Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through Multidomain interventions via facE-to-facE and video communication plaTforms in mild cognitive impairment (SUPERBRAIN-MEET): Protocol for a Multicenter Randomized Controlled Trial

  • Soo Hyun Cho (Department of Neurology, Chonnam National University Medical School and Chonnam National University Hospital) ;
  • Hae Jin Kang (Department of Medical Nutrition (AgeTech-Service Convergence Major), Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Yoo Kyoung Park (Department of Medical Nutrition (AgeTech-Service Convergence Major), Graduate School of East-West Medical Science, Kyung Hee University) ;
  • So Young Moon (Department of Neurology, Ajou University School of Medicine) ;
  • Chang Hyung Hong (Department of Psychiatry, Ajou University School of Medicine) ;
  • Hae Ri Na (Department of Neurology, Bobath Memorial Hospital) ;
  • Hong-Sun Song (Department of Sports Sciences, Korea Institute of Sports Science) ;
  • Muncheong Choi (Department of Neurology, Ajou University School of Medicine) ;
  • Sooin Jeong (Department of Psychiatry, Ajou University School of Medicine) ;
  • Kyung Won Park (Department of Neurology, Dong-A University College of Medicine) ;
  • Hyun Sook Kim (Department of Neurology, CHA Bundang Medical Center, CHA University) ;
  • Buong-O Chun (Graduate School of Physical Education, College of Arts and Physical Education, Myongi University) ;
  • Jiwoo Jung (Rowan Inc.) ;
  • Jee Hyang Jeong (Department of Neurology, Ewha Womans University College of Medicine) ;
  • Seong Hye Choi (Department of Neurology, Inha University College of Medicine)
  • Received : 2023.12.29
  • Accepted : 2024.01.18
  • Published : 2024.01.31
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Abstract

Background and Purpose: The SoUth Korea study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention (SUPERBRAIN) proved the feasibility of multidomain intervention for elderly people. One-quarter of the Korean population over 65 years of age has mild cognitive impairment (MCI). Digital health interventions may be cost-effective and have fewer spatial constraints. We aim to examine the efficacy of a multidomain intervention through both face-to-face interactions and video communication platforms using a tablet personal computer (PC) application in MCI. Methods: Three hundred participants aged 60-85 years, with MCI and at least one modifiable dementia risk factor, will be recruited from 17 centers and randomly assigned in a 1:1 ratio to the multidomain intervention and the waiting-list control groups. Participants will receive the 24-week intervention through the tablet PC SUPERBRAIN application, which encompasses the following five elements: managing metabolic and vascular risk factors, cognitive training, physical exercise, nutritional guidance, and boosting motivation. Participants will attend the interventions at a facility every 1-2 weeks. They will also engage in one or two self-administered cognitive training sessions utilizing the tablet PC application at home each week. They will participate in twice or thrice weekly online exercise sessions at home via the ZOOM platform. The primary outcome will be the change in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to study end. Conclusions: This study will inform the effectiveness of a comprehensive multidomain intervention utilizing digital technologies in MCI.

Keywords

Acknowledgement

This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and Korea Dementia Research Center (KDRC) funded by the Ministry of Health and Welfare and Ministry of Science and ICT, Republic of Korea (HU21C0016), grants from the National Research Council of Science and Technology (NST) Aging Convergence Research Center (CRC22011-600) and the Institute of Information and Communications Technology Planning and Evaluation (IITP) (2022-0-00448) funded by the Ministry of Science and ICT, Republic of Korea, and grants from Chonnam National University (Grant numbers 2021-2207 and 2022-2648). The funders were not involved in the study design, operations such as the selection and management of sites, writing of the report, and the decision to submit the report for publication, and do not have ultimate authority over any of these activities.

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