• Title/Summary/Keyword: Artificial skin

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Contraction Behavior of Collagen Gel and Fibroblats Activity in Dermal Equivalent Model

  • Yang, Eun-Kyung;Lee, Doo-Hoon;Park, Sue-Nie;Choe, Tae-Boo;Park, Jung-Keug
    • Journal of Microbiology and Biotechnology
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    • v.7 no.4
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    • pp.267-271
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    • 1997
  • We developed a dermal equivalent (DE) which was engineered using human dermal fibroblasts and a matrix of collagen gel. The in vitro construction of the DE was accomplished by casting a porcine collagen type I solution plus concentrated medium with isolated and cultured fibroblasts. These constructs were attached to culture dishes or left floating in culture medium. Contraction of attached gels results in decreased gel thickness without a change in gel diameter, and contraction of floating gels results in decreased gel thickness and diameter. After contraction, there was no increase in cell number in floating gels, but cells in attached gels began to increase after about 4 days of the lag phase in cell growth curve. At this lag phase, addition of fibroblast growth factor (FGF) at a concentration of $0.1{\mu}$/ml promoted cell proliferation in the attached collagen gels, but no effect in floating gels. These results indicate that the method of contraction had an influence on the extracellular matrix (ECM) organization, and this influenced not only cell growth but also fibroblast responsiveness to FGF. This suggests that attached collagen gel is more suitable as a dermal equivalent than the floating gel. And the final contracted area of attached gel is much larger than that of the floating gel since floating gel is contracted in all directions but attached gel is contracted only vertically.

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Growth characteristics of 2-year-old cultivars in Korean ginseng (Panax ginseng C. A. Meyer) conditioned artificial wet injury (인위적인 습해 유발조건에서 2년생 인삼 품종의 생육특성)

  • Kim, Jang-Uk;Lee, Jung-Woo;Jo, Ick-Hyun;Kim, Dong-Hwi;Kim, Kee-Hong;Kim, Young-Chang
    • Korean Journal of Agricultural Science
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    • v.42 no.4
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    • pp.299-304
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    • 2015
  • This study was conducted to investigate growth characteristics to develop the technique to select resistant cultivar by wet injury at an early stage through the automatic irrigation maintaining 30, 20, 10 kPa respectively using native variety, Chunpoong, Yunpoong, Gumpoong and Sunun. The aerial growth was decreased at 10 kPa compared to 30 kPa. In addition, the survival rate was decreased by 66.6%, 62.3%, 33.8% at 30, 20, 10 kPa, respectively. The survival rate of Chunpoong and Gumpoong were higher than others at 10 kPa. While root growth characteristics such as root length, root weight, number of lateral root and side root were tended to decrease, root diam was no significant or increased. And the more humid condition is, the more the incidence rate of rusty root and rough skin were tended to increase. The epidermal thickness of Chunpoong and Gumpoong was increased but the figures of native variety, Yunpoong and Sunun were decreased at 10 kPa compared to 30 kPa. But, the tissue stiffness of root was decreased at 10 kPa compared to 30 kPa.

A Study on the Formativeness of Shamanism Expressed in Modern Fashion (현대 패션에 표현된 무속의 조형성 연구)

  • Kwon, Jin;Kwon, Myoung-Sook
    • Journal of the Korean Society of Costume
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    • v.58 no.6
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    • pp.1-11
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    • 2008
  • The purpose of this study was to investigate how formativeness of shamanism has expressed and developed in modern fashion. Formative expression of shamanism in modern fashion has expressed in the way of on style, color, material and pattern as follows; Style has made animal and human incorporated by expressing abstract animal on the part or whole of costume and it has reconstructed traditional shaman costume into modern costume. Skin colors of living bodies which exist in nature, such as black, blown, yellow and grey, were used to symbolize spirit and low brightness of colors such as blue, white and black were also used to symbolize hyperspace. Artificial materials which imitate animal figure and genuine materials from animal were used. Various natural materials used in traditional shaman costume were also used. Animal patterns and abstract patterns symbolizing the celestial heaven and lower world, and patterns shown on wall painting and rock painting has appeared. The meaning of shamanism in modern fashion can be identified as interchangeable movement of time and space, a cosmic outlook on the world and ration. Spiritually designed costume has made fashion move to hyperspace in spirit trip. Modern fashion with shamanism has expressed its cosmic outlook on the world or universal wish beyond human's real world by patterns such as bird figure which means the celestial heaven and lower world. Corporation and transition of human and animal were symbolized as shaman hypernatural intercourse with designs expressed in costume using a part of animal or animal's characteristics.

A Study on the Knowledge-Based T.P.N. System (1) (지식 구조화 경정맥 완전 영양공급 시스템의 개발에 관한 연구 (I))

  • Jeon, Gye-Rok;Choe, Sam-Gil;Byeon, Geon-Sik
    • Journal of Biomedical Engineering Research
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    • v.11 no.2
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    • pp.305-314
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    • 1990
  • In this paper we have implemented and tested TPN which is system to supply sufficent nutrition to nutritionally deficient patient by means of ES (expert system) a kind of A.1 (artificial intelligence) . This system affords to evaluation of nutritional state of patient which is essential to physi- cian. who performs TPN, decision of performing TPN and management of patient-data & calculation of information needing to making TPN fluid. The features were as follolv 1. we input data, take ideal weight of patient and 24hr's creatlnln In urine according to chart in system compare TSF (triceps skin fold), MAC (mid-arm circumference), AMC (arm muscle circumference) to 5th, 15th, 50th percentile and evaluate the nutritional state of patient. 2. Calculation of protein & nonprotein calorie needing to treament of patient can be made exactly by stress factor, activity factor and body temperature. 3. patient's personal recording needing to management of patient date name of chief doc- tor, name of department of admission, chart number, history can by taken very easily. 4. The way of system operating is pull-down Menu one, It can be processing very efficiently. 5. Date processing in system, we can manage memory volume of computer verlr efficiently using of dynamic allocation variables. 6. We can make it very easy to edit & revise the input data, processed data is saved to diskette in 2 files (TDF, THF) , these are semipermanent preservation.

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Effect of Pretreatment on Dyeability and Functionalities of Summer Rayon fabrics Finished by Gallnut Extract (전처리가 오배자 추출물에 의한 여름용 인견직물의 염색 및 기능성 향상에 미치는 영향)

  • Hwang, Hyun Ju;Hong, Kyung Hwa
    • Fashion & Textile Research Journal
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    • v.18 no.2
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    • pp.244-251
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    • 2016
  • Viscose rayon filament fabrics have been called 'artificial silk' and beloved as summer clothing materials for a long time in Korea. This is because the viscose rayon filament fabrics reveals glossy surface and cool touch feeling compared to other conventional fabrics composed of staple fibers. Therefore, we tried to prepare the higher value added viscose rayon filament fabrics for summer textile products. In this study, we applied gallnut extract to the viscose rayon filament fabric to develop summer fabrics with natural color and multi-functions such as antibacterial and antioxidant properties. This process also pursue eco-friendly and multi-functional fabric finishing from the natural material "gallnut". In addition, various pre-treatment with cationizer, chitosan, or chito-oligomer was applied to the finishing process to improve the finishing efficacy and durability. Consequently, it was found that the active component of gallnut extract was successfully incorporated to the viscose rayon filament fabric through a pad-dry-cure process. And, the treated viscose rayon filament fabrics showed excellent antibacterial and antioxidant properties. Therefore, it was expected that the rayon filament fabrics treated by gallnut extract could be used as effective summer fabrics preventing the growth of bacteria and skin ageing as well as providing cool touch feeling. However, the pre-treatments were not that meaningful on the functionalities but effective on coloring.

Transparent and Flexible All-Organic Multi-Functional Sensing Devices Based on Field-effect Transistor Structure

  • Trung, Tran Quang;Tien, Nguyen Thanh;Seol, Young-Gug;Lee, Nae-Eung
    • Proceedings of the Korean Vacuum Society Conference
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    • 2011.02a
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    • pp.491-491
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    • 2011
  • Transparent and flexible electronic devices that are light-weight, unbreakable, low power consumption, optically transparent, and mechanical flexible possibly have great potential in new applications of digital gadgets. Potential applications include transparent displays, heads-up display, sensor, and artificial skin. Recent reports on transparent and flexible field-effect transistors (tf-FETs) have focused on improving mechanical properties, optical transmittance, and performances. Most of tf-FET devices were fabricated with transparent oxide semiconductors which mechanical flexibility is limited. And, there have been no reports of transparent and flexible all-organic tf-FETs fabricated with organic semiconductor channel, gate dielectric, gate electrode, source/drain electrode, and encapsulation for sensor applications. We present the first demonstration of transparent, flexible all-organic sensor based on multifunctional organic FETs with organic semiconductor channel, gate dielectric, and electrodes having a capability of sensing infrared (IR) radiation and mechanical strain. The key component of our device design is to integrate the poly(vinylidene fluoride-triflouroethylene) (P(VDF-TrFE) co-polymer directly into transparent and flexible OFETs as a multi-functional dielectric layer, which has both piezoelectric and pyroelectric properties. The P(VDF-TrFE) co-polumer gate dielectric has a high sensitivity to the wavelength regime over 800 nm. In particular, wavelength variations of P(VDF-TrFE) molecules coincide with wavelength range of IR radiation from human body (7000 nm ~14000 nm) so that the devices are highly sensitive with IR radiation of human body. Devices were examined by measuring IR light response at different powers. After that, we continued to measure IR response under various bending radius. AC (alternating current) gate biasing method was used to separate the response of direct pyroelectric gate dielectric and other electrical parameters such as mobility, capacitance, and contact resistance. Experiment results demonstrate that the tf-OTFT with high sensitivity to IR radiation can be applied for IR sensors.

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Pre-clinical Screening Methods for Evaluating Anti-wrinkle Effect

  • Cho Moon Kyun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.29 no.2 s.43
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    • pp.37-65
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    • 2003
  • Nowadays, we find out new anti-wrinkle-care-ingredients by in vitro searching methods using many kind of cell-culture-models for investigation of the effective anti-wrinkle-care-ingredients. But, theses new ingredients don't have effect on the human-model for anti-wrinkle, not likely on in vitro. In other words, there are so many differences between the effects on in vitro models and the clinical human models, practically. But, we actually have difficulty in putting all of the new anti-wrinkle-care-ingredients to the test on human models directly. To solve this problem, we have investigated that by using the artificial skin-culture-model or the animal model, In this lecture I will review the detail of assessment method far evaluation of anti-wrinkle agents in vitro and animal model and discuss the pros and cons of each method. Then I will present the results of Preclinical Screening trials, And especially animal model may be a good candidate for evaluation of anti-wrinkle agents.

Study on the Development of Home Care Nursing Intervention Protocol for Stroke Patients (뇌졸중 환자의 가정간호중재 프로토콜 개발)

  • Yoo Ji-Soo
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.7 no.1
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    • pp.122-136
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    • 2000
  • Stroke patient needs rehabilitation after receiving an acute treatment in a hospital. When stroke patient gets involved in an early discharge program, home care nurse plays a pivotal role to make them to gain a full strength and to come back to his/her prior life before he/she is sick. In spite of the importance of home care nursing intervention protocol for home care nurses to perform home care nursing autonomously, home care nursing intervention protocol for stroke patient is rarely developed. Therefore this study was conducted to develop home care nursing protocol that is applicable for stroke patients in home care nursing area. 41 home care nursing charts for stroke patients registered in home care nursing agencies from December 1st 1994 to August 31st 1999 at Y hospitals in Seoul and Won-Ju city were analyzed. 44 home care nurses who were having over three years' experience on stroke patients were participated in this study as a user validity validation group. The results of this study are as follows. 1. 28 nursing diagnoses were selected on the basis of evaluation of nursing diagnoses of stroke patients presented in a previous literature and case studies on home care nursing. 2. 17 nursing diagnoses were classified through the frequency analysis of home care nursing charts for 41 stroke patients who had received home care nursing. The order of sequence was like these: impaired skin integrity, risk for infection, nutritional deficit, impaired physical mobility, constipation, knowledge deficit, ineffective airway clearance, anxiety in family members, risk for aspiration, self care deficit, altered urinary elimination, ineffective individual coping, social isolation, risk for injury, self-esteem disturbance, impaired verbal communication, fatigue of family caregiver. 3. Based on validation on expert and user validities, 44 nursing interventions which were above ICV=.80 were chosen. 4. Nursing intervention protocols which showed above ICV=.90 were developed and were like these; pressure ulcer care, position change, preventive care for circulatory dysfunction, tube care : catheter, vital sign monitor, constipation/impaction management, artificial airway management, suction of airway secretion, environmental management : safety, and fall prevention.

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Color stability of thermochromic pigment in maxillofacial silicone

  • Kantola, Rosita;Lassila, Lippo V.J.;Tolvanen, Mimmi;Valittu, Pekka K.
    • The Journal of Advanced Prosthodontics
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    • v.5 no.2
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    • pp.75-83
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    • 2013
  • PURPOSE. Maxillofacial silicone elastomer is usually colored intrinsically with color pigments to match skin colors. The purpose of this study was to investigate the color stability of a maxillofacial silicone elastomer, colored with a thermochromic, color changing pigment. MATERIALS AND METHODS. Disc-shaped maxillofacial silicone specimens were prepared and divided into 3 groups: a conventionally colored control group, one group additionally colored with 0.2 wt% thermochromic pigment, and one group with 0.6 wt% thermochromic pigment. Half of the surface of each specimen was covered with an aluminium foil. All of the specimens were exposed to UV radiation in 6 hour cycles over 46 days. In between the UV exposures, half of the specimens were stored in darkness, at room temperature, and the other half was stored in an incubator, at a humidity of 97% and a temperature of $+37^{\circ}C$. Color measurements were made with a spectrophotometer and registered according to the CIELAB $L^*a^*b^*$ color model system. The changes in $L^*$, $a^*$ and $b^*$ values during artificial aging were statistically analyzed by using paired samples t-test and repeated measures ANOVA. P-values <.05 were considered as statistically significant. RESULTS. The UV exposure resulted in visually noticeable and statistically significant color changes in the $L^*$, $a^*$ and $b^*$ values in both of the test groups containing thermochromic pigment. Storage in the incubator lead to statistically significant color changes in the $a^*$ and $b^*$ values of the specimens containing thermochromic pigment, compared to those stored at room temperature. CONCLUSION. The specimens containing thermochromic pigment were very sensitive to UV radiation, and the thermochromic pigment is not suitable, as such, to be used in maxillofacial prostheses.

An Evaluation of Aerobic Exercise Wear Mobility as a Basic Criterion for Universal Design (에어로빅복의 유니버설 디자인을 위한 동작 적합성 평가)

  • Sohn, Ju-Hee;Choi, Jeong-Wha;Kang, Tae-Jin
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.3 s.162
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    • pp.343-350
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    • 2007
  • This study compared and studied the clothing mobility of two types of aerobic clothes - those made of currently popular stretch materials and those made of new stretch materials that were specially developed for this study. The focus of the comparison was on the range of joint movement during activity, and the physiological burden imposed on the body by the clothes. In total, 18 experiments were carried out under controlled conditions in an artificial climatic chamber with a temperature of $25{\pm}1^{\circ}C$, air humidity of $60{\pm}5^{\circ}C$ and negligible air movement. Each exercise program consisted of a 30-minute of aerobic workout and a 20-minute rest following the exercise. Measurements were taken to determine the following: physiological reactions (whole-body and local sweat rates), subjective sensations(of temperature, humidity, comfort, tightness, and clothing wetness), joint angle(measured with a goniometer), and so on. The results of the study us as follows: Material B excels in clothing mobility. Material C excels in sweat absorbency and drying speed. Material A was found to be the hottest material, while material C was found to be slightly hot through the analysis of the change in pre- and post-exercise bodyweight(= amount of sweat). Regarding the amount of evaporated sweat, material A>material C>material B. Material B produced the smallest amount of evaporated sweat. The wider the range of joint movement, the smaller the amount of sweat and the lower the average skin temperature.