• Journal of Chest Surgery
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• 제57권1호
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• pp.44-52
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• 2024

Background: Visceral pleural invasion (VPI) is a poor prognostic factor that contributes to the upstaging of early lung cancers. However, the preoperative assessment of VPI presents challenges. This study was conducted to examine intraoperative pleural carcinoembryonic antigen (pCEA) level and maximum standardized uptake value (SUVmax) as predictive markers of VPI in patients with clinical T1N0M0 lung adenocarcinoma. Methods: A retrospective review was conducted of the medical records of 613 patients who underwent intraoperative pCEA sampling and lung resection for non-small cell lung cancer. Of these, 390 individuals with clinical stage I adenocarcinoma and tumors ≤30 mm were included. Based on computed tomography findings, these patients were divided into pleural contact (n=186) and non-pleural contact (n=204) groups. A receiver operating characteristic (ROC) curve was constructed to analyze the association between pCEA and SUVmax in relation to VPI. Additionally, logistic regression analysis was performed to evaluate risk factors for VPI in each group. Results: ROC curve analysis revealed that pCEA level greater than 2.565 ng/mL (area under the curve [AUC]=0.751) and SUVmax above 4.25 (AUC=0.801) were highly predictive of VPI in patients exhibiting pleural contact. Based on multivariable analysis, pCEA (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.14-7.87; p=0.026) and SUVmax (OR, 5.25; 95% CI, 1.90-14.50; p=0.001) were significant risk factors for VPI in the pleural contact group. Conclusion: In patients with clinical stage I lung adenocarcinoma exhibiting pleural contact, pCEA and SUVmax are potential predictive indicators of VPI. These markers may be helpful in planning for lung cancer surgery.

• 경영정보학연구
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• 제22권2호
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• pp.25-41
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• 2020

5G 네트워크 상용화를 앞두고 가상현실(VR) 등 실감형 미디어 산업에 대한 관심이 더욱 높아지고 있다. 하지만 VR 관련 기존 연구는 주로 영상 기술의 활용에만 초점이 맞춰져 있고, 영상의 소비와 인기 요인에 대한 연구는 미흡한 상황이다. 이에 본 연구는 VR 영상의 조회수에 영향을 미치는 요인을 밝혀내어, VR 영상 서비스 운영 및 콘텐츠 제작 측면에서 실무적인 시사점을 제공하고자 한다. 700개 VR 영상 대상으로 조회수에 대한 영향요인을 분석한 결과, 사용자 평가 요인인 좋아요 수 및 어지러워요 수가 가장 큰 영향력을 미치는 것을 확인하였다. 또한 일반 정보 요인인 영상 길이 및 경과일, 내용적 특성 요인인 속편 여부, 각색(One Source Multi Use; OSMU) 여부, 카테고리 등이 순서대로 조회수에 영향을 미쳤다. 반면 VR 영상 등록자의 팔로워 수는 조회수에 영향을 주지 못하였다. 본 연구 결과를 통해 VR 영상의 인기 및 확산을 위해 사용자 평가를 중심으로 영상 추천 및 큐레이션을 제공할 필요성이 있음을 확인하였다.

• 한국방재안전학회논문집
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• 제16권4호
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• pp.19-31
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• 2023

미래 기후 시나리오에 따르면 우리나라 자연재해의 주요 요인인 태풍의 강도는 강해질 것으로 전망된다. 태풍 강도 증가는 내습 파고 상승으로 이어져 주거, 산업, 관광 등의 용도로 인구 및 건물 밀집도가 높은 연안 지역의 대규모 피해발생 가능성이 높은 상황이다. 따라서 본 연구에서는 동해 해양기상부이 관측자료를 분석하여 최대 유의파고가 나타난 태풍 마이삭(202009) 내습 기간에 대해 파랑추산 수치모형실험을 수행하였다. 파랑추산실험 경계조건은 JMA-MSM의 바람장과 SSP5-8.5 미래 기후 시나리오의 태풍 중심기압 감소율을 적용한 바람장을 사용하였다. 파랑추산실험 결과 SSP5-8.5 시나리오에서 속초항 방파제 전면에서의 파고는 4.06 m에서 4.68 m로 15.27% 증가하였다. 또한, 심해설계파 147-2 격자점 위치에서의 재현빈도는 최소 2배 이상 증가하는 것으로 산출되어, 현재 해안구조물 설계 시 관행적으로 적용하는 50년 재현빈도 심해설계파에 대한 제고가 필요하다.

• Korean Journal of Radiology
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• 제24권4호
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• pp.338-348
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• 2023

Objective: Patients with a history of ischemic stroke are at risk for a second ischemic stroke. This study aimed to investigate the relationship between carotid plaque enhancement on perfluorobutane microbubble contrast-enhanced ultrasonography (CEUS) and future recurrent stroke, and to determine whether plaque enhancement can contribute to risk assessment for recurrent stroke compared with the Essen Stroke Risk Score (ESRS). Materials and Methods: This prospective study screened 151 patients with recent ischemic stroke and carotid atherosclerotic plaques at our hospital between August 2020 and December 2020. A total of 149 eligible patients underwent carotid CEUS, and 130 patients who were followed up for 15-27 months or until stroke recurrence were analyzed. Plaque enhancement on CEUS was investigated as a possible risk factor for stroke recurrence and as a possible adjunct to ESRS. Results: During follow-up, 25 patients (19.2%) experienced recurrent stroke. Patients with plaque enhancement on CEUS had an increased risk of stroke recurrence events (22/73, 30.1%) compared to those without plaque enhancement (3/57, 5.3%), with an adjusted hazard ratio (HR) of 38.264 (95% confidence interval [CI]:14.975-97.767; P < 0.001) according to a multivariable Cox proportional hazards model analysis, indicating that the presence of carotid plaque enhancement was a significant independent predictor of recurrent stroke. When plaque enhancement was added to the ESRS, the HR for stroke recurrence in the high-risk group compared to that in the low-risk group (2.188; 95% CI, 0.025-3.388) was greater than that of the ESRS alone (1.706; 95% CI, 0.810-9.014). A net of 32.0% of the recurrence group was reclassified upward appropriately by the addition of plaque enhancement to the ESRS. Conclusion: Carotid plaque enhancement was a significant and independent predictor of stroke recurrence in patients with ischemic stroke. Furthermore, the addition of plaque enhancement improved the risk stratification capability of the ESRS.

• Tuberculosis and Respiratory Diseases
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• 제87권1호
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• pp.65-79
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• 2024

Background: Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods: We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results: Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strong positive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specific version of St. George's Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725, p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078, p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forced expiratory volume in 1 second (FEV₁)/forced vital capacity demonstrated significant correlation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1 alpha (ρ=0.3897 and p=0.0068). FEV₁ exhibited significant correlation with CCL11/eotaxin (ρ=0.4445 and p=0.0017). Conclusion: Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed.

• 대한치위생과학회지
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• 제6권2호
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• pp.25-35
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• 2023

연구배경: 전신질환을 보유한 대상자를 위한 임상치과위생사 주도의 치위생관리과정에서의 중요성을 강조하고자 임상적 자료를 근거로 치과 임플란트에 영향을 미치고 있는 전신질환을 파악하고자 하였다. 연구방법: 치과 임플란트에 영향을 미치는 전신질환을 파악하고자 2023년 3월 1일부터 5월 31일까지 문헌고찰을 실시하였으며, 검색 시기는 2000년 1월~2020년 12월까지 국내·외 학술지에 게재된 연구 논문을 대상으로 하였다. 검색에 활용된 국내 database는 학술정보서비스(RISS), 누리미디어(DBpia), 한국학술정보(http://www.papersearch.net;KISS)를 활용하였으며, 국외 database는 Pubmed에서 '치과 임플란트 실패'와 '임플란트와 전신질환' 그리고 Dental implant failures와 Dental implant and systemic disease를 검색하여 전체 383편 중 최종적으로 13편의 자료를 선별하여 분석하였다. 결과: 임플란트의 누적생존률은 평균 94.3%이었으며 실패율은 5.7%이었다. 임상적으로 임플란트와 관련된 전신 질환에 대한 분석결과는 당뇨에 대한 연구가 13편(100.0%)으로 가장 높은 빈도를 차지하였으며 고혈압과 흡연에 대한 연구가 각각 8편(61.5%), 심혈관질환 7편(53.8%), 골관련 질환은 5편(38.5%) 순으로 위험요인이 조사되었다. 그 외 간질환 및 갑상선 이상 그리고 혈액이상 질환과 장기이식 및 감염성 질환 등이 확인되었다. 결론: 임상 치과위생사는 조절되지 않는 전신질환은 임플란트 실패의 위험요인이므로 전신질환이 임플란트에 미치는 영향에 대한 인식과 치위생 사정-판단-수행-평가 등의 주기적인 예방적 치위생관리 과정에서 환자와의 정보공유로 지속적으로 건강한 구강상태를 유지하도록 하여야 할 것이다.

• 대한감각통합치료학회지
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• 제22권1호
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• pp.69-84
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• 2024

목적 : 본 연구에서는 발달성협응장애와 발달성협응장애 아동을 대상으로 한 과제-중심 접근법을 문헌 고찰을 통하여 알아보고자 하였다. 본론 : 본 연구는 발달성협응장애의 정의, 진단, 원인, 평가에 대한 전반적인 개요를 제시한다. 또한 신경운동과제훈련(Neuromotor Task Training; NTT)과 인지기반작업수행(Cognitive Orientation to daily Occupational Performance; CO-OP)의 중재 전략에 대해 알아보기 위해 2000년 1월부터 2023년 9월까지 게재된 국외 문헌 18편을 분석하였다. 선정된 문헌에서 언급된 중재의 목적은 작업치료 실행체계 4판(Occupational Therapy Practice Framework-4; OTPF-4)의 기준에 따라 분류하였다. 분류 결과, NTT는 클라이언트 요인(client factor) 영역에 대한 목표 설정의 빈도가 높았고, CO-OP는 작업(occupation) 영역에 대한 목표만을 설정하였다. 이러한 목표 설정의 차이는 두 중재 간 전략의 차이로 설명된다. 결론 : 발달성협응장애에 대한 전반적인 개요와 과제-중심 접근법의 중재에 대한 전략의 이해는 질환에 대한 인식도를 높이고 근거 기반 임상을 위한 기초 자료가 될 것이다.

• 대한치매학회지
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• 제23권1호
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• pp.30-43
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• 2024

Background and Purpose: The SoUth Korea study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) proved the feasibility of multidomain intervention for elderly people. One-quarter of the Korean population over 65 years of age has mild cognitive impairment (MCI). Digital health interventions may be cost-effective and have fewer spatial constraints. We aim to examine the efficacy of a multidomain intervention through both face-to-face interactions and video communication platforms using a tablet personal computer (PC) application in MCI. Methods: Three hundred participants aged 60-85 years, with MCI and at least one modifiable dementia risk factor, will be recruited from 17 centers and randomly assigned in a 1:1 ratio to the multidomain intervention and the waiting-list control groups. Participants will receive the 24-week intervention through the tablet PC SUPERBRAIN application, which encompasses the following five elements: managing metabolic and vascular risk factors, cognitive training, physical exercise, nutritional guidance, and boosting motivation. Participants will attend the interventions at a facility every 1-2 weeks. They will also engage in one or two self-administered cognitive training sessions utilizing the tablet PC application at home each week. They will participate in twice or thrice weekly online exercise sessions at home via the ZOOM platform. The primary outcome will be the change in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to study end. Conclusions: This study will inform the effectiveness of a comprehensive multidomain intervention utilizing digital technologies in MCI.

• 방사선산업학회지
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• 제17권2호
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• pp.161-172
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• 2023

Coal-fired power plants handle large quantities of coal, one of the most prominent NORM, and the coal ash produced after the coal is burned can be tens of times more radioactive than the coal. Workers in these industries may be exposed to internal exposure by inhalation of particles while handling NORM. This study evaluated the size, concentration, particle shape and density, and radioactivity concentrations of airborne suspended particles in the main processes of a coal-fired power plant. Finally, the internal radiation dose to workers from particle inhalation was evaluated. For this purpose, airborne particles were collected by size using a multi-stage particle collector to determine the size, shape, and concentration of particles. Samples of coal and coal ash were collected to measure the density and radioactivity of particles. The dose conversion factor and annual radionuclide inhalation amount were derived based on the characteristics of the particles. Finally, the internal radiation dose due to particle inhalation was evaluated. Overall, the internal radiation dose to workers in the main processes of coalfired power plants A and B ranged from 1.47×10^-5~1.12×10^-3 mSv y^-1. Due to the effect of dust generated during loading operations, the internal radiation dose of fly ash loading processes in both coal-fired power plants A and B was higher than that of other processes. In the case of workers in the coal storage yard at power plants A and B, the characteristic values such as particle size, airborne concentration, and working time were the same, but due to the difference in radioactivity concentration and density depending on the origin of the coal, the internal radiation dose by origin was different, and the highest was found when inhaling coal imported from Australia among the five origins. In addition, the main nuclide contributing the most to the internal radiation dose from the main processes in the coal-fired power plants was thorium due to differences in dose conversion factors. However, considering the external radiation dose of workers in coal-fired power plants presented in overseas research cases, the annual effective dose of workers in the main processes of power plants A and B does not exceed 1mSv y^-1, which is the dose limit for the general public notified by the Nuclear Safety Act. The results of this study can be utilized to identify the internal exposure levels of workers in domestic coal-fired power plants and will contribute to the establishment of a data base for a differential safety management system for NORM-handling industries in the future.

• International Journal of Computer Science & Network Security
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• 제24권7호
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• pp.128-142
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• 2024

Creation and implementation of export-oriented strategy is an urgent issue of economic development of any country. In an export-oriented model of economic development, exports should be a means of promoting economic growth and a tool to strengthen existing and potential competitive advantages. Agricultural production is the key factor in exports and the source of foreign exchange earnings in many countries. However, the export potential of agricultural producers may be inefficiently fulfilled due to the heterogeneity of countries in terms of economic development, trade relations and border policy. The aim of the research is to study the nature, main trends and problematic aspects of fulfilling the export potential of agricultural production in the context of aggravating food crisis. The study involved general scientific methods (induction and deduction, description, analysis, synthesis, generalization) and special (statistical method, economic analysis, descriptive statistics and interstate comparisons, graphical method). The need to ensure food security by countries around the world urges the importance of the agricultural sector as a catalyst for economic development, sources of foreign exchange earnings, investment direction, etc. The study of agricultural specialization led to the conclusion that wheat and sugar are goods with the highest export potential. It is substantiated that the countries of South America, OECD, North America and Europe have the highest level of realization of export potential of agricultural production, and African countries are import-dependent. In addition, the low export orientation of Africa and Asia due to the peculiarities of their natural and climatic conditions is established based on the assessment of export-import operations in the regional context. The internal and external export potential of each of the regions is analysed. Economic and mathematical simulation of assessing the impact of the most important factors on the wheat exports volumes was applied, which allowed predicting wheat exports volume and making sound management decisions regarding the realization of the export potential of agricultural companies. The inverse correlation between the exports volume and wheat consumption per capita, and the direct correlation between the effective size and area of land used for wheat cultivation was established through the correlation and regression analysis.