• 치위생과학회지
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• 제23권4호
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• pp.369-377
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• 2023

Background: In this study, we investigated the potential use of keratin for oral tissue regeneration. Keratin is well-known for its effectiveness in skin regeneration by promoting keratinization and enhancing the elasticity and activity of fibroblasts. Because of its structural stability, high storability, biocompatibility, and safety in humans, existing research has predominantly focused on its role in skin wound healing. Herein, we propose using keratin proteins as biocompatible materials for dental applications. Methods: To assess the suitability of alpha-keratin protein as a substrate for cell culture, keratin was extracted from human hair via PEGylation. Viabilities of primary human gingival fibroblasts (HGFs) and human oral keratinocytes (HOKs) were assessed. Fluorescence immunostaining and migration assays were conducted using a fluorescence microscope and confocal laser scanning microscope. Wound healing and migration assays were performed using automated software to analyze the experimental readout and gap closure rate. Results: We confirmed the extraction of alpha-keratin and formation of the PEG-g-keratin complex. Treatment of HGFs with keratin protein at a concentration of 5 mg/ml promoted proliferation and maintained cell viability in the test group compared to the control group. HOKs treated with 5 mg/ml keratin exhibited a slight decrease in cell proliferation and activity after 48 hours compared to the untreated group, followed by an increase after 72 hours. Wound healing and migration assays revealed rapid closure of the area covered by HOKs over time following keratin treatment. Additionally, HOKs exhibited changes in cell morphology and increased the expression of the mesenchymal marker vimentin. Conclusion: Our study demonstrated the potential of hair keratin for soft tissue regeneration, with potential future applications in clinical settings for wound healing.

• 한국컴퓨터정보학회논문지
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• 제28권11호
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• pp.53-63
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• 2023

본 연구는 고령층의 치매 예방을 위한 선별검사 수단으로 자동화된 기계학습(AutoML)을 활용하여 인지기능 장애 예측모형을 개발하였다. 연구 데이터는 한국지능정보사회진흥원의 '치매 고위험군 웨어러블 라이프로그 데이터'를 활용하였다. 분석은 구글 코랩 환경에서 PyCaret 3.0.0이 사용하여 우수한 분류성능을 보여주는 5개의 모형을 선정하고 앙상블 학습을 진행하여 모형을 통합한 뒤, 최종 성능평가를 진행하였다. 연구결과, Voting Classifier, Gradient Boosting Classifier, Extreme Gradient Boosting, Light Gradient Boosting Machine, Extra Trees Classifier, Random Forest Classifier 모형 순으로 높은 예측성능을 보이는 것으로 나타났다. 특히 '수면 중 분당 평균 호흡수'와 '수면 중 분당 평균 심박수'가 가장 중요한 특성변수(feature)로 확인되었다. 본 연구의 결과는 고령층의 인지기능 장애를 보다 효과적으로 관리하고 예방하기 위한 수단으로 기계학습과 라이프로그의 활용 가능성에 대한 고려를 시사한다.

• Animal Bioscience
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• 제37권2호
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• pp.184-192
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• 2024

Objective: This study aims to investigate the genetic structure and characteristics of the Angus cattle population in Hungary. The survey was performed with the assistance of the Hungarian Hereford, Angus, Galloway Association (HHAGA). Methods: Genetic parameters of 1,369 animals from 16 Angus herds were analyzed using the genotyping results of 12 microsatellite markers with the aid of PowerMarker, Genalex, GDA-NT2021, and STRUCTURE software. Genotyping of DNA was performed using an automated genetic analyzer. Based on pairwise identity by state values of animals, the Python networkx 2.3 library was used for network analysis of the breed and to identify the central animals. Results: The observed numbers of alleles on the 12 loci under investigation ranged from 11 to 18. The average effective number of alleles was 3.201. The overall expected heterozygosity was 0.659 and the observed heterozygosity was 0.710. Four groups were detected among the 16 Angus herds. The breeders' information validated the grouping results and facilitated the comparison of birth weight, age at first calving, number of calves born and productive lifespan data between the four groups, revealing significant differences. We identified the central animals/herd of the Angus population in Hungary. The match of our group descriptions with the phenotypic data provided by the breeders further underscores the value of cooperation between breeders and researchers. Conclusion: The observation that significant differences in the measured traits occurred among the identified groups paves the way to further enhancement of breeding efficiency. Our findings have the potential to aid the development of new breeding strategies and help breeders keep the Angus populations in Hungary under genetic supervision. Based on our results the efficient use of an upcoming genomic selection can, in some cases, significantly improve birth weight, age at first calving, number of calves born and the productive lifespan of animals.

• Nutrition Research and Practice
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• 제18권2호
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• pp.294-307
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• 2024

BACKGROUND/OBJECTIVES: Dietitians frequently use nutrition education tools to facilitate dietary counselling sessions. Nevertheless, these tools may require adaptation to keep pace with technological advancements. This study had a 2-fold purpose: first, to identify the types of nutrition education tools currently in use, identify their limitations, and explore dietitians' perspectives on the importance of these tools; second, to investigate the features that dietitians prefer in digital nutrition education tools. SUBJECTS/METHODS: A semi-structured face-to-face interview was conducted among 15 dietitians from selected public hospitals, primary care clinics, and teaching hospitals in Malaysia. Inductive thematic analysis of the responses was conducted using NVivo version 12 software. RESULTS: Most dietitians used physical education tools including the healthy plate model, pamphlets, food models, and flip charts. These tools were perceived as important as they facilitate the nutrition assessment process, deliver nutrition intervention, and are time efficient. However, dietitians described the current educational tools as impersonal, outdated, limited in availability due to financial constraints, unhandy, and difficult to visualise. Alternatively, they strongly favoured digital education tools that provided instant feedback, utilised an automated system, included a local food database, were user-friendly, developed by experts in the field, and seamlessly integrated into the healthcare system. CONCLUSION: Presently, although dietitians have a preference for digital educational tools, they heavily rely on physical nutrition education tools due to their availability despite the perception that these tools are outdated, impersonal, and inconvenient. Transitioning to digital dietary education tools could potentially address these issues.

• Korean Journal of Radiology
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• 제24권9호
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• pp.849-859
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• 2023

Objective: The prognostic value of the volume and density of skeletal muscles in the abdominal waist of patients with colon cancer remains unclear. This study aimed to investigate the association between the automated computed tomography (CT)-based volume and density of the muscle in the abdominal waist and survival outcomes in patients with colon cancer. Materials and Methods: We retrospectively evaluated 474 patients with colon cancer who underwent surgery with curative intent between January 2010 and October 2017. Volumetric skeletal muscle index and muscular density were measured at the abdominal waist using artificial intelligence (AI)-based volumetric segmentation of body composition on preoperative pre-contrast CT images. Patients were grouped based on their skeletal muscle index (sarcopenia vs. not) and muscular density (myosteatosis vs. not) values and combinations (normal, sarcopenia alone, myosteatosis alone, and combined sarcopenia and myosteatosis). Postsurgical disease-free survival (DFS) and overall survival (OS) were analyzed using univariable and multivariable analyses, including multivariable Cox proportional hazard regression. Results: Univariable analysis showed that DFS and OS were significantly worse for the sarcopenia group than for the non-sarcopenia group (P = 0.044 and P = 0.003, respectively, by log-rank test) and for the myosteatosis group than for the non-myosteatosis group (P < 0.001 by log-rank test for all). In the multivariable analysis, the myosteatotic muscle type was associated with worse DFS (adjusted hazard ratio [aHR], 1.89 [95% confidence interval, 1.25-2.86]; P = 0.003) and OS (aHR, 1.90 [95% confidence interval, 1.84-3.04]; P = 0.008) than the normal muscle type. The combined muscle type showed worse OS than the normal muscle type (aHR, 1.95 [95% confidence interval, 1.08-3.54]; P = 0.027). Conclusion: Preoperative volumetric sarcopenia and myosteatosis, automatically assessed from pre-contrast CT scans using AI-based software, adversely affect survival outcomes in patients with colon cancer.

• International Journal of Computer Science & Network Security
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• 제24권3호
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• pp.59-70
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• 2024

Background: The COVID-19 pandemic (the form of coronaviruses) developed at the end of 2019 and spread rapidly to almost every corner of the world. It has infected around 25,334,339 of the world population by the end of September 1, 2020 [1] . It has been spreading ever since, and the peak specific to every country has been rising and falling and does not seem to be over yet. Currently, the conventional RT-PCR testing is required to detect COVID-19, but the alternative method for data archiving purposes is certainly another choice for public departments to make. Researchers are trying to use medical images such as X-ray and Computed Tomography (CT) to easily diagnose the virus with the aid of Artificial Intelligence (AI)-based software. Method: This review paper provides an investigation of a newly emerging machine-learning method used to detect COVID-19 from X-ray images instead of using other methods of tests performed by medical experts. The facilities of computer vision enable us to develop an automated model that has clinical abilities of early detection of the disease. We have explored the researchers' focus on the modalities, images of datasets for use by the machine learning methods, and output metrics used to test the research in this field. Finally, the paper concludes by referring to the key problems posed by identifying COVID-19 using machine learning and future work studies. Result: This review's findings can be useful for public and private sectors to utilize the X-ray images and deployment of resources before the pandemic can reach its peaks, enabling the healthcare system with cushion time to bear the impact of the unfavorable circumstances of the pandemic is sure to cause

• 정보보호학회논문지
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• 제34권1호
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• pp.21-29
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• 2024

ICT와 network의 발달로 규모가 커진 IT 인프라의 보안 관리가 매우 어려워지고 있다. 많은 회사나 공공기관에서 시스템과 네트워크 보안 관리에 어려움을 겪고 있다. 또한 하드웨어와 소프트웨어의 복잡함이 커짐에 따라 사람이 모든 보안을 관리한다는 것은 불가능에 가까워지고 있다. 따라서 네트워크 보안 관리에 AI가 필수적이다. 하지만 실제 네트워크 환경에 공격 모델을 구동하는 것은 매우 위험하기에 실제와 유사한 네트워크 환경을 구현하여 강화학습을 통해 사이버 보안 시뮬레이션 연구를 진행하였다. 이를 위해 본 연구는 강화학습을 네트워크 환경에 적용하였고, 에이전트는 학습이 진행될수록 해당 네트워크의 취약점을 정확하게 찾아냈다. AI를 통해 네트워크의 취약점을 발견하면, 자동화된 맞춤 대응이 가능해진다.

• Korean Journal of Radiology
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• 제22권12호
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• pp.2017-2025
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• 2021

Objective: To evaluate the accuracy and clinical efficacy of a hybrid Greulich-Pyle (GP) and modified Tanner-Whitehouse (TW) artificial intelligence (AI) model for bone age assessment. Materials and Methods: A deep learning-based model was trained on an open dataset of multiple ethnicities. A total of 102 hand radiographs (51 male and 51 female; mean age ± standard deviation = 10.95 ± 2.37 years) from a single institution were selected for external validation. Three human experts performed bone age assessments based on the GP atlas to develop a reference standard. Two study radiologists performed bone age assessments with and without AI model assistance in two separate sessions, for which the reading time was recorded. The performance of the AI software was assessed by comparing the mean absolute difference between the AI-calculated bone age and the reference standard. The reading time was compared between reading with and without AI using a paired t test. Furthermore, the reliability between the two study radiologists' bone age assessments was assessed using intraclass correlation coefficients (ICCs), and the results were compared between reading with and without AI. Results: The bone ages assessed by the experts and the AI model were not significantly different (11.39 ± 2.74 years and 11.35 ± 2.76 years, respectively, p = 0.31). The mean absolute difference was 0.39 years (95% confidence interval, 0.33-0.45 years) between the automated AI assessment and the reference standard. The mean reading time of the two study radiologists was reduced from 54.29 to 35.37 seconds with AI model assistance (p < 0.001). The ICC of the two study radiologists slightly increased with AI model assistance (from 0.945 to 0.990). Conclusion: The proposed AI model was accurate for assessing bone age. Furthermore, this model appeared to enhance the clinical efficacy by reducing the reading time and improving the inter-observer reliability.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.494-500
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• 2019

본 연구는 탄약운반장갑차의 장약이송 소프트웨어 최적 설계를 통해 장약이송 시 파손을 방지하는 것을 목표로 하고 있다. 탄약운반장갑차는 자동화된 장약이송시스템이 적용되어 있다. 군 운용 중 장약 적재 시 간헐적으로 장약이 파손되는 현상이 발생하여 다음과 같은 개선방법을 연구하였고, 입증시험을 실시하였다. 장약 이송기의 속도가 높을 경우 충격력이 증가하기 때문에 적재 속도를 기존보다 60% 감소 시켰고, 포스 게이지를 활용하여 충격력을 측정하였다. 충격력 측정 결과 평균 45% 감소하는 것을 확인 할 수 있었다. 적재관 내부의 간섭 등에 의한 이송기의 부하 발생 시 서보제어기의 최대전류 11A를 출력하면 장약이 파손 될 가능성이 있다. 또한, 최대전류가 낮을 경우 장약적재가 불가하기 때문에 적정 값을 찾아야 했고, 이는 시험을 통하여 최적의 최대전류 값 6.5A를 도출하였다. 최적설계 입증 시험에는 종이지관장약과 실제장약을 적용하여 시험 하였다. 종이지관 장약과 실제 장약으로 탄운차에 장약 적재시험을 실시한 결과 장약의 파손이 발생하지 않았으며, 장약 적재가 정상적으로 이루어져 설계 개선이 타당한 것을 입증하였다.

• 정보처리학회논문지A
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• 제16A권6호
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• pp.453-462
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• 2009

소프트웨어의 지적 재산권 보호 및 인증에 대한 관심과 중요성이 커지면서 소프트웨어에 대한 표절 탐색 및 보호, 판단에 대한 연구가 활발 하게 진행되고 있다. 지금까지 표절에 대한 연구는 주로 속성 계산, 토큰 패턴, 프로그램 파스트리, 유사도 측정 알고리즘 등을 이용해 두 프로 그램을 비교하는데 초점을 두었다. 이와 더불어, 표절과 협동(collaboration)을 구분하는 것은 표절연구에서 매우 중요하다. 본 논문에서는 극단 치 분포 확률 모델을 이용한 소스코드 클러스터링을 위한 알고리즘을 제안한다. 본 논문에서는 먼저 두 프로그램 먼저 두 프로그램 $P_a$와 $P_b$ 의 유사도를 측정하는 비대칭거리측정함수 pdist($P_a$, $P_b$)를 제안하고, 모든 소스코드 쌍에 대해 pdist($P_a$, $P_b$)를 통해 측정된 유사도를 간선무게로 하는 표절방 향그래프(PDG)를 생성한다. 그리고 본 논문에서는 표절방향그래프를 굼벨거리그래프(GDG)로 변환한다. pdist($P_a$, $P_b$) 점수 분포는 극단치 확률 분포로 잘 알려진 굼벨분포(Gumbel distribution)와 매우 유사하다. 또한, 본 논문에서는 의사표절(pseudo- plagiarism)을 새롭게 정의한다. 의사표절은 프로그램의 강한 기능적 제약사항으로 인해 발생하는 가상 표절의 한 종류이다. 본 논문에서는 ICPC(International Collegiate Programming Contest)와 KOI(Korean Olympiad for Informatics) 대회에 제출된 18개 프로그램 그룹의 700개 이상의 소스코드에 대해 실험을 진행하였다. 실험결과 프로그램 그룹에 포함된 표절 프로그램들을 찾았으며, 소스코드 클러스터링 알고리즘은 의사표절과 실제표절 프로그램 그룹을 효과적으로 구분하였다.