• 생약학회지
• /
• 제43권3호
• /
• pp.217-223
• /
• 2012

In the present study, we investigated anti-inflammatory activity of artemisinic acid in HaCaT cells and RAW264.7 cells. Artemisinic acid showed inhibitory activity on macrophage-derived chemokines (MDC) expression, a factor related with atopic dermatitis (AD), in interferon (IFN)-${\gamma}$ and tumor necrosis factor (TNF)-${\alpha}$-stimulated HaCaT cells. In the study on action mechanism, pretreated artemisinic acid reduced the phosphorylation of STAT1 and p38 and the degradation of $I{\kappa}B$ by IFN-${\gamma}$ and TNF-${\alpha}$ stimulations. However, artemisinic acid didn't show the inhibitory activity on LPS-induced inflammatory mediators (NO, $PGE_2$, IL-6) in RAW264.7 cell. These results indicate that artemisinic acid inhibits IFN-${\gamma}$ and TNF-${\alpha}$-induced MDC expression through inhibition of signal factors, STAT1, NF-${\kappa}B$, and p38, in HaCaT keratinocytes.

• Applied Biological Chemistry
• /
• 제33권2호
• /
• pp.174-176
• /
• 1990

Oxidation of artemisinic acid was attempted with chromium trioxide-pyridine complex. Epi-Deoxyarteannuin B was formed almost quantitatively, while expected keto artemisinic acid was not the major product. The physical and spectral data of the product are presented(Received March 9, 1990, Accepted May 25, 1990)