• 제목/요약/키워드: Anxiety disorders

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불안과 노어에피네프린 (Anxiety and Norepinephrine System)

  • 심현보;유범희
    • 대한불안의학회지
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    • 제2권1호
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    • pp.3-8
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    • 2006
  • Anxiety has been suggested to be related to many neurotransmitters in brain, such as norepinephrine, serotonin, dopamine, cholecystokinin, and gamma-amino butyric acid. There are many studies to examine the relationship between anxiety and norepinephrine, and norepinephrine seems to be clearly related to the development of anxiety. We suggest that future studies to explore the pathophysiology of anxiety should be necessary, which include studies on antianxiety drugs, genetic studies, animal model studies, and brain imaging studies.

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후천성면역결핍증후군(Acquired Immune Deficiency Syndrome ; AIDS) 환자의 정신질환 유병률과 심리사회적 적응 (Prevalence of Psychiatric Disorders and Psychosocial Adjustment in Patients with Acquired Immune Deficiency Syndrome(AIDS))

  • 박휘준;홍진표;우준희;안준호
    • 대한불안의학회지
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    • 제5권2호
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    • pp.103-111
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    • 2009
  • Objectives : We examined quality of life, psychosocial adjustments to illness, changes in sexual functioning, and prevalence of psychiatric disorders in AIDS patients compared to patients with chronic hepatitis B virus infection (CHB). Methods : Thirty-one men with AIDS and 50 men with CHB were enrolled. The Short-Form 12-Item Health Survey (SF-12), the Psychosocial Adjustment to Illness Scale (PAIS), and the Changes in Sexual Functioning Questionnaire short form (CSFQ-14) were administered. Results on these assessments were compared between the 31 AIDS patients and 50 CHB patients. The Structured Clinical Interview for DSMIV (SCID) was administered to determine the psychiatric diagnosis only for the AIDS patients. Results : The Physical Component Summary score (PCS) was lower in AIDS patients than in CHB patients (p<0.001). In the section examining sexual relationships, AIDS patients exhibited a lower level of adjustment (p<0.05) and had more changes in sexual function (p<0.05) than did CHB patients. Administration of the SCID to AIDS patients indicated that the lifetime prevalence of any psychiatric disorder was 56.7% ; 43.3% for mood disorders, 33.3% for alcohol use disorders, 26.7% for anxiety disorders, and 20% for adjustment disorder. Patients who had experienced any psychiatric disorder had more severe psychosocial distress (p=0.004) and evidenced a lower level of overall psychosocial adjustment (p=0.030) than patients who had not. Conclusion : We showed that AIDS patients have a high prevalence of psychiatric disorders, and that AIDS patients with psychiatric disorders were particularly low in levels of psychosocial adjustment. Thus, careful attention should be given to psychiatric aspects of AIDS patients emphasizing the early diagnosis and treatment of psychiatric disorders.

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한국판 단축된 자기보고형 MINI (MINI 정신건강 평가)의 타당도 연구 (A Validation Study of the Abbreviated Self-Rated Korean Version of MINI (MINI Patient Health Survey))

  • 임세원;송한수;오윤희;신호철;조광현;정상근;오강섭
    • 대한불안의학회지
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    • 제3권1호
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    • pp.32-40
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    • 2007
  • Objectives : To investigate the validity of an abbreviated self-rated Korean version of MINI (Mini International Neuropsychiatric Interview) patient health survey which screening social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder. Methods : 115 subjects completed MINI and MINI patient health survey. The validity of MINI patient health survey was assessed by whether the results from MINI patient health survey were compatible with the results from MINI or not. The Cohen's kappa value, specificity, sensitivity, positive predictive value, and negative predictive value was calculated for this purpose. Results : The Kappa values of social anxiety disorder (0.60), panic disorder (0.49), generalized anxiety disorder (0.60) and major depressive disorder without other co-morbid disorder (0.59) were at least moderate in strength of agreement. Conclusion : The abbreviated self-rated Korean version of MINI patient health survey has the moderate to good validity in social anxiety disorder, panic disorder, generalized anxiety disorder, and major depressive disorder without other co-morbid disorders. Our result suggests that this instrument might be useful for screening above 4 disorders if it is used under careful supervision of experienced clinicians.

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Evaluation of Anxiety and Depression in Patients with Disc Displacement according to Diagnostic Criteria for Temporomandibular Disorders

  • Park, Junhyong;Shim, Young-Joo;Lim, Hyun-Dae;Lee, You-Mee;Kang, Jin-Kyu
    • Journal of Oral Medicine and Pain
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    • 제43권4호
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    • pp.125-130
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    • 2018
  • Purpose: The etiology of temporomandibular disorders (TMDs) is complex and multifactorial including trauma, anatomical, pathophysiological, social and psychological factors. Psychological factors can induce or sustain TMDs in various ways. And psychological problems, such as anxiety and depression can be occurred due to TMDs. Therefore, evaluation of psychological factors in patients with TMDs is important. Although disc displacement (DD) is crucial in clinical situation, most of studies have focused on the relationship of psychosocial factors and myofascial pain. And also, Subtypes of DD can cause different degrees of discomfort, it is necessary to evaluate the psychological states of the patients according to the subtype. The Hospital Anxiety Depression Scale (HADS) is one of the self-report questionnaire to evaluate the psychological factors. HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) are assessed through 14 questions. The purpose of this study was to evaluate anxiety and depression assessed by HADS in patients diagnosed with subtypes of DD according to diagnostic criteria for TMDs. Methods: Four hundred thirty nine patients were diagnosed as one of the subtypes of DD. One hundred fourty nine subjects with no symptoms were set as control groups. All of them answered the HADS for Koreans. The cut-off score for anxiety and depression was set a score of 8. The chi-square test was performed to evaluate association between DD and anxiety/depression. Results: There was a significant difference in HADS-D between five groups (p<0.01). However, there was no significant difference in HADS-A. All the DD groups showed a significant difference in HADS-D compared with the control group except the DD without reduction without limited opening group. The DD without reduction with limited opening group showed the highest rates in HADS-D (40.4%). Conclusions: Based on the above results, it is necessary to consider the depression in treatment of the patients with DDs.

2006 한국인의 불안 : 불안 리서치 결과 보고 (2006 Korean Anxiety : Report on Anxiety Research Results)

  • 정상근;권준수;2006 한국인의 불안 리서치 그룹
    • 대한불안의학회지
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    • 제2권2호
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    • pp.115-121
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    • 2006
  • Objectives : We performed this '2006 Korean Anxiety Research' to understand the actual state about Korean anxiety and get the basic data for mental health promotion. Methods : Semistructured questionnaire and Beck Anxiety Inventory -Korean version (BAI) were administered to total 1,000 adults (20-69 years old 501 male & 499 female adults living in Seoul and 5 metropolitan cities in Korea) on March 20th~31st, 2006. Results : Anxious subjects by the total score of BAI was 3.3%. But the responders the item 'I am in the anxious state' was 25% among total subjects. 6% (n=59) among total subjects were the responders experienced the anxiety requiring usually the counselling or treatment. The frequency of their anxiety was most commonly 1 to 2 times/month. The main causes of their anxiety were 'their health problems or illness', 'economic difficulty', 'interpersonal conflicts'. But 'help by health professional' among their usual anxiety reduction methods' was only 15% among them. Only 19% among them were under the treatment of anxiety. Only 27% among 48 subjects not under the treatment of anxiety had a desire for the anxiety treatment in the near future. Conclusion : Some people in the anxious state impairing their daily lives were not yet under the treatment. And most of them had no desire for the anxiety treatment. Therefore we will systematically plan the further health education on the anxiety-related problems for the Korean mental health promotion and the quality of life.

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불안의 생물학적 근원 (The Neurobiology of Anxiety)

  • 석정호;김세주;김찬형
    • 대한불안의학회지
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    • 제1권1호
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    • pp.7-13
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    • 2005
  • Anxiety is one of the basic emotions which human experiences across different cultures in the world and it can be observed in mammals. Our understanding of the neurobiology of this emotion has made some advances, even though it has not been completed, with the development and advance in the investigation method including neuroimaging, neurochemical, and genetic approaches. In this article, the neuroanatomical and neurochemical basis of anxiety is reviewed. The amygdaloid complex has been known to playa key role in processing of anxiety or fear. It has extensive afferent and/or efferent connections with cortical and subcortical structures. The mesial temporal structures including hippocampus appear to be involved in acquisition of anxiety and related behaviors. The prefrontal cortical structures appear to play important roles in conscious awareness of anxiety and in modulating anxiety and related behavior. The bed nucleus of the stria terminalis (BNST) is known to playa critical role in unconditioned fear response. The central noradrenergic system and hypothalamo-pituitary-adrenal axis are known to play important roles in modulating and expressing anxiety-related responses. Anxiety has been gathering attentions from many investigators and numerous preclinical and clinical investigations of anxiety and anxiety disorders have been done. In particular, neural plasticity in critical period and the psychobiological factors related to resilience to extreme stress and anxiety are important issues in this field.

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