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B-mode ultrasound images of the carotid artery wall: correlation of ultrasound with histological measurements

  • Gamble G.;Beaumont B.;Smith H.;Zorn J.;Sanders G.;Merrilees M.;MacMahon S.;Sharpe N.
    • 대한예방의학회:학술대회논문집
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    • 1994.02b
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    • pp.169-179
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    • 1994
  • B-mode ultrasound is being used to assess carotid atherosclerosis in epidemiological studies and clinical trials. Recently the interpretation of measurements made from ultrasound images has been questioned. This study examines the anatomical correlates of B-mode ultrasound of carotid arteries in vitro and in situ in cadavers. Twenty-seven segments of human carotid artery were collected at autopsy. pressure perfusion fixed in buffered 2.5% gluteraldehyde and 4% paraformaldehyde and imaged using an ATL UM-8 (10 MHz single crystal mechanical probe). Each artery was then frozen, sectioned and stained with van Gieson or elastin van Gieson. The thickness of the intima. media and adventitia were measured 'to an accuracy of 0.01 mm from histological sections using a calibrated eye graticule on a light microscope. Shrinkage artifact induced by histological preparation was determined to be 7.8%. Digitised ultra sound images of the artery wall were analysed off-line. The distance from the leading edge of the first interface ($LE_{1}$) to the leading edge of the second interface ($LE_2$) was measured using a dedicated programme. $LE_{1}$-$LE_{2}$ measurements were correlated against histological measurements corrected for shrinkage. Mean values for the far wall were: ultra sound $LE_{1}$-$LE_{2}$ (0.97 mm, S.D. 0.26), total wall thickness (1.05 mm, S.D. 0.37), adventitia (0.35 mm, S.D. 0.16), media (0.61 mm, S.D. 0.18). intima (0.09 mm, S.D. 0.13). Ultrasound measurements corresponded best with total wall thickness, rather than elastin or the intima-media complex. Excision of part of the intima plus media or removal of the adventitia resulted in a corresponding decrease in the $LE_{1}$-$LE_{2}$ distance of the B-mode image. Furthermore. increased wall thickness due to intimal atherosclerotic thickening correlated well with $LE_{1}$-$LE_{2}$ distance of the B-mode images. B-mode images obtained from the carotid arteries in situ in four cadavers also corresponded best with total wall thickness measured from histological sections and not with the thickness of the intima plus media. In conclusion, the $LE_{1}$-$LE_{2}$ distance measured on B-mode images of the carotid artery best represents total wall thickness of intima plus media plus adventitia and not intima plus media alone.

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Network Coding-Based Fault Diagnosis Protocol for Dynamic Networks

  • Jarrah, Hazim;Chong, Peter Han Joo;Sarkar, Nurul I.;Gutierrez, Jairo
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.4
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    • pp.1479-1501
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    • 2020
  • Dependable functioning of dynamic networks is essential for delivering ubiquitous services. Faults are the root causes of network outages. The comparison diagnosis model, which automates fault's identification, is one of the leading approaches to attain network dependability. Most of the existing research has focused on stationary networks. Nonetheless, the time-free comparison model imposes no time constraints on the system under considerations, and it suits most of the diagnosis requirements of dynamic networks. This paper presents a novel protocol that diagnoses faulty nodes in diagnosable dynamic networks. The proposed protocol comprises two stages, a testing stage, which uses the time-free comparison model to diagnose faulty neighbour nodes, and a disseminating stage, which leverages a Random Linear Network Coding (RLNC) technique to disseminate the partial view of nodes. We analysed and evaluated the performance of the proposed protocol under various scenarios, considering two metrics: communication overhead and diagnosis time. The simulation results revealed that the proposed protocol diagnoses different types of faults in dynamic networks. Compared with most related protocols, our proposed protocol has very low communication overhead and diagnosis time. These results demonstrated that the proposed protocol is energy-efficient, scalable, and robust.

Dual Nano-Electrospray and Mixing in the Taylor Cone

  • Radionova, Anna;Greenwood, David R.;Willmott, Geoff R.;Derrick, Peter J.
    • Mass Spectrometry Letters
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    • v.7 no.1
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    • pp.21-25
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    • 2016
  • Dual-channel nano-electrospray has recently become an ionization technique of great promise especially in biological mass spectrometry. This unique approach takes advantage of the mixing processes that occurs during electrospray. Understanding in more detail the fundamental principles influencing spray formation further study of the origins of the mixing processes: (1) in a Taylor cone region, (2) in charged droplets or (3) in both environments. The dual-channel emitters were made from borosilicate theta-shape glass tubes (O.D. 1.2 mm) and had a tip diameters of less than 4 μm. Electrical contact was achived by deposition of a thin film of an appropriate metal onto the surface of the emitter. The experimental investigation of the Taylor cone formation in a dual-channel electrospray emitter has been carried out by injection of polystyrene beads (diameter 3 μm) at very low concentrations into one of the channels of the non-tapered theta-glass tubes. High-speed camera experiments were set up to visualize the mixing processes in Taylor cone regions for dual-channel emitters. Mass spectra from dual nano-electrospray are presented.

Response of structure with controlled uplift using footing weight

  • Qin, X.;Chouw, N.
    • Earthquakes and Structures
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    • v.15 no.5
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    • pp.555-564
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    • 2018
  • Allowing structures to uplift in earthquakes can significantly reduce or even avoid the development of plastic hinges within the structure. The permanent deformations in the structure can thus be minimized. However, uplift of footings can cause additional horizontal movements of a structure. With an increase in movement relative to adjacent structures, the probability of pounding between structures increases. This experimental study reveals that the footing mass can be used to control the vertical displacement of footing and thus reduce the horizontal displacements of an upliftable structure. A four storey model structure with plastic hinges and uplift capability was considered. Shake table tests using ten different earthquake records were conducted. Three different footing masses were considered. It is found that the amplitude of footing uplift can be greatly reduced by increasing the mass of the footing. As a result, allowing structural uplift does not necessary increase the horizontal displacement of the structure. The results show that with increasing footing weight, the interaction between structural and footing response can increase the contribution of the higher modes to the structural response. Consequently, the induced vibrations on secondary structure increase.

An Overview of Mobile Edge Computing: Architecture, Technology and Direction

  • Rasheed, Arslan;Chong, Peter Han Joo;Ho, Ivan Wang-Hei;Li, Xue Jun;Liu, William
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.10
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    • pp.4849-4864
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    • 2019
  • Modern applications such as augmented reality, connected vehicles, video streaming and gaming have stringent requirements on latency, bandwidth and computation resources. The explosion in data generation by mobile devices has further exacerbated the situation. Mobile Edge Computing (MEC) is a recent addition to the edge computing paradigm that amalgamates the cloud computing capabilities with cellular communications. The concept of MEC is to relocate the cloud capabilities to the edge of the network for yielding ultra-low latency, high computation, high bandwidth, low burden on the core network, enhanced quality of experience (QoE), and efficient resource utilization. In this paper, we provide a comprehensive overview on different traits of MEC including its use cases, architecture, computation offloading, security, economic aspects, research challenges, and potential future directions.

Hypoglycemic Properties of Polysaccharides Extracted from Ganoderma lucidum in Alloxan-Induced Diabetic Rats

  • Gao, Yihuai;Gao, He;Chan, Eli;Tan, Wenbo;Lan, Jin;Koh, Hwee-Ling;Chen, Guoliang;Zhou, Shufeng
    • Preventive Nutrition and Food Science
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    • v.9 no.3
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    • pp.240-244
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    • 2004
  • A recent randomized and double-blind placebo-controlled clinical study bas indicated that Ganoderma lucidum polysaccharides (GLP) decrease blood glucose in patients with type II diabetes. The aim of this study was to investigate the effect of the GLP extract in alloxan-induced diabetic rats. Oral administration of GLP at 0.25, 0.5 and 1.0 g/kg for 4 weeks resulted in a reduction of blood glucose levels by 12.5, 18.7 and 33.7% respectively, while glibenclamide treatment brought the hyperglycemic value down to normal. The hyperglycemic effect was supported by a significant decrease in glycosylated haemoglobin and increased plasma insulin levels (p<0.01) in a dose- and time-dependent manner. This study showed that GLP has similar hypoglycemic effects as glibenclamide in alloxan-induced diabetic rats.

Field studies of wind induced internal pressure in a warehouse with a dominant opening

  • Guha, T.K.;Sharma, R.N.;Richards, P.J.
    • Wind and Structures
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    • v.16 no.1
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    • pp.117-136
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    • 2013
  • A field study of wind-induced internal pressures in a flexible and porous industrial warehouse with a single dominant opening, of various sizes for a range of moderate wind speeds and directions, is reported in this paper. Comparatively weak resonance of internal pressure for oblique windward opening situations, and hardly discernible at other wind directions, is attributed to the inherent leakage and flexibility in the envelope of the building in addition to the moderate wind speeds encountered during the tests. The measured internal pressures agree well with the theoretical predictions obtained by numerically simulating the analytical model of internal pressure for a porous and flexible building with a dominant opening. Ratios of the RMS and peak internal to opening external pressures obtained in the study are presented in a non-dimensional format along with other published full scale measurements and compared with the non-dimensional design equation proposed in recent literature.

Scaling methods for wind tunnel modelling of building internal pressures induced through openings

  • Sharma, Rajnish N.;Mason, Simon;Driver, Philip
    • Wind and Structures
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    • v.13 no.4
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    • pp.363-374
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    • 2010
  • Appropriate scaling methods for wind tunnel modelling of building internal pressures induced through a dominant opening were investigated. In particular, model cavity volume distortion and geometric scaling of the opening details were studied. It was found that while model volume distortion may be used to scale down buildings for wind tunnel studies on internal pressure, the implementation of the added volume must be done with care so as not to create two cavity resonance systems. Incorrect scaling of opening details was also found to generate incorrect internal pressure characteristics. Furthermore, the effective air slug or jet was found to be longer when the opening was near a floor or sidewall as evidenced by somewhat lower Helmholtz frequencies. It is also shown that tangential flow excitation of Helmholtz resonance for off-centre openings in normal flow is also possible.

A numerical approach for simulating the behaviour of timber shear walls

  • Loo, Wei Yuen;Quenneville, Pierre;Chouw, Nawawi
    • Structural Engineering and Mechanics
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    • v.42 no.3
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    • pp.383-407
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    • 2012
  • A numerical approach to simulate the behaviour of timber shear walls under both static and dynamic loading is proposed. Because the behaviour of timber shear walls hinges on the behaviour of the nail connections, the force-displacement behaviour of sheathing-to-framing nail connections are first determined and then used to define the hysteretic properties of finite elements representing these connections. The model nails are subsequently implemented into model walls. The model walls are verified using experimental results for both monotonic and cyclic loading. It is demonstrated that the complex hysteretic behaviour of timber shear walls can be reasonably represented using model shear walls in which nonlinear material failure is concentrated only at the sheathing-to-framing nail connections.