• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.180-184
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• 2005

An experimental study is performed to evaluate the performance and the efficiency by humidifying MEA and by making the double-tied catalyst layers in a fuel cell system which is taken into account the physical and thermal concept. An electrical output produced by PEFC(polymer Electrolyte Fuel Cell) is measured to assess the performance of the stack and the efficiency is also evaluated according to the different situation in which is placed with and without the humidification of MEA (Membrane Electrolyte Assembly). Subsequently, It is found that the measured values of stack voltage and current are influenced by the stack temperature, humidification, and the double-tied catalyst layers which gives more enhanced values to apply for electric units.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1999.04a
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• pp.295-295
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• 1999

• Journal of the Korean Operations Research and Management Science Society
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• v.23 no.4
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• pp.63-73
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• 1998

With the success of flexible manufacturing systems(FMSs), flexible assembly systems(FASs) have been developed to automatic factories further. As in a cellular FMS, a celluar FAS is considered as the most flexible and feasible assembly systems configuration. This paper presents a method for the integrated layout design in cellular FASs. Unlike the traditional paper, this paper deals with the formation of cells and the layout of cells for jobs with operation times on different machines. The procedure in this paper consists of two distinct phases. The first phase presents machine arrangement in a double rows flowline. cell formation not to allow intercellular movements, and integrated layout design in cellular FASs considering the characteristics of FAS, layout, and production factors This phase uses older optimal algorithm. The second phase proposes to balance the system with an objective of reducing the degree of workload deviation in the cells. Simulated annealing method is used to balance the system. This phase also shows the integrated layout design in cellular FASs with the cost less than total cost of the first phase.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.39 no.4
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• pp.414-427
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• 1990

This paper presents the development of the graphic simulator for an assembly workcell. The assembly workcell consists of two PUMA 560 manipulators, a conveyor belt system, a work table, and a vision sensor. In this study, the Petri Net theory is applied to model the assembly workcell and to construct the simulator. The event scheduling approach is used to simulate the cell. In order to show the graphic display of the simulation process, robot modelling, component modelling, and world modelling are included. The developed simulator is used to display the transition of the system state during the simulation. It is also used as a tool in selection the best resource states by studying the performance of the system as the resource states are changed.

• BMB Reports
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• v.49 no.9
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• pp.459-473
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• 2016

Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.

• KSBB Journal
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• v.13 no.4
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• pp.369-377
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• 1998

To analyze the unique aspects of biomolecular processing for monoclonal antibody (MAb) production and secretion, the simple working model based on 3-compartment (endoplasmic reticulum, Golgi apparatus, and extracellular medium) was developed. Based on in vitro MAb assembly experimental results, the kinetic model for MAb assembly in the endoplasmic reticulumn was proposed. The dynamics of MAb assembly and secretion was simulated using methematica program. According to the simulation results, the proposed 3-compartment model provides an efficient means to predict the specific MAb productivity as well as intracompartmental concentrations of MAb in endoplasmic reticulum, Golgi apparatus, and extracellular compartment model. In vivo profiles of MAb intermediates gave good agreements with the simulation profiles predicted by the intracellular compartment model. Furthermore, results of such analysis can help in directing the control strategy for optimum biomolecular processing in a mammalian cell culture system.

• Journal of the Korean Society of Industry Convergence
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• v.13 no.2
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• pp.107-112
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• 2010

The automation and Cell-Line of manufacturing process are going to be new trend in the industry spot. But workers bodily burden by manual labour is still doing repeatedly at many processes. It is appearing to workers bodily burden (Shoulder, waist, hand, wrist, leg) with repeating works at assembly line which is from the static working space. The analysis with 6 Sigma Tool at specific standard assembly line improve the point at issue for unsuitable items and analyzed objects. Physical pain of worker is solved by the improvement action for the factor of 7 items with the result of analysis. It was known to be improved by solving of workers burden related to the change of 6 Sigma level from 2.16 to 4.1 at assembly line.

• BMB Reports
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• v.45 no.8
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• pp.427-432
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• 2012

Primary cilia, single hair-like appendage on the surface of the most mammalian cells, were once considered to be vestigial cellular organelles for a past century because of their tiny structure and unknown function. Although they lack ancestral motility function of cilia or flagella, they share common ground with multiciliated motile cilia and flagella on internal structure such as microtubule based nine outer doublets nucleated from the base of mother centrioles called basal body. Making cilia, ciliogenesis, in cells depends on the cell cycle stage due to reuse of centrioles for cell division forming mitotic spindle pole (M phase) and assembling cilia from basal body (starting G1 phase and maintaining most of interphase). Ciliary assembly required two conflicting processes such as assembly and disassembly and balance between these two processes determines the length of cilia. Both process required highly conserved transport system to supply needed substance to grow tip of cilia and bring ciliary turnover product back to the base of cilia using motor protein, kinesin and dynein, and transport protein complex, IFT particles. Disruption of ciliary structure or function causes multiple human disorder called ciliopathies affecting disease of diverse ciliated tissues ranging from eye, kidney, respiratory tract and brain. Recent explosion of research on the primary cilia and their involvement on animal development and disease attracts scientific interest on how extensively the function of cilia related to specific cell physiology and signaling pathway. In this review, I introduce general features of primary cilia and recent progress in understanding of the ciliary length control and signaling pathways transduced through primary cilia in vertebrates.

• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.377-383
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• 2019

Targeting at simulating the application of thorium-uranium (TU) fuel in the CANDU-6 reactor, this paper analyzes the process using the code DRAGON/DONJON where the discrete TU fuel pins are applied in the CANDU-6 reactor under the time-average equilibrium refueling. The results show that the coolant void reactivity of the assembly analyzed in this paper is lower than that of 37-element bundle cell with natural uranium and 37-element bundle cell with mixed TU fuel pins; that the max time-average channel/bundle power of the core meets the limits - less than 6700kW/860 kW; that the fuel conversion ratio is higher than that of the CANDU-6 reactor with natural uranium; and that the exit burnup increases to 13400 MWd/tU. Thus, the simulation in this paper with the fuel in the 37-element bundle cell using discrete TU fuel pins can be considered to be applied in CANDU-6 reactor with adequate modifications of the core structure and operating modes.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1915-1919
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• 1991

The efficiency of automated assembly line is increased by realizing the automation of each assembly cell, monitoring the line information and developing the real-time line control system it. which production flow is controllable. In this paper, the several modules which are important factors when constructing automated real-time control system, such as, line control S/W module, real-time model change module, error handling module and line production management S/W module, are developed. For developing these important programming modules, real-time control and multi-tasking techniques are integrated. In this paper, operating method of real-time line control in PCB automated assembly line is proposed and for effective control of production line by using multi-tasking technique, proper operating method for relating real-time line control with multi-tasking is proposed by defining the levels of signals and tasks. CIM-Oriented modular programming method considering expandability and flexibility will be added for further research in the future.