• 제목/요약/키워드: Antitumor

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Antitumor Substances from Higher Plants in Asian Region

  • Itokawa, Hideji;Takeya, Koichi
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 1996년도 International Symposium on the Development of Anti Cancer Resources From Plants및 1996년도 한국자원식물학회 정기학술 발표회
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    • pp.10-11
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    • 1996
  • In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.

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Syntheses and antimicrobial and antitumor activities of isatin derivatives

  • Chough, Yun-Sung;Kang, Kun-Il
    • 약학회지
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    • 제17권3호
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    • pp.141-146
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    • 1973
  • Eight isatin N-Mannich bases were synthesized and tested their antimicrobial and antitumor activities. N-Piperidinomethylisatin-(N-cyclohexyl)-thiosemicarbazone is active against St. aureus at 10${\mu}$g/disk and isatin thiosemicarbazone against P. chrysogenum at 10${\mu}$g disk.

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Antitumor Substances from Higher Plants in Asian Region

  • Hideji Itokawa;Koichi Takeya
    • 한국자원식물학회지
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    • 제8권3호
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    • pp.341-364
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    • 1995
  • In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.

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오미자 물추출물의 항종양 활성에 대한 효과 (Study on Antitumor Activity of Water Extract of Omija(Schizandra chinensis Baillon))

  • 이정숙;이성우
    • 동아시아식생활학회지
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    • 제2권1호
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    • pp.103-107
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    • 1992
  • The antitumor activity of Omija water extract on sarcoma 180 transplanted intraperitoneal administration in ICR mice was investigated. combined treatment with Omija water extract and Cyclophosphamide augmented antivity against the solid form of Sarcoma 180 in ICR mice.

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한국산 생약으로부터 항암물질의 개발 (제13보). -농길리 추출물의 세포독성 및 항암작용에 관한 연구- (Development of Anticancer Agents from Korean Medicinal Plants. Part 13. -Studies on the Cytotoxicity and Antitumor Activity of Herba crotalariae sessiliflorae-)

  • 신민교;송호준;강영성;유홍선;한두석;강길웅;백승화
    • 생약학회지
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    • 제30권2호
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    • pp.130-136
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    • 1999
  • The cytotoxic and antitumor activity of Herba cratalariae sessiliflorae on cultured NIH 3T3 fibroblast and human oral epitheloid carcinoma cells were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) colorimetric method. The light microscopic study was carried out to observe morphological changes of cultured mouse fibroblast and human oral epitheloid carcinoma cells (KB). These results were obtained as follows; Ethyl acetate, chloroform and hexane extracts showed a significant cytotoxicity in NIH 3T3 fibroblast, but the other extracts did not show. All extracts exhibited a significant antitumor activity in human oral epitheloid carcinoma cells, but ethanol extract did not show a antitumor activity. Hexane extract showed low cytotoxic effect, but exhibited the most antitumor activity. The MTT absorbance in NIH 3T3 fibroblast was significantly decreased by treatment with chloroform, ethyl acetate and hexane extracts respectively. Human oral epitheloid carcinoma cells was significantly decreasd by treatment with all extracts with the exception of ethanol extract. The difference in MTT absorbance in two cell Types was most remarkable when treated with water and hexane extracts. Cholroform and hexane extracts showed the strongest effect in growth inhibition of human oral epitheloid carcinoma cells. These results indicated that water extract possessed no cytotoxicity and a strong antitumor activity.

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