• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2003.10a
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• pp.451-454
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• 2003

This study was mainly conducted to derive the design drought rainfall by the consecutive duration using probability weighted moments with rainfall in the regional drought frequency analysis. Selecting the drought rainfall series by the consecutive durations of drought observed for the long period all over the regions in Korea, optimal regionalization of the drought rainfall was classified by the climatologically and geographically homogeneous regions. Using the L-moment ratio and Kolmogorov- Smimov test, resonable frequency distribution for the drought rainfall was selected by the regions and consecutive periods of drought. Design drought rainfalls by the regions and consecutive durations were derived and compared by at-site and regional drought frequency analysis using the method of L-moments.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.17-20
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• 2005

This paper presents an overview analysis on the observed wind shear at Pohang Steel Works, focusing on diurnal patterns and the frequency of high nighttime shear at the site in case of land breeze. In addition, this paper discusses the importance of accurate shear estimates for reliable evaluation of wind energy density. In order for a long-term correlation of the site, three Measure-Correlate-Predict methods were tested with Pohang wind data and it was shown that the linear MCP gives poor estimation due to the geographic characteristics of complex terrain where the severe transformation of wind direction was accompanied.

• New & Renewable Energy
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• v.1 no.2 s.2
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• pp.26-33
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• 2005

This paper presents and overview analysis on the observed wind shear at Pohang Steel Works. focusing on diurnal patterns and the frequency of high nighttime shear at the site in case of land breeze. In addition, this paper discusses the importance of accurate shear estimation for reliable evaluation of wind energy density. In order for long-term correlation of the site, three Measure-Correlate-Predict methods were tested with Pohang wind data and it was shown that the linear MCP gives poor estimation due to the topological characteristics of complex terrain where the severe transformation of wind direction was accompanied.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2317-2325
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• 2014

P-glycoprotein (P-gp) is a member of the ATP-Binding Cassette transporter superfamily and mediates transmembrane efflux of many drugs. Since it is involved in multi-drug resistance activity in various cancer cells, the development of P-gp inhibitor is one of the major concerns in anticancer therapy. Human P-gp protein has at least two "functional" drug binding sites that are called "H" site and "R" site, hence it has multi-binding-specificities. Though the amino acid residues that constitute in drug binding pockets have been proposed by previous experimental evidences, the shapes and the binding poses are not revealed clearly yet. In this study, human P-gp structure was built by homology modeling with available crystal structure of mouse P-gp as a template and docking simulations were performed with inhibitors such as verapamil, hoechst33342, and rhodamine123 to construct the interaction between human P-gp and its inhibitors. The docking simulations were performed 500 times for each inhibitor, and then the interaction frequency of the amino acids at the binding poses was analyzed. With the analysis results, we proposed highly contributing residues that constitute binding pockets of the human P-gp for the inhibitors. Using the highly contributing residues, we proposed the locations and the shapes of verapamil binding site and "R" site, and suggested the possible position of "H" site.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.4
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• pp.245-256
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• 2016

In the companion paper (I - Database and Site Response Analyses), site-specific response analyses were performed at more than 300 domestic sites. In this study, a new site classification system and design response spectra are proposed using results of the site-specific response analyses. Depth to bedrock (H) and average shear wave velocity of soil above the bedrock ($V_{S,Soil}$) were adopted as parameters to classify the sites into sub-categories because these two factors mostly affect site amplification, especially for shallow bedrock region. The 20 m of depth to bedrock was selected as the initial parameter for site classification based on the trend of site coefficients obtained from the site-specific response analyses. The sites having less than 20 m of depth to bedrock (H1 sites) are sub-divided into two site classes using 260 m/s of $V_{S,Soil}$ while the sites having greater than 20 m of depth to bedrock (H2 sites) are sub-divided into two site classes at $V_{S,Soil}$ equal to 180 m/s. The integration interval of 0.4 ~ 1.5 sec period range was adopted to calculate the long-period site coefficients ($F_v$) for reflecting the amplification characteristics of Korean geological condition. In addition, the frequency distribution of depth to bedrock reported for Korean sites was also considered in calculating the site coefficients for H2 sites to incorporate sites having greater than 30 m of depth to bedrock. The relationships between the site coefficients and rock shaking intensity were proposed and then subsequently compared with the site coefficients of similar site classes suggested in other codes.

• Journal of Korea Water Resources Association
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• v.41 no.4
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• pp.405-412
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• 2008

Rainfall quantiles were estimated by applying the FORGEX method. The circle network and two elliptical ones with the ratios of 1 to 1.5 and 1 to 2.0 were used and compared to find appropriate one for rainfall data. Annual maximum data were collected from 376 sites and standardized by the median. The networks were organized from the subject sites and then pooled and netmax data were collected from each network. Then, the growth curves and quantiles were estimated. When the subject site had small differences of quantiles from index flood method and at-site frequency analysis, those of the estimated quantiles from circle and elliptical networks were small. In contrast, the sites where the quantile differences are big have big differences of quantiles from circle and elliptical networks. The estimated quantiles from the elliptical network are more accurate than those from the circle network, because the ellipse network contains more sites in South Korea. Moreover, the ellipse with ratio of 1 to 2.0 shows closer quantiles to those from index flood method than one with ratio of 1 to 1.5. It is, therefore, found that the FORGEX method with 1 to 2.0 ellipse network is appropriate regional frequency analysis in South Korea.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.11a
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• pp.97-100
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• 2006

This study performed numerical analysis for obtaining optimal frequency and damping ratio of tuned mass damper (TMD) using 20 seismic loads measured at rock site. The structures of $1{\sim}2$ second natural period were considered, and optimal frequency and damping ratio were estimated for different mass ratio in terms of displacement and absolute acceleration response control. Numerical results showed that the values of the optimal parameters were different those from previous study by Hartog.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.1
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• pp.27-34
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• 2009

Site amplification should be considered in order to estimate Soil-Structure Interaction (SSI), seismic source and attenuation parameters with a greater degree of reliability. The horizontal to vertical (H/V) ratio technique, originally proposed by Nakamura (1989), has been applied to analyze the surface waves in microtremor records. Recently, its application has been extended to the shear wave energy of strong motion in order to study the site transfer function. The purpose of this paper is to estimate the H/V spectral ratio using the observed data from 9 seismic stations distributed within the Southern Korean Peninsula, from the Odesan earthquake (2007/01/20). The results show that most of the stations have more stable amplification characteristics in a low frequency band than in a high frequency band. However, each seismic station showed its own characteristic resonant frequency and low and high frequency. The resonant frequency at each station should be estimated carefully, because the quality of seismic data is dependent on the resonant frequency. It can be obtained more reliable results of seismic source and attenuation parameters, if seismic ground motions which deconvolved from site transfer function is used. The site amplification data from this study can be used to generally classify the sites within the Southern Korean Peninsula.

• Geomechanics and Engineering
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• v.18 no.6
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• pp.639-650
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• 2019

Time-domain commercial codes are widely used to evaluate the seismic behavior of tunnels. Those tools offer a good insight into the performance and the failure mechanism of tunnels under earthquake loading. Viscous damping is generally employed in the dynamic analysis to consider damping at very small strains in some cases, and the Rayleigh damping is commonly used one. Many procedures to obtain the damping parameters have been proposed but they are seldom discussed. This paper illustrates the influence of the Rayleigh damping formulation on the tunnel visco-elastic behavior under earthquake. Four Rayleigh damping determination procedures and three soil shear velocity profiles are accounted for. The results show significant differences in the free-field and in the tunnel response caused by different procedures. The difference is somewhat decreased when the soil site fundamental frequency is increased. The conventional method which consists of using solely the first soil natural mode to determine the viscous damping parameters may lead to an unsafe seismic design of the tunnel. In general, using five times site fundamental frequency to obtain the damping formulation can provide relatively conservative results.

• Journal of the Korean Society of Physical Medicine
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• v.11 no.4
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• pp.49-54
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• 2016

PURPOSE: The purpose of this study was to determine the effect of different frequencies (4Hz and 100Hz) of transcutaneous electrical nerve simulation (TENS) on pain relief using c-fos expression in the spinal cord of rat osteoarthritis to investigate the appropriate frequency for pain relief. METHODS: Total of 30 Sprague-Dawley rats was used and randomly divided 2 groups according TENS frequency and applicate the TENS during 3 period (3 days, 7 days, 10 days). The induction of osteoarthritis by 3mg monosodium iodoacetat was injected into the right knee joint of rats. Three days later, commercially available TENS unit was used for stimulation was set to 20minutes on 3, 7, 10 days after surgery. Western blot analysis system was used to detect immunoreactive proteins. The thickness of the bands were photographically measured by Scion Image. RESULTS: When investigating the c-fos expression of TENS on spinal cord in OA knee over 10 days, between-groups differences in c-fos expression reached a significant level by day 10. For within-groups comparisons, the c-fos expression decreased significantly across days in low- and high-frequency TENS groups. CONCLUSION: Whether at low- and high-frequency, the TENS as a therapy obtained beneficial effects of pain relief and TNES at high-frequency is more beneficial effects on the pain relief when TENS applied at injury site.