• YAKHAK HOEJI
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• v.41 no.3
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• pp.294-297
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• 1997

The efficient synthesis of xanthone derivatives, which are important intermediates in the synthesis of psorospermin as a anticancer agent, from 3-(benzyloxy)-2-hydroxybenzoic ac id and 6-allyl-3,5-dihydroxyl-1-tosyloxybenzene as a starting material will be reported herein.

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.132.2-133
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• 2001

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.956-956
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• 2005

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.118-118
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• 2002

It has been reported that vitamin K analogues have various pharmacological effects such as antiviral, antifungal, anticancer, and antiplatelet activities. It has also been reported that some synthetic naphthoquinone compounds showed antiplatelet activities.(omitted)

• Bulletin of the Korean Chemical Society
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• v.31 no.12
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• pp.3826-3829
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• 2010

• Natural Product Sciences
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• v.4 no.4
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• pp.185-202
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• 1998

A large number of chemical constituents have been reported from the Himalayan yew [Taxus baccata (Linn) or T. wallichiana (Zucc)]. These constituents are mainly taxoids and phenolics. Taxol, a lead anticancer agent, is the most important constituent. Other compounds have also been found to possess interesting biological properties. The literature concerning the chemistry and bioactivity of the constituents of the Himalayan yew has been briefly reviewed.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.54-55
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• 2003

Radiation therapy has been used for the cancer treatment externally or internally. The external radiation therapy has been widely used, but for the lack of its selectivity it requires strong radiation dose causing the dermal irritation and radiation effect of the normal tissues or organs. So we investigate non-clinical and clinical studies of “Milican inj.”, in which chitosan is chelated with 166-Holmium, as an anticancer agent for internal radiation therapy. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.228.1-228.1
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• 2002

Hypoxia in solid tumors is known to contribute to intrinsic chemoresistance. Tirapazamine(TPZ). a hypoxia-selective cytotoxin. showed synergism with radiation or cytotoxic agents. Paclitaxel(PTX) is a highly active anti-cancer agent against Non small cell lung cancer(NSCLC), however. due to poor penetration into central hypoxic region of tumor tissue. combination with TPZ has been suggested to enhance its efficacy. (omitted)

• Biomolecules & Therapeutics
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• v.3 no.1
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• pp.47-53
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• 1995

DA-125, a new anthracycline antitumor antibiotic, was administered at dose levels of 0, 0.2, 0.6 and 1.8 mg/kg/day intravenously to pregnant New Zealand White rabbits from day 6 through 18 of gestation. The does were subjected to the caesarean section on day 28 of gestation. Effects of test agent on general toxicity of does and embryonic development of F1 fetuses were examined. At 1.8 mg/kg, the organ weight for ovary of does was significantly decreased. The decrease in the number of corpus lutea, implantations and litter size, and the increase in the rate of resorptions were also observed. In addition, various types of external, visceral and skeletal malformations occurred in fetuses at an incidence of 7.7, 7.7 and 20.6%, respectively. The results show that the no effect dose levels (NOELs) of DA-125 are 0.6 mg/kg/day for does and F1 fetuses.

• Korean Journal of Environmental Biology
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• v.26 no.2
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• pp.115-120
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• 2008

Earlier we have described new water-soluble Ag- and Zn-derivatives of tetrachloride meso-tetra (4-N-oxiethylpyridyl) porphyrin (TOEtPyP) as potential anticancer drugs. In this work the effect of one of these metal porphyrins, TOEtPyP Ag, on the cell population kinetics was studied in vitro using morphological and biochemical techniques. The results suggested that TOEtPyP Ag action consisted in the simultaneous suppression of the cell growth and activation of the cell death. About 40% of the cells were shown to die via apoptotic pathway. So, the porphyrin studied may be attributed to inducers of both necrotic and apoptotic processes. The results obtained support our previous assertion that TOEtPyP Ag may be considered as a potential chemotherapeutic agent.