• 제목/요약/키워드: Antineoplastic

검색결과 167건 처리시간 0.023초

무균조제 항암제 취급의 안전관리 (Assessment of Occupational Exposure to Antineoplastic Agents in a Healthcare Setting)

  • 이수미;정선영;임현정;박효정;이수연;전은용;손기호
    • 약학회지
    • /
    • 제55권2호
    • /
    • pp.81-90
    • /
    • 2011
  • Most antineoplastic agents are nonselective in their mechanism of action, affecting noncancerous as well as cancerous cells, and resulting in acute effects such as irritation of mucous membranes and chronic effects such as genotoxicity, teratogenicity, and carcinogenicity. Healthcare workers occupationally exposed to antineoplastic agents are at risk. The present study aimed to develop and apply methods to monitor occupational exposure to antineoplastic agents, using cyclophosphamide (CP) as the model compound. To monitor environmental and biological exposure, potentially contaminated surfaces were wiped and 24 hour urine samples were collected from workers. Liquid chromatography combined with tandem mass spectrometry was performed, with a limit of detection of 0.05 ng/ml. Measurable amounts of CP were detected on 92% of the sampled surfaces, with a geometric mean of 175.22 $ng/m^2$. Despite the environmental contamination of the model compound, CP was below the detection limit in all urine samples. If workplace contamination cannot be completely avoided, it is importance to reduce exposure to the lowest possible levels. To this aim, efforts to minimize occupational exposure along with biological and environmental monitoring are required. The standardized sampling techniques, and specific and sensitive analytical methods reported in this study may be helpful in assessing occupational exposure and devising strategies to reduce exposure.

Studies on Anti-cancerous Substances from Higher Plane in East Asian Region

  • Takeya, Koichi
    • 한국자원식물학회:학술대회논문집
    • /
    • 한국자원식물학회 1999년도 The 6th International Symposium on the Development of Anti-Cancer Resource from Plants
    • /
    • pp.1-45
    • /
    • 1999
  • To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for ncancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids, lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically Oridonin isolated from Rabdosia ssp.is now investigated for clinical trials in China. Moreover, camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity. This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifolia, has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential. Some efforts are continued in National Cancer Institute NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin III, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected in Japan, China, Korea, Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia in mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma (KB) cells in our laboratory, as primary screening. In this meeting, I will present on antitumor and cytotoxic substances of the higher plants (Rubia cordifolia, Ailanfhus Vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var drupacea, etc.) selected from above screening tests.

  • PDF

Studies on Anti-Cancerous Substances from Higher Plants in East Asian Region

  • Takeya, Koichi
    • Plant Resources
    • /
    • 제3권1호
    • /
    • pp.1-45
    • /
    • 2000
  • To date many kinds of compounds have been obtained from plants kingdom as antineoplastic and anti-cancerous agents. However, there is no special type of compounds for cancer therapy. Various types of substances are effective for various types of cancers and tumors: for instance, alkaloids. lignans, terpenes and steroids etc. Curcumol obtained from Curcuma aromatica was tested and noticed to be effective against cancer of the uterine cervix clinically. Oridonin isolated from Rabdosia ssp. is now investigate for clinical trials in China. Moreover camptothecine isolated from Camptotheca acuminata is also antineoplastic alkaloid, but is very toxic. Chemical modification has been tried to decrease its toxicity This compound is now using as clinical agent. Harringtonin was investigated as an anticancerous drug in China. Taxol, a compound with a taxane ring isolated from the bark of Taxus brevifotia. has been demonstrated to have substantial anticancer activity in patients with solid tumors refractory standard chemotherapy. Supply of this drug has severely limited full exploration of its antineoplastic potential Some efforts are continued in National Cancer Institute(NCI) Washington for surveying various Taxus species for optimal taxol content, improvement in semi-synthesis from baccatin 111, improvement in method of extraction, and development of alternative renewable resources. Further, there are many compounds which have been reported as antineoplastic agents. On the other hand, we have screened on higher plants collected In Japan, China, Korea. Southeast Asia and South America for antineoplastic activity, which has been done using Sarcoma 180 ascites in mice, P388 Iymphocytic leukemia In mice, Chinese hamster lung V-79 cells, P388 cells and nasopharynx carcinoma(KB) cells in our laboratory, as primary screening. In this meeting, 1 will present on antitumor and cytotoxic substances of the higher plants(Rubis cordifolia, Ailanthus vilmoriniana, Aster tataricus, Taxus cuspidata var. nana, Cephalotaxus harringtonia var. drupacea, etc.) selected from above screening tests.

  • PDF

국내 허가사항에 반영된 약물 유전정보 분석 (Analysis of Pharmacogenetic Information in Korea Drug Labels)

  • 이미진;김수경;이정;곽혜선;최경희
    • 한국임상약학회지
    • /
    • 제31권1호
    • /
    • pp.21-26
    • /
    • 2021
  • Background: Pharmacogenomics is the study of how genetic mutations in patients affect their response to drugs. Pharmacogenomic studies aim to maximize drug effects and minimize adverse drug events. The Food and Drug Administration and the European Medicine Agency published guidelines for pharmacogenetics in 2005 and 2006, respectively; the Korean Ministry of Food and Drug Safety followed suit in 2015. Methods: This study analyzed pharmacogenomic information in the Korean Ministry of Food and Drug Safety's integrated drug information system to evaluate whether domestic pharmaceutical products reflect the current research on pharmacogenomic differences. Results: In June 2020, the Korean pharmacogenomic database contained genomic data on 90 compounds. Of these, 45 compounds were classified as "Antineoplastic and immunomodulating agents." The other 45 non-antineoplastic agents were in the following categories: Anti-infectives, Mental & behavior disorder, Hormone & metabolism related diseases, Cardiovascular system, Skin & subcutaneous tissue disease, Genito-urinary system and sex hormones, Blood and blood forming organs, Nervous system, Alimentary tract and metabolism, Musculo-skeletal system, and Other conditions including the respiratory system. In addition, 30 additives unrelated to the main ingredient were associated with genetic precautions. Conclusion: This study showed that antineoplastic and immunomodulating agents accounted for half the drugs associated with pharmacogenetic information. For antitumor and immunomodulatory drugs, genomic tests were recommended depending on the indication; this was in contrast to genomic testing recommendations for non-antineoplastic medications. Genomic tests were rarely requested or recommended for non-antineoplastic medications because the relationships between genotype and efficacy among those drugs were relatively weak.

제암성물질의 합성에 관한 연구 VI 2,4-Dihydroxy-5-nitropropiophenone 유도체의 합성 및 항종양시험 (Studies on the Synthesis of Antineoplastic Agents. VI. Synthesis and Antineoplastic Activity of 2,4-Dihydroxy-5-nitropropiophenone Derivatives.)

  • 정원근;이남복
    • 약학회지
    • /
    • 제17권2호
    • /
    • pp.115-121
    • /
    • 1973
  • Seven ${\beta}$-substituted-2,4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the sunthesized compounds, ${\beta}$-(1-methyl-1-hydroxymlethy) ethylamino-2, 4-dihydrocy-5-nitropropiophenone and ${\beta}$(1,1-dihydorxymethyl) ethylamino-2,4-dihydroxy-5-dihyropropiophenone and ${\beta}$-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.

  • PDF

흰쥐에서의 신규 항암제 BR-28702-2의 체내동태 (Pharmacokinetic Study on BR-28702-2, a New Anticancer Drug, in Rats)

  • 용철순;이신웅;전철수;채희상;신원섭;백우현
    • Biomolecules & Therapeutics
    • /
    • 제3권2호
    • /
    • pp.97-103
    • /
    • 1995
  • The purpose of this study was to determine pharmacokinetic parameters of BR-28702-2, a new antineoplastic agent which is the conjugate of nucleotide and phospholipid, and to compare them with those of ara-C. Male rats were cannulated in the left femoral vein and received a single i.v. bolus dose of either BR-28702-2 or ara-C. BR-28702-2 was also administered i.p. and plasma samples were analyzed by reversedphase HPLC. The t$_{1}$2($\beta$)/ of ara-C(1.22 hr.) was significantly smaller than that of BR-28702-2(4.420 hr.). The absolute bioavailability of BR-28702-2 after i.p. injection was 1.125%. This lower bioavailability, together with previous reports that marked antineoplastic activity was observed when given i.p., indicates that BR-28702-2 would act as a depot system to release active moieties. Further works, therefore, need to be done to characterize active metabolites.

  • PDF

키토산 가수분해물의 In Vitro 항종양성 (In Vitro Antineoplastic Effects of Chitosan Hydrolysates on Various Tumor Cell Lines)

  • 박헌국
    • 한국식품영양학회지
    • /
    • 제22권4호
    • /
    • pp.639-643
    • /
    • 2009
  • 키토산 가수분해물의 세포 독성 및 항종양성 실험에서 키토산 가수분해물은 정상세포주인 Vero E6(Africa green monkey kidney cell)에 대한 세포 독성을 거의 나타내지 않았다. 정상세포주에 대한 키토산 가수분해물의 $IC_{50}$값은 1,107.95 ${\mu}g/m{\ell}$이었다. 키토산 가수분해물은 폐암 세포주인 A549, 방광암 세포주인 J82, 대장암 세포주인 SNU-C4, 위암 세포주인 SNU-1, 유방암 세포주인 ZR75-1 등과 같은 사람의 종양세포주에 대한 in vitro 항종양성을 나타내었다. 종양세포주에 대한 키토산 가수분해물의 $IC_{50}$값은 A549, J82, SNU-C4, SNU-1, ZR75-1 세포주의 경우에 각각 421.06 ${\mu}g/m{\ell}$, 417.99 ${\mu}g/m{\ell}$, 445.54 ${\mu}g/m{\ell}$, 380.65 ${\mu}g/m{\ell}$, and 460.49 ${\mu}g/m{\ell}$이었다.

애기졸각버섯 배양(培養) 균사(菌絲)의 항암(抗癌) 성분(成分)의 정제(精製) 및 화학(化學) 분석(分析) (Studies on Antitumor Components of Cultured Basidiomycetes - Purification and Chemical Analysis of Antineoplastic Constituents of Cultured Mycelia of Laccaria laccata -)

  • 김유진;이정옥;심미자;김성원;최응칠;김병각
    • 한국균학회지
    • /
    • 제12권1호
    • /
    • pp.35-43
    • /
    • 1984
  • 애기졸각버섯의 균사를 액내 진탕 배양법으로 배양하여 항종양성 성분을 생성시키고 이 성분의 특징을 밝히기위하여 위의 방법으로 배양된 균사체를 증류수로 가온 추출하였으며 그 추출물을 이온 교환수지 및 겔여과크로마토그라피법으로 정제하였다. 이 정제과정에서 분리된 5개의 분획에 대하여 각각 항종양 실험을 시행하였던 바, 그 정제의 정도에 비례하여 항암작용이 증가하였으며, 최종 분획 E를 1회 10mg/kg용량으로 백서에 투여하였을 때 75%의 종양 억제율을 나타내었으며, 다당류 81% 및 단백질 4%를 함유하고 있었다. 이 성분은 백서의 복강내 마크로훼이지의 수를 증가시켰으며 이 성분을 laccaran으로 명명한다.

  • PDF

전통 약용식물 및 각종 식물의 항암 효과에 대한 연구 (III) (Antineoplastic Effect of Extracts from Traditional Medicinal Plants and Various Plants (III))

  • 현진원;임경화;성민숙;강삼식;백우현;배건우;조현;김형자;우은란;박호군;박재갑;양용만
    • 생약학회지
    • /
    • 제27권2호
    • /
    • pp.105-110
    • /
    • 1996
  • Antineoplastic activity against human gastric and colon carcinoma cell lines was tested in eighty-three species of Korean plants including Korean medicinal plants which have been frequently used in oriental herb prescriptions. The plant materials were extracted with methanol and the cytotoxic activity was tested using a calorimetric tetrazolium assay (MTT assay). Twenty-six plant extracts against gastric carcinoma cell line, eighteen extracts against colon carcinoma cell line and fourteen plant extracts against both carcinoma cell lines showed antineoplastic activity at the concentration of less than $100{\mu}g/ml$. The effective components from four species have been isolated and reported.

  • PDF

Occupational Exposure to Antineoplastic Drugs: Identification of Job Categories Potentially Exposed throughout the Hospital Medication System

  • Hon, Chun-Yip;Teschke, Kay;Chua, Prescillia;Venners, Scott;Nakashima, Lynne
    • Safety and Health at Work
    • /
    • 제2권3호
    • /
    • pp.273-281
    • /
    • 2011
  • Objectives: Studies examining healthcare workers' exposure to antineoplastic drugs have focused on the drug preparation or drug administration areas. However, such an approach has probably underestimated the overall exposure risk as the drugs need to be delivered to the facility, transported internally and then disposed. The objective of this study is to determine whether drug contamination occurs throughout a facility and, simultaneously, to identify those job categories that are potentially exposed. Methods: This was a multi-site study based in Vancouver, British Columbia. Interviews were conducted to determine the departments where the drugs travel. Subsequent site observations were performed to ascertain those surfaces which frequently came into contact with antineoplastic drugs and to determine the job categories which are likely to contact these surfaces. Wipe samples were collected to quantify surface contamination. Results: Surface contamination was found in all six stages of the hospital medication system. Job categories consistently found to be at risk of exposure were nurses, pharmacists, pharmacy technicians, and pharmacy receivers. Up to 11 job categories per site may be at risk of exposure at some point during the hospital medication system. Conclusion: We found drug contamination on select surfaces at every stage of the medication system, which indicates the existence of an exposure potential throughout the facility. Our results suggest that a broader range of workers are potentially exposed than has been previously examined. These results will allow us to develop a more inclusive exposure assessment encompassing all healthcare workers that are at risk throughout the hospital medication system.