• 한국농공학회:학술대회논문집
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• 한국농공학회 2003년도 학술발표논문집
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• pp.451-454
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• 2003

This study was mainly conducted to derive the design drought rainfall by the consecutive duration using probability weighted moments with rainfall in the regional drought frequency analysis. Selecting the drought rainfall series by the consecutive durations of drought observed for the long period all over the regions in Korea, optimal regionalization of the drought rainfall was classified by the climatologically and geographically homogeneous regions. Using the L-moment ratio and Kolmogorov- Smimov test, resonable frequency distribution for the drought rainfall was selected by the regions and consecutive periods of drought. Design drought rainfalls by the regions and consecutive durations were derived and compared by at-site and regional drought frequency analysis using the method of L-moments.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2005년도 춘계학술대회
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• pp.17-20
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• 2005

This paper presents an overview analysis on the observed wind shear at Pohang Steel Works, focusing on diurnal patterns and the frequency of high nighttime shear at the site in case of land breeze. In addition, this paper discusses the importance of accurate shear estimates for reliable evaluation of wind energy density. In order for a long-term correlation of the site, three Measure-Correlate-Predict methods were tested with Pohang wind data and it was shown that the linear MCP gives poor estimation due to the geographic characteristics of complex terrain where the severe transformation of wind direction was accompanied.

• 신재생에너지
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• 제1권2호
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• pp.26-33
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• 2005

This paper presents and overview analysis on the observed wind shear at Pohang Steel Works. focusing on diurnal patterns and the frequency of high nighttime shear at the site in case of land breeze. In addition, this paper discusses the importance of accurate shear estimation for reliable evaluation of wind energy density. In order for long-term correlation of the site, three Measure-Correlate-Predict methods were tested with Pohang wind data and it was shown that the linear MCP gives poor estimation due to the topological characteristics of complex terrain where the severe transformation of wind direction was accompanied.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2317-2325
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• 2014

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily and mediates transmembrane efflux of many drugs. Since it is involved in multi-drug resistance activity in various cancer cells, the development of P-gp inhibitor is one of the major concerns in anticancer therapy. Human P-gp protein has at least two "functional" drug binding sites that are called "H" site and "R" site, hence it has multi-binding-specificities. Though the amino acid residues that constitute in drug binding pockets have been proposed by previous experimental evidences, the shapes and the binding poses are not revealed clearly yet. In this study, human P-gp structure was built by homology modeling with available crystal structure of mouse P-gp as a template and docking simulations were performed with inhibitors such as verapamil, hoechst33342, and rhodamine123 to construct the interaction between human P-gp and its inhibitors. The docking simulations were performed 500 times for each inhibitor, and then the interaction frequency of the amino acids at the binding poses was analyzed. With the analysis results, we proposed highly contributing residues that constitute binding pockets of the human P-gp for the inhibitors. Using the highly contributing residues, we proposed the locations and the shapes of verapamil binding site and "R" site, and suggested the possible position of "H" site.

• 한국지진공학회논문집
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• 제20권4호
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• pp.245-256
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• 2016

In the companion paper (I - Database and Site Response Analyses), site-specific response analyses were performed at more than 300 domestic sites. In this study, a new site classification system and design response spectra are proposed using results of the site-specific response analyses. Depth to bedrock (H) and average shear wave velocity of soil above the bedrock ($V_{S,Soil}$) were adopted as parameters to classify the sites into sub-categories because these two factors mostly affect site amplification, especially for shallow bedrock region. The 20 m of depth to bedrock was selected as the initial parameter for site classification based on the trend of site coefficients obtained from the site-specific response analyses. The sites having less than 20 m of depth to bedrock (H1 sites) are sub-divided into two site classes using 260 m/s of $V_{S,Soil}$ while the sites having greater than 20 m of depth to bedrock (H2 sites) are sub-divided into two site classes at $V_{S,Soil}$ equal to 180 m/s. The integration interval of 0.4 ~ 1.5 sec period range was adopted to calculate the long-period site coefficients ($F_v$) for reflecting the amplification characteristics of Korean geological condition. In addition, the frequency distribution of depth to bedrock reported for Korean sites was also considered in calculating the site coefficients for H2 sites to incorporate sites having greater than 30 m of depth to bedrock. The relationships between the site coefficients and rock shaking intensity were proposed and then subsequently compared with the site coefficients of similar site classes suggested in other codes.

• 한국수자원학회논문집
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• 제41권4호
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• pp.405-412
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• 2008

본 연구에서는 지역빈도해석 기법 중 하나인 FORGEX 기법을 이용하여 확률강우량을 추정하였다. 기존의 원형 네트워크와 1:1.5, 1:2의 비율을 갖는 타원형 네트워크가 한국의 강우자료에 적합한 방법인지를 판단하기 위해 3 가지 경우를 비교 분석하였다. 이 분석을 위해서 남한지역의 376개 지점의 연최대강우자료를 추출하고, 이 자료들을 연최대자료의 중간값으로 표준화하였다. 네트워크는 분석 대상 지점을 중심으로 형성되며, pooled points와 netmax 자료를 각 네트워크에서 매년 추출한다. 그리고 성장곡선(growth curve)을 유도하고 주어진 재현기간에 따른 확률강우량을 추정한다. 지점빈도해석과 지역빈도해석의 대표적인 기법인 홍수지수법(index flood method), FORGEX 기법이 적용되었고, 이를 통해 얻은 결과를 비교 분석하였다. 또한 36개 지점에 원형과 타원형 네트워크를 이용한 FORGEX 기법을 적용하였고, 그 결과를 비교 분석하였다. 결과적으로 대상지점의 지점빈도해석으로 구한 확률강우량과 지역빈도해석으로 구한 확률강우량의 차이가 적을 때 원형과 타원형 네트워크의 추정된 확률강우량의 차이도 적었다. 그러나 지점빈도해석의 결과와 홍수지수법 결과의 차이가 클 때 원형과 타원형 네트워크로 추정된 확률강우량의 차이도 컸다. 타원형 네트워크가 더 많은 지점을 포함할 때, 타원으로부터 추정된 확률강우량 값은 원으로 구해진 값보다 높은 정확도를 보였다. 그리고 타원의 비율이 1:2일 때가 1:1.5보다 홍수지수법으로 구한 확률강우량 값에 가까웠다. 그러므로 1:2 비율의 타원을 적용한 FORGEX 기법이 한국의 지역빈도해석에 적합한 방법이라 할 수 있다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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• pp.97-100
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• 2006

This study performed numerical analysis for obtaining optimal frequency and damping ratio of tuned mass damper (TMD) using 20 seismic loads measured at rock site. The structures of $1{\sim}2$ second natural period were considered, and optimal frequency and damping ratio were estimated for different mass ratio in terms of displacement and absolute acceleration response control. Numerical results showed that the values of the optimal parameters were different those from previous study by Hartog.

• 한국지진공학회논문집
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• 제13권1호
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• pp.27-34
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• 2009

지진원, 지각감쇠 및 구조물과 지반상호간의 동적 특성 등을 신뢰성 있게 평가하기 위해 지반의 증폭특성을 반드시 고려하여야 한다. 주파수 영역에서 H/V 스펙트럼 비를 구하는 방법은 Nakamura(1989)에 의해 처음으로 제시되어 초기에는 지반의 상시미동의 표면파의 특성을 이해하기 위해 제시되어 한계점이 존재하나 근래에 와서 강진동의 전단파 에너지 등에 적용범위가 확장되면서 지반의 동적인 증폭특성(지반증폭함수) 연구에 많이 이용되고 있다. 본 논문에서는 오대산 지진(2007/01/20)으로부터 관측된 9개의 지반진동을 이용하여 H/V 스펙트럼 비를 분석하였고 결과를 이용하여 국내에 분포되어 있는 지진관측소 부지의 지반증폭 특성을 분석하였다. 분석결과 대부분의 지진관측소의 H/V 스펙트럼 비는 저주파수 영역에서는 고주파수 영역에 비해 다소 안정된 지반증폭 특성을 보여주었다. 하지만 지진관측소마다 고유주파수, 고주파수 및 저주파수 대역에서 서로 다른 지반증폭 특성을 보여주었다. 특히 각각 관측소 부지의 고유주파수는 각 관측소의 지진자료의 질을 좌우하므로 정확한 분석이 필요하다. 관측된 지반진동 자료를 이용하여 지진원 및 지각감쇠 요소를 분석할 경우 결과값의 왜곡을 피하기 위해 지반증폭 정보를 제거하면 신뢰성이 보다 향상된 값을 얻을 수 있다. 물론 지반증폭은 국내 지반의 분류 연구에 중요한 정보를 제공한다는 점에서 대단히 중요하다.

• Geomechanics and Engineering
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• 제18권6호
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• pp.639-650
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• 2019

Time-domain commercial codes are widely used to evaluate the seismic behavior of tunnels. Those tools offer a good insight into the performance and the failure mechanism of tunnels under earthquake loading. Viscous damping is generally employed in the dynamic analysis to consider damping at very small strains in some cases, and the Rayleigh damping is commonly used one. Many procedures to obtain the damping parameters have been proposed but they are seldom discussed. This paper illustrates the influence of the Rayleigh damping formulation on the tunnel visco-elastic behavior under earthquake. Four Rayleigh damping determination procedures and three soil shear velocity profiles are accounted for. The results show significant differences in the free-field and in the tunnel response caused by different procedures. The difference is somewhat decreased when the soil site fundamental frequency is increased. The conventional method which consists of using solely the first soil natural mode to determine the viscous damping parameters may lead to an unsafe seismic design of the tunnel. In general, using five times site fundamental frequency to obtain the damping formulation can provide relatively conservative results.

• 대한물리의학회지
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• 제11권4호
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• pp.49-54
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• 2016

PURPOSE: The purpose of this study was to determine the effect of different frequencies (4Hz and 100Hz) of transcutaneous electrical nerve simulation (TENS) on pain relief using c-fos expression in the spinal cord of rat osteoarthritis to investigate the appropriate frequency for pain relief. METHODS: Total of 30 Sprague-Dawley rats was used and randomly divided 2 groups according TENS frequency and applicate the TENS during 3 period (3 days, 7 days, 10 days). The induction of osteoarthritis by 3mg monosodium iodoacetat was injected into the right knee joint of rats. Three days later, commercially available TENS unit was used for stimulation was set to 20minutes on 3, 7, 10 days after surgery. Western blot analysis system was used to detect immunoreactive proteins. The thickness of the bands were photographically measured by Scion Image. RESULTS: When investigating the c-fos expression of TENS on spinal cord in OA knee over 10 days, between-groups differences in c-fos expression reached a significant level by day 10. For within-groups comparisons, the c-fos expression decreased significantly across days in low- and high-frequency TENS groups. CONCLUSION: Whether at low- and high-frequency, the TENS as a therapy obtained beneficial effects of pain relief and TNES at high-frequency is more beneficial effects on the pain relief when TENS applied at injury site.