• 제목/요약/키워드: Anxiety Disorder

검색결과 801건 처리시간 0.035초

인지 과제 및 긍정적 정서 유발에 대한 주요 우울장애 환자의 심장 박동 변이(Heart Rate Variability, 이하 HRV) 양상 (Heart Rate Variability of Patients with Major Depressive Disorder under Cognitive and Emotional Stimulus)

  • 이창수;김대석;정명기;김원;우종민
    • 대한불안의학회지
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    • 제3권1호
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    • pp.26-31
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    • 2007
  • Object : This study was designed to assess the change of heart rate variability (HRV) during stimulation test among the patients with major depressive disorder. Methods : 15 patients with major depressive disorder (MDD) and 15 normal controls were enrolled in this study. We sequentially measured HRV at baseline, during cognitive stimuli and emotional stimuli. Results : There are significant differences between the two groups in HRV index, TINN on baseline state and under cognitive stimulus. Conclusion : Stimulation protocol using HRV can be useful in estimating autonomic nervous function.

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신경성 식욕부진증의 생물학-Treasure의 모델에 근거하여 (The Biology of Anorexia Nervosa-Based on Treasure's Model)

  • 김율리
    • 대한불안의학회지
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    • 제3권2호
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    • pp.69-76
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    • 2007
  • Anorexia nervosa is a physical and psychosocial disorder that occurs most frequently in adolescent girls and young adult women. A decade ago, anorexia nervosa was rare outside of the developed western countries. However, it is now becoming a common clinical problem among young women in Korea. It is not enough to merely focus on relieving patients from the symptoms of "not eating," which is a practice that has been adopted by some forms of hospital care. The evidence base to guide treatment is limited. Nevertheless, there is the hope that a better understanding of the factors that play a role in the initiation and maintenance of disordered eating behaviors may be lead to more sophisticated treatments. This review aims to look beyond the overt "not eating" phenotype of anorexia nervosa and considers eating disorder endophenotypes based on Treasure's model. The first part of the review sets the basis for a framework of potential eating disorder endophenotypes. A description of the evidence of disordered eating behaviors as well as the clinical and psychopathological features associated with the central control of appetite follow. Finally, we describe how endophenotypes can be translated into treatments.

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외상 후 초기중재 (Early Interventions After Trauma)

  • 박주언;이병철;정영은;채정호
    • 대한불안의학회지
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    • 제5권2호
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    • pp.75-79
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    • 2009
  • In this article, we review the efficacy of early interventions after traumatic incidents and during acute stress disorder (ASD). There are some evidences that psychopharmacological medications such as propronolol, morphine, and hydrocortisone are effective in the prevention of posttraumatic stress disorder (PTSD). Considering the role of selective serotonin reuptake inhibitors in hippocampal neurogenesis and an animal model of PTSD, early administration of selective serotonin reuptake inhibitors is also fairly promising. Other pharmacological treatments including benzodiazepines did not treat ASD nor prevent PTSD. There are good evidences that cognitive behavioral therapy including cognitive therapy and prolonged exposure is a valuable intervention for ASD and the most effective prevention for PTSD. No contolled researches on eye movement desensitization&reprocessing, psychodynamic psychotherapy and hypnotherapy have performed. Recent randomized controlled studies using psychological debriefing did not prove as a useful intervention for the prevention of PTSD until now, although the efficacy of debriefing has been at the centre of controversy.

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미세먼지노출이 신경정신장애에 미치는 영향 (Adverse Effect of Exposure to Ambient Particular Matter on Neuropsychiatric Disorder)

  • 임명호;김종헌;권호장;정해관
    • 대한불안의학회지
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    • 제16권2호
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    • pp.57-75
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    • 2020
  • Particular matter is steadily increasing due to environmental factors at domestic and abroad such as industry and economy. Recently, the exposure particular matters has been reported to increase the risk not only for morbidity and mortality, but also for diseases of the respiratory system, cardiovascular system and central nervous system/neuropsychiatric disorder. Although the causes of neuropsychiatric diseases are genetic and environmental factors, it is necessary to pay more attention to environmental factors in terms of prevention. We mainly describe environmental factors that affect neuropsychiatric disorders, mainly on particular matter, which is one of harmful environmental substances. In the current study, we reviewed evidence for the presence of particular matter or particular matter related harmful air pollutants-O3, SO2, NO2/NOx, traffic related air pollution, that may represent risk factors for the development of neuropsychiatric disorder.

신경정신과 약물을 복용해 온 우울증 환자의 불면증에 삼황사심탕(三黃瀉心湯)을 병행 투여하여 호전된 1례(例) (A case of insomnia incurable by neuropsychiatric medication alone, but made possible with Sarn-Hwang-Sa-Sim-Tang)

  • 석선희;김주호;김근우;구병수
    • 동의신경정신과학회지
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    • 제17권3호
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    • pp.117-129
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    • 2006
  • Insomnia is one of the most common clinical symptom those almost patients with neuropsychiatric disorder complain. and the most common cause of insomnia in neuropsychiatric disorder is the major depressive disorder. We experienced a 59 year-old male who complained of recurrent insomnia in spite of taking medicines(nervines, antidepressants, etc,) during 30 years. We had given herbal medicine, acupuncture treatment and aroma therapy with continuing medications. The patient had several sypmtoms as anxiety, agitation, feeling thirsty, chronic constipation, and etc. beside the insomnia. After the patient took the herbal medicine, especially Sam-Hwang-Sa-Sim-Tang, he could have a sound sleep and be relaxed. In this case, we concluded that oriental medical treatment can be an effective remedy of chronic insomnia that responds to neuropsychiatric medications incompletely and Sam-Hwang-Sa-Sim-Tang is effective to a kind of insomnia with agitation, anxiety, thirsty, constipation, and etc.

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영아살해와 임신거부증을 주소로 내원한 경계선 인격장애의 치료사례 (Borderline Personality Disorder with Infanticide and Denial of Pregnancy : A Case Report)

  • 정세미나;백기청;이준형;김경민;도진아;임명호
    • 대한불안의학회지
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    • 제8권2호
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    • pp.161-166
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    • 2012
  • Though infanticide, killing the baby after birth of the neonate and denial of pregnancy, are very rare psychiatric disorder, they have been receiving a lot of social concerns. We report and review infanticide and denial of pregnancy administration in a 19 year-old adolescent with bipolar disorder and borderline personality disorder. Patients with a young age, cognitive immaturity, an unwanted child, hid the pregnancy facts were consistent with the results of previous studies. In addition, the patient's impulsivity and emotional instability is affecting infanticide. After inpatient care with pharmacotherapy (escitalopram 20mg, alprazolam 1.5 mg, clonazepam 0.5 mg, valproate sodium 1,100-1,300 mg, and quetiapine 100-400 mg) and supportive psychotherapy, and there were significant improvement of clinical symptoms.

화상환자의 외상후 스트레스 장애 증상에 대한 영향 요인 : 울분, 우울, 삶의 의미 (Factors Influencing Posttraumatic Stress Disorder Symptoms in Burn Injured Patients : Embitterment, Depression and Meaning in Life)

  • 황지현;이병철;채정호
    • 대한불안의학회지
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    • 제15권1호
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    • pp.29-34
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    • 2019
  • Objective : To determine predictors of posttraumatic stress disorder (PTSD) symptoms in burn injured patients and evaluate factors for identifying high risk group of PTSD. Methods : This study examined sixty one patients aged in the range of 19-65 years with burn injuries. All subjects completed self-assessment inventories about PTSD (The PTSD Check List for DSM-5. PCL-5), depression (Patient Health Questionnaire-9, PHQ-9), embitterment (Posttraumatic embitterment disorder self-rating scale, PTED scale) and meaning of life (Meaning in Life Questionnaire, MLQ). Stepwise multiple regression and ROC curve analysis were the tools used for analysis. Results : The results revealed higher depression, embitterment and lower presence of meaning in life predicted severe PTSD symptoms. ROC analysis indicated PTED scale and PHQ-9 were useful for discriminating high risk group of PTSD. Conclusion : The present study established that the need to consider embitterment, depression and meaning of life for alleviation and prevention of PTSD symptoms in burn patients.

영과잉포아송회귀분석을 활용한 안정병동에 입원한 정신질환자의 공격행동 예측요인 (Predictors for Aggressive Behavior of Patients with Mental Illness in a Closed Psychiatric Ward using Zero-Inflated Poisson Regression: A Retrospective Study)

  • 김정호;신성희
    • 동서간호학연구지
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    • 제28권2호
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    • pp.160-169
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    • 2022
  • Purpose: This study was conducted to identify predictors related to aggressive behavior of patients with mental illness admitted to a closed psychiatric ward. Methods: This study adopted a retrospective design which analyzed the hospital medical records of 363 patients with mental illness admitted to the psychiatric closed ward of a university hospital in Seoul, Korea. The collected data were analyzed using SPSS IBM 20.0 and STATA 12.0 SE. ZIP (Zero-Inflated Poisson) and count data analysis were used for the factor influencing the occurrence and frequency of aggressive behavior. Results: The results of ZIP model showed that the factors influencing non-probability of aggressive behavior were anxiety, non-adherence, and frustration. In addition, the factors influencing frequency of aggressive behavior were bipolar disorder and personality disorder trait. Conclusion: We found that bipolar disorder, frustration, and non-adherence are more likely to increase the likelihood of aggressive behavior in patients with mental illness. In particular, patients diagnosed with bipolar disorder were 1.95 times more likely to engage in repetitive aggressive behavior compared to those without a diagnose. However, since the results were different form previous studies, further studies on the traits of anxiety and personality disorders are needed.

Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder

  • Lee, Bombi;Sur, Bongjun;Yeom, Mijung;Shim, Insop;Lee, Hyejung;Hahm, Dae-Hyun
    • The Korean Journal of Physiology and Pharmacology
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    • 제20권4호
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    • pp.357-366
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    • 2016
  • Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open field after SPS. IBU administration significantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis $factor-{\alpha}$, $interleukin-1{\beta}$, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These findings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.

유산 경험이 있는 여성 공황장애 환자의 임상적 특성 (Clinical Characteristics of Female Panic Disorder Patients with Abortion History)

  • 황혜진;오종수;방민지;원은수;이강수;최태규;이상혁
    • 생물정신의학
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    • 제26권2호
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    • pp.65-70
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    • 2019
  • Objectives The objective of this study is to investigate differences in clinical characteristics between female panic disorder (PD) patients with abortion history (PD+A) and without abortion history (PD-A). Methods We examined data from 341 female patients diagnosed with PD. We divided the patients with PD into PD+A (82 patients) and PD-A (259 patients) to compare demographic and clinical characteristics. The following instruments were applied : stress coping strategies, NEO-neuroticism, the Anxiety Sensitivity Index-Revised (ASI-R), the Albany Panic and Phobia Questionnaire (APPQ), the Beck Depression Inventory, the Beck Anxiety Inventory (BAI) and the Sheehan Disability Scale. Results Compared to the PD-A, the PD+A group showed no significant difference in coping strategies. However, significantly higher scores in neuroticism, the ASI-R, the APPQ and the BAI were observed. In terms of health-related disability, the PD+A group did not show significant difference. Conclusions Our results suggest that the PD+A group may differ from the PD-A group in trait markers such as neuroticism and anxiety sensitivity, and abortion history may be associated with panic-related symptom severity. Our study suggests that further consideration is needed on such clinical characteristics in PD patients with abortion history.