• Title/Summary/Keyword: Association constant

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A Study on the Topography Change of the Before and After Construction at Geum River Estuary Dike (금강하구둑 축조 전·후의 지형변화에 관한 연구)

  • Hong, Sung-Kun;Shin, Moon-Seup;Kang, Shin-Jung;Kim, Jae-Hyoung
    • Journal of Korea Water Resources Association
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    • v.39 no.2 s.163
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    • pp.179-186
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    • 2006
  • We analyzed the harmonic and non-harmonic constant of Geum River estuary to know tidal change of the before and after construction at Geum River estuary dike. As a result of analysis, the harmonic and non-harmonic constant after estuary dike building increased. Also, depth change analyzed at each section by using each year chart data. As a result, scour was occurred in the channel between south and north side guide bank. And accretion was occurred at channel from Kunsan outer port to estuary dike. Tidal change was judged as the effect of construction and dredge, watergate closing at Geum River estuary dike. And water depth change is a cause by effection of Geum River estuary dike construction and, south-north side guide bank, Kunjang country industrial complex furtherance business, seamangeum 4th sea bankment construction.

Drug-Biomacromolecule Interaction (XIII)-Effect of ionic Strength, pH and Temperature on Binding of Cephalothin to Bovine Serum Albumin- (약물과 생체고분자 간의 상호작용(제 13보)-세파로친과 소혈청알부민의 결합에 미치는 이온강도, pH 및 온도의 영향)

  • Kim, Chong-Kook;Lim, Yun-Su;Yang, Ji-Sun;Jeong, Eun-Ju
    • Journal of Pharmaceutical Investigation
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    • v.19 no.3
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    • pp.163-171
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    • 1989
  • To investigate the protein binding characteristics of cephalothin, the effects of ionic strength, pH and temperature on the binding of cephalothin to bovine serum albumin (BSA) were studied by UV difference spectrophotometric method. With increasing ionic strength at constant PH and temperature, association constant decreased, but the number of binding sites sites was about 2 constantly. It may be deduced that the binding process is not only due to electrostatic forces. And the increased association constant at high ionic strength is explained by conformational changes of BSA from complex to subunits. The pH effect on the affinity of interaction indicated that the binding affinity of drug is higher in the neutral region than in the alkaline region. And, at high pH value, the number of binding sites decreased from 2 to 1 because of the conformational changes of BSA in alkaline region. The decrease in binding affinity of BSA to drug with increasing temperature was characteristic of an exothermic reaction. And the negative sign of ${\Delta}G^{\circ}$ meant that the binding process occurs spontaneously under the experimental conditions. In cephalothin-BSA complex formation, since the net enthalpy change value and entropy change value are positive, it is assumed that hydrophobic bindings are predominant in this binding process.

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Estimation of Aggregate Matching Function in Korea (한국의 구인·구직 매칭함수 추정)

  • Lee, Daechang
    • Journal of Labour Economics
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    • v.38 no.1
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    • pp.1-30
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    • 2015
  • The aggregate matching function is estimated to explain dynamics among job seekers, vacancies and new hires in Korea. Due to measurement errors inherent in vacancies data, I introduce a latent variable for job openings and use the instrumental variables to correct its endogeneity. Matching efficiency is also estimated using some explanatory variables like job seekers' characteristics and public employment services. The result shows that Korea's matching function also exhibits a constant returns to scale.

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Investigation on the Interaction of Gabapentin with Bovine Serum Albumin by Spectroscopic Techniques

  • Ashoka, S.;Seetharamappa, J.;Kandagal, P.B.;Shaikh, S.M.T.
    • Journal of Photoscience
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    • v.12 no.3
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    • pp.113-117
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    • 2005
  • Spectroscopic investigations on the interaction of gabapentin (GBP) with bovine serum albumin (BSA) were reported. The association constant of GBP-BSA system was determined at different temperatures (298, 302, 306 and 311 K) based on the fluorescence quenching results. The GBP was found to quench the fluorescence of BSA through static mechanism. Thermodynamic parameters, the standard enthalpy change, $({\Delta}H^o)$ and the standard entropy change $({\Delta}S^o)$ were observed to be $-9.61{\pm}0.008\;kJ\;mol^{-1}$ and $3.58{\pm}0.011\;Jmol^{-1}K{-1}$ respectively. These indicated that the hydrophobic and electrostatic forces played a role in the interaction of GBP with BSA. The negative value of ${\Delta}G^o$ revealed that the binding reaction is spontaneous. The circular dichroism studies indicated the conformational changes in BSA upon interaction with GBP. The effect of some metal ions on the binding constant was also investigated.

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Analysis of Stratified Lake using an Eddy Diffusion and a Mixed-layer Models

  • Kim, Kyung-sub
    • Korean Journal of Hydrosciences
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    • v.8
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    • pp.111-123
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    • 1997
  • A one-dimensional eddy diffusion model and a mixed-layer model are developed and applied to simulate the vertical temperature profiles in lakes. Also the running result of each method are compared and analyzed. In an eddy diffusion model, molecular diffusivity is neglected and eddy diffusivity which does not need lake-specific fitting parameter and constant lake's level are applied. The heat exchanges at the water surface and the bottom are formulated by the energy balance and zero energy gradient, respectively. In a mixed-layer model, two layers approach which has a constant thickness is adopted. The application of these models which use explicit finite difference and Runge-Kutta methods respectively demonstrates that the models simulate water temperatures efficiently.

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Study on the Interaction between Curcumin and Ethylamines by Absorption and Fluorescence Spectroscopic Techniques

  • Kim, Sung Hoon;Gwon, Seon Yeong;Lee, Eun-Mi;Bae, Jin-Seok
    • Textile Coloration and Finishing
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    • v.27 no.4
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    • pp.340-344
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    • 2015
  • The interaction between curcumin(1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and ethylamines was studied in DMSO:$H_2O$(5:1, v/v) using absorption and fluorescence measurements. The association constant, $K_{ass}$, and the Stern-Volmer constants were calculated by the Benesi-Hildebrand and Stern-Volmer equation, respectively. Curcumin displayed marked UV-Vis absorption changes and highly responsive fluorescence quenching in the presence of ethylamine and the quenching ability was enhanced almost linearly with the concentration of ethylamines. The apparent Stern-Volmer constant measured for the ethylamine-curcumin system was about 1000-fold greater than that of the triethylamine-curcumin system, indicating considerably greater quenching efficiency of ethylamines.

Correlation Between Exposure Rate and Quasi-Effective Energy of Natural Radiation in Japan -TLD Application-

  • Nakajima, Toshiyuki
    • Journal of Radiation Protection and Research
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    • v.12 no.1
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    • pp.54-60
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    • 1987
  • The quasi-exposure rate and the quasi-effective energy of the natural radiation in the field at 47 monitoring points around nuclear power plants have been studied with the pair filter thermoluminescence dosimeter system. The results of the six years observation showed that the relationship between the quasi-exposure rate $X_q$, and quasi-effective energy $E_q$ can be represented as a hyperbolic function: $X_q=A+C/(E_q-B)$, where the constants A and B correspond to the quasi-exposure rate of cosmic-rays and the minimum quasi-effective energy of natural radiation, respectively. Furthermore, the constant A is in close agreement with the values obtained by using ionization chambers and scintillation detectors. The constant B is approximately 0.68 MeV, closely corresponding to the mean energy of the photons emitted from natural uranium.

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A Numerical evaluation of Constant Head Injection Test (수치 모사를 이용한 정압주입시험)

  • Park, Kyung-Woo;Kim, Kyung-Su;Koh, Yong-Kwon
    • Proceedings of the Korea Water Resources Association Conference
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    • 2009.05a
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    • pp.1918-1923
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    • 2009
  • 결정질 암반에서 지하수의 수리적 특성을 파악하기 위해 수행되고 있는 수리시험 방법은 정률법, 정압법, 순간주입(회복)법 등 세 가지로 구분할 수 있다. 본 연구에서 다루는 정압주입시험 (Constant Head Injection Test, CHIT)은 위의 정압법의 한 종류로 토목공학, 지질공학 분야에서 대상 구간의 투수계수 추정을 위해 널리 쓰이는 수리 시험이며, 이는 단일 패커나 이중패커를 이용하여 시험 구간을 격리하고, 격리된 구간에 일정한 압력으로 물을 주입하여 주입되는 물의 양을 파악함으로써, 시험 구간의 수리전도도(Hydraulic conductivity)를 산출하는 전통적인 수리시험이다. 본 연구에서는 수치실험을 통해 시험 구간 및 주입 압력의 크기 등 인위적인 요인에 의해 도출되는 투수계수가 어떻게 달라지는지에 대해 평가해 보았다. 일반적으로 단열 암반에서 수행한 정압주입시험의 해석에 있어 매질을 균질, 등방성 다공질이라는 가정으로 구간별 투수량계수를 산출하기 때문에, 다공성 매질의 지하수 유동을 모사하는 MODFLOW를 수치모사 코드로서 이용하였다. 시험구간의 크기 및 주입압력에 대한 민감도 분석 결과, 시험구간의 크기에 상관없이 수치모의에서 입력한 수리전도도 값에 비해 낮은 수리전도도 값이 산출되었으며, 주입 압력이 클수록 산출되는 수리전도도 값이 매질의 수리전도도 값과 차이가 났다. 민감도 분석 결과 현장수리시험에서 정압 주입시험에 의한 구간별 수리전도도 산출함에 있어 시험구간의 크기와 주입 압력 값에 대하여 고려해야 한다고 판단된다.

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