• Genomics & Informatics
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• v.2 no.4
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• pp.174-179
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• 2004

We developed various plasmid cloning vectors that are useful in the construction of genomic and shotgun libraries. Two medium copy vectors, pCUGlblu21 (pCb21) and pAGlblu21 (pAb21), which are resistant to kanamycin ($Km^R$) and chloramphenicol ($Cam^R$), respectively, are useful for cloning DNA inserts ranging from 5kb to 15kb. Two high copy vectors, pCUGlblu31 (pCb31) and pAGlblu31 (pAb31), containing $Km^R$ and $Cam^R$, respectively, are useful for DNA inserts less than 5kb. These vectors are well adapted for large-scale genome sequencing projects by providing choice of copy number and selectable marker. The small vector size is another advantage of these vectors. All vectors contain lacZa including multicloning sites that originated from pBluscriptllsk- for easy cloning and sequencing. Two medium copy vectors contain unique and rare cutting Swal (ATTTAAAT) restriction enzyme sites for easy determination of insert size. We developed two combined vectors, pC21A31 and pC31A21, which are combinations of (pCb21 + pAb31) and (pCb31 + pAb21), respectively. These two vectors provide four choices of vectors such as $Km^R$ and medium, $Cam^R$ and high, $Cam^R$ and medium, and $Km^R$ and high copy vectors by restriction enzyme cutting, dephosphorylation, and gel purification. These vectors were successfully applied to high throughput shotgun sequencing of rice, tomato, and brassica BAC clones. With an example of extremely biased hydro sheared 3 kb shotgun library of a tomato BAC clone, which is originated from cytogenetically defined peri-centromeric region, we suggest the utility of an additional 10 kb library for sequence assembly of the difficult-to-assemble BAC clone.

• World Technopolis Review
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• v.4 no.2
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• pp.79-86
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• 2015

Over the last two decades, interest increased with regard to how some research universities made direct impacts on surrounding regional economic activities and growth. Although the role of basic research for most research universities has remained strong, pressure has intensified to broaden its missions to include helping local and regional economic development efforts. Consequently, many research universities have evolved their basic scientific research mission from the production of scientific knowledge to the sharing and exchange of knowledge with local industries by actively engaging in local economic development (Uyarra 2010). Previous examination has shown that most research universities contribute to local and regional economic development by various functions they provide. They are as follows: Creation of Knowledge, Human-capital creation, Transfer of existing know-how, Technological innovation, Capital investment, Regional leadership, Knowledge infrastructure production and Influence in regional milieu (Drucker and Goldstein 2007). This paper will review the existing literature on the role of universities and its impacts on local regional economic growth and development. In addition, this paper will show how two major research universities (The University of Arizona and Arizona State University) have contributed to the growth of Arizona during last two decades. It is believed that the existence of these two research universities have been instrumental in making industries more diverse and highly attractive, particularly in the Phoenix Metropolitan Area.

• Molecules and Cells
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• v.46 no.3
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• pp.165-175
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• 2023

The transcription factor Nrf2 was originally identified as a master regulator of redox homeostasis, as it governs the expression of a battery of genes involved in mitigating oxidative and electrophilic stress. However, the central role of Nrf2 in dictating multiple facets of the cellular stress response has defined the Nrf2 pathway as a general mediator of cell survival. Recent studies have indicated that Nrf2 regulates the expression of genes controlling ferroptosis, an iron-and lipid peroxidation-dependent form of cell death. While Nrf2 was initially thought to have anti-ferroptotic function primarily through regulation of the antioxidant response, accumulating evidence has indicated that Nrf2 also exerts anti-ferroptotic effects via regulation of key aspects of iron and lipid metabolism. In this review, we will explore the emerging role of Nrf2 in mediating iron homeostasis and lipid peroxidation, where several Nrf2 target genes have been identified that encode critical proteins involved in these pathways. A better understanding of the mechanistic relationship between Nrf2 and ferroptosis, including how genetic and/or pharmacological manipulation of Nrf2 affect the ferroptotic response, should facilitate the development of new therapies that can be used to treat ferroptosis-associated diseases.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.41.2-41.2
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• 2015

Steward Observatory has a rich and diverse program of investigations, with significant groups working on star and planet formation and astrobiology, galaxy and quasar formation and evolution, technology for adaptive optics and interferometry, computational astrophysics, and effectiveness of educational practice. To support this work, Steward operates and offers a range of observational and other facilities, including the Large Binocular Telescope, the MMT, the Magellan Telescopes, the Arizona Radio Observatory, and a suite of 1- and 2-m class telescopes. A special opportunity for IR astronomy exists with Arizona now running UKIRT. Steward Observatory astronomers would welcome the opportunity to form genuine scientific collaborations that are mutually beneficial for high-impact projects and improving the observing facilities.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.35-41
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• 2003

Rock mass characterization is an integral part of rock engineering design. Much of the information for rock mass characterization comes from field fracture mapping and data collecting. This paper describes two technologies that can be used to assist with the field mapping and data collecting activities associated with rock mass characterization: digital image processing and 3D laserscanning. The basis for these techniques is described, as well as the results of field case studies and an analysis of the error in estimating fracture orientation.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.70.2-70.2
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• 2015

Scientific collaborations and observational programs have been on-going between astronomers in Korea and the Steward Observatory/University of Arizona. I will present such existing collaboration models/examples between research groups or individuals and astronomers in KASI or in other institutions and universities in Korea. Building on existing collaborations we would like to further develop opportunities for future scientific collaborations and encourage scholarly exchanges between students, researchers, and faculty members in Korea and Steward Observatory/University of Arizona. In this talk I will also discuss current status of observational programs of Korean astronomers using U of A facilities (MMT and Magellan), as well as successful collaboration examples between Steward Observatory and astronomical institutions in other countries.

• Transactions on Electrical and Electronic Materials
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• v.8 no.1
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• pp.15-20
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• 2007

Conditioner wear, copper polish rates, pad temperature and coefficient of friction (COF) are measured for two novel Mitsubishi Materials Corporation designs during an extended wear and polishing test. Both designs are coated with a $Teflon^{TM}$ film to reduce substrate wear and chemical attack. Using optical interferometry, changes in the coating that result in gradual changes in diamond exposure are measured. Theories of the COF, conditioning, and polishing are applied to explain the observed performance differences between the designs.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10a
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• pp.431-441
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• 1991

A robust H$_{\infty}$ control design methodology and its application to a Space Station attitude and momentum control problem are presented. This new approach incorporates nonlinear multi-parameter variations in the state-space formulation of H$_{\infty}$ control theory. An application of this robust H$_{\infty}$ control synthesis technique to the Space Station control problem yields a remarkable result in stability robustness with respect to the moments-of-inertia variation of about 73% in one of the structured uncertainty directions. The performance and stability of this new robust H$_{\infty}$ controller for the Space Station are compared to those of other controllers designed using a standard linear-quadratic-regulator synthesis technique.que.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.72.1-72.1
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• 2010

We present infrared and millimeter observations of the active star-forming complex W51. A $1.25\;deg\times1.00\;deg$ region that includes the W51 complex was covered in the J = 2 - 1 transition of the $^{12}CO$ and $^{13}CO$ molecules with the University of Arizona Heinrich Hertz Submillimeter Telescope. We use a statistical equilibrium code to estimate physical properties of the molecular gas. Using Spitzer data we identify young stellar objects (YSOs) and fit model spectral energy distributions to these sources and constrain their physical properties. We compare the molecular cloud morphology with the distribution of infrared and radio continuum sources and find associations between molecular clouds and YSOs. We estimate that about 1% of the cloud mass is currently in YSOs.

• 한국도로학회:학술대회논문집
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• 2004.10a
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• pp.67-73
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• 2004