• Title/Summary/Keyword: Artificial host

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Interactions between Water-Soluble Polyparacyclophanes and Drugs (I) -Design and Synthesis of Water-Soluble Polyparacyclophanes Containing Diphenyl Ether Skeletons- (수용성 폴리파라시클로판류와 약물과의 상호작용 (제1보) -디페닐에텔을 골격으로 하는 수용성 폴리파라시클로판류의 설계 및 합성-)

  • Chun, In-Koo;Lee, Min-Hwa;Kim, Shin-Keun
    • Journal of Pharmaceutical Investigation
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    • v.18 no.2
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    • pp.89-97
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    • 1988
  • A series of novel water-soluble paracyclophanes containing two diphenyl ether skeletons and two bridging aliphatic chains of various length were designed and prepared to develop artificial host compounds which might provide efficient hydrophobic field. They were 1,5,19,23-tetraaza-12,30-dioxa[5,1.5.1] paracyclophane (6), 1,6,20,25-tetraaza-13,32-dioxa[6.1.6.1]paracyclophane (7), 1,7,21,27-tetraaza-14,34-dioxa[7.1.7.1]paracyclophane (8) and 1,8,22,29-tetraaza-15,36-dioxa[8.1.8.1]paracyclophane (9). As the corresponding acyclic analogue, 4,4'-dimethylaminodiphenyl ether (11) was synthesized for the comparative study of further host-guest interaction.

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Anthracnose of Statice Caused by Glomerella cingulata (Stonem.) Spaulding & Schrenk in Chonbuk Province (Glomerella cingulata (Stonem.) Spauld. & Schrenk에 의한 스타티스 탄저병)

  • 최정식;정성수;김정만;소인영
    • Korean Journal Plant Pathology
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    • v.10 no.2
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    • pp.148-150
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    • 1994
  • Anthracnose of statice (Limonium sp. var. Misty Blue and L. sinuatum Mill. cv. Early Blue) occurred up to 20% in vinyl-houses at Buan, Imsil and Namwon from July to November, 1993. All isolates from the anthracnose symptoms were identified as Glomerella cingulata (Stonem.) Spauld. & Schrenk and its anamorph was Colletotrichum gloeosporioides (Pens.) Sacc. Pathogenicity of the isolates was ascertained on the statice host by artificial inoculation. The symptoms on leaves appeared as circular brown spots in early stage and developed to zonate spots. The spot aggregated and diseased leaves were blighted. The symptom also developed on the stems of severely infected plants and the infected branches were blighted. A lots of acervuli developed on the lesions of stems. Acervuli on necrotic lesions were setose, rounded and elongated. Setae variable in length, 1~4 septate, brown, slightly swollen at the base and tapered to the apex on which conidia were occasionally borned. Statice was revealed as the new host of G. cingulata.

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Two Newly Identified Gymnosporangium Species, G. japonicum and G. cornutumn, in Korea

  • Yun, Hye-Young;Lee, Seung-Kyu;Lee, Kyung-Joon;Kim, Kyung-Hee
    • The Plant Pathology Journal
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    • v.19 no.6
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    • pp.274-279
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    • 2003
  • Two Gymnosporangium species, G. japonicum and G. cornutum, causing cedar-apple rust, were newly identified in Korea, and a new aecial host for each fungus was found by artificial inoculation. Detailed descriptions of the species were made based on macroscopic features (symptoms and signs) and light and scanning electron microscopic observations of spores and peridial cells. G. japonicum from Juniperus chinensis var. horizontalis had Photinia villosa as its new aecial host G. cornutum from J. rigida showed its aecial stage on Sorbus alnifolia.

Mycorrhizal Synthesis of Périgord Black Truffle (Tuber melanosporum) with Mexican Oak Species

  • Guevara-Guerrero, Gonzalo;Pacioni, Giovanni;Leonardi, Marco;Ocanas, Fortunato Garza;Hernandez, Rigoberto Gaitan
    • Microbiology and Biotechnology Letters
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    • v.50 no.1
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    • pp.40-50
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    • 2022
  • The Périgord black truffle (Tuber melanosporum) is an edible fungus and among the most expensive foods worldwide. It is the basis of a multimillion-dollar bio-business. Truffle farming does not exist in Mexico, and no formal studies have been conducted on its culture. This report describes the mycorrhizal synthesis (i.e., artificial union of fungus with host) of T. melanosporum with oak species native to Mexico (Quercus polymorpha, Q. fusiformis, and Q. canbyi). The mycorrhizal association was successful in Q. polymorpha and Q. fusiformis, as confirmed morphologically and using T. melanosporum molecular primers (ITSML/ITS4LNG). The effect of the ectomycorrhizal fungus on host growth (stem diameter) was statistically significant. Illustrations of the study are presented.

Winter Olympics Mascots: Features and Attributes

  • Myeong Hee, SEONG;Dong Geun, LEE;Hyuk Jin, LEE
    • Journal of Sport and Applied Science
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    • v.7 no.1
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    • pp.1-10
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    • 2023
  • Purpose: This paper analyzed the features of Winter Olympics mascots in chronological order by examining the evolution of mascots and presented the attributes of the Winter Olympics mascots from Innsbruck 1976 to Beijing 2022. Research design, data, and methodology: This paper conducted an exploratory study on the thinking to understand the characteristics of 13 Winter Olympics Mascots through literature review. Results: First, the mascot is a fictional character, usually an artificial character that represents the locality of the host city, including animals, human figures, and local inhabitants. Second, Schneemann, Innsbruck 1976 was known as the first official Winter Olympics mascot. Third, 19 mascots out of a total of 24 mascots were created using animals. Conclusions: The six attributes of the Winter Olympics mascots were identified: friendliness, symbolic meaning, originality, diversity, value, and identity of a special location. Above all, Winter Olympics has a locality that includes areas covered with ice and snow. From this point of view, the Olympics mascot highlights the image of snow and ice and the physical environment that includes it.

Development of a Real-time OS Based Control System for Laparoscopic Surgery Robot (복강경 수술로봇을 위한 실시간 운영체제 기반 제어 시스템의 개발)

  • Song, Seung-Joon;Park, Jun-Woo;Shin, Jung-Wook;Kim, Yun-Ho;Lee, Duk-Hee;Jo, Yung-Ho;Choi, Jae-Seoon;Sun, Kyung
    • Journal of Biomedical Engineering Research
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    • v.29 no.1
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    • pp.32-39
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    • 2008
  • This paper reports on a realtime OS based master-slave configuration robot control system for laparoscopic surgery robot which enables telesurgery and overcomes shortcomings with conventional laparoscopic surgery. Surgery robot system requires control system that can process large volume information such as medical image data and video signal from endoscope in real-time manner, as well as precisely control the robot with high reliability. To meet the complex requirements, the use of high-level real-time OS (Operating System) in surgery robot controller is a must, which is as common as in many of modem robot controllers that adopt real-time OS as a base system software on which specific functional modules are implemened for more reliable and stable system. The control system consists of joint controllers, host controllers, and user interface units. The robot features a compact slave robot with 5 DOF (Degree-Of-Freedom) expanding the workspace of each tool and increasing the number of tools operating simultaneously. Each master, slave and Gill (Graphical User Interface) host runs a dedicated RTOS (Real-time OS), RTLinux-Pro (FSMLabs Inc., U.S.A.) on which functional modules such as motion control, communication, video signal integration and etc, are implemented, and all the hosts are in a gigabit Ethernet network for inter-host communication. Each master and slave controller set has a dedicated CAN (Controller Area Network) channel for control and monitoring signal communication with the joint controllers. Total 4 pairs of the master/slave manipulators as current are controlled by one host controller. The system showed satisfactory performance in both position control precision and master-slave motion synchronization in both bench test and animal experiment, and is now under further development for better safety and control fidelity for clinically applicable prototype.

Unsupervised learning with hierarchical feature selection for DDoS mitigation within the ISP domain

  • Ko, Ili;Chambers, Desmond;Barrett, Enda
    • ETRI Journal
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    • v.41 no.5
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    • pp.574-584
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    • 2019
  • A new Mirai variant found recently was equipped with a dynamic update ability, which increases the level of difficulty for DDoS mitigation. Continuous development of 5G technology and an increasing number of Internet of Things (IoT) devices connected to the network pose serious threats to cyber security. Therefore, researchers have tried to develop better DDoS mitigation systems. However, the majority of the existing models provide centralized solutions either by deploying the system with additional servers at the host site, on the cloud, or at third party locations, which may cause latency. Since Internet service providers (ISP) are links between the internet and users, deploying the defense system within the ISP domain is the panacea for delivering an efficient solution. To cope with the dynamic nature of the new DDoS attacks, we utilized an unsupervised artificial neural network to develop a hierarchical two-layered self-organizing map equipped with a twofold feature selection for DDoS mitigation within the ISP domain.

The Effect of a Long-Term Cyclic Strain on Human Dermal Fibroblasts Cultured in a Bioreactor on Chitosan-Based Scaffolds for the Development of Tissue Engineered Artificial Dermis

  • Lim, Sae-Hwan;Son, Young-Sook;Kim, Chun-Ho;Shin, Heung-Soo;Kim, Jong-Il
    • Macromolecular Research
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    • v.15 no.4
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    • pp.370-378
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    • 2007
  • Mechanical stimulation is known to activate several cellular signal transduction pathways, leading to the induction of signaling molecules and extracellular matrix (ECM) proteins, thereby modulating cellular activities, such as proliferation and survival. In this study, primary human dermal fibroblasts (HDFs) were seeded onto chitosan-based scaffolds, and then cultured for 3 weeks in a bioreactor under a cyclic strain of 1 Hz frequency. Compared to control samples cultured under static conditions, the application of a cyclic strain stimulated the proliferation of HDFs in I week, and by week 3 the thickness of the cell/scaffold composites increased 1.56 fold. Moreover, immunohistochemical staining of the culture media obtained from the cell/scaffold samples subjected to the cyclic strain, revealed increases in the expression and secretion of ECM proteins, such as fibronectin and collagen. These results suggest that the preconditioning of cell/scaffold composites with a cyclic strain may enhance the proliferation of HDFs, and even facilitate integration of the engineered artificial dermal tissue into the host graft site.

Susceptibility of rainbow trout Oncorhynchus mykiss and cherry salmon Oncorhynchus masou against Ichthyophthirius multifiliis (무지개송어와 산천어의 백점충에 대한 감수성)

  • Kim, Yi-Cheong;Kim, Jin-Do;Jee, Bo-Young;Jung, Sung-Hee;Seo, Jung-Soo;Park, Sung-Woo
    • Journal of fish pathology
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    • v.22 no.3
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    • pp.193-200
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    • 2009
  • This study was performed to natural infection of Ichthyophthirius multifiliis and mortalities of two fish species were compared at 10${^{\circ}C}$ and 17${^{\circ}C}$ after artificial infection with the parasite. Subsequently compared to motality by the artificial infection with the different parasite orgin of host at 17${^{\circ}C}$ using rainbow trout Oncorhynchus mykiss. The prevalence of Ichthyophthirius multifiliis in cherry salmon was higher than that in rainbow trout during the periods of low temperature but no difference in high temperature season. The parasite was not detectable in culturing water and detritus except May that of density has been high. Susceptibility to the parasite was higher in cherry salmon than in rainbow trout at 10${^{\circ}C}$ of water temperature but no difference between two fish species at 17${^{\circ}C}$. When rainbow trout were infected with Ichthyophthirius multifiliis from rainbow trout and cherry salmon at 17${^{\circ}C}$, there was no difference in death of host. These results suggest that cherry salmon have higher susceptibility to Ichthyophthirius multifiliis than rainbow trout at low temperature.