• 대한의생명과학회지
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• 제11권2호
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• pp.89-101
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• 2005

Obesity is increasing worldwide and has become a major health burden in Western societies affecting every third American and every fifth European. Obesity makes a major contribution to morbidity and mortality, predisposing individuals to cardiovascular disease and diabetes. Many new substances are currently being investigated for their usefulness in the pharmacotherapy of obesity. Most anti-obesity drugs can be divided into four groups: those that reduce food intake; those that alter metabolism; those that increase thermogenesis; and those that regulate hormone involved in feeding behavior. In this article we review these and other agents available in various countries for the treatment of obesity. Perhaps more importantly, we have focussed on areas of potential productivity in the future. Over the last 5 or so years, this impetus in obesity research has provided us with exciting new drugs targets involved in the regulation of feeding behavior and cellular mechanism involved in energy expenditure. Recent development in the quest for control of human obesity include the discovery of hormones, neuropeptides, receptors and transcription factors involved in feeding behavior, metabolic rate and adipocyte development. For developing new, perhaps even more specific pharmacological agents, further research is needed to understand the individual different genetic and physiological basis of obesity. It remains the hope of research scientists that in the not too distant future we shall see a new class of anti-obesity drugs arising logically from the molecular biology revolutions.

• 아동학회지
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• 제29권5호
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• pp.79-96
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• 2008

This study analyzed differences of role behaviors of participants in bullying according to bystanders' characteristics. Participants were 112 $5^{th}$, $6^{th}$ and $7^{th}$ grade students. Bystanders' characteristics of empathy, negative attitudes about bullying, psychological burden, distorting of consequences, and attribution of blame were classified by K-Means Cluster Analysis into three groups with similar characteristics : lack of empathy/cognitive distorting, anti-bullying, and perception of cost groups. Major findings were that : the lack of empathy/cognitive distorting group had higher levels of bullying behavior than the anti-bullying group and higher levels of victimization than the perception of cost group. The anti-bullying group showed higher levels of defense behavior than the lack of empathy/cognitive distorting group. Implications for future research were discussed.

• 대한기계학회논문집A
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• 제26권10호
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• pp.2172-2179
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• 2002

In this paper, we examine the dynamic electromechanical behavior of an edge crack in a piezoelectric ceramic layer bonded between two elastic layers under the combined anti-plane mechanical shear and in-plane electric transient loadings. We adopted both the permeable and impermeable crack boundary conditions. Fourier transforms are used to reduce the problem to the solution of two pairs of dual integral equations, which are then expressed to a Fredholm integral equation of the second kind. Numerical values on the dynamic energy release rate are presented to show the dependences upon the geometry, material combination, electromechanical coupling coefficient and electric field.

• 가족자원경영과 정책
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• 제7권1호
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• pp.77-89
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• 2003

This study examines factors to influence consumers’reliability, and satisfactions for consumer anti-site, and willingness to visit that site again among consumers utilizing anti-sites. According to the results of this study, first, male, consumers utilizing electronic commerce were more likely to visit anti-site. Consumers were more likely to write their own message and reply other consumers’message in anti-site when they have purpose to complain about their dissatisfaction regarding the process of purchase behavior. Second, consumer's satisfaction is higher in cases of consumers having higher recognition of necessity of anti-site, visiting not required to affiliate the members of anti-site, and being reliable sites. Third, consumers were more likely to use anti-site again when they had higher recognition in the necessity of anti-site and were more satisfied. Finally, in order to facilitate the utilization of anti-sites, those solutions include systematic classification and management of writings listed in the site, active management of the site managers, solutions for criticisms on the writings listed and lack of objectivity of information provided, and active searches for solutions rather than listing of writings on discontents and resistance.

• 대한한의학회지
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• 제36권1호
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• pp.9-21
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• 2015

Objectives: Realgar has been frequently used for skin disorders in history of herbal medicine. However, the efficacy of realgar has not been examined in atopic dermatitis(AD). In this study, the effects of realgar on AD were investigated, especially on pruritus and inflammation. Methods: AD lesions were induced in the shaved backs of BALB/c mice through repeated application of DNCB. The mice were treated for 11 days with 1% realgar ($100{\mu}L/day$). Histological changes in skin thickness were observed. The anti-pruritic effects of realgar were evaluated by the change in numbers of scratching behavior of mice and expression of substance P. The expressions of cytokines IL-4 and IL-6 were measured. Also, anti-inflammatory effects of realgar were examined on expressions of NF-${\kappa}B$, phospho-$I{\kappa}B{\alpha}$ and mitogen-activated protein kinases (MAPKs). Results: Realgar decreased skin thickness (both dermal and epidermal) 38% and 17% respectively, compared to positive control, DNCB group. The scratching behavior of mice was reduced by 42% and expression of substance P was significantly less. Cytokines IL-4 and IL-6 were significantly reduced by 52.6% and 77.6%, respectively. The expressions of NF-${\kappa}B$, phospho-$I{\kappa}B{\alpha}$ and MAPKs (phospho-ERK1/2, -p38 and -JNK) were significantly suppressed with marked effects on phospho-ERK1/2. Conclusions: The collective results suggest that realgar shows anti-pruritic and anti-inflammatory effects on AD. And realgar might be a potential therapeutic candidate for treatment of atopic dermatitis.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.446-449
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• 1997

Yard cranes are very useful equipments for handling of heavy containers. But rope-driven yard cranes must have a little of sway and skew motion because ropes arc passive mechanical device. So many researches have been concentrated on anti-sway algorithm controlling trolley speed. But control algorithm of trolley speed is not practical in windy weather. In this paper, we are going to propose a new structure for anti-sway. This structure uses aux. :opes. The control strategy with auxiliary rope is very useful to sway control of yard crane because rope length is shorter than quay-sidc container cranes. In this paper, we derive cquatlons of motion of trolley system which have anti-sway controller to use auxiliary rope. And we propose the control strategy and analyse the behavior of the proposed system.

• 생약학회지
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• 제44권1호
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• pp.60-69
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• 2013

The worldwide prevalence and severity of allergic diseases including atopic and contact dermatitis has increased dramatically over the past decade, especially in developed countries. Mast cells are important effector cells in allergic reactions. The purpose of this study was undertaken to investigate the anti-allergic and anti-pruritic effects of Diospyros lotus leaf extract (DLE). DLE was prepared by extracting with distilled water. In the present study, we investigated the effect of DLE on the production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\alpha}$) and histamine in rat peritoneal mast cells (RPMCs), and on the skin lesion, leukocyte infiltration and scratching behavior in mice. Phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 significantly increased TNF-${\alpha}$ and IL-$1{\beta}$ production compared with media control. However, TNF-${\alpha}$ and IL-6 production increased by PMA plus A23187 treatment were significantly inhibited by DLE in a dose-dependent manner. DLE also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. Moreover, DLE administration had an inhibitory effects on the scratching behavior induced by pruritogen (compound 48/80, histamine) in ICR mice. Furthermore, DLE inhibited the skin lesions, inflammatory and mast cells in hairless mice sensitized by 2,4-dinitrofluorobenzene (DNFB). DLE administration reduced the IL-4 and IgE production induced by DNFB sensitization in hairless mice. These results suggest that DLE has a potential use as a herb medicine for treatment against allergy and pruritus-related disease.

• 대한가정학회지
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• 제46권3호
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• pp.103-116
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• 2008

With increasing of communication technology in cyber-space, the space of consumer complain behavior moved from off-line to on-line, so called anti-site. No researches, however, really have done how the anti-sites worked for promoting consumer rights through consumer complain behaviors in cyber space. The purpose of this research was to give some suggestions for activating anti-site for promoting consumer rights. For this purpose, questionnaire on-line survey was conducted from April, 12 to 24, 2004. And 143 samples, who were visiting anti-site during survey period, were selected. Main findings were as following: First, visitors had rather positive confidence with informations in anti-sites. Second, visitors thought that anti-sites were working rather well in implementing consumer movement by sharing their experiences, and by supporting complaining space in cyber. Visitors, however, thought that anti-sites were not working well as a space for companies, not by giving their attentions on consumers' complains. Third, the satisfaction level of visitors was found to be rather high in terms of informations in anti-sites, and to be rather low in terms of companies' attentions on anti-sites and management of anti-sites. Based on results, some suggestions of activating anti-site for promoting consumer rights were as following: First, visitors should not only get information, but support new and useful informations for others. And also it was suggested that visitors should join consumer movement through anti-site actively. Second, companies should pay attentions on anti-sites for their sake because anti-sites could give very useful information improving customer satisfaction, and finally reducing cost and increasing profit.

• 한국간호교육학회지
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• 제10권2호
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• pp.229-238
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• 2004

This study was conducted to identify the factors affecting smoking cessation behavior of the university student smokers for developing the effective smoking cessation program. For this purpose, data were collected from 64 students registrated at the university health center for anti-smoking acupuncture through May, 2003. Data were analyzed with percentile, mean, t-test, ANOVA, pearson correlation by SPSS/PC program. The results were as follows ; There was significant relationship in the scores on perceived benefits(t=-2.05, p=.045), chance-health locus of control(t=-2.28, p=.026) and nicotine dependence (t=-1.96, p=.056) according to the grade. And also there was significant increase in the nicotine dependence in the higher grades. There were significant positive relationship between external locus of control and perceived benefits(r=.389, p=.001), perceived barriers and benefits(r=.457, p=.000), and significant negative relationship between the daily life activities and perceived barriers(r=-.350, p=.005). From these results, it can be concluded that the effective smoking cessation program could be considered of perceived benefits & barriers, and nicotine dependence to promote anti-smoking behavior for university student smokers.

• KIEE International Transactions on Electrophysics and Applications
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• 제4C권1호
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• pp.31-34
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• 2004

This paper presents the fabrication and testing of a two-way pressure regulation micro shunt valve with an anti-siphon effect that can be implanted in hydrocephalus patients. This micro shunt valve consists of a silicone rubber membrane and a valve seat for the opening pressure control as well as the anti-siphon behavior. The two-way pressure regulation and the anti-siphon effect of the micro shunt valve are verified experimentally for various sizes of membranes and valve seats.