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Selection of Effective Herbal Medicines for Parkinson's Disease Based on the Text Mining of the Classical Korean Medical Literature Donguibogam

  • Bae, Hyo Won;Lee, Tae Wook;Choi, Byung Tae;Shin, Hwa Kyoung;Yun, Young Ju
    • The Journal of Korean Medicine
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    • v.42 no.4
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    • pp.120-132
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    • 2021
  • Objectives: The prevalence of Parkinson's disease is on an upward trend along with an increase in the aging population but there is no available treatment that halts the progression of neurodegeneration. This study reports a numerical analysis on Donguibogam and suggests novel herbal drugs, which have never been researched before but found to be deemed effective in this study. Methods: Referring to 71 Korean medicine symptom terms that represent the symptoms of Parkinson's disease, 4170 prescriptions described in Donguibogam were classified into two groups based on whether their main effects were effective for Parkinson's disease or not. Comparing the two groups, the chi-square test was performed to select statistically significant herbs, while the t-test, Wilcoxon test, and descriptive statistics were performed to determine the appropriate dose. Results: One hundred and twenty-seven prescriptions effective for Parkinson's disease were identified. The chi-square test determined 17 herbs that are effective for symptomatic treatment. Among the medicinal herbs, the authors suggest Osterici seu Notopterygii Radix et Rhizoma, Ephedrae Herba, Aconiti Tuber, Myrrha, Sinomeni Caulis et Rhizoma, and Aconiti Kusnezoffii Tuber as herbal candidates that have never been studied for Parkinson's disease. Through the statistical tests, it was judged that the mean value of the dose of the entire prescription was the appropriate dose for each herb. Conclusions: Seventeen herbs were selected for Parkinson's disease and the appropriate daily dose were calculated. Furthermore, this study presented a new process that applies a statistical method to traditional medical literature and preselecting herbs deemed effective for specific diseases.

Money as a Polycontextual Value and Means of Self-Identification of a Modern Person: Traditional vs Virtual

  • S. Khrypko;Qi Yang;M. Kozlovets;I. Chornomordenko;M. Kolinko ;V. Havronenko;O. Lobanchuk;Н. Salo
    • International Journal of Computer Science & Network Security
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    • v.23 no.2
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    • pp.1-12
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    • 2023
  • The article examines the axiological psycho-philosophical understanding of the phenomenon of money and its value role in modern society. The traditional and virtual context of the representation of the money phenomenon is considered.Following the ideas of G. Simmel, the authors consider money not only as a purely economic, but also a psycho-philosophical, cultural and social phenomenon. Money appears as a result of cultural development of the world and gradually forms a monetary culture as a space of economic and social interaction of people. Under the influence of the monetary culture of one or another historical period, the character of a person's economic activity, values and life orientations are formed. Modern money culture is often called financial civilization. Peculiarities of modern monetary culture are studied, its main features and problems are determined in the article. The problem of the peculiarities of the constructive and destructive attitude of the individual towards money is identified; a psycho-philosophical and cultural-identification typology of people is described, which is based on clinical observations and interpreted through the prism of psychoanalytic theory. The concept of money is highlighted from the standpoint of a social-psychological approach. The theoretical foundations of money's influence on the decision-making process and human behavior are also revealed.

Modified p-y curves to characterize the lateral behavior of helical piles

  • Hyeong-Joo, Kim;James Vincent, Reyes;Peter Rey, Dinoy;Tae-Woong, Park;Hyeong-Soo, Kim;Jun-Young, Kim
    • Geomechanics and Engineering
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    • v.31 no.5
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    • pp.505-518
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    • 2022
  • This study introduces soil resistance multipliers at locations encompassed by the zone of influence of the helix plate to consider the added lateral resistance provided to the helical pile. The zone of influence of a helix plate is a function of its diameter and serves as a boundary condition for the modified soil resistance springs. The concept is based on implementing p-multipliers as a reduction factor for piles in group action. The application of modified p-y springs in the analysis of helical piles allows for better characterization and understanding of the lateral behavior of helical piles, which will help further the development of design methods. To execute the proposed method, a finite difference program, HPCap (Helical Pile Capacity), was developed by the authors using Matlab. The program computes the deflection, shear force, bending moment, and soil resistance of the helical pile and allows the user to freely input the value of the zone of influence and Ω (a coefficient that affects the value of the p-multiplier). Results from ten full-scale lateral load tests on helical piles embedded at depths of 3.0 m with varying shaft diameters, shaft thicknesses, and helix configurations were analyzed to determine the zone of influence and the magnitude of the p-multipliers. The analysis determined that the value of the p-multipliers is influenced by the ratio between the pile embedment length and the shaft diameter (Dp), the effective helix diameter (Dh-Dp), and the zone of influence. Furthermore, the zone of influence is recommended to be 1.75 times the helix diameter (Dh). Using the numerical analysis method presented in this study, the predicted deflections of the various helical pile cases showed good agreement with the observed field test results.

The new criterion on performance-based design and application to recent earthquake codes

  • Azer A. Kasimzade;Emin Nematli;Mehmet Kuruoglu
    • Earthquakes and Structures
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    • v.24 no.1
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    • pp.11-20
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    • 2023
  • "Performance-based design (PBD)" is based on designing a structure with choosing a performance target under design criteria to increase the structure's resistance against earthquake effect. The plastic hinge formation is determined as one of the fundamental data in finite elements nonlinear analysis to distinguish the condition of the structure where more significant potential damage could occur. If the number of plastic hinges in the structure is increased, the total horizontal load capability of the structure is increased, also. Theoretically, when the number of plastic hinges of the plane frame structure reaches "the degree of hyperstaticity plus one", the structure will reach the capability of the largest ultimate horizontal load. As the number of plastic hinges to be formed in the structure increases towards the theoretical plastic hinge number (TPHN), the total horizontal load capability of the structure increases, proportionally. In the previous studies of the authors, the features of examining the new performance criteria were revealed and it was formulated as follows "Increase the total number of plastic hinges to be formed in the structure to the number of theoretical plastic hinges as much as possible and keep the structure below its targeted performance with related codes". With this new performance criterion, it has been shown that the total lateral load capability of the building is higher than the total lateral load capability obtained with the traditional PBD method by the FEMA 440 and FEMA 356 design guides. In this study, PBD analysis results of structures with frame carrier systems are presented in the light of the Turkey Building Earthquake Code 2019. As a result of this study, it has been shown that the load capability of the structure in the examples of structures with frame carrier system increases by using this new performance criterion presented, compared to the results of the examination with the traditional PBD method in TBEC 2019.

Dietary Behavior of Students in the Busan Area as Determined Using the Nutritional and Dietary Diagnostic System (어린이 식생활스크리닝(DST)을 이용한 부산지역 초등학생의 식행동 및 영양상태 평가)

  • Jin-seon Song;Youngshin Han;Kyung A Lee
    • Journal of the Korean Dietetic Association
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    • v.29 no.2
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    • pp.86-99
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    • 2023
  • In this study, the authors surveyed the dietary habits of all elementary school students registered with the Busan Metropolitan City Office of Education using an online questionnaire called the Dietary Screening Test (DST). The DST consists of 36 items, and these were divided into 5 factors: life rhythm, meal quality, eating development, eating temperament characteristics, and eating habit characteristics. Data were collected from 153,017 students attending 304 schools in Busan, and the responses of 4,020 were included in the analysis. The study was undertaken to document growth and development and diagnose nutrition and dietary problems to provide basic data for the development of customized nutrition education and counseling programs. Results showed that 13.5% and 14.3% of participants were classified as overweight or required weight management for obesity, respectively; 6.7% were underweight. Additionally, 37.0% and 9.5% of children required parental attention at bedtime and sleeping hours, and 14.2% ate too quickly or too slowly. Furthermore, food group consumptions were unbalanced, 25.0% and 64.4% of participants ate grains and protein less than twice a day, respectively, and 72.3% and 74.5% ate kimchi and vegetables less than twice a day, respectively. In contrast, 28.8% of respondents consumed sweet snacks daily or 5~6 times weekly. These findings highlight the need for a standardized school nutrition counseling manual and individually customized nutrition counseling programs to address the nutrition and dietary problems of elementary school students in Busan.

Utilization of Pavilions by a Group of Governors in Jeolla-do and Gyeongsang-do During the Early Joseon Period, Revealed by Miam Diary and Jaeyeongnam Diary (『미암일기』와 『재영남일기』에 드러난 조선 전기 전라도·경상도 관찰사 일행의 누정 활용)

  • Lim, Hansol
    • Journal of architectural history
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    • v.32 no.6
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    • pp.7-21
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    • 2023
  • This research aims to understand the specific aspects of the utilization of the pavilion by a group of governors in the mobile office system of the early Joseon Dynasty through two diaries written in the 16th century. Miam Diary by Yu Hee-chun, a governor of Jeolla Province, and Jaeyeongnam Diary by Hwang Sa-woo, a chief aide of Gyeongsang Province, are important historical materials that reveal the utilization patterns of the pavilion by the governor, who was the decision maker and main user of governmental pavilions. As a result of analyzing the two diaries, the utilization of governmental pavilions was concentrated in the hot summer season, May to July, which is closely related to the perception of temperature and humidity. While pavilions are mostly used as office and banquet places, some notable usage patterns have been identified. When there were several governmental pavilions in a town, the order of appreciation was determined by considering the location and scenery, and the pavilions were also used as a place to encourage learning as governors taught Confucian scholars well. Governmental pavilions functioned as a device to visualize hierarchy through seating and accommodation arrangements. The authors of the diaries left comments on the famous pavilions and sometimes went to see the pavilions after asking for permission from the superior. This research is meaningful in that it reconstructed the relationship network and phases of the times of governmental pavilions scattered across the country through institutions and daily life.

Augmenting external surface pressures' predictions on isolated low-rise buildings using CFD simulations

  • Md Faiaz, Khaled;Aly Mousaad Aly
    • Wind and Structures
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    • v.37 no.4
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    • pp.255-274
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    • 2023
  • The aim of this paper is to enhance the accuracy of predicting time-averaged external surface pressures on low-rise buildings by utilizing Computational Fluid Dynamics (CFD) simulations. To achieve this, benchmark studies of the Silsoe cube and the Texas Tech University (TTU) experimental building are employed for comparison with simulation results. The paper is structured into three main sections. In the initial part, an appropriate domain size is selected based on the precision of mean pressure coefficients on the windward face of the cube, utilizing Reynolds Averaged Navier-Stokes (RANS) turbulence models. Subsequently, recommendations regarding the optimal computational domain size for an isolated building are provided based on revised findings. Moving on to the second part, the Silsoe cube model is examined within a horizontally homogeneous computational domain using more accurate turbulence models, such as Large Eddy Simulation (LES) and hybrid RANS-LES models. For computational efficiency, transient simulation settings are employed, building upon previous studies by the authors at the Windstorm Impact, Science, and Engineering (WISE) Lab, Louisiana State University (LSU). An optimal meshing strategy is determined for LES based on a grid convergence study. Three hybrid RANS-LES cases are investigated to achieve desired enhancements in the distribution of mean pressure coefficients on the Silsoe cube. In the final part, a 1:10 scale model of the TTU building is studied, incorporating the insights gained from the second part. The generated flow characteristics, including vertical profiles of mean velocity, turbulence intensity, and velocity spectra (small and large eddies), exhibit good agreement with full-scale (TTU) measurements. The results indicate promising roof pressures achieved through the careful consideration of meshing strategy, time step, domain size, inflow turbulence, near-wall treatment, and turbulence models. Moreover, this paper demonstrates an improvement in mean roof pressures compared to other state-of-the-art studies, thus highlighting the significance of CFD simulations in building aerodynamics.

The crack propagation of fiber-reinforced self-compacting concrete containing micro-silica and nano-silica

  • Moosa Mazloom;Amirhosein Abna;Hossein Karimpour;Mohammad Akbari-Jamkarani
    • Advances in nano research
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    • v.15 no.6
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    • pp.495-511
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    • 2023
  • In this research, the impact of micro-silica, nano-silica, and polypropylene fibers on the fracture energy of self-compacting concrete was thoroughly examined. Enhancing the fracture energy is very important to increase the crack propagation resistance. The study focused on evaluating the self-compacting properties of the concrete through various tests, including J-ring, V-funnel, slump flow, and T50 tests. Additionally, the mechanical properties of the concrete, such as compressive and tensile strengths, modulus of elasticity, and fracture parameters were investigated on hardened specimens after 28 days. The results demonstrated that the incorporation of micro-silica and nano-silica not only decreased the rheological aspects of self-compacting concrete but also significantly enhanced its mechanical properties, particularly the compressive strength. On the other hand, the inclusion of polypropylene fibers had a positive impact on fracture parameters, tensile strength, and flexural strength of the specimens. Utilizing the response surface method, the relationship between micro-silica, nano-silica, and fibers was established. The optimal combination for achieving the highest compressive strength was found to be 5% micro-silica, 0.75% nano-silica, and 0.1% fibers. Furthermore, for obtaining the best mixture with superior tensile strength, flexural strength, modulus of elasticity, and fracture energy, the ideal proportion was determined as 5% micro-silica, 0.75% nano-silica, and 0.15% fibers. Compared to the control mixture, the aforementioned parameters showed significant improvements of 26.3%, 30.3%, 34.3%, and 34.3%, respectively. In order to accurately model the tensile cracking of concrete, the authors used softening curves derived from an inverse algorithm proposed by them. This method allowed for a precise and detailed analysis of the concrete under tensile stress. This study explores the effects of micro-silica, nano-silica, and polypropylene fibers on self-compacting concrete and shows their influences on the fracture energy and various mechanical properties of the concrete. The results offer valuable insights for optimizing the concrete mix to achieve desired strength and performance characteristics.

Comparison of Effectiveness of Manual Therapy for Infant Crying: systematic review and meta-analysis of randomized controlled trials

  • Ui Jin Park;Hye In Jeong;Kyeong Han Kim
    • Journal of Pharmacopuncture
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    • v.26 no.4
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    • pp.285-297
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    • 2023
  • Objectives: The aim of this systematic review and meta-analysis is to assess and compare the effectiveness of manual therapy in alleviating infant crying, a common symptom of nocturnal crying (NC) and infantile colic (IC). Methods: Total effective rate, crying time and adverse events were used as outcome indicators. To assess the quality, the risk of bias was determined for each study by two authors, using the Cochrane Collaboration's risk of bias tool. RevMan 5.0 was used for data analysis. A total of 98 articles were identified from 6 electronic databases. Results: Among them, twenty-seven studies which included 13 NC and 14 IC were included. Meta-analysis showed favorable effects tuina therapy on total effective rate (TER) of NC (RR: 1.20 [95% CI 1.05 to 1.37], p = 0.007), chiropractic therapy on crying time change of IC (SMD: -0.83 [95% CI -1.61 to -0.06], p = 0.04) and massage on total crying time of IC (SMD: -0.86 [95% CI -1.09 to -0.63], p < 0.00001). This systematic review compares different manual therapies for the treatment of NC and IC. While tuina, chiropractic, and massage show results in alleviating symptoms, the overall evidence remains limited due to the low quality and heterogeneity of the included studies. Conclusion: Therefore, further high-quality research with unified control groups is needed to establish manual therapy as a recommended treatment option for NC and IC. Protocol registration number is CRD42022348143 01/08/2022.

AN APPROACH FOR ESTIMATING TOTAL COST OF OCCUPATIONAL SAFETY FOR BUILDING CONSTRUCTIONS

  • Gurkan Emre Gurcanli;Nesimi Teoman Korkutan;Ugur Mungen
    • International conference on construction engineering and project management
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    • 2011.02a
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    • pp.168-175
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    • 2011
  • Construction accidents are major problem in Turkish Construction industry and especially fatally rates are very high. Current legislative system on occupational safety in Turkey enforces employers to implement safety measures as well as safety management systems. However level of consciousness in the industry is unsatisfactory and safety are perceived as extra cost and unnecessary expenditure. Moreover, especially in small residential building constructions which have a big share in the industry and unfortunately safety measures to mitigate or abate construction risks do not exist. The study focuses on small residential building construction sites and in the scope of this study, thirty building projects are examined. For each building project, project cost including labour and material costs, service and consultancy costs for mechanical, electrical systems as well as architectural and structural services, costs for supervision and finally general expenditures for construction site facilities were calculated. On the other hand, occupational safety costs for personal protective equipment, collective protective measures, consultancy and training were determined. Work breakdown structures were established and for each work item firstly occupational risks were evaluated and furthermore according to risk scores safety measures to be implemented were defined and related costs were calculated. The study gave results for total safety cost on average, in terms of percentage of total project cost (3.73% of total project cost), safety cost per man-hour (0.40 USD) and safety cost in terms of unit construction area (11.60 USD per square meter). Since safety management is a part of whole project management process, study gives suggestions and techniques to calculate safety costs and implement safety measures as a part of project management service for professionals. Authors believe that suggested approach may easily developed by the usage of more data to establish a model for estimation not only for building construction sites but also for all construction projects.

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