• 한국임상약학회지
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• 제7권1호
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• pp.45-49
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• 1997

The effect of the light on the stability of 5-fluorouracil admixture was investigated. Four sets of 5-fluorouracil admixture were prepared using 50 mg/ml injection in $5\%$ dextrose solution in PVC bags and glass bottles: (1) 5-fluorouracil 1 mg/ml concentration in glass bottles, (2) 5-fluorouracil 1 mg/ml in PVC bags, (3) 5-fluorouracil 10 mg/ml in glass bottles, and (4) 5-fluorouracil 10 mg/ml in PVC bags. In each set, one group was protected from the light (control group) and the other group was exposed to the fluorescent light (study group). All admixtures were stored at room temperature for 72 hours. Also, 5-fluorouracil injections (50 mg/ml) were prepared in plastic syringes. Half of the samples of 50 mg/ml concentration were protected from the light (control group) and the other half were exposed to the fluorescent light (study group). These were stored at room temperature for 48 hours. After visual inspection, the pHs of each admixture were determined. The 5-fluorouracil concentrations were measured by high-performance liquid chromatography with UV detection, with 5-bromouracil as an internal standard. Over the study period, no visual changes were observed. The pHs of 5-fluorouracil admixtures were in the range of $8.2\~8.5$. The peak area ratios (5-FU/5-BrU) of 5-fluorouracil admixtures protected from the light were compared with those of the admixtures exposed to the light. There was no statistically significant difference between two groups during the study period (p>0.05). In conclusion, 5-fluorouracil admixtures in $5\%$ dextrose solution exposed to the light were stable for 72 hours.

• 한국임상약학회지
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• 제7권1호
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• pp.17-21
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• 1997

Cefaclor is a second generation cephalosporin antibiotic that shows a potent antibacterial activity against both Gram-positive and Gram-negative bacteria, when it is orally administered. Due to its patent expiration, a number of generic drugs have been marketed, but not yet elucidated to ensure therapeutic equivalence. In this study, cefaclor capsules manufactured by Chong Kun Dang were bioequivallently assessed by comparing with $Ceclor^{TM}$ introduced originally by Daewoong Lilly. A total of 16 healthy male volunteers were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of cefaclor in plasma were measured upto 6 hours following a single oral administration of two capsules (500 mg of cefaclor) by high-performance liquid chromatography with UV detection. Although the plasma concentration at 6 hours was not detected, the computed half-life of cefaclor was approximately 0.5 hours. The area under the concentration-vs-time curve from 0 to 4 hours $(AUC_{0-4h})$ was calculated by the trapezoidal summation method. The differences in mean values of $AUC_{0-4h}$, peak plasma concentration $(C_{max})$, and time to peak concentration $(T_{max})$ between the two products were $4.63\%,\;1.84\%,\;and\3.28\%$, respectively. The least significant differences at $\alpha4= 0.05 for $AUC_{0-4h},\;C_{max},\;and\;T_{max}\;were\;6,53\%,\;4.05\%,\;and\;6.47\%$, respectively. In conclusion, the test drug was bioequivalent with the reference drug.

• 한국지하수토양환경학회지:지하수토양환경
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• 제16권4호
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• pp.23-30
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• 2011

Risk based pollution level of Pb and Cd in metal contaminated soils depending on physicochemical properties of soil in a target site was assessed using biotic ligand model. Heavy metal activity in soil solution defined as exposure activity (EA) was assumed to be toxic to Vibrio fischeri and soil organisms. Predicted effective activity (PEA) determined by biotic ligand model was compared to EA value to calculate risk quotient. Field contaminated soils (n = 10) were collected from a formes area and their risk based pollution levels were assessed in the present study using the calculated risk quotient. Concentrations of Pb determined by aqua regia were 295, 258, and 268 mg/kg in B, H and J points and concentrations of Cd were 4.73 and 6.36 mg/kg in G and I points, respectively. These points exceeded the current soil conservation standards. However, risk based pollution levels of the ten points were not able to be calculated because concentrations of Pb and Cd in soil solution were smaller than detection limits or one (i.e., non toxic). It was because heavy metal activity in soil solution was dominant toxicological form to organisms, not a total heavy metal concentration in soil. In addition, heavy metal toxicity was decreased by competition effect of major cations and formation of complex with dissolved organic carbon in soil solution. Therefore, it is essential to consider site-specific factors affecting bioavailability and toxicity for estimating reliable risk of Pb and Cd.

• Journal of Oral Medicine and Pain
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• 제21권1호
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• pp.37-54
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• 1996

In this thesis, a new superimposition scheme using a computer vision system was proposed with 7 pairs of skull and ante-mortem photographs, which were already identified through other tests and DNA fingerprints at the Korea National Institute of Scientific Investigation. At this computer vision system, an unidentified skull was caught by video-camcoder with the MPEG and a ante-mortem photograph was scanned by scanner. These two images were processed and superimposed using pixel processing. Recognition of the individual identification by anatomical references was performed on the two superimposed images. These results were as followings. 1. For the enhancement of skull and ante-mortem photographs, various image processing schemes, such as SMOOTH, SHARPEN, EMBOSS, MOSAIC, ENGRAVE, INVERT, NEON and COLOR TO MONO, were applied using 3*5 window processing. As an image processing result of these methods, the optimal techniques were NEON, INVERT and ENGRAVE for the edge detection of skull and ante-mortem photograph. 2. Using various superimposition image processing techniques (SRCOR, SRCAND, SRCINVERT, SRCERASE, DSTINVERT, MERGEPAINT) were compared for the enhancement of image recognition. 3. By means of the video camera, the skull image was inputed directly to a computer system : superimposing it on the ante-mortem photograph made the identification more precise and time-saving. As mentioned above, this image processing techniques for the superimposition of skull and ante-mortem photographs simply used the previous approach, In other wrods, taking skull photographs and developing it to the same size as the ante-mortem photographs. This system using various image processing techniques on computer screen, a more precise and time-saving superimposition technique could be able to be applied in the area of individual identification in forensic practice.

• 한국전자파학회논문지
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• 제29권7호
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• pp.523-531
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• 2018

본 논문에서는 항공기 기반 단일채널 FMCW-SAR(frequency modulated continuous wave - synthetic aperture radar) 복원영상 내 이동물체 분석을 위해 합성개구레이다의 모호성 함수(SAR ambiguity function)를 이용한 상대속도 분석기법에 대해 설명한다. 안테나와 이동물체 간의 상대속도 변화를 분석하기 위해서 FMCW 신호모델 기반 정지 이동물체 간 신호변환특성을 분석하고, 이동물체의 변환특성을 고려한 모호성 함수를 모의실험하였다. 복원영상 내 이동물체의 상대속도 변화는 도식화된 모호성 함수의 최고점으로부터 추정될 수 있으며, 상대속도의 변화가 클수록 정지 이동물체 구분이 가능하게 된다. 이를 실제 항공기 기반 관측 자료로부터 복원된 FMCW-SAR 영상에 적용하여 모호성 함수를 이용한 이동물체 식별과 상대속도 분석결과를 관측지역 내 실험조건과 비교분석하였다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2014년도 춘계학술대회
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• pp.79-80
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• 2014

우리나라에서 해양오염사고는 일반적으로 선박에 의한 유출유에 기인한다. 2014년 1월 31일 여수에서 그리고 2월 15일 부산에서 해양오염사고가 발생하였다. 일반적으로 해상에서의 기름 배출 감시 및 유출유 모니터링에는 합성개구레이더가 이용되고 있다. 따라서 2013년 발사된 다목적실용위성-5호(KOMPSAT-5)가 정상 운영되는 시점에서는 그 활용성이 기대된다. 지난 오염사고 당시에는 다목적실용위성-3호 등 고해상도 광학위성이 관측되었다. 본 발표에서는 유출유의 광학적 특성을 기반으로 한 해석을 수행하고, 유출 해역 산정을 이루어졌다. 마지막으로 우리나라의 해양오염 감시와 대응을 위한 원격탐사기술의 역할과 방향에 대한 설명을 하고자 한다.

• 한국정보통신학회논문지
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• 제22권5호
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• pp.772-778
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• 2018

컴퓨팅, 통신, 그리고 미세 전자기계 기술의 최근 발달로 인하여 무선 센서 네트워크 응용들이 군사용으로부터 물체 추적, 화재 탐지, 그리고 차량 센서 네트워크와 같은 많은 상업적인 분야로 확산되고 있다. 어떤 응용들에서는 WSNs를 구성하고 있는 센서 노드들이 모니터링 지역에서 생산한 버스티한 데이터를 최종 목적지인 싱크 노드까지 제한된 시간 내에 전달해야 하는 경우가 있다. 본 논문에서는 제한된 시간 내에 버스티 패킷을 전달해야 하는 응용에 적합한 BTF-MAC을 제안한다. BTF-MAC 프로토콜은 동기식 듀티 사이클 MAC 프로토콜이며, 슬롯 예약 및 데이터 트래픽에 적응적으로 동작 구간을 확대하는 메커니즘을 가진다. 성능 분석 결과 BTF-MAC 프로토콜이 관련 프로토콜인 DW-MAC이나 SR-MAC 등에 비해 에너지 소모나 전송지연 비교에서 훨씬 우수한 결과를 보여준다.

• 한국전자거래학회지
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• 제16권3호
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• pp.249-261
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• 2011

e-Business 시장의 폭발적 성장으로 기존의 오프라인 기업들이 e-Business 시장으로 진입하게 되었으며, 이는 e-Business 시장의 과도한 경쟁을 야기 시켰다. 이에 기업들은 키워드 광고, 이메일 광고, 배너 광고 등의 온라인 마케팅에 대한 투자를 확대하고 있다. 그러나 기존의 온라인 마케팅 방법들은 방문자를 사이트로 유입시키는 데에만 초점을 맞추고 있으며, 방문자들이 사이트로 유입 후 구매로 전환시키기 위한 방법을 제시하지 못함으로써 마케팅의 투자 대비 효과는 점점 감소하고 있다. 본 논문에서는 사이트에 유입된 방문자를 대상으로 전환율을 높임으로써 마케팅의 효과를 높일 수 있는 실시간 온라인 마케팅 시스템 (ROMS: Realtime Online Marketing System)을 제안하고 개발하였다. ROMS는 방문자 행동을 실시간으로 수집하여 방문자 행동을 분석함으로써 방문자의 정보 및 행동을 실시간으로 모니터링 할 수 있으며, 방문자의 컨텍스트 특성에 따라 개인화된 마케팅을 수행할 수 있다.

• Clinical and Experimental Pediatrics
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• 제61권1호
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• pp.24-29
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• 2018

Purpose: The aim of this study was to evaluate the diagnostic accuracy of urinary biomarkers, such as neutrophil gelatinase-associated lipocalin (uNGAL) and ${\beta}-2$ microglobulin (uB2MG), in early detection of urinary tract infection (UTI) in infants aged <3 months with fever. Methods: A total of 422 infants aged <3 months (male:female=267:155; mean age, 56.4 days), who were admitted for fever, were retrospectively included in this study. We compared uNGAL and uB2MG between the UTI and non-UTI groups at the time of admission. The sensitivity, specificity, accuracy, and area under the curve (AUC) of uNGAL and uB2MG for use in diagnosing UTI were assessed. Results: Among 422 patients, 102 (24.2%) were diagnosed with UTI. Levels of uNGAL were higher in the UTI group than in the non-UTI group (366.6 ng/mL vs. 26.9 ng/mL, P<0.001). Levels of uB2MG were not different between the 2 groups. Multivariate analysis revealed that uNGAL was an independent predictive factor for UTI (P=0.033). The sensitivity, specificity, and accuracy were 90.2%, 92.5%, and 91.9% for uNGAL, and 48.0%, 43.8%, and 44.8% for uB2MG, respectively. AUC of uNGAL was 0.942 and that of uB2MG was 0.407. Conclusion: Accuracy of uNGAL in the diagnosis of UTI is high in febrile infants aged <3 months. uNGAL can help in the early diagnosis and treatment of UTI in infants.

• 대한원격탐사학회지
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• 제30권4호
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• pp.465-480
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• 2014

본 연구에서는 최근 발생한 집중호우 사례들 중 예보가 어려워 피해가 컸던 두 사례(2010년 9월 21일, 2011년 8월 9일)에 대해 적외영상과 수증기영상의 시 공간적인 변화 특성을 분석하였다. 두 사례에서 한반도지역에 집중호우를 유발한 대류 세포들은 적외영상에서 하층운이 광범위하게 분포하고 수증기 영상에서는 명역과 암역의 경계(boundary)에서 생성되는 특징을 보였다. 또한 대류 세포들의 이동속도 차에 의한 총 5번의 병합과정 중 4번의 병합과정에서 대류 세포들의 병합 후 대류 세포는 더욱 발달되었으며 강수 강도도 급격하게 강화되었다. 대류시스템에서의 강우강도 변화는 휘도온도의 평균보다 최소 휘도온도의 시간적 변화와 밀접하게 관련된 것으로 판단되며 대류 세포들의 병합도 집중호우의 강도 변화에 영향을 주는 주요 인자로 생각된다. 대류 세포들의 병합은 영상동화를 통해 어느 정도 예측이 가능하지만 대류 세포의 탐지는 적외 및 수증기 영상 모두에서 일정 강도 이상 발달한 상태에서만 탐지가 가능하였다.