• 한국도로학회논문집
• /
• 제14권3호
• /
• pp.25-32
• /
• 2012

현재 도로포장 설계법에 따르면, 동상방지층의 두께는 지역별 온도조건에 따라 결정되는 동결깊이에 의해 결정되며 동상방지층의 지지력은 설계에서 고려되지 않고 있다. 동상방지층을 도로포장체에서 구조층으로 고려할 경우에는 기존 도로포장층의 두께를 감소시킬 수 있으며 보다 경제적인 도로 포장단면을 구성할 수 있다. 본 연구에서는 동상방지층의 지지력을 평가하기 위한 통계적 모형을 개발하였다. 동상방지층의 구조적 역할을 규명하고 동상방지층 구조적 평가 모형 개발을 위하여 2m 이하 저성토부, 절토부 및 절성경계부 등을 구분하여 포장 하부층에서 Falling Weight Deflectormeter(FWD) 시험을 계절별로 수행하였다. 본 시험은 동방방지층의 유무에 따른 지지력 차이를 규명하기 위하여 동방방지층이 있는 구간과 없는 구간으로 구분하여 수행하였다. 본 시험결과, 동상방지층이 설치된 구간에서의 FWD 처짐량이 동상방지층 미설치 구간에 비해 0.4~82.6% 작게 측정되어 동상방지층이 포장체에서 지지력을 검증하였다. 다양한 FWD 처짐지수와 동상방지층 두께와의 상관관계를 조사한 결과, 보조기층 파손지수의 차이값(${\Delta}BDI$)과 동상방지층 두께와의 상관도가 가장 높았다. 본 논문에서는 ${\Delta}BDI$값을 선형혼합효과 모형에 적용하여 동상방지층을 구조적으로 평가할 수 있는 모형을 개발하였다.

• 대한한방부인과학회지
• /
• 제21권1호
• /
• pp.55-82
• /
• 2008

Purpose: In this study, we evaluated anti-inflammatory activity and anti-thrombosis effect of Manbunbang(MBB) prescribed to chronic PID patients. Methods: We studied inhibitory effect of platelet aggregation, suppression effect of GPIIb/IIIa activity and inhibitory effect of $TXB_2$ and $PGE_2$ biosynthesis which were caused by ADP, epinephrine, collagen and arachidonic acid in vitro. And suppression of pulmonary embolism, changes of related factors in dextran coagulation condition model and anti-oxidative effect of oxidative damage were studied in vivo. Results: MBB extract showed LD50 of $200\;{\mu}g/ml$ or higher in mouse lung fibroblast cells, and significantly decreased the GPT and GPT level in dextran coagulation condition model compared to the control. MBB extract showed dose-dependent inhibition effect on platelet coagulation induced by ADP, epinephrine, collagen, arachidonic acid. MBB extract showed dose-dependent inhibition effect on GPIIb/IIIa activities compared to the control. MBB extract significantly suppressed TXB2 and PGE2 biosynthesis compared to the control. MBB extract suppressed pulmonary embolism triggered by collagen and epinephrine by 37.5% compared to the control. MBB extract significantly suppressed the decrease of speed of bloodstream caused by blood coagulation in dextran coagulation condition model compared to the control. Concluson : The results strongly suggest the anti-inflammatory activity of Manbunbang through anti-thrombus. Various applications using Manbunbang on inflammatory diseases are anticipated. Anti-oxidative efficacy comparison data between the Manbunbang prescription and the drug compositions may be used as important clinical information, and further investigation of anti-oxidative activities of Chrysanthemum indicum and Rhemaniae Radix should be followed.

• Archives of Pharmacal Research
• /
• 제28권7호
• /
• pp.848-853
• /
• 2005

Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1 % inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7 -day model of multiple treatment of TPA (38.1 % inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin $E_2$ production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

• 전자공학회논문지D
• /
• 제35D권2호
• /
• pp.60-69
• /
• 1998

Polysilicon surface mdoification tecnique is developed to reduce the sticking of microstructures fabricated by micromachining. Modified anti-sticking grain holes are simply formed by two-step dry eth without additional photolithography nor deposition of thin films. Both process-induced sticking and in-use sticking are successfully reduced more than two times by adopting grain holed polysilicon substrate. A sticking model for cantilever beam is derived. This model includes bending moment stems from stress gradient along the thickness directionof structural polysilicon. Because the surface tension of rinse liquid and the surface energy of the solids to be stuk tend to decrease in recently developed anti-sticking techniques, the effect of stress gradient will play an important role to analyze the sticking phenomena. Effect of the temperature during post-release rinse and dry is modelled and verified experimentally. Based on developed anti-sticking polysilicon structure and the sticking model, sticking of microstructure, fabricated by simple wet process including sacrificial layer etch and rinse with deionized water without special equimpment for post-release rinse and dry was alleviated more than 3.5 times.

• Natural Product Sciences
• /
• 제23권2호
• /
• pp.108-112
• /
• 2017

Anti-inflammatory, anti-arthritic and analgesic activity of each herbal extract, which is extracted from Bacopa monnieriis, Cassia fistula and Phyllanthus polyphyllus, respectively. The treatment of herbal extract exhibited anti-inflammatory effect as a dose-dependent manner, from 1.25 mg/kg to 12.5 mg/kg, in acute inflammatory models (carrageen and egg-albumin induced rat hind paw edema). It also elicited significant anti-inflammatory activity in chronic inflammatory models (cotton pellet granuloma and Freund's adjuvant induced polyarthritis in rat). In cotton pellet granuloma test, the extract exhibited the inhibitory effect of 23 and 57% at the dose of 6.25 and 12.5 mg/kg, respectively. In Freund's adjuvant induced model, the treatment of the extract of 1.25, 6.25 and 12.5 mg/kg showed the inhibitory effect of 23, 56 and 66% at 8 days, respectively. In the acetic acid-induced model, the extract significantly reduced abdominal writhing in mice when compared to the control group, reducing the mean number of writhing from $41{\pm}2$ in the control group to $17{\pm}3$ and $15{\pm}2$ at the dose of 6.25 and 12.5 mg/kg. From these experiments, the extract, which was extracted from the combination of Bacopa monnieriis, Cassia fistula and Phyllanthus polyphyllus, (w/w/w = 1/2/1) is surprisingly found a significant analgesic and anti-inflammatory activity.

• Advances in Traditional Medicine
• /
• 제7권2호
• /
• pp.121-127
• /
• 2007

Curcumin, a dietary pigment responsible for the yellow color of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti- inflammatory, anti-tumor, anti-oxidant, and anti-viral activity. In order to examine the potency of the curcumin in inflammation we used carrageenan induced rat hind paw odema model. As curcumin is practically water insoluble, it is hypothesized that pharmacological activity of curcumin could be improved by enhancing its water solubility. Water soluble complexes of curcumin with cyclodextrins were prepared and screened for greater solubility. Pure curcumin 100 mg/kg body weight along with curcumin complexes equivalent to 100 mg/kg body weight of pure curcumin were tested for the anti-inflammatory activity in Wister rats male rats using carrageenan induced hind paw edema model and compared with that of the reference compound diclofenac sodium at a dose level of 10 mg/kg body weight. Results were statistically analyzed using ANOVA. All the treatment groups showed statistically significant anti-inflammatory activity compared with that of vehicle control and positive control.

• 동의생리병리학회지
• /
• 제36권3호
• /
• pp.89-93
• /
• 2022

Earthing, caused by direct skin contact with the Earth's surface, is used to reduce the symptoms of inflammation (fever, fever, swelling and pain). However, there is little evidence to support the anti-inflammatory effects of earthing mattresses. Therefore, this study was conducted to investigate whether anti-inflammatory effect of earthing mattress using an in vivo animal model. The anti - inflammatory effect was evaluated by measuring ear thickness and foot volume in 12-O-tetradecanoylphorbol-13 acetate (TPA) - induced ear edema and carrageenan - induced paw edema model, respectively. Balb/c mouse in carrageenan paw edema model showed significant anti - inflammatory effect in the group treated with earthing mattress for 4 hours or 24 hours for 3 days. For females, the anti-inflammatory effect was greater when the earthing mattress was added to the mattress than the mattress alone treatment. From the above results, it was found that the female responds more to the effect of the earthing as well as the mattress effect. In addition, when the male and female Balb/c mice were exposed to mattresses and earthing mattresses for 24 h for 3 days, respectively, the mattress and earthing mattresses showed significant inhibition of IL (Interleukin)-1β levels compared to the control. In the TPA ear edema model, Balb/c mouse showed significant anti - inflammatory effect in the group treated with the earthing mattress for 4 hours or 24 hours for 3 days. Both males and females showed more anti-inflammatory effects when they were exposed to earthing mattresses with mattresses added to the mattresses. From the above results, it was found that both male and female respond to the effect of earthing as well as the mattress effect in the TPA ear edema model. In conclusion, in this study, we have verified that earthing mattress shows inhibitory effects on TPA and carrageenan-induced inflammation. From these results, it is suggested that the anti-inflammatory effect can be expected by applying the earthing mattress to patients suffering from inflammatory diseases. However, there is a need to pinpoint exactly how the earthing mattress relieves inflammation, and further research is needed to investigate the mechanism.

• Journal of the korean society of oceanography
• /
• 제37권1호
• /
• pp.20-26
• /
• 2002

The offshore extension of the East Korean Warm Current (EKWC) mostly turns anti-cyclonically around the Ulleung Warm Eddy (UWE). This fact needs to be dynamically explained because a rectilinear stream past a circular cylinder is normally expected to have a flow pattern symmetric about the stream axis. For this purpose, a simple analytical model is presented in this paper. This model shows that the EKWC's tendency to be anti-cyclonic around the UWE is due to the anti cyclonic circulation generated around the UWE. This tendency results from the geostrophic adjustment between the UWE and the ambient EKWC water. As the strength of the UWE decreases, relative to the EKWC, this model shows that the flow pattern gradually changes from circular to rectilinear.

• 한국해양공학회지
• /
• 제22권4호
• /
• pp.84-89
• /
• 2008

It is hard to find experimental data for a model test of small high-speed planning boats. It is difficult to verify the performance seen in a model test for a high-speed boat because the ship-model scale-ratio is very small and the flow velocity of the circulating water channel and the X-carriage speed of the towing tank are restricted. Therefore most hull-form designs for high-speed small boats depend on the sea-trial test result for similar boats or evaluation through numerical calculations. This study investigated the anti-rolling effect of the stern sub-body in a 50-knot doss planning boat. To carry out this work, new model test procedures were set up in the actual sea. Using this method, the anti-rolling effect of the stern sub-body was investigated. A stern sub-body attached to a planning boat was proved to be effective in reducing the roll and pitch angle.

• 한국군사과학기술학회지
• /
• 제14권4호
• /
• pp.639-647
• /
• 2011

In this paper, we have designed the Anti-Aircraft Artillery(AAA) model for the surface-to-air virtual engagement. The AAA model for the virtual combat simulation needs to detect the present target and estimate the target flight trajectory to find the aiming point. To find collision point of projectile fired from the artillery with the moving air target, we have presented the estimating technique for artillery aiming point. And we have analyzed the target probability of kill using Calton Hit function. Anti-air threat envelops are presented when the target velocity, position and the arrangement of four AAA are varying. Then we have compared the analyzed result using developed model with AEM model of MSA program.