• 한국생물정보학회:학술대회논문집
• /
• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
• /
• pp.250-261
• /
• 2004

A novel method for ab initio prediction of protein tertiary structures, PROFESY (PROFile Enumerating SYstem), is introduced. This method utilizes secondary structure prediction information and fragment assembly. The secondary structure prediction of proteins is performed with the PREDICT method which uses PSI-BLAST to generate profiles and a distance measure in the pattern space. In order to predict the tertiary structure of a protein sequence, we assemble fragments in the fragment library constructed as a byproduct of PREDICT. The tertiary structure is obtained by minimizing the potential energy using the conformational space annealing method which enables one to sample diverse low lying minima of the energy function. We apply PROFESY for prediction of some proteins with known structures, which shows good performances. We also participated in CASP5 and applied PROFESY to new fold targets for blind predictions. The results were quite promising, despite the fact that PROFESY was in its early stage of development. In particular, the PROFESY result is the best for the hardest target T0161.

• Elastomers and Composites
• /
• 제44권4호
• /
• pp.366-372
• /
• 2009

본 연구에서는 휴대폰 카메라용 렌즈모듈의 구조를 최적화하기 위한 연구를 수행하고자 한다. 휴대폰 카메라용 렌즈모듈의 안정적인 작동을 위해 경통부와 외장부간 결합력의 적절한 유지가 필요한데, 본 연구에서는 유한요소해석을 사용하여 적절한 결합력 유지를 위한 나사 간섭부 설계변수의 영향에 대해 고찰하였다. 또한 실험계획법을 적용하여 렌즈모듈 설계변수 최적화를 위한 연구를 수행하고, 실험계획법 결과에 대한 통계적인 분석을 통해 최적 조건을 선정하여 결합토크의 크기를 원하는 범위 내로 유지하고 동시에 산포를 감소시킴으로써 제품품질 향상에 기여하고자 한다.

• 대한기계학회논문집A
• /
• 제24권11호
• /
• pp.2732-2741
• /
• 2000

Combination of magnetic recording technology and optical recording technology such as Near Field Optical Recording is watched recently. In order to accomplish this technology, the development of an electromagnetic driven mm-sized mirror shifting laser beam in track direction have to needed. In Near Field Optical Recording System, shifting laser beam in track direction mean as fine tracking and means as coarse tracking. Therefore in Near Field Optical Recording, 2-stage actuator is composed of servo controller in reading or recording information on disc layer. In our research, through design and simulation process of driven mm-sized mirror, we arrange systematically design process of driven mm-sized mirror having good frequency transfer characteristics. Design and simulation processes included modal analysis of spring, calculation of magnetic moment according to the number of turns and geometric configuration of coil and magnetic circuit analysis meaning that calculation of magnetic flux density in air gap of magnetic circuit. After that we design and make parts of driven mm-sized mirror, assemble and evaluate our electriomagnetic driven mm-sized mirror. we compared design values with actual characteristic values and present solution scheme. Through these processes we performed manufacturing of an electromagnetic driven mm-sized mirror having good frequency-domain characteristics and high sensitivity characteristics.

• Reproductive and Developmental Biology
• /
• 제34권2호
• /
• pp.73-79
• /
• 2010

We investigated the microtubule dynamics, including the inheritance of donor centrosomes and the mitotic spindle assembly occurring during the first mitosis of somatic cell nuclear transfer (SCNT) embryos in pigs. SCNT embryos were fixed 15 min and 1 h after fusion in order to assess the inheritance pattern of the donor centrosome. The distribution and dynamic of the centrosome and microtubule during the first mitotic phase of SCNT embryos were also evaluated. The frequency of embryos evidencing $\gamma$-tubulin spots (centrosome) was 93.2% in the SCNT embryos 15 min after fusion. In the majority of the SCNT embryos (61.5%), however, no centrosome was observed 1 h after fusion. The frequency of the embryos with no or abnormal mitotic spindles 20 h after fusion was 19.6%. The $\gamma$-tubulin spots were detected near the nuclei of somatic cells regardless of cell cycle phase, whereas $\gamma$-tubulin spots in the SCNT embryos were observed only during the inter-anaphase transition. These results showed that the donor centrosome is inherited into the SCNT embryos, but failed to assemble the normal mitotic spindles during first mitotic phase in some SCNT embryos.

• Industrial Engineering and Management Systems
• /
• 제7권3호
• /
• pp.189-196
• /
• 2008

This paper proposes a way of designing of a global logistics system for "the international cooperative global complementary production system" (ICGCPS) constructed in ASEAN region. ICGCPS is a global production system with several production bases located in a number of countries. In order to assemble the final products and sell them in the domestic market, each production base produces only special kinds of components and parts with the total demand required all the participating countries, and supplies them to the other production bases each other. In the ICGCPS, there are a number of important decision-making problems such as identifying which countries are suitable to produce specified components and parts, and deciding how to transport components and parts between the production bases. In the initial period of this system, each production base focused on its domestic market so that the final products it produced were sold only in the country where the base was located. Recently, some production bases have expanded sales to overseas markets. Taking this fact into account, we propose a production and transportation planning model in this paper that takes into account the export quantity of the final products, formulating it into a mathematical programming problem. Using this, we propose a way for managing the supply chain processes of the ICGCPS in order to improve performance measurements such as the total lead-time, the inventory quantity at the depot and the average rate of loading. A numerical example is presented to clarify the procedure proposed in this paper.

• 한국정보과학회논문지:소프트웨어및응용
• /
• 제34권12호
• /
• pp.1011-1020
• /
• 2007

독립적으로 개발된 상용 컴포넌트들을 소스 코드 수정 없이 조립하여 재사용하기 위해서는 컴포넌트간 인터페이스 불일치 문제를 해결해야 한다. 본 논문에서는 이러한 문제를 해결하기 위한 새로운 컴포넌트 모델 및 조립 방법을 제안한다. 제안한 컴포넌트 모델은 각 컴포넌트가 서비스를 제공하는 하위 컴포넌트의 인터페이스에 의존하는 대신 서비스 요청에 관한 인터페이스를 독자적으로 정의하여 내장하고 이를 메타데이타로 노출한다. 조립 시에는 컴포넌트들의 요청 및 서비스 제공 인터페이스에 대한 메타데이타를 읽어 글루 컴포넌트 템플릿 코드를 자동 생성하여 인터페이스 정합에 필요한 중재 코드를 삽입하는 구조이다. 또 프레임워크에서 컴포넌트들에 대한 인스턴스를 관리하고 런타임시 의존성 주입 방식으로 조립을 수행하며, 글루 컴포넌트를 미들웨어 서비스 포인트 및 실시간 모니터링 포인트로 활용하는 방안도 제안한다. 이와 한께 본 논문은 제안한 컴포넌트 모델에 따르는 컴포넌트를 개발하고 조림하는 도구를 구현하여, 실용 가능성을 입증하였다.

• 대한안전경영과학회지
• /
• 제11권2호
• /
• pp.111-115
• /
• 2009

As shown in the accident analysis from 2007, it has been found that causes of accidents on large-scale projects are different from those found in general construction projects. A 300-question survey regarding systematic and practical aspects of safety problems at construction sites was distributed to ten (10) different companies. Participants were to respond subjectively, so that the results could be used to assemble the first formal questionnaire survey. They were collected and compiled by an advisory committee for this study. The resulting surveys were then sent to the division chiefs of the top 100 construction companies in Korea, in order to improve the response rate. The Department of Safety & Health Direction, and the :Ministry of Labor, ROK sent the same sheets to medium and small construction companies that placed within 101-200th of all Korea construction companies. The above safety engineers were classified into four (4) levels, from 1st to 4th, followed by the project dollar amount and risk level. Formulae were developed to assign safety engineers to construction sites by engineer level, the project dollar amount, and the project risk level. Conclusions are summarized as follows: 1) Reviewing the assignment system of experienced safety engineers to large scaled projects - The more experienced the engineers assigned to a project, the higher the level of accident prevention. 2) Enforcing the assignment of advanced level safety engineers to large-scaled sites - At least one advanced-level safety engineer should be assigned to construction sites with projects valued at $15million USD (15,000,000,000). 3) For assigning safety engineers by risk level - Twenty models have been developed to calculate the number of safety engineers to be assigned by risk level. In the future, risk level for each job should be established by the government (as is now the practice in Germany).

• 대한인간공학회지
• /
• 제25권3호
• /
• pp.49-60
• /
• 2006

Technological encroachment provides human operators with flood of information that must be analyzed to understand the environment and make judgments that lead to strategic actions. Further, the environment is not static and therefore uncertain, changing its aspect dynamically. Complexity accompanied with its dynamics imposes substantial difficulty to human operators' task. Criticality of having situational understanding becomes more important than ever. Situationalunderstanding requires the human operators possessing tacit knowledge in order for them to make the sense out of the situation while interacting with information from many heterogeneous sources, the notion of sensemaking. Sensemaking refers to the process of developing mental framework to assemble pieces of information representing different aspects of the environment that can be used to develop one's own actionable knowledge to implement their judgments in the uncertain environment. Therefore, judgment process and performance is a key component of sensemaking process. Among many judgment and decision making models, the lens model with its extension can be utilized to partially describe the judgmental aspect of sensemaking. One of the lens model parameters, unmodeled knowledge, can be a corresponding quantitative measure for the tacit knowledge that plays an important role in sensemaking. In this paper, a comprehensive literature for sensemaking is provided to formally define the notion of sensemaking in the military domain. Also, it is proposed that there is a crucial link between the sensemaking and human judgment process and performance from the lens model perspective. Potential implications for experimental framework are also proposed.

• 조명전기설비학회논문지
• /
• 제20권8호
• /
• pp.22-29
• /
• 2006

IEC 규격을 기반으로 최근에 개정된 KS 규격에 따라 등전위 접지시스템이 중요하게 자리매김 하였으며, 전원시스템의 안정성을 위해 서지보호소자의 사용이 급격히 증가하고 있다. 내재된 비선형 저항성분으로 뛰어난 V-I 특성을 가지는 $Z_nO$ 바리스터는 서지전압을 제한하여 서지전류로 환류시키기 위해 전원용 보호기로 주로 사용되고 있다. 이러한 $Z_nO$ 바리스터는 교류 전원선에 접속하기 위해서 몇 가지 회로조합 형태로 구성되어 사용되는데, 사용자는 바리스터를 직렬 혹은 병렬로 조합하여 사용함에 있어서 안전에 직접적으로 관련된 기능이나 열적 안정성을 포함한 많은 것들을 고려하여야 한다. 본 논문에서는 40[kA]의 전류용량을 가지는 단일 바리스터 소자와 직렬 혹은 병렬 회로조합의 바리스터에 대하여 잔류전압, 방전전류, 누설전류, 표면온도를 측정하여 각각의 조합형태에 따라 안정성을 비교하였다.

• BMB Reports
• /
• 제35권2호
• /
• pp.186-193
• /
• 2002

The acid-bible subunit (ALS) associates with the insulinlike growth factor (IGF)-I or II, and the IGF binding protein-3 (IGFBP-3) in order to form a 150-kD complex in the circulation. This complex may regulate the serum IGFs by restricting them in the vascular system and promoting their endocrine actions. Little is known about how ALS binds to IGFBP3, which connects the IGFs to ALS. Xenopus oocyte was utilized to study the function of ALS in assembling IGFs into the ternary complexes. Xenopus oocyte was shown to correctly translate in vitro transcribed mRNAs of ALS and IGFBP3. IGFBP3 and ALS mRNAs were injected in a mixture, and their products were immunoprecipitated by antisera against ALS and IGFBP3. Contrary to traditional reports that ALS interacts only with IGF-bound IGFBP3, this study shows that ALS is capable of forming a binary complex with IGFBP3 in the absence of IGF When cross-linked by disuccinimidyl suberate, the band that represents the ALS-IGFBP3 complex was evident on the PAGE. IGFBP3 movement was monitored according to the distribution between the hemispheres. Following a localized translation in the vegetal hemisphere, IGFBP3 remained in the vegetal half in the presence of ALS. However, the mutant IGFBP3 freely diffused into the animal half, despite the presence of ALS, which is different from the wild type IGFBP3. This study, therefore, suggests that ALS may play an important role in sequestering IGFBP3 polypeptides via the intermolecular aggregation. Studies using this heterologous model will lead to a better understanding of the IGFBP3 and ALS that assemble into the ternary structure and circulate the IGF system.