, musculoskeletal disease, heart problem and pain for the past 6 months. Results : 1. MHRT was not significantly different between peripheral facial palsy group and healthy control group(P=0.18). 2. SDNN was not significantly different between peripheral facial palsy group and healthy control group(P=0.41). 3. RMSSD was not significantly different between peripheral facial palsy group and healthy control group(P=0.93). 4. TP was not significantly different between peripheral facial palsy group and healthy control group(P=094). 5. LF and HF were not significantly different between peripheral facial palsy group and healthy control group((P=0.34, 0.30). 6. LF/HF ratio was significantly different between peripheral facial palsy group and healthy control group(P=0.04). Conclusion : LF/HF ratio is generally used as autonomic nerve system evaluation and there was significantly statistical difference between peripheral facial palsy group and healthy control group.

• 대한의료기공학회지
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• 제10권1호
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• pp.130-157
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• 2007

The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers' daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don't have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don't have case history, and HF was high when they don't have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don't affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.

• Journal of Acupuncture Research
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• 제25권6호
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• pp.109-116
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• 2008

Objectives : This study investigated the effect of imbalance of autonomic nerve system on the idiopathic facial palsy by the comparison Heart Rate Variability results of Facial palsy group and healthy control group, and to clarify correlation between House-Brackmann Grade and Heart Rate Variability results. Methods : 119 idiopathic facial palsy patients and 88 health subjects who underwent HRV test were retrospectively reviewed based on medical records. We compared between the HRV results of facial palsy group and that of normal control group, and also compared the HRV results of facial palsy subgroup classified by House-Brackmann Grade. Results 1. All HRV results－Mean Heart Rat(MHRT), Standard Deviation of all the Normal RR intervals(SDNN), Total Power(TP), Very Low Frequency(VLF), Low Frequency(LF), High Frequency(HF), ratio betwween the Low Frequency and High Frequency power(LF/HF ratio) of facial palsy group are decreased compared to that of normal control group, especially SDNN, TP, VLF, LF, LF/HF ratio showed significant difference(p<0.05). 2. HRV results showed no significant correlation in House-Brackmann Grade. Conclusions : This study showed that lower HRV results of facial palsy group than normal control group and suggests that imbalance of autonomic nerve system related with facial palsy. HRV could be a objective tool to reflect condition of idiopathic facial palsy patients.

• Korean Journal of Acupuncture
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• 제29권4호
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• pp.554-562
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• 2012

Objectives : The purpose of this research is to verify the effects of the Electromagnetic acupuncture(EMA) on BL15 by Pupil size variability(PSV) which is directly related to the activation of the Autonomic Nervous System. Methods : Thirty male subjects participated in this study and were divided into three groups(non-stimulated, manual acupuncture and EMA group). The size of pupil was measured in the cube place of $60{\times}60{\times}60$ cm in order to avoid the effect of the surrounding circumstances. All subjects were measured the size of left pupil about 200sec in the constant illumination. Results : We observed the decrease in PSV of manual acupuncture group compared to non-stimulation group, but it was not significant statistically(p>0.05). The decrease in PSV of EMA group was observed in comparison to two groups, and we confirmed the result of significant difference statistically(p<0.05). Conclusions : We concluded that EMA treatment method is enough to activate in the parasympathetic nerve system by inducing the biotransformation.

• Journal of Korean Biological Nursing Science
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• 제11권1호
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• pp.32-41
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• 2009

Purpose: This study was to identify the effects of aroma inhalation therapy on heart rate variability and anxiety in the context of urodynamics study. Method: The data were collected from 64 patients who were receiving urodynamics at the C University Medical Center in Seoul, 23 in the experimental group, 22 in the placebo group and 19 in the control group. In the experiment, the subjects of the experimental group inhaled a mixture of lavender and bergamot for 5 min, the subjects of the placebo group inhaled geranyl acetate oil for 5 min and the subjects of the control group relaxed for 5 min. The instruments used in this study included the state anxiety inventory and heart rate variability. Result: The score of state anxiety was no significant differences between the three groups after aroma-inhalation. Also, the sympathetic nerve activity and parasympathetic nerve activity was no significant differences between the three groups after aroma-inhalation. Autonomic nerve balance was maintained significantly in the experimental group as compared to the control groups after aroma-inhalation. Conclusion: The aroma inhalation therapy was very effective in balancing the autonomic nervous system in the patients undergoing urodynamic study.

• 대한불안의학회지
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• 제2권2호
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• pp.101-107
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• 2006

Object : Since autonomic nerve system dysfunction was known as the mechanism of panic disorder, many researchers used heart rate variability (HRV) as means of measuring autonomic nerve function of patients with panic disorder. We aimed to examine the effect of paroxetine medication for 3 months on symptom improvement and change of heart rate variability of the patients with panic disorder. Methods : The subjects were patients with panic disorder who visited the psychiatric outpatient clinic of Samsung Medical Center in Seoul. We included panic disorder patients who were aged from 20 to 50 and in normal BMI range (from 18 to 30) to minimize the effect of age and weight on HRV data. We excluded the patients with EKG abnormalities, hypertension or other major psychiatric disorders. They took 20-40 mg paroxetine medication a day for 3 months. Alprazolam was used only during the first month to control the acute panic symptoms and was tapered off after that. We measured the acute panic inventory (API), Hamilton rating scale for anxiety and depression (HAM-A & HAM-D), Spielberger state-trait anxiety inventory (STAIS, STAIT), and Beck depression inventory (BDI) in order to assess clinical improvement of the patients. And we measured time and frequency domain HRV in the resting, standing and cognitive stress states to assess the change of HRV. All measurements were done before and after paroxetine treatment. Result : After paroxetine medication, patients showed significant improvement in all psychiatric scales. In time domain of HRV, standard deviations of all R-R intervals (SDNN) were significantly increased in all states. In frequency domain of HRV, the ratio of high frequency to total power (HF/TP) in the standing state was significantly increased. Conclusion : After 3 months paroxetine medication, panic disorder patients showed significant clinical improvement and change in HRV data such as SDNN in all states and HF/TP ratio in the standing state. This result suggests that paroxetine medication is effective for the improvement of autonomic nerve system dysfunction in panic disorder patients.

• 한국산학기술학회논문지
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• 제16권7호
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• pp.4450-4458
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• 2015

본 연구의 목적은 Yoga와 Pilates 운동 수행이 자율신경계에 미치는 영향을 분석하여 운동처방의 임상적 기초 자료를 제공하고자 하였다. 피험자는 체육전공 대학생 20명을 요가운동군(Yoga Group)과 필라테스운동군(Pilates Group)에 각각 10명씩 배정하였고, 자율신경계 측정은 운동 전, 운동 직후, 회복기 30분 후에 이루어졌다. 그 결과 첫째, 요가는 스트레스 지수와 평균맥박이 시기의 주효과와 시기와 집단의 상호작용효과의 유의한 차이를 보였다. 둘째, 요가는 교감활성과 자율신경균형이 시기의 주효과, 시기와 집단의 상호작용효과, 집단의 주효과 모두 유의한 차이를 보였다. 셋째, 맥박다양성, 부교감활성도, SDNN, RMSSD는 시기의 주효과는 유의한 차이를 보였고, 시기와 집단의 상호작용효과와 집단의 주효과는 통계적으로 유의한 차이를 나타내지 않았다. 따라서 요가는 스트레스 지수를 낮추고 평균맥박 감소의 효과를 얻을 수 있으며, 특히 요가 운동이 필라테스 운동보다 교감활성 감소와 자율신경균형에 더 긍정적인 영향을 미치는 것으로 사료된다.

• 융합정보논문지
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• 제9권3호
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• pp.56-67
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• 2019

본 연구는 농도별 로즈마리 오일 흡입에 따른 기억력, 집중력, 및 자율신경계 반응을 확인하기 위한 비동등성 대조군 전후 실험설계로 65세 이상 노인에게 아몬드 캐리어 오일 흡입군(대조군), 10% 로즈마리 오일 흡입군(실험군 A)과 100% 로즈마리 오일 흡입군(실험군 B)으로 각 오일을 시향지에 묻혀 5분간 흡입하도록 하였고 기억력, 집중력 및 자율신경계 반응을 측정하였다. 수집된 총 89명의 자료는 SPSS win 24.0를 이용하여 반복측정 ANOVA로 분석하였다. 결과는 기억력 평가인 즉각 회상(F=.42, p=.656), 지연 회상(F=.45, p=.639) 재인 검사(F=1.45, p=.242)와 집중력 평가인 숫자 바로 외우기(F=1.53, p=.223)와 숫자 거꾸로 외우기(F=.46, p=.636)에서 세 군 간의 유의한 차이가 없었다. 또한 자율신경계 반응 결과, 교감신경 활성도(LF)(F=.19, p=.828), 부교감신경 활성도(HF)(F=.37, p=.694), 자율신경계 활성도비(LH/HF)(F=1.39, p=.256), 수축기 혈압(F =.37, p=.694) 및 이완기 혈압(F=1.25, p=.291)에서 세 군 간의 유의한 차이가 없었다. 따라서 아몬드 캐리어 오일, 10%와 100% 로즈마리 에센셜 오일 5분간 흡입은 65세 이상 노인의 기억력, 집중력, 자율신경계 반응에 통계적으로 유의한 영향을 주지 않는 것으로 나타났다.