• 제목/요약/키워드: Antioxidant Vitamins

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Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease

  • Kang, Dong Hoon;Kang, Sang Won
    • Biomolecules & Therapeutics
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    • 제21권2호
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    • pp.89-96
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    • 2013
  • Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant systems. Imbalance in these systems causes oxidative or reductive stress which triggers cellular damage or aberrant signaling, and leads to dysregulation. Paradoxically, large clinical trials have shown that non-specific ROS scavenging by antioxidant vitamins is ineffective or sometimes harmful. ROS production can be locally regulated by cellular antioxidant enzymes, such as superoxide dismutases, catalase, glutathione peroxidases and peroxiredoxins. Therapeutic approach targeting these antioxidant enzymes might prove beneficial for prevention of ROS-related atherosclerotic vascular disease. Conversely, the development of specific antioxidant enzyme-mimetics could contribute to the clinical effectiveness.

A Study on the Status of Antioxidant Vitamins and Serum Lipids in Korean Adults

  • Jang, Hyun-Suk;An, Kyung-Choon;Kwon, Chong-Suk
    • Preventive Nutrition and Food Science
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    • 제4권1호
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    • pp.62-69
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    • 1999
  • The present study was aimed at investigating whether there are sex-related differences in serum levels of lipids, retinol , $\alpha$-tocopherol and ascorbic acid in Korean adults. Serum levels of antioxidant vitamins and lipids were determined algon with anthropometric measurements in 53 healthy male subjects with mean age 42.7$\pm$12.2 years and 44 female subjects with mean age 46.7$\pm$10.3 years. from Taegu in Korea. BMI and W/H ration of the men were 22.66$\pm$2.47, 0.88$\pm$0.04 and those fo thewomen were 23.36$\pm$3.44, 0.84$\pm$0.05 respectively. Systolic and diastolic blood pressures were 121.67$\pm$14.8, 79.3$\pm$12.4 in the men and 123.1 $\pm$17.5 , 78.8$\pm$10.9 in the women respectively. Average serum levels of total cholesterol, LDL-and HDL-cholesterol and triglyceride were 165.8$\pm$36.4, 102.6$\pm$31.2, 41.1$\pm$10.5 and 110.2$\pm$57.8mg/dl in the and 169.1$\pm$39.1, 113.7$\pm$36.2, 38.1 $\pm$8.6, and 85.2$\pm$37.7mg/dl in the women respectively. Thirteen percent of menans thirtyeight percent of women had LDL-cholesterol over 130mg/dl. Serum levels of retinol, $\alpha$tocopherol, ad ascorbic acid were 43.25 $\pm$15.51, 17.93$\pm$7.07, 115.24$\pm$63.25ug/dl in the men and 31.80$\pm$15.39, 17.41$\pm$6.12, an d144.99$\pm$89.87ug/dl in the women respectively. Serum vitamin E showed positive correlations with total cholesterol and LDL-cholesterol and triglyceride.

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한국인 제2형 합병증동반 당뇨병 환자에 있어 과산화지질, 항산화 효소, 및 항산화비타민에 관한 연구 (The Study of Lipid-peroxidation, Antioxidant Enzymes, and the Antioxidant Vitamins in NIDDM Patients with Microvascular-diabetic Complications)

  • 하애화
    • Journal of Nutrition and Health
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    • 제32권1호
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    • pp.17-23
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    • 1999
  • The purpose of this study was to determine the extent of oxidative stress in NIDDM patients with diabetic complications and to determine the relationship between oxidative stress and diabetic complications. For this study, 139 NIDDM patients were recruited, 85 with diabetic complications and 54 without complications were recruited. The concentration of malondialdehyde(MDA) and the activities of antioxidant enzymes including catalase, superoxide dismutase(SOD), gluthatione peroxidase(GSH-Px)were determined. The daily intakes and plasma concentrations of beta-carotene, lycopene, lutein nd alpha-tocopherol were determined by food frequency questionnaire and by high performance liquid chromatography(HPLC), respectively. Among the antioxidant enzymes studied, only GSH-Px activity was lower in NIDDM patient, with diabetic complications than in those without complications(2.91$\pm$0.80 vs 3.54$\pm$0.44 U/mgHb, p<0.05). Those NIDDM patients with diabetic complications had higher MDA concentrations than those without diabetic complications(1.40$\pm$0.25 vs 1.25$\pm$0.11 nmol/ml, p<0.05). There were no significant differences in the dietary intakes of total carotenoids(2854 vs 2824ug/day)or vitamin E (9.5$\pm$3.2 vs 9.5$\pm$2.0mg/day)between NIDDA patients with and without complications. However, the plasma concentrations of beta-carotene and lycopene were significantly lower in NIDDM patients with complications than in NIDDM patients without complications (Beta-carotene : 24.2$\pm$12.5 vs 33.1$\pm$16.2(ug/dl), lycopene : 2.8$\pm$2.1 vs 4.3$\pm$2.8(ug/dl)). This study showed that in NIDDM patients with complications, the lipid peroxidation of erythrocytes was higher increased and the antioxidant reserves were significantly dipleted, compared with NIDDM patients without complications. The lower plasma concentrations of beta-carotene and lycopene in NIDDM patients may be due to the presence of diabetic complication, not due to the lower dietary intakes of antioxidant vitamins. To define the role of carotenoids in diabetes, more experimental and clinical studies are needed.

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Serum Antioxidant Vitamins and Erythrocyte Lipid Peroxide Levels in Female Adolescent Smokers

  • Kim, Jung-Hee;Moon, Jeong-Suk;Lee, Hee-Won
    • Journal of Community Nutrition
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    • 제1권1호
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    • pp.16-24
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    • 1999
  • The purpose of this study was to investigate the association between adolescent smoking and antioxidant vitamins. Subjects were 87 non-smokers and 90 smokers. who were female high school students. Smokers were divided into tow groups by smoking status, 35 light smokers (packyear<1) and 53 heavy smokers(packyear$\geq$1). Dietary intakes were examined through questionnaires and nutrient intakes of vitamin C and A were analyzed by smoking status using Computer Aided Nutritional analysis program for professional (CAN-PRO). Serum vitamin C level was measured by 2,4-dinitrophenylhydrazine method and serum levels of vitamin A and E were measured by HPLC. Erythrocyte lipid peroxide levels was measured by thiobarbituric acid reactive substance (TBARS) method. All data were statistically analyzed by SAS PC package program. The mean vitamin C intakes of non-smokers, light smokers and heavy smokers were 58.2mg/day, 50.1 mg/day 58.1mg/day, respectively. The mean vitamin A intakes of non-smokers, light and heavy smokers were 28.1$\mu\textrm{g}$R.E./day, 278.7$\mu\textrm{g}$R.E./day and 289.6$\mu\textrm{g}$R.E./day, respectively. There was no significant difference in dietary intakes of antioxidant vitamins by smoking status. However, the serum vitamin C level, 11.40mg/l in heavy smokers was 12% lower than that of than that of 12.70mg/l in non-smokers. The serum vitamin A level was not significantly different among the groups. Vitamin E level, 8.79mg/l in heavy smokers was 8% lower than that of 9.53mg/l in non-smokers. There was no significant correlation between the dietary intakes and serum levels of vitamin A and C. The erythrocyte TBARS level, 1.90nmol/ml in light smokers was significantly lower (p<0.05) than 2.71 nmol/ml in heavy smokers or non-smokers. The correlation data showed that the cerythrocyte TBARS level had a significant positive correlation with packyear. Overall results might suggest that cigarette smokers with a longer smoking history need more dietary intakes of vitamin C and E than do non-smokers to reach the same serum level.

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데침시간에 따른 톳의 주요성분 및 항산화 활성의 변화 (Changes of chemical components and antioxidant activities in Hizikia fusiformis(Harvey) OKAMURA with blanching times)

  • 김진아;이종미
    • 한국식품조리과학회지
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    • 제20권2호
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    • pp.219-226
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    • 2004
  • This study was performed to investigate the change of chemical components and antioxidant activities in Hizikia fusiformis(Harvey) OKAMURA with blanching times. For chemical composition, the contents of minerals (K, Ca, Na, Mg, Fe, Cu, Mn and Zn), vitamins (vitamin C, ${\beta}$-carotene and ${\alpha}$-tocopherol) and total polyphenol were analyzed. The antioxidant activity was determined through free radicals (DPPH radical, superoxide anion radical, hydroxyl radical and hydrogen peroxide) scavenging activity and linoleic acid peroxidation inhibitory activity. As the blanching time increased, the contents of all minerals, vitamin C and total polyphenol decreased. However ${\beta}$-carotene and ${\beta}$-tocopherol were not affected by the blanching time. In addition antioxidant activities decreased with increasing blanching time.

데침조건에 따른 감태의 생리활성 성분 및 항산화 활성의 변화 (The Changes of Biologically Functional Compounds and Antioxidant Activities in Ecklonia cava with Blanching Times)

  • 김진아;이종미
    • 한국식생활문화학회지
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    • 제19권4호
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    • pp.369-377
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    • 2004
  • This study was performed to investigate the change of biologically functional compounds and antioxidant activities in Ecklonia cava with blanching times. As biologically functional compounds, the contents of minerals(K, Ca, Na, Mg, Fe, Cu, Mn and Zn), vitamins($vitamin\;C,\;{\beta}-carotene\;and\;{\alpha}-tocopherol$) and total polyphenol were analyzed. And antioxidant activity was determined through free radicals(DPPH radical, superoxide anion radical, hydroxyl radical and hydrogen peroxide) scavenging activity and linoleic acid peroxidation inhibitory activity. As the blanching time increased, the contents of minerals, vitamin C, ${\beta}-carotene$ and total polyphenol were decreased however ${\alpha}-tocopherol$ was not affected by blanching time, and antioxidant activities were decreased with blanching time.

우리나라 성인의 한식 섭취율에 따른 다량영양소 및 항산화 비타민 섭취현황 : 2007~2012년 국민건강영양조사 자료를 이용하여 (Estimated macronutrients and antioxidant vitamins intake according to Hansik consumption rate among Korean adults: Based on the Korea National Health and Nutrition Examination Survey 2007~2012)

  • 김성아;전신영;홍은주;정효지
    • Journal of Nutrition and Health
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    • 제49권5호
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    • pp.323-334
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    • 2016
  • 본 연구에서는 우리나라 19세 이상 성인의 한식 섭취율과 그에 따른 식생활 특성을 파악하기 위해 제 4 5기 국민건강영양조사 (2007~2012) 자료의 24시간 회상법 자료와 한식 데이터베이스 및 상용식품 중 영양소 함량 데이터베이스를 연계하여, 1일 한식 섭취율과 영양소 및 항산화 비타민 섭취량을 추정하였다. 그 결과 대상자 33,069명 중 75%가 1일 한식 섭취율이 75% 이상이었고, 한식 중에서는 배추김치, 잡곡밥, 쌀밥 순으로 섭취빈도가 높았다. 한식 섭취율이 높은 군일수록 대상자의 평균 연령이 통계적으로 유의하게 높았고, 가구소득이 가장 낮은 1분위와 교육수준이 가장 낮은 1분위의 비율이 통계적으로 유의하게 높았다. 한식 섭취율에 따른 4분위군의 영양소 섭취 양상을 살펴보았을 때, 한식 섭취율이 높은 군일수록 에너지, 단백질, 지방의 평균 섭취량이 통계적으로 유의하게 낮았고, 항산화 비타민 중에서는 비타민 A, ${\beta}$-카로틴과 ${\beta}$-크립토잔틴, 비타민 C가 한식 섭취율과 양의 관계를 보였으며, 레티놀, ${\alpha}$-카로틴 비타민 E 섭취량은 음의 관계를 보였다. 또한 한식 섭취율이 높은 군일수록 감자 및 전분류, 두류, 종실류, 채소류, 과일류, 해조류의 섭취가 높았고, 곡류, 당류, 우유 유제품, 유지류 등의 섭취가 낮았다. 이상의 결과를 요약하면, 한식 섭취율이 높은 군은 그렇지 않은 군에 비해 에너지 섭취량이 적고, 다량영양소 중 탄수화물의 에너지 비율은 높은 반면, 지방의 에너지 비율은 적었다. 한식 섭취율은 비타민 A, ${\beta}$-카로틴과 ${\beta}$-크립토잔틴, 비타민 C 등의 항산화 비타민 섭취량과 유의한 양의 연관성이 있었으며, 성, 연령, 소득수준 등이 각각 동일할 때에도, 한식 섭취율이 높은 군은 낮은 군에 비해 항산화 영양상태가 우수함을 확인할 수 있었다. 한식의 섭취 수준에 따른 건강 영향을 구명하기 위한 후속연구의 수행이 필요한 것으로 사료된다.

EFFECTS OF ANTIOXIDANTS ON DI(2-EHTYLHEXYL)PHTHALATE INDUCED ENDOCRINE DISRUPTION

  • Kim, In-Sun;Lee, Byung-Mu
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.132-132
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    • 2002
  • Effects of antioxidant vitamins were investigated in di(2-ethylhexyl) phthalate (DEHP)-induced endocrine disruption toxicity. After rats were treated with DEHP, and vitamin C and vitamin E were supplemented for 30 days.(omitted)

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