• 동의신경정신과학회지
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• 제8권1호
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• pp.81-93
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• 1997

In order to investigate the anti-stress effect of Hyangbujapalmultnag in immobilization stress rats, the change of body weight, and, the humoral and cellular immune response were measured.The following results were obtained.1. The decrease of the body weight was significantly inhibited in test group, comparing with the control group.2 In the plaque fomation test, the number of the plaque in the control group was decreased but, the decreased in test group was significantly inhibited, comparing with the control group.3. In the hemagglutination titer, the control group was decreased on the serum antibody titer, but, the decreased in test group was significantly inhibited, comparing with the control group.4. In the footpad swelling response, the differences between the control and test group were not shown.

• 대한한의학회지
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• 제22권3호
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• pp.129-140
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• 2001

Objectives : The aim of this study was to evaluate the effects of Punsimgi-eum(fenxingi-yin) in rat model of depression induced by chronic mild stress (CMS). Methods : The change of the consumption of sucrose solution was measured, and the open field test and passive avoidance conditioning test were performed to investigate the anti-depressive effect of Punsimgi-eum(fenxingi-yin). Results : The results were as follows; I. The consumption of sucrose solution was significantly reversed in the test group at 5, 7 and 8 weeks, but there was no significant change in the control group. 2. There was no significant change of body weight after 8 weeks in each group 3. In the open field test, there was significant increase of exploratory activity in the test group. 4. In the passive avoidance test, the test group showed differences in the maintenance of retention from the control group at the 2-week training-testing interval. Conclusions : The present results suggest that Punsimgi-eum(fenxingi-yin) has an anti-depressive effect.

• Composites Research
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• 제16권5호
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• pp.21-27
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• 2003

선형 압전 이론(theory of linear piezoelectricity)을 이용하여 면외전단 충격(anti-plane shear impact)을 받는 기능경사 압전 세라믹(functionally graded piezoelectric ceramic)의 중앙에 존재하는 균열(central crack)의 동적 응답에 대해 연구한다. 기능경사 압전재료의 물성치(material property)는 두께방향을 따라 연속적으로 변한다고 가정한다. 라플라스 변환(Laplace transform)과 푸리에 변환(Fourier transform)을 사용하여 두 쌍의 복합적분 방정식을 구성하며, 이를 제2종 Fredholm 적분 방정식(Fredholm integral equations of the second kind)으로 표현한다. 재료 물성치의 변화도(gradient of material properties)와 전기하중(electric loading)의 영향을 보기 위해 동응력세기계수(dynamic stress intensity factor)에 대한 수치 결과를 제시하였다.

• 동의신경정신과학회지
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• 제17권3호
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• pp.57-65
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• 2006

Objectives: The purpose of this research is to investigate the effects of Benson's Relaxation Technique on autonomic nervous system for normal subjects with Heart Rate Variability(HRV) and find out relationship with anti - stress effects. Methods: First, Benson's Relaxation Technique was applied on 5 normal subjects for three weeks. Then HRV was examined for 15 minutes Benson's Relaxation Technique application. Next, Benson's Relaxation Technique each 8 times was applied on 5 normal subjects for 1 weeks. Then :HRV was examined each 5 minutes before and after Benson's Relaxation Technique application. Results: 1. SDNN, SDSD increased continuously in HRV for three weeks Benson's Relaxation Technique application. 2. Mean HRV, SDNN, SDSD were significant different in HRV between before and after Benson's Relaxation Technique application at fourth week. Conclusion: The results suggest that Benson's Relaxation Technique application have shown anti-stress effects and the more Benson's Relaxation Technique is repeated, the more effective.

• 한국압력기기공학회 논문집
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• 제7권4호
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• pp.51-56
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• 2011

Steam generator is one of the main equipments that affect safety and long term operation in nuclear power plants. Fluid flows inside and outside of the steam generator tubes and induces vibration. To prevent the vibration the tubes are supported by AVB (anti vibration bar). When the steam generator tube contact to AVB, it is damaged by the accumulation of wear and corrosion. Therefore studies are required to determine the effects of the gap between the steam generator tube and AVB. In order to obtain the stress and the displacement distributions of the steam generator tube, three dimensional finite element analyses were performed by using the commercial program ANSYS. Using the calculated the stress and the displacement distributions, the static residual strength of the steam generator tube can be evaluated. The results show that the stress and displacement of the steam generator tube increase significantly compared with the results from a zero-gap model.

• 생약학회지
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• 제50권2호
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• pp.96-101
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• 2019

Methanol extract of Helianthus tuberosus L. (Compositae) flower was investigated to research the anti-oxidative activity by using a Caenorhabditis elegans model system. Ethyl acetate soluble fraction of the methanol extract showed the most potent DPPH radical scavenging activity. The ethyl acetate fraction was measured on its activities of superoxide dismutase (SOD), catalase, and oxidative stress tolerance with reactive oxygen species (ROS) level in C. elegans. Furthermore, in order to verify if regulation of stress-response gene is responsible for the increased stress tolerance of C. elegans which treated by the ethyl acetate fraction, we checked SOD-3 expression using a transgenic strain. Consequently, the ethyl acetate fraction of H. tuberosus flower increased the catalase and SOD activities in a dose-dependent manner in C. elegans, reduced ROS accumulation dose-dependently. Besides, the ethyl acetate fraction-treated CF1553 worms showed higher SOD-3::GFP intensity than the control group.

• 대한의생명과학회지
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• 제26권4호
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• pp.249-255
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• 2020

Radiation therapy is one of the primary options for the treatment of malignant tumors. Even though it is an effective anti-cancer treatment, it can cause serious complications owing to radiation-induced damage to the normal tissue around the tumor. It was recently reported that normal stem cell response to the genotoxic stress of ionizing radiation can boost the therapeutic effectiveness of radiation by repairing damaged cells. Therefore, we focused on annexin A-1 (ANXA1), one of the genes induced by low-dose irradiation, and assessed whether it can protect adipose-derived stem cells (ADSCs) against oxidative stress-induced damage caused by low-dose irradiation and improve effectively cell survival. After confirming ANXA1 expression in ADSCs transfected with an ANXA1 expression vector, exposure to hydrogen peroxide (H2O2) was used to mimic cellular damage induced by a chronic oxidative environment to assess cell survival under oxidative conditions. ANXA1-transfected ADSCs demonstrated that increased viability compared with un-transfected cells and exhibited enhanced anti-oxidative properties. Taken together, these results suggest that ANXA1 could be used as a potential therapeutic target to improve the survival of stem cells after low-dose radiation treatment.

• Geomechanics and Engineering
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• 제29권6호
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• pp.683-696
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• 2022

Dams are inevitably planned to be built on thick overburden with high permeability and deformability. The connection part between concrete cut-off wall in overburden and earth core in dam body is not only a key part of the anti-seepage system, but also a weak position. Large uneven settlement will be aroused at the concoction part. However, the interaction behavior and the scope of the connection part cannot be determined effectively. In this paper, numerical analysis of a high earth core dam built on thick overburden was carried out with large deformation FE method. The mechanical behavior of the connection part was detail studied. It can be drawn that there is little differences in dam integral deformation for different analysis method, but big differences were found at the connection part. The large deformation analysis method can reasonably describe the process that concrete wall penetrates into soil. The high plasticity clay has stronger ability to adapt to large uneven deformation which can reduce stress level, and stress state of concrete wall is also improved. The scope of high plasticity clay zone in the connection part can be determined according to stress level of soils and penetration depth of concrete wall.

• 한국응용과학기술학회지
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• 제35권3호
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• pp.975-984
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• 2018

마치현 추출물에 대한 생리활성 소재로서 응용 가능성을 확인하고자 하였다. 마치현 추출물의 측정 결과, 플라보노이드, 폴리페놀 함량과 DPPH radical 소거능을 확인하였으며, 세포실험 결과 HaCaT, RAW 264.7, RBL-2H3 세포에서 유의한 세포독성은 나타나지 않았으며. $H_2O_2$에 의한 유발되는 산화적 스트레스에 대한 HaCaT 세포는 마치현 에탄올 $100{\mu}g/mL$ 농도에서 83% 보호효과가 확인되었다. RAW 264.7 세포에 대한 마치현 추출물의 항염 효과를 확인 결과 저농도에서도 nitric oxide 생성이 억제되었으며, S. aureus, S. epidermidis, P. acnes 균에서도 마치현 추출물의 농도 의존적으로 항균 활성이 확인되었다. 본 연구는 마치현 추출물의 항산화, 항염증 및 항균 효과를 가지는 생리 활성 물질로서 활용 가능성을 확인하였다.

• 한국식품영양과학회지
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• 제32권6호
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• pp.942-947
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• 2003

장미(Rosa multiflora) 열매 추출물 1.0%, 3.0% 및 5.0%를 주재로 하여 개발한 기능성 스트레스 해소 요구르트 음료(RFEY-1.0, RFEY-3.0, RFEY-5.0 groups)로써 동물실험으로서 Communication box를 사용하여 사회ㆍ심리적 스트레스를 유발한 다음, 스트레스의 지표물질로서 혈액중의 코르티코스테론(CS)의 분비량 및 뇌조직의 노르아드레날린(NA)의 분비량과 대사산물로서 MHPG-SO$_4$의 생성량 및 NA/MHPG-SO$_4$ ratio를 분석하여 장미 열매 추출물을 주재로 한 항스트레스 요구르트 음료의 항스트레스효과(anti-stress effect)를 평가하였다. 스트레스 자극에 의해 증가하는 것으로 혈액 중에 분비되는 CS의 분비량은 RFEY-1.0, RFEY-3.0, RFEY-5.0의 투여그룹에서는 대조그룹 대비 각각 11.7%, 16.0%, 24.7%의 CS의 분비량이 유의적으로 감소하였다. 또한 스트레스 자극에 의하여 뇌조직에서 분비되는 NA의 분비량을 비교하여 보면 장미 요구르트 음료 RFEY-1.0, RFEY-3.0, RFEY-5.0의 투여그룹에서는 대조그룹 대비 각각 15.6%, 25.0%, 40.8%나 유의적으로 증가하였다. 뇌조직에서 NA의 대사산물로서 스트레스 자극에 의하여 증가되는 것으로 알려진 MHPG-SO$_4$의 생성량은 대조그룹 대비 각각 17.0%, 25.3%, 28.4%나 유의적으로 감소하였다. 또한 스트레스 자극에 의하여 감소되기 때문에 스트레스 지표(stress index)로서 널리 사용되고 있는 NA/MHPG-SO$_4$ ratio도 대조그룹 대비 RFEY-1.0, RFEY-3.0, RFEY-5.0의 투여그룹은 각각 39.5%, 67.3% 및 96.3%의 유의적인 증가효과가 인정되었다. 이상의 실험 결과를 종합해 볼 때 장미열매 추출물을 주재로 한 장미 요구르트의 항스트레스작용은 매우 효과적일 것으로 기대된다.