• Molecular & Cellular Toxicology
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• 제4권3호
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• pp.246-252
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• 2008

Tumor tissue is usually contaminated by normal tissue components, which reduces the sensitivity of analysis for exploring genetic alterations. Although microdissection has been adopted to minimize the contamination of tumor DNA with normal cell components, there is a concern over the amount of microdissected DNA not enough to be applied to array-CGH reaction. To amplify the extracted DNA, several whole genome amplification (WGA) methods have been developed, but objective comparison of the array-CGH outputs using different types of WGA methods is still scarce. In this study, we compared the performance of non-amplified microdissected DNA and DNA amplified in 2 WGA methods such as degenerative oligonucleotide primed (DOP)-PCR, and multiple strand displacement amplification (MDA) using Phi 29 DNA polymerase. Genomic DNA was also used to make a comparison. We applied those 4 DNAs to whole genome BAC array to compare the false positive detection rate (FPDR) and sensitivity in detecting copy number alterations under the same hybridization condition. As a result microdissected DNA method showed the lowest FPDR and the highest sensitivity. Among WGA methods, DOP-PCR amplified DNA showed better sensitivity but similar FPDR to MDA-amplified method. These results demonstrate the advantage and applicability of microdissection for array-CGH analysis, and provide useful information for choosing amplification methods to study copy number alterations, especially based on precancerous and microscopically invaded lesions.

• 한국통신학회논문지
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• 제21권12호
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• pp.3205-3214
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• 1996

In this paper, the microstrip phased array antennas with coupling-slots for the base station of mobile communication is proposed and anlyzed with accurate analysis method which is based on both reciprocity principle and full-wave analysis. The basis functions used for the numerical analysis are determined depending upon the accuracy, convergence properties of the solution, and the computation time. The patch uses 3 EB mode and the slot uses IPWS mode. The designed phased array antenna has 8 slot-coupled microstrip patch array elements and the beam scanning capability is obtained by using the 4-bit PIN-diode phase shifters as switching devices which are consisted of the loaded line phase shifters for 30.deg. and 60.deg. and the reflection type phase shifters for 90.deg. and 180.deg. repectively. The 4-bits phase shifters which aremade by connecting each phase shifter have about 2.deg.-3.deg. phase errors and their insertion loss are about 3dB for each phase state. The fabricated 8-element phased array antenna with 4-bits phase shifters provides 12.deg.-14.deg. beamwidths depending on the scanning angle and is capable of scanning its beam to .+-.45.deg. with 9.deg. intervals, and the gain 12dBi. The overall results show that the slot-coupled phased array antenna has great advantages of wideband, high gain and reduced spurious radiation. Also, the antenna can be made small and thin. Furthermore, the scanning property of this antenna allows for its application in several areas, such as mobile communication system and PCS.

• 한국항공우주학회지
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• 제42권12호
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• pp.1057-1064
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• 2014

정지궤도위성은 다수의 탑재체를 하나의 위성체 플랫폼에 탑재하고 2010년 6월 26일에 발사되었다. 태양기간 동안 인공위성에서 요구되는 전력은 태양전지 배열기 윙에서 생성된다. 태양전지는 Spectrolab사의 적층법을 사용한 RWE Space사의 Gaget 2로 명명되는 GaInP/GaAs/Ge 3중 접합 셀이다. 본 논문은 정지궤도 비행 데이터에 대한 경향을 분석한 결과를 바탕으로 설계수명 말기에서 태양전지 배열기의 전력 성능을 평가하였다. 설계수명 말기에서 예측한 태양전지 배열기의 전력 성능은 태양전지 배열기 제작사가 제공한 전력 성능과 비교하였다. 경향분석 결과를 통해 태양전지 셀은 현저한 성능감소 없이 정상적으로 동작되고 있다.

• 융합정보논문지
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• 제10권7호
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• pp.138-146
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• 2020

본 논문은 다양한 설계하중조건 상태에서 자동채염기 구조설계의 성능분석과 개선을 위해 실험계획법을 이용한 설계민감도 평가와 대리모델의 특성에 대한 비교연구를 수행하였다. 실험계획법은 수치해석 기반의 직교배열설계 방법을 이용하였다. 설계인자는 주요 구조부재의 두께치수 변수를 고려하였고, 응답치는 중량과 강도성능을 선정하였다. 직교배열실험을 통해 설계인자 별 응답치에 대한 정량적인 영향도를 분석하였다. 또한 최소의 중량증감으로 구조성능을 개선할 수 있는 최적의 설계조건을 탐색하였다. 직교배열실험 결과를 이용하여 반응표면모델, 크리깅모델, 그리고 체비쇼프 직교 다항식과 같은 다양한 대리모델을 생성하였다. 대리모델의 결과를 통해 직교배열실험 결과의 타당성을 검증하였다. 자동채염기 구조설계 공간 탐색에는 반응표면모델이 가장 적합한 대리모델로 평가되었다.

• 대한전기학회논문지:전력기술부문A
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• 제54권3호
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• pp.107-116
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• 2005

The paper addresses modeling and analysis of a grid-connected photovoltaic generation system (PV system). PSCAD/EMTDC, an industry standard simulation tool for studying the transient behavior of electric power system and apparatus, is used to conduct all aspects of model implementation and to carry out extensive simulation study. This paper is aimed at sharing with the PSCAD/EMTDC user community our user-defined model for PV system applications, which is not yet available as a standard model within PSCAD/EMTDC. An equivalent circuit model of a solar cell has been used for modeling solar array. A series of parameters required for array modeling have been estimated from general specification data of a solar module. A PWM voltage source inverter (VSI) and its current control scheme have been implemented. A maximum power point tracking (MPPT) technique is employed for drawing the maximum available energy from the PV array. Comprehensive simulation results are presented to examine PV array behaviors and PV system control performance in response to irradiation changes. In addition, dynamic responses of PV array and system to network fault conditions are simulated and analysed.

• 한국정보전자통신기술학회논문지
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• 제3권2호
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• pp.31-38
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• 2010

PBG 구조의 메타물질 설계시 패턴 형태와 배열 구조에 따른 금지대역(bandgap)을 정확하게 설계하기 어려운 문제가 있다. 본 논문에서는 2차원 배열구조로 어떤 모양의 패턴에 대해서도 빠르고 정확하게 원하는 금지대역을 설계할 수 있는 방법을 제안한다. 2차원 평면상의 메타물질 구조는 주기배열로 이루어져 있기 때문에 FDTD 수치해석 방법에 주기경계조건을 부여함으로서 계산영역을 줄였다. 또한 각 패턴이 갖는 L, C 값을 2차원적으로 고려하여 계산하였기 때문에 보다 정확한 설계가 가능하였다. 5GHz 대역에서 정사각형 패턴을 갖는 메타물질을 설계하여 기존의 마이크로스트립 선로를 이용한 1차원 메타물질 해석 값과 비교하였을 때 정확도가 평균적으로 14.7% 향상됨을 확인할 수 있었다.

• Journal of Power Electronics
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• 제18권5호
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• pp.1489-1500
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• 2018

Partial shading analysis of large-scale photovoltaic (PV) arrays has recently become a theoretically and numerically challenging issue, and it is necessary for PV system designers. The main contributions of this study are the following: 1) A PSIM-based macro-model was employed because it is remarkably fast, has high precision, and has no convergence issues. 2) Three types of equivalent macro-models were developed for the transformation of a small PV sub-array with uniform irradiance to a new macro-model. 3) On the basis of the proposed new macro-model, a tearing method was established, which can divide a large-scale PV array into several small sub-arrays to significantly improve the efficiency improvement of a simulation. 4) Three platforms, namely, PSIM, PSpice, and MATLAB, were applied to evaluate the proposed tearing method. The proposed models and methods were validated, and the value of this research was highlighted using an actual large-scale PV array with 2420 PV modules. Numerical simulation demonstrated that the tearing method can remarkably improve the simulation efficiency by approximately thousands of times, and the method obtained a precision of nearly 6.5%. It can provide a useful tool to design the optimal configuration of a PV array with a given shading pattern as much as possible.

• 한국소음진동공학회논문집
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• 제19권9호
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• pp.922-927
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• 2009

The transducers used in active sonar on surface ships are packed in a specific geometry in the array drum in order to meet the requirements such as the source level, directional beam pattern, etc. This paper describes the acoustic characteristics of the cylindrical array which is based on a 64 vertical staves arrangement, each stave composed 5 independent transducers. Firstly, the single transducer on the rigid baffle in the water is analyzed with the Finite Element Method. From the result of the FE analysis nodal velocities on the radiation surface is calculated and used with the boundary conditions of the transducers mounted on the array drum. Then the acoustic pressure is calculated in the field points using the Boundary Element Method and the other acoustic informations, the source level, beam pattern, near field and far-field distance, were acquired.

• 한국산업보건학회지
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• 제20권1호
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• pp.29-40
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• 2010

This study was aimed at investigating the gene expression profile in basal ganglia of cadmium exposed rat based on cDNA array analysis. For cDNA array analysis, adult Sprague-Dawley male rats (350 ${\pm}$ 25 g) were intraperitoneally injected with 2.0 mg/kg body weight/day of CdCl2 (0.3 ml) for 5 days. For doserelated gene expression analysis rats were intraperitoneally injected with 0.0, 0.1, 0.3, 1.0 mg/kg body weight/day of CdCl$_2$ for 5 days. Control rats were injected with equal volume of saline. Cadmium concentration of brain was analyzed by atomic absorption spectrophotometer. For cDNA array, RNA samples were extracted from basal ganglia and reverse-transcribed in the presence of [${\alpha}$32P]-dATP. Membrane sets of the Atlas Rat 1.2 array II and Toxicology array 1.2 (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. RT-PCR was employed to validate the relative gene expression patterns obtained from the cDNA array. Northern blot hybridization methods were employed to assess the dose-related gene expression. Among the 2352 cDNAs, 671 genes were detected in both array sets and 63 genes of 38 classes showed significant (more than two fold) changes in expression. Thirty five of these genes were up-regulated and twenty eight were down-regulated in the cadmium exposed group. According to the dose-related gene expression analysis, heat shock 27 kDa protein (HSP27), neurodegeneration-associated protein 1 (Neurodap 1) genes were significantly up-regulated and melatonin receptor 1a (Mel1a), Kinesin family member 3C (KIF3C), novel kinesinrelated protein (KIF1D) genes were significantly downregulated even in the low-dose of cadmium exposed group (0.1 mg/kg body weight/day). Conclusions Sixty three genes detected in this study can give some more useful informations about the cadmium-induced neurotoxicity in the basal ganglia. As well as, HSP27, Neurodap1, Mel1a, KIF3C and KIF1D genes may be useful for the study of the cadmium-induced neurotoxicity because these genes showed dramatic changes of mRNA levels in response to the low dose of cadmium exposure.

• 한국유체기계학회 논문집
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• 제16권6호
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• pp.40-47
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• 2013

In this paper, a numerical study was performed to investigate the performance characteristics of a pre-heater. The effects of fin pitch and fin array type(in-line, staggered, leaned array) were reported in terms of Colburn j-factor and Fanning friction factor f, as a function of Re. Three-dimensional numerical simulation has been performed by using flow analysis program, FLUENT 13.0. The results show that Colburn j-factor decreases with the decrease of fin pitch attached in the annular tube. But the fin pitch has little effect on f-factor. The staggered array and leaned array show improved heat transfer performance compared with in-line array, so that Colburn j-factor was increased. It also shows that the f-factor of leaned array is the highest in the studied range of Reynolds number.