• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7941-7945
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• 2014

Catechol-O-methyltransferase (COMT) is involved in estrogen metabolism and is vital to estrogen-induced carcinogenesis, including that of ovarian cancer. Although many recent epidemiologic studies have investigated associations between the COMT rs4680 polymorphism and ovarian cancer risk, the results remain inconclusive. We therefore performed a meta-analysis to derive a more precise estimate of associations. Systematic searches of the PubMed, Embase, Web of Science, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and Chinese Biomedicine databases were undertaken to retrieve eligible studies. Odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were pooled to assess the strength of the association. In total, 8 case-control studies involving 1,293 cases and 2,647 controls were included in the meta-analysis. Overall, the results showed no evidence of significant association between the COMT rs4680 polymorphism and ovarian cancer risk in any of the assessed genetic models. Subgroup analyses by ethnicity also did not reveal any significant association in any genetic model (p>0.05). In conclusion, our findings suggest that the COMT rs4680 polymorphism may not contribute to the risk of ovarian cancer.

• Journal of Dental Rehabilitation and Applied Science
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• v.33 no.2
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• pp.80-87
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• 2017

Purpose: The aim of this study was to assess the physical properties of a novel resin-based endodontic sealer, Any-Seal, in comparison with AH Plus Jet. Materials and Methods: Flow, radiopacity and compressive strength were examined according to ISO 6876/2001. For flow test, 0.05 mL of sealer was placed between glass plate and 100 g weight were applied. Ten minutes after mixing the sealers, the load was removed and the diameters of the compressed sealer discs were measured. For radiopacity, 10 mm diameter and 1 mm thickness sample were fabricated and took radiograph with an aluminum step-wedge and analyzed using imaging program. For compressive strength test, $4mm{\times}6mm$ cylindrical specimen was fabricated and tested after 24 hours and 1 week using Universal testing machine. Results: Both tested sealers were consistent with ISO 6876/2001 in the flow and radiopacity test. The flow values of both sealers were not significantly different (P > 0.05). AH Plus Jet had significantly higher radiopacity (P < 0.05). AH Plus Jet showed higher compressive strength at both time intervals (P < 0.05). Conclusion: Any-Seal showed low compressive strength until after 1 week, so its physical and biological aspect should be evaluated more before clinical use.

• Journal of Educational Research in Mathematics
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• v.8 no.1
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• pp.217-235
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• 1998

The purpose of this study is to define the altenative assessment and to suggest the method of scoring system. Alternative assessment includes any type of assessment in which student create reponses to a question rather than choosing a responses form given list( as for multiple choice, true/false, or matching). Alternative assessment can includes short answer questions, essay, performances, oral presentation, demonstrations, exhibitions, portfolios, and etc. To evaluate the each type of assessment, we can apply the method of holistic scoring and analytic scoring system. Also we have to concern the type of scoring mechanism directly relate to what we want to assess, our purpose for assessment fitting into the educational enterprise. Before applying the alternative assessment in our classroom, we need to step back and reconsider all our design features and teachers' responsibility.

• Asian-Australasian Journal of Animal Sciences
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• v.3 no.4
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• pp.337-341
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• 1990

An investigation was conducted to determine whether the rumen modifiers lasalocid and avoparcin, when included in molasses/urea based supplements, enhanced liveweight performance, in early weaned calves. As part of the study the broad-spectrum parasiticle Avermectin B1 was given to the calves to assess any undesirable side effects on animals of less than four months of age. There were no significant (p>0.05) liveweight responses to supplementation when the rumen modifiers lasalocid and avoparcin were included in supplement rations. Lasalocid reduced supplement intake, however, it had no adverse effect on liveweight gain. Avoparcin substantially improved growth when cottonseed meal was included in the ration. Weaners treated with Avermectin B1 tended to show a greater liveweight gain than untreated weaners during the experiment (p<0.10) and no adverse side effects were noted.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.181-184
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• 2004

There are reports showing that electromagnetic fields (EMFs) emitted at non-thermal levels may be associated with biological alterations in target cells. In this study it is objected to assess the potential influences of EMFs produced by cellular phones on fetal heart rate. Non Stress Test (NST) is a widely used method of fetal monitoring and assessing fetal health and well-being. Sixty volunteers with uncomplicated term pregnancies were studied by a Spacelabs AM-67 Doppler ultrasound monitor. Fetal Heart Rate recordings were obtained while there were no Cellular Phone around for 10 minutes. Afterwards, all patients were exposed to EMFs for 10 minutes. NST was performed while they were holding the CP on stand-by mode and then on dialing mode, each for 5 minutes. The recordings were analyzed with respect to baseline heart rate, accelerations and decelerations. The Wilcoxon matched-pairs signed-ranks test was used to compare these variables. The results indicate that EMFs emitted by CP do not cause any demonstrable effects on baseline FHR, acceleration or deceleration.

• Structural Engineering and Mechanics
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• v.53 no.4
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• pp.745-765
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• 2015

A nonlinear Finite Element (FE) algorithm is proposed to analyze the Reinforced Concrete (RC) columns subjected to Cyclic Loading (CL), Cyclic Oriented Lateral Force and Axial Loading (COLFAL), Monotonic Loading (ML) or Oriented Pushover Force and Axial Loading (OPFAL) in any direction. In the proposed algorithm, the following parameters are considered: uniaxial behavior of concrete and steel elements, the pseudo-plastic hinge produced in the critical sections, and global behavior of RC columns. In the proposed numerical simulation, the column is discretized into two Macro-Elements (ME) located between the pseudo-plastic hinges at critical sections and the inflection point. The critical sections are discretized into Fixed Rectangular Finite Elements (FRFE) in general cases of CL, COLFAL or ML and are discretized into Variable Oblique Finite Elements (VOFE) in the particular cases of ML or OPFAL. For pushover particular case, a fairly fast converging and properly accurate nonlinear simulation method is proposed to assess the behavior of RC columns. The proposed algorithm has been validated by the results of tests carried out on full-scale RC columns.

• Toxicological Research
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• v.16 no.1
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• pp.67-71
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• 2000

It has been demonstrated that the injection of naked DNA expressing vascular endothelial growth factor 165(VEGFl165) to the affected area can provide significant therapeutic effects on peripherol artery occlusive diseases. Success with this type of gene therapy highly depends on the quality of the vector delivering the therapeutic gene, especially in terms of the level and duration of gene expression in the localized area. We have recently developed a vector expressing VEGF165(pCK-VEGF) for the treatment of peripheral artery occulsive diseases and demonstrated high level expression of VEGF165 in mouse skeletal muscle. This study was designed to assess the acute toxicity of intramuscularly injected pCK-VEGF in BALB/c mice and Sprague-Dawely rats. There was no evidence of any changes in clinical signs, body weights, or gross pathological signs. We estimate LD50 values of pCK-VEGF higher than 50mg/kg in mice and 20 mg/kg in rats by intramuscular injection.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.592-597
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• 1996

The KALIMER core, of which nuclear design is largely governed by inherent safety and reactivity control issues, is fueled with metallic fuel, and the initial core will be loaded with 20% enriched Uranium metal fuel. KALIMER safety design objectives include the accommodation of unprotected, ATWS events without operator action, and without the support of active shutdown, shutdown heat removal, or any automatic system without damage to the plant and without jeopardizing public safety. The transient analysis of the core designs has been focused on severe events to assess the margins in the design, and ATWS events are the most severe events that must be accommodated by the KALIMER design. The ATWS performance has been evaluated for the preliminary initial core design of KALIMER with a particular emphasis on the inherent negative reactivity feedback effects, including the Doppler, sodium density, fuel axial expansion, core radial expansion, and control rod driveline expansion. Results show that the Uranium metal core design meets the temperature limits with margin.

• Journal of Chest Surgery
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• v.17 no.2
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• pp.286-291
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• 1984

To assess the correct role of operation in the management of bronchiectasis, two hundred and fifteen patients with bronchiectasis seen at the Thoracic & Cardiovascular Surgery Dept. of Catholic Medical College in Korea between 1972 & 1981 were reviewed and studied the combined disease [Pulmonary tuberculosis, paranasal sinusitis and general nutrition]. The result were as follows: 1.The incidence ratio of male to female was 1.8:1 & the age of second decade occupied 4596 of the total. 2.Bronchiectasis may occur in any lobe, however the vast majority of the cases are occur in dependent portion of the lung - basilar segment of the lower lobes, middle lobe, and lingular segment. Isolated upper lobe bronchiectasis is commonly associated with tuberculosis. 3.The bronchiectasis combined with the paranasal sinusitis was 25 patients [11.6%] in our cases and these occurred usually in both lower lung fields. 4.The average body weight of bronchiectasis patients were about 10 kilogram less than compairing to predicted normal body weight of Korean healthy person.

• Advances in Traditional Medicine
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• v.8 no.3
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• pp.215-221
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• 2008

In this present study Indian traditional Ayurvedic herbal formulation Amritaristo has been studied to assess the general pharmacological effect on mice. The drug showed no significant activity on the neuropharmacological test models experimented. The increased pentobarbital sleeping time was considered related with hepatic metabolism of pentobarbital. The formulation exhibited a non-significant reduction of gastrointestinal motility, and devoid of any acute diuretic activity. The tested drug revealed antidiarrhoeal activity on castor oil-induced model, whereas on magnesium sulphate-induced model no effect was observed.