• The Korean Journal of Physiology
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• 제14권1호
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• pp.31-39
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• 1980

Changes in cardiac performances were observed under variations of the arterial and/or venous pressures with K-loading or K-depletion in turtle heart. Hearts were perfused with turtle Ringer-Locke's solutions containing various levels of potassium ion concentration. When venous pressure increased from 4 to 12 cm $H_2O$, cardiac output increased from $6.2{\pm}0.68$ to $15.7{\pm}0.75\;ml/min$, concomittantly. On the contrary, cardiac output decreased during the elevation of arterial pressure. Stroke work increased more prominently during the arterial pressure elevation than during the elevation of venous pressure. During K-depletion$(1{\sim}2mEq/L)$, cardiac output increased to two times that of normal K-concentration$(3{\sim}6\;mEq/L)$ group. Heart rate increased also, but less markedly. In K-loaded$(7{\sim}8\;mEq/L)$ group, both the cardiac output and heart rate decreased but stroke volume rather increased, because heart rate decrement was disproportionate to that of cardiac output. We concluded that in perfused turtle heart, cardiac output variation was more sensitive to K_depletion whereas heart rate to K-loading.

• 대한간호학회지
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• 제40권3호
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• pp.433-441
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• 2010

Purpose: This study was performed to identify effects of pneumoperitoneum on hemodynamic changes of hypertensive patients undergoing laparoscopic colectomy under general anesthesia. Methods: Data collection was done from January 2 to June 10, 2008. Seventy-six patients, including 38 hypertensive patients, who had taken antihypertensive drugs more than 1 month and 38 normotensive patients undergoing laparoscopic colectomy were enrolled in this study. The hemodynamic parameters were heart rate (HR), mean arterial pressure (MAP) and cardiac output (CO) which were measured 7 times from before induction of anesthesia to 5 min after deflation of the pneumoperitoneum. Collected data were analyzed using Repeated Measures ANOVA and Bonferroni comparison method. Results: HR in the hypertensive group was significantly decreased at deflation of the pneumoperitoneum and 5 min after deflation of the pneumoperitoneum (p=.012). MAP in the hypertensive group was not different from the normotensive group (p=.756). CO in hypertensive group was significantly lower than normotensive group (p<.001) from immediately after pneumoperitoneum to 5 min after deflation of the pneumoperitoneum. Conclusion: The results indicate that pneumoperitoneum during laparoscopic surgery does not lead to clinically negative hemodynamic changes in heart rate, mean arterial pressure or cardiac output of hypertensive patients, who have taken antihypertensive drugs for more than 1 month.

• 전기학회논문지
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• 제61권6호
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• pp.885-890
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• 2012

In this study, a new blood pressure measuring system was proposed and implemented. An additional small-cuff was placed on the center of a inner cuff to measure morphological signals and new oscillometric ratio. The proposed BP-measuring system is composed of an external cuff, an inner cuff and a small-cuff. Oscillation signal from small-cuff is interpolated with 7th-order fitting polynomials and SBP, DBP ratio were 22.2% and 87.7%. Experimental data were gathered from 20 volunteers ($25{\pm}4$ years) and arterial blood pressure values were compared with auscultation, sphygmomanometers, small-cuff and inner-cuff. As a result, the difference in systolic BP between auscultation and the small-cuff was 1.93(${\pm}1.28$) mmHg, and the inner-cuff was 4.53(${\pm}4.39$) mmHg, and sphygmomanometer was 6.68(${\pm}3.99$) mmHg, and the corresponding difference in diastolic BP was 2.50(${\pm}2.04$) mmHg, 3.50(${\pm}3.19$) mmHg, 7.35(${\pm}5.62$), respectively.

• The Korean Journal of Physiology
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• 제7권2호
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• pp.31-37
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• 1973

The effects of ethanol extacts of aconite root (Aconitum koreanum) on mean arterial pressure, heart rate, pulse pressure, and respiration were investigated and also studied the effect on electrical activation of the hypothalamus in cats. From the present experiment the following results were obtained. 1) On administering 5 mg or 10 mg aconite extracts per kg of body weight, the mean arterial blood pressure declined markedly possibly as the result of negative inotropic and chronotropic effects of aconite. 2) From the enhanced pressor responses to intravenously injected epinephrine, the existance of vasodilatory effect of the aconite was suggested. 3) After administration of aconite extract, no significant differences were observed in the presser responses to carotid occlusion and to electrical stimulation of the hypothalamus. It is, therefore, concluded that the aconite extract exerts no significant effect on the excitability of hypothalamus as well as medullary cardiovascular center of cats. 4) After administration of $5{\sim}10$ mg/kg aconite extracts, respiratory rate was increased while depth of respiration decreased. On the otherhand, respiratory rate was markedly decreased by injection of 20 mg/kg aconite into animal.

• 한국산학기술학회논문지
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• 제10권8호
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• pp.1926-1938
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• 2009

본 연구에서는 혈압 측정 시 생체 임피던스가 변화하는 현상을 이용하여 혈류량 변화를 검출하는 시스템을 구현하였다. 혈압의 측정은 오실로메트릭법을 적용하였으며, MAA 알고리즘을 이용하여 평균 동맥압을 산출한 후 평균 동맥압에 대한 여러 가지 특성비율을 설정하여 수축기 및 이완기 혈압을 추정하였다. 인체 임피던스 측정은 교류 정전류원과 락인-증폭기를 이용하였으며, 측정 부위에 인가되는 커프 압력에 의해 생체 임피던스 변화량을 이용하여 혈류량 변화를 측정하였다.

• Journal of Chest Surgery
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• 제27권9호
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• pp.770-778
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• 1994

Here analized the chest physiologic changes caused by various degrees of spontaneous pneumothorax in 77 patients admitted in Pusan National University Hospital from Jan. 1991 to Aug.1992. The results were summarized as follow: 1. There were 59 patients of primary spontaneous pneumothorax and 18 of secondary spontaneous pneumothorax. 2. The intrapleural pressure risings were paralled to the increasing sizes of pneumothorax, especiallythe intrapleural pressure changes were significant in large pneumothorax. In the secondary spontaneous pneumothoraces the intrapleural pressure were relatively higher than primary in the same sizes of pneumothorax. 3. The intensity of chest pain was paralled to the increasing sizes and intrapleural pressures of the pneumothorax, but the degrees of dyspnea had no linear interrelationship. 4. The pulse rate, cardiac output, and arterial PO2 started to change from positive intrapleural pressure, and significant changes were noted between 6 to 9 mmHg of intrapleural pressure. But the arterial PCO2 changes had no interrelationship to the degrees of pneumothorax.

• Archives of Pharmacal Research
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• 제21권4호
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• pp.370-373
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• 1998

Ten substituted phenacyl derivatives of 4-hydroxypiperidine were synthesized and studied for their effects on the mean arterial blood pressure (MABP) in normotensive anaesthetized rats and smooth muscles contractions of isolated rabbit jejunum. Two derivatives caused fall in blood pressure at the dose of 10-20 mg/kg and one rise in blood pressure at the dose of 20 mg/kg. Two compounds exhibited biphasic response (hypotensive followed by hypertensive) and one gave triphasic response at 10 mg/kg dose. Rest of four derivatives were found devoid of any effect on mean arterial blood pressure up to the dose of 30 mg/kg. All the derivatives except two caused relaxant effect on the spontaneous contraction of rabbit jejunum at the dose range of 0.1 -2 mg/kg.

• The Korean Journal of Physiology
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• 제22권2호
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• pp.231-243
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• 1988

This study was performed to investigate the mechanism of changes in arterial blood pressure, as a typical example of somatosympathetic reflex, induced by activation of muscular afferent nerves. Cats were anesthetized with ${\alpha}-chloraloae$ (60 mg/kg, i.p.). Afferent fibers in muscle nerve were activated by various method muscle contraction, electrical stimulation of muscle nerves, intraarterial injection of some algesic substances and noxious mechanical stimulation etc-and the evoked changes in arterial blood pressure were monitored. The effects of intravenous or direct spinal administration of morphine on the changes in arterial blood pressure induced by activation of the muscle afferent fibers were observed and also the effects of spinal lesions made in the $L1{\sim}L3$ spinal cord on them were studied to identify the ascending spinal pathways of the somatosympathetic reflexes. Followings are the results obtained. 1) The stimulation of medial gastrocnemius nerve under non-paralyzed condition with C-strength, low frequency (lower than 20 Hz) stimuli elicited a depressor response and a pressor response was elicited with C-strength, high frequency stimuli, of which the maximal response was observed at 100 Hz stimulation. 2) When the animal was paralyzed, depressor response to stimulation of the medial gastrocnemius nerve was observed with C-strength, $0.5{\sim}5Hz$ stimuli although the amplitude of the depressor response was decreased. The maximal pressor response was observed during stimulation with C-strength, $20{\sim}100Hz$ stimuli. 3) Intraarterial injection of some algesic substances induced marked pressor responses while noxious mechanical stimulation of the medial gastrocnemius muscle was not enough to elicit any significant changes (larger than 10 mmHg) in arterial blood pressure. 4) Systemically administered morphine (2 mg/kg) lowered the arterial blood pressure immediately and persistently and it was reversed by administration of naloxone. Direct spinally administered morphine did not elicit any changes. 5) The pressor response elicited by the activation of muscle afferent nerves was strengthened by systemic morphine administration while the depressor response tended to decrease. 6) Morphine administered on the spinal cord directly, decreased pressor response but did not change depressor response. From the above results it is concluded that there are separate groups of afferent nerves in the medial gastrocnemius nerve, which elicit pressor and depressor responses and the spinal ascending pathways of them are also separated from each other.

• 전기전자학회논문지
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• 제11권3호
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• pp.108-116
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• 2007

This paper proposed an analyzable parameter and its analytic method to provide more accurate information than currently employed 4 channels system which uses pulse wave velocity (PWV) information of the volume pulse wave measured from 4 arterial channels for the characterization of arterial vessel. In order to verify the volume pulse waves on 4 sites were simultaneously acquired subjects aged from 12 to 81 years old. and the proposed parameters were extracted from time (UT) was then compared with blood pressure. Then, the regression analyses were done relationships among the proposed parameter and others, such as aging, pulse transit time pressure (BP). The followings are the results of linear regression analysis of the proposed parameter for total 50 normal subjects. We selected any two subjects (58 years and 27 years) and measured PPG (photoplethysmogram) and BP of before and after exercise. The coefficient of correlations between BP and UT observed was -0.928 for 50 years subject, and -0.922 for 20 years subject. For total 50 normal subjects, in case of correlation between the pulse transit time and BP, the result showed -0.170 on left side and -0.233 on right side, and the coefficient value of correlation between the pulse transit time and UT was -0.607 on left side and -0.510 on right side. UI is strongly correlated with the pulse transit time than BP. Hence, we believe that the proposed parameter is related with the index of arterial stiffness.

• 한국임상수의학회지
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• 제28권1호
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• pp.40-45
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• 2011

Cardiovascular changes caused by $CO_2$ pneumoperitoneum during laparoscopic ovariohysterectomy (LOVH) were measured in nine healthy mixed breed dogs ($16.7{\pm}4.6kg$). The dogs were premedicated with the combination of atropine, acepromazine, and butorphanol. General anesthesia was induced with propofol and maintained with isoflurane in oxygen. Controlled ventilation maintained partial pressure of end-tidal $CO_2$ between 35-45 mmHg. The $CO_2$ pneumoperitoneum was maintained at a constant pressure of 12 mmHg and the dog was placed in the $15^{\circ}$ Trendelenburg position as LOVH was performed. Dorsal pedal artery was catheterized for measurements of heart rate (HR) and invasive arterial blood pressure (IBP). Prior to the intraperitoneal insufflation, baseline measurements of HR and IBP were made every minute for a total of 10 min. Then, measurements of HR and IBP were made every 5 min following intraperitoneal insufflation and were also made every 5 min following desufflation for a total of 10 min. The $CO_2$ pneumoperitoneum during LOVH resulted in a significant (P < 0.05) increase in systolic arterial blood pressure at the time of the onset of insufflation. In addition, diastolic and mean arterial blood pressure increased significantly (P < 0.05) at the time of the onset of insufflation and 5 min following insufflation. The mean heart rate did not change significantly during LOVH. Although IBP showed sharp initial rise following the $CO_2$ pneumoperitoneum, the changes were within physiological acceptable limits in these healthy, ventilated dogs.